Skip NavigationSkip to Content
Return Return to Search Results

Anthropometric Measures, Body Mass Index, and Pancreatic Cancer A Pooled Analysis From the Pancreatic Cancer Cohort Consortium (PanScan)

  1. Author:
    Arslan, A. A.
    Helzlsouer, K. J.
    Kooperberg, C.
    Shu, X. O.
    Steplowski, E.
    Bueno-de-Mesquita, H. B.
    Fuchs, C. S.
    Gross, M. D.
    Jacobs, E. J.
    LaCroix, A. Z.
    Petersen, G. M.
    Stolzenberg-Solomon, R. Z.
    Zheng, W.
    Albanes, D.
    Amundadottir, L.
    Bamlet, W. R.
    Barricarte, A.
    Bingham, S. A.
    Boeing, H.
    Boutron-Ruault, M. C.
    Buring, J. E.
    Chanock, S. J.
    Clipp, S.
    Gaziano, J. M.
    Giovannucci, E. L.
    Hankinson, S. E.
    Hartge, P.
    Hoover, R. N.
    Hunter, D. J.
    Hutchinson, A.
    Jacobs, K. B.
    Kraft, P.
    Lynch, S. M.
    Manjer, J.
    Manson, J. E.
    McTiernan, A.
    McWilliams, R. R.
    Mendelsohn, J. B.
    Michaud, D. S.
    Palli, D.
    Rohan, T. E.
    Slimani, N.
    Thomas, G.
    Tjonnel, A.
    Tobias, G. S.
    Trichopoulos, D.
    Virtamo, J.
    Wolpin, B. M.
    Yu, K.
    Zeleniuch-Jacquotte, A.
    Patel, A. V.

  2. Author Address

    [Arslan, Alan A.] NYU, Dept Obstet & Gynecol, Sch Med, New York, NY 10016 USA. [Arslan, Alan A.; Zeleniuch-Jacquotte, Anne] NYU, Dept Environm Med, Sch Med, New York, NY 10016 USA. [Arslan, Alan A.; Zeleniuch-Jacquotte, Anne] NYU, Inst Canc, New York, NY 10016 USA. [Helzlsouer, Kathy J.] Mercy Med Ctr, Prevent & Res Ctr, Baltimore, MD USA. [Kooperberg, Charles; LaCroix, Andrea Z.; McTiernan, Anne] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98104 USA. [Shu, Xiao-Ou; Zheng, Wei] Vanderbilt Univ, Dept Med, Div Epidemiol, Vanderbilt Epidemiol Ctr, Nashville, TN USA. [Shu, Xiao-Ou; Zheng, Wei] Vanderbilt Univ, Vanderbilt Ingram Canc Ctr, Nashville, TN USA. [Steplowski, Emily] Informat Management Serv Inc, Silver Spring, MD USA. [Bueno-de-Mesquita, H. Bas] Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven, Netherlands. [Bueno-de-Mesquita, H. Bas] Univ Med Ctr Utrecht, Dept Gastroenterol & Hepatol, Utrecht, Netherlands. [Fuchs, Charles S.; Wolpin, Brian M.] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. [Fuchs, Charles S.; Giovannucci, Edward L.; Hankinson, Susan E.; Hunter, David J.; Wolpin, Brian M.] Brigham & Womens Hosp, Channing Lab, Boston, MA 02115 USA. [Gaziano, J. Michael] Brigham & Womens Hosp, Div Prevent Med, Phys Hlth Study, Boston, MA 02115 USA. [Gaziano, J. Michael] Brigham & Womens Hosp, Div Aging, Phys Hlth Study, Boston, MA 02115 USA. [Gaziano, J. Michael] Brigham & Womens Hosp, Div Cardiovasc Med, Phys Hlth Study, Boston, MA 02115 USA. [Manson, JoAnn E.] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA. [Buring, Julie E.] Harvard Univ, Sch Med, Dept Ambulatory Care & Prevent, Boston, MA USA. [Gross, Myron D.] Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA. [Jacobs, Eric J.; Patel, Alpa V.] Amer Canc Soc, Dept Epidemiol, Atlanta, GA 30329 USA. [Petersen, Gloria M.; Bamlet, William R.] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA. [McWilliams, Robert R.] Mayo Clin, Dept Oncol, Coll Med, Rochester, MN USA. [Stolzenberg-Solomon, Rachael Z.; Albanes, Demetrius; Amundadottir, Laufey; Chanock, Stephen J.; Hartge, Patricia; Hoover, Robert N.; Hutchinson, Amy; Jacobs, Kevin B.; Mendelsohn, Julie B.; Thomas, Gilles; Tobias, Geoffrey S.; Yu, Kai] NCI, Div Canc Epidemiol & Genet, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA. [Amundadottir, Laufey; Chanock, Stephen J.] NCI, Lab Translat Genom, Div Canc Epidemiol & Genet, NIH,Dept Hlth & Human Serv, Bethesda, MD 20892 USA. [Lynch, Shannon M.] NCI, Div Canc Control & Populat Sci, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA. [Barricarte, Aurelio] CIBER Epidemiol & Salud Publ, Barcelona, Spain. [Barricarte, Aurelio] Publ Hlth Inst Navarra, Pamplona, Spain. [Bingham, Sheila A.] Univ Cambridge, MRC Ctr Nutr & Canc, Cambridge, England. [Boeing, Heiner] German Inst Human Nutr, Potsdam, Nuthetal, Germany. [Boutron-Ruault, Marie-Christine] INSERM, Villejuif, France. [Boutron-Ruault, Marie-Christine] Inst Gustave Roussy, Villejuif, France. [Clipp, Sandra] George W Comstock Ctr Publ Hlth Res & Prevent, Hagerstown, MD USA. [Gaziano, J. Michael] Harvard Univ, Sch Publ Hlth, Massachusetts Vet Epidemiol Res & Informat Ctr, Vet Affairs Boston Healthcare Syst, Boston, MA 02115 USA. [Giovannucci, Edward L.] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA. [Giovannucci, Edward L.; Hankinson, Susan E.; Hunter, David J.; Kraft, Peter; Manson, JoAnn E.; Trichopoulos, Ditnitrios] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. [Kraft, Peter] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA. [Hutchinson, Amy; Jacobs, Kevin B.] NCI, Core Genotyping Facil, Adv Technol Program, SAIC Frederick Inc, Frederick, MD 21701 USA. [Jacobs, Kevin B.] Bioinformed Consulting Serv LLC, Gaithersburg, MD USA. [Manjer, Jonas] Malmo Univ Hosp, Dept Surg, Malmo, Sweden. [Michaud, Dominique S.] Univ London Imperial Coll Sci Technol & Med, Div Epidemiol Publ Hlth & Primary Care, London, England. [Palli, Domenico] Canc Res & Prevent Inst, Mol & Nutr Epidemiol Unit, Florence, Italy. [Rohan, Thomas E.] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA. [Slimani, Nadia] Int Agcy Res Canc, F-69372 Lyon, France. [Tjonneland, Anne] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark. [Trichopoulos, Ditnitrios] Univ Athens, Sch Med, Dept Hyg & Epidemiol, Athens, Greece. [Virtamo, Jarmo] Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland.;Arslan, AA, NYU, Dept Obstet & Gynecol, Sch Med, 550 1st Ave,TH 528, New York, NY 10016 USA.;alan.arslan@nyumc.org
    1. Year: 2010
    2. Date: May
  2. Journal: Archives of Internal Medicine
    1. 170
    2. 9
    3. Pages: 791-802
  4. Type of Article: Article
  5. ISSN: 0003-9926
  1. Abstract:

    Background: Obesity has been proposed as a risk factor for pancreatic cancer. Methods: Pooled data were analyzed from the National Cancer Institute Pancreatic Cancer Cohort Consortium (PanScan) to study the association, between prediagnostic anthropometric measures and risk of pancreatic cancer. PanScan applied a nested case-control study design and included 2170 cases and 2209 control subjects. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression for cohort-specific quartiles of body mass index (BMI [calculated as weight in kilograms divided by height in meters squared]), weight, height, waist circumference, and waist to hip ratio as well as conventional BMI categories (underweight, <18.5; normal weight, 18.5-24.9; overweight, 25.0-29.9; obese, 30.0-34.9; and severely obese, >= 35.0). Models were adjusted for potential confounders. Results: In all of the participants, a positive association between increasing BMI and risk of pancreatic cancer was observed (adjusted OR for the highest vs lowest BMI guartile, 1.33; 95% Cl, 1.12-1.58; P-trend<.001). In men, the adjusted OR for pancreatic cancer for the highest vs lowest quartile of BMI was 1.33 (95% Cl, 1.04-1.69; P-trend<.03), and in women it was 1.34 (95% Cl, 1.05-1.70; P-trend=.01). Increased waist to hip ratio was associated with increased risk of pancreatic cancer in women (adjusted OR for the highest vs lowest quartile, 1.87; 95% Cl, 1.31-2.69; P-trend=.003) but less so in men. Conclusions: These findings provide strong support for a positive association between BMI and pancreatic cancer risk. In addition, centralized fat distribution may increase pancreatic cancer risk, especially in women. Arch Intern Med. 2010;170(9):791 -802

    See More

  1. Keywords:

External Sources

  1. View record in Web of Science®
  2. WOS: 000277357800009

Library Notes

  1. Fiscal Year: FY2009-2010
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel