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Enantioselective biocatalytic reactions on (+/-)-aryl alkyl ketones with native and modified porcine pancreatic lipase

  1. Author:
    Husain, M.
    Kumar, V.
    Kumar, R.
    Shakil, N. A.
    Sharma, S. K.
    Prasad, A. K.
    Olsen, C. E.
    Gupta, R. K.
    Malhotra, S. V.
    Van Der Eycken, E.
    Depass, A. L.
    Levon, K.
    Parmar, V. S.

  2. Author Address

    [Husain, Mofazzal; Kumar, Vineet; Kumar, Rajesh; Shakil, Najam A.; Sharma, Sunil K.; Prasad, Ashok K.; Parmar, Virinder S.] Univ Delhi, Dept Chem, Bioorgan Lab, Delhi 110007, India. [Husain, Mofazzal; Gupta, Rajendra K.] GGSIP Univ, Sch Biotechnol, Delhi, India. [Husain, Mofazzal; Van Der Eycken, Erik] Katholieke Univ Leuven, Dept Chem, LOMAC, Louvain, Belgium. [Kumar, Vineet; Malhotra, Sanjay V.] NCI, Lab Synthet Chem, Dev Therapeut Program Support, Frederick, MD 21701 USA. [Olsen, Carl E.] Univ Copenhagen, Fac Life Sci, Dept Nat Sci, Frederiksberg, Denmark. [Depass, Anthony L.] Long Isl Univ, Dept Biol, Brooklyn, NY USA. [Levon, Kalle] Polytech Univ, Dept Chem, Brooklyn, NY 11201 USA. [Shakil, Najam A.] Indian Agr Res Inst, Div Agr Chem, New Delhi 110012, India.;Parmar, VS, Univ Delhi, Dept Chem, Bioorgan Lab, Delhi 110007, India.;virparmar@gmail.com
    1. Year: 2010
    2. Date: Jun
  2. Journal: Biocatalysis and Biotransformation
    1. 28
    2. 3
    3. Pages: 172-184
  4. Type of Article: Article
  5. ISSN: 1024-2422
  1. Abstract:

    Porcine pancreatic lipase (PPL), pre-incubated with acetophenone in tetrahydrofuran, fails to recognize ortho- and para acyloxy functions with respect to the nuclear carbonyl group in (+/-)-2,4-diacyloxyphenyl alkyl ketones and produces novel aryl alkyl ketones in moderate-to-highly optically active forms; this result supports the hypothesis on the mechanism of action of PPL in deacylation reactions on peracylated polyphenolics.

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External Sources

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  2. DOI: 10.3109/10242421003734704
  3. View record in Web of Science®
  4. WOS: 000280098700003

Library Notes

  1. Fiscal Year: FY2009-2010
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