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The Ev-O-Derived Cell Line Df-1 Supports the Efficient Replication of Avian Leukosis-Sarcoma Viruses and Vectors

  1. Author:
    Schaeferklein, J.
    Givol, I.
    Barsov, E. V.
    Whitcomb, J. M.
    Vanbrocklin, M.
    Foster, D. N.
    Federspiel, M. J.
    Hughes, S. H.

  2. Author Address

    Hughes SH NCI FREDERICK CANC RES & DEV CTR RETROVIRAL REPLICAT & VECTOR DESIGN SECT FREDERICK, MD 21702 USA NCI FREDERICK CANC RES & DEV CTR RETROVIRAL REPLICAT & VECTOR DESIGN SECT ABL BASIC RES PROGRAM FREDERICK, MD 21702 USA MAYO CLIN & MAYO FDN PROGRAM MOL MED ROCHESTER, MN 55905 USA VIROLOG INC S SAN FRANCISCO, CA 94080 USA UNIV MINNESOTA DEPT ANIM SCI ST PAUL, MN 55108 USA
    1. Year: 1998
  2. Journal: Virology
    1. 248
    2. 2
    3. Pages: 305-311
  4. Type of Article: Article
  1. Abstract:

    The lack of a well-behaved permanent, adherent, nontransformed chicken cell line has made some experiments with avian leukosis-sarcoma viruses (ASLV) and vectors considerably more difficult. The EV-O-derived line, DF-I, supports the efficient replication of subgroups (A), (B), and (C) ASLV, as well as amphotrophic murine leukemia virus and an ASLV-derived vector that has its env gene derived from the env gene from an amphotrophic murine leukemia virus. The cell line responds appropriately to the expression of a transforming oncogene (v-myc) to a growth suppressor gene [p21(wail)] and can be sorted (using FAGS) ii infected by an ASLV vector that expresses GFP. (C) 1998 Academic Press. [References: 13]

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