Skip NavigationSkip to Content
Return Return to Search Results

Interferon-alpha Produces Significant Decreases in HIV Load

  1. Author:
    Tavel, J. A.
    Huang, C. Y.
    Shen, J.
    Metcalf, J. A.
    Dewar, R.
    Shah, A.
    Vasudevachari, M. B.
    Follmann, D. A.
    Herpin, B.
    Davey, R. T.
    Polis, M. A.
    Kovacs, J.
    Masur, H.
    Lane, H. C.

  2. Author Address

    [Tavel, Jorge A.; Huang, Chiung-Yu; Shen, Jean; Metcalf, Julia A.; Follmann, Dean A.; Herpin, Betsey; Polis, Michael A.] NIAID, Div Clin Res, NIH, Bethesda, MD 20892 USA. [Davey, Richard T.; Lane, H. Clifford] NIAID, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA. [Kovacs, Joseph; Masur, Henry] NIH, Dept Crit Care Med, Warren Grant Magnuson Clin Ctr, Bethesda, MD 20892 USA. [Dewar, Robin; Shah, Akram; Vasudevachari, M. B.] Sci Applicat Int Corp, Frederick, MD USA.;Tavel, JA, NIAID, Div Clin Res, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.;jtavel@niaid.nih.gov
    1. Year: 2010
    2. Date: Jul
  2. Journal: Journal of Interferon and Cytokine Research
    1. 30
    2. 7
    3. Pages: 461-464
  4. Type of Article: Article
  5. ISSN: 1079-9907
  1. Abstract:

    A randomized, controlled clinical trial was started in the pre-HAART era to compare the efficacy of zidovudine (AZT) and interferon-alpha (IFN-alpha) either alone or in combination to reduce HIV viremia, maintain CD4(+) cell count, and decrease time to AIDS progression and death. The purpose of the current study was to compare the effects of AZT and IFN on HIV load using modern technology. One hundred and eighty patients with CD4(+) counts above 500 cells/mm(3) were randomized to receive AZT alone, IFN-alpha alone, or AZT and IFN-alpha in combination. CD4(+) cell count and HIV load at baseline and at the last follow-up visit were compared, and time to AIDS or death was calculated by treatment group. At a mean follow-up of 45 weeks, the mean change in log HIV RNA was -0.06 for the AZT alone group, -0.47 for the AZT plus IFN-alpha group (P = 0.01 versus AZT group), and -0.35 for the IFN-alpha alone group (P = 0.02 versus AZT group). There was no significant difference among groups in change in total CD4(+) count or in time to AIDS or death. Since treatment with IFN-alpha produces significant decreases in HIV load, additional studies of IFN-alpha as part of a combination regimen are warranted.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1089/jir.2009.0090
  3. View record in Web of Science®
  4. WOS: 000279850900001

Library Notes

  1. Fiscal Year: FY2009-2010
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel