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IL28B Polymorphism Does Not Determine Outcomes of Hepatitis B Virus or HIV Infection

  1. Author:
    Martin, M. P.
    Qi, Y.
    Goedert, J. J.
    Hussain, S. K.
    Kirk, G. D.
    Hoots, W. K.
    Buchbinder, S.
    Carrington, M.
    Thio, C. L.

  2. Author Address

    [Kirk, Gregory D.; Thio, Chloe L.] Johns Hopkins Univ, Baltimore, MD 21205 USA. [Martin, Maureen P.; Qi, Ying; Carrington, Mary] NCI, Canc & Inflammat Program, Expt Immunol Lab, SAIC Frederick, Frederick, MD 21701 USA. [Goedert, James J.] NCI, Infect & Immunoepidemiol Branch, Div Canc Epidemiol & Genet, Rockville, MD USA. [Hoots, W. Keith] NHLBI, Div Blood Dis & Resources, Bethesda, MD 20892 USA. [Hussain, Shehnaz K.] Univ Calif Los Angeles, Los Angeles, CA USA. [Buchbinder, Susan] Univ Calif San Francisco, San Francisco, CA 94143 USA.;Thio, CL, Johns Hopkins Univ, 855 N Wolfe St,Ste 520, Baltimore, MD 21205 USA.;cthio@jhmi.edu
    1. Year: 2010
    2. Date: Dec
  2. Journal: Journal of Infectious Diseases
    1. 202
    2. 11
    3. Pages: 1749-1753
  4. Type of Article: Article
  5. ISSN: 0022-1899
  1. Abstract:

    An IL28B haplotype strongly determines the outcome of natural and interferon-alpha treated hepatitis C virus (HCV) infection. To assess whether the polymorphism marking the haplotype (rs12979860) also affects other interferon-alpha responsive chronic viral illnesses, namely hepatitis B virus (HBV) and human immunodeficiency virus (HIV) type 1 infections, we genotyped 226 individuals with HBV persistence, 384 with HBV recovery, and 2548 with or at high risk for HIV infection. The C/C genotype of rs12979860 was not associated with HBV recovery (odds ratio, 0.99), resistance to HIV infection (odds ratio, 0.97), or HIV disease progression (P>1.05). This IL28B single-nucleotide polymorphism affects the immune response to HCV but not to HBV or HIV.

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External Sources

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  2. DOI: 10.1086/657146
  3. View record in Web of Science®
  4. WOS: 000283799900019

Library Notes

  1. Fiscal Year: FY2010-2011
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