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The Major Genetic Determinants of HIV-1 Control Affect HLA Class I Peptide Presentation

  1. Author:
    Pereyra, F. P.
    Jia, X. M.
    McLaren, P. J.
    Telenti, A.
    de Bakker, P. I. W.
    Walker, B. D.
    Ripke, S.
    Brumme, C. J.
    Pulit, S. L.
    Carrington, M.
    Kadie, C. M.
    Carlson, J. M.
    Heckerman, D.
    Graham, R. R.
    Plenge, R. M.
    Deeks, S. G.
    Gianniny, L.
    Crawford, G.
    Sullivan, J.
    Gonzalez, E.
    Davies, L.
    Camargo, A.
    Moore, J. M.
    Beattie, N.
    Gupta, S.
    Crenshaw, A.
    Burtt, N. P.
    Guiducci, C.
    Gupta, N.
    Gao, X. J.
    Qi, Y.
    Yuki, Y.
    Piechocka-Trocha, A.
    Cutrell, E.
    Rosenberg, R.
    Moss, K. L.
    Lemay, P.
    O'Leary, J.
    Schaefer, T.
    Verma, P.
    Toth, I.
    Block, B.
    Baker, B.
    Rothchild, A.
    Lian, J.
    Proudfoot, J.
    Alvino, D. M. L.
    Vine, S.
    Addo, M. M.
    Allen, T. M.
    Altfeld, M.
    Henn, M. R.
    Le Gall, S.
    Streeck, H.
    Haas, D. W.
    Kuritzkes, D. R.
    Robbins, G. K.
    Shafer, R. W.
    Gulick, R. M.
    Shikuma, C. M.
    Haubrich, R.
    Riddler, S.
    Sax, P. E.
    Daar, E. S.
    Ribaudo, H. J.
    Agan, B.
    Agarwal, S.
    Ahern, R. L.
    Allen, B. L.
    Altidor, S.
    Altschuler, E. L.
    Ambardar, S.
    Anastos, K.
    Anderson, B.
    Anderson, V.
    Andrady, U.
    Antoniskis, D.
    Bangsberg, D.
    Barbaro, D.
    Barrie, W.
    Bartczak, J.
    Barton, S.
    Basden, P.
    Basgoz, N.
    Bazner, S.
    Bellos, N. C.
    Benson, A. M.
    Berger, J.
    Bernard, N. F.
    Bernard, A. M.
    Birch, C.
    Bodner, S. J.
    Bolan, R. K.
    Boudreaux, E. T.
    Bradley, M.
    Braun, J. F.
    Brndjar, J. E.
    Brown, S. J.
    Brown, K.
    Brown, S. T.
    Burack, J.
    Bush, L. M.
    Cafaro, V.
    Campbell, O.
    Campbell, J.
    Carlson, R. H.
    Carmichael, J. K.
    Casey, K. K.
    Cavacuiti, C.
    Celestin, G.
    Chambers, S. T.
    Chez, N.
    Chirch, L. M.
    Cimoch, P. J.
    Cohen, D.
    Cohn, L. E.
    Conway, B.
    Cooper, D. A.
    Cornelson, B.
    Cox, D. T.
    Cristofano, M. V.
    Cuchural, G.
    Czartoski, J. L.
    Dahman, J. M.
    Daly, J. S.
    Davis, B. T.
    Davis, K.
    Davod, S. M.
    DeJesus, E.
    Dietz, C. A.
    Dunham, E.
    Dunn, M. E.
    Ellerin, T. B.
    Eron, J. J.
    Fangman, J. J. W.
    Farel, C. E.
    Ferlazzo, H.
    Fidler, S.
    Fleenor-Ford, A.
    Frankel, R.
    Freedberg, K. A.
    French, N. K.
    Fuchs, J. D.
    Fuller, J. D.
    Gaberman, J.
    Gallant, J. E.
    Gandhi, R. T.
    Garcia, E.
    Garmon, D.
    Gathe, J. C.
    Gaultier, C. R.
    Gebre, W.
    Gilman, F. D.
    Gilson, I.
    Goepfert, P. A.
    Gottlieb, M. S.
    Goulston, C.
    Groger, R. K.
    Gurley, T. D.
    Haber, S.
    Hardwicke, R.
    Hardy, W. D.
    Harrigan, P. R.
    Hawkins, T. N.
    Heath, S.
    Hecht, F. M.
    Henry, W. K.
    Hladek, M.
    Hoffman, R. P.
    Horton, J. M.
    Hsu, R. K.
    Huhn, G. D.
    Hunt, P.
    Hupert, M. J.
    Illeman, M. L.
    Jaeger, H.
    Jellinger, R. M.
    John, M.
    Johnson, J. A.
    Johnson, K. L.
    Johnson, H.
    Johnson, K.
    Joly, J.
    Jordan, W. C.
    Kauffman, C. A.
    Khanlou, H.
    Killian, R. K.
    Kim, A. Y.
    Kim, D. D.
    Kinder, C. A.
    Kirchner, J. T.
    Kogelman, L.
    Kojic, E. M.
    Korthuis, T.
    Kurisu, W.
    Kwon, D. S.
    LaMar, M.
    Lampiris, H.
    Lanzafame, M.
    Lederman, M. M.
    Lee, D. M.
    Lee, J. M. L.
    Lee, M. J.
    Lee, E. T. Y.
    Lemoine, J.
    Levy, J. A.
    Llibre, J. M.
    Liguori, M. A.
    Little, S. J.
    Liu, A. Y.
    Lopez, A. J.
    Loutfy, M. R.
    Loy, D.
    Mohammed, D. Y.
    Man, A.
    Mansour, M. K.
    Marconi, V. C.
    Markowitz, M.
    Marques, R.
    Martin, J. N.
    Martin, H. L.
    Mayer, K. H.
    McElrath, M. J.
    McGhee, T. A.
    McGovern, B. H.
    McGowan, K.
    McIntyre, D.
    McLeod, G. X.
    Menezes, P.
    Mesa, G.
    Metroka, C. E.
    Meyer-Olson, D.
    Miller, A. O.
    Montgomery, K.
    Mounzer, K. C.
    Nagami, E. H.
    Nagin, I.
    Nahass, R. G.
    Nelson, M. O.
    Nielsen, C.
    Norene, D. L.
    O'Connor, D. H.
    Ojikutu, B. O.
    Okulicz, J.
    Oladehin, O. O.
    Oldfield, E. C.
    Olender, S. A.
    Ostrowski, M.
    Owen, W. F.
    Pae, E.
    Parsonnet, J.
    Pavlatos, A. M.
    Perlmutter, A. M.
    Pierce, M. N.
    Pincus, J. M.
    Pisani, L.
    Price, L. J.
    Proia, L.
    Prokesch, R. C.
    Pujet, H. C.
    Ramgopal, M.
    Rathod, A.
    Rausch, M.
    Ravishankar, J.
    Rhame, F. S.
    Richards, C. S.
    Richman, D. D.
    Rodes, B.
    Rodriguez, M.
    Rose, R. C.
    Rosenberg, E. S.
    Rosenthal, D.
    Ross, P. E.
    Rubin, D. S.
    Rumbaugh, E.
    Saenz, L.
    Salvaggio, M. R.
    Sanchez, W. C.
    Sanjana, V. M.
    Santiago, S.
    Schmidt, W.
    Schuitemaker, H.
    Sestak, P. M.
    Shalit, P.
    Shay, W.
    Shirvani, V. N.
    Silebi, V. I.
    Sizemore, J. M.
    Skolnik, P. R.
    Sokol-Anderson, M.
    Sosman, J. M.
    Stabile, P.
    Stapleton, J. T.
    Starrett, S.
    Stein, F.
    Stellbrink, H. J.
    Sterman, F. L.
    Stone, V. E.
    Stone, D. R.
    Tambussi, G.
    Taplitz, R. A.
    Tedaldi, E. M.
    Theisen, W.
    Torres, R.
    Tosiello, L.
    Tremblay, C.
    Tribble, M. A.
    Trinh, P. D.
    Tsao, A.
    Ueda, P.
    Vaccaro, A.
    Valadas, E.
    Vanig, T. J.
    Vecino, I.
    Vega, V. M.
    Veikley, W.
    Wade, B. H.
    Walworth, C.
    Wanidworanun, C.
    Ward, D. J.
    Warner, D. A.
    Weber, R. D.
    Webster, D.
    Weis, S.
    Wheeler, D. A.
    White, D. J.
    Wilkins, E.
    Winston, A.
    Wlodaver, C. G.
    van't Wout, A.
    Wright, D. P.
    Yang, O. O.
    Yurdin, D. L.
    Zabukovic, B. W.
    Zachary, K. C.
    Zeeman, B.
    Zhao, M.
    Int, H. I. V. C. S.

  2. Author Address

    [Pereyra, Florencia; Walker, Bruce D.; Brumme, Chanson J.; Carrington, Mary; Piechocka-Trocha, Alicja; Cutrell, Emily; Rosenberg, Rachel; Moss, Kristin L.; Lemay, Paul; O'Leary, Jessica; Schaefer, Todd; Verma, Pranshu; Toth, Ildiko; Block, Brian; Baker, Brett; Rothchild, Alissa; Lian, Jeffrey; Proudfoot, Jacqueline; Alvino, Donna Marie L.; Vine, Seanna; Addo, Marylyn M.; Allen, Todd M.; Altfeld, Marcus; Le Gall, Sylvie; Streeck, Hendrik; Bazner, Suzane; Birch, Christopher; Bradley, Meg; Kwon, Douglas S.; Nagami, Ellen H.; Pae, Eunice; Rathod, Almas; Tsao, Alice; Ueda, Peggy; Zeeman, Beth] Massachusetts Inst Technol & Harvard, Massachusetts Gen Hosp, Regon Inst, Boston, MA USA. [Pereyra, Florencia; Kuritzkes, Daniel R.; Sax, Paul E.; Farel, Claire E.; Johnson, Jennifer A.; Liu, Anne Y.; McGowan, Katherine; Theisen, William] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Div Infect Dis, Boston, MA 02115 USA. [Jia, Xiaoming] Harvard Mit Div Hlth Sci & Technol, Boston, MA USA. [McLaren, Paul J.; de Bakker, Paul I. W.; Ripke, Stephan; Pulit, Sara L.; Plenge, Robert M.; Gianniny, Lauren; Crawford, Gabriel; Sullivan, Jordan; Gonzalez, Elena; Davies, Leela; Camargo, Amy; Moore, Jamie M.; Beattie, Nicole; Gupta, Supriya; Crenshaw, Andrew; Burtt, Noel P.; Guiducci, Candace; Gupta, Namrata; Henn, Matthew R.] Harvard & MIT, Broad Inst, Cambridge, MA USA. [McLaren, Paul J.; de Bakker, Paul I. W.; Pulit, Sara L.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Div Genet, Boston, MA 02115 USA. [Telenti, Amalio] Univ Lausanne, Inst Microbiol, Lausanne, Switzerland. [de Bakker, Paul I. W.] Univ Med Ctr Utrecht, Dept Med Genet, Div Biomed Genet, Utrecht, Netherlands. [de Bakker, Paul I. W.] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands. [Walker, Bruce D.] Howard Hughes Med Inst, Chevy Chase, MD USA. [Ripke, Stephan] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Ctr Human Genet Res,Dept Med, Boston, MA USA. [Gao, Xiaojiang; Qi, Ying; Yuki, Yuko] NCI, Canc & Inflammat Program, Expt Immunol Lab, SAIC Frederick, Frederick, MD 21701 USA. [Kadie, Carl M.] Microsoft Res, Redmond, WA USA. [Carlson, Jonathan M.; Heckerman, David] Microsoft Res, Los Angeles, CA USA. [Graham, Robert R.] Genentech Inc, San Francisco, CA 94080 USA. [Plenge, Robert M.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Div Rheumatol Immunol & Allergy, Boston, MA 02115 USA. [Deeks, Steven G.; Hecht, Frederick M.; Hunt, Peter; Lampiris, Harry; Levy, Jay A.; Martin, Jeffrey N.] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Haas, David W.] Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA. [Shafer, Robert W.] Stanford Univ, Palo Alto, CA 94304 USA. [Gulick, Roy M.] Cornell Univ, Weill Med Coll, New York, NY 10021 USA. [Shikuma, Cecilia M.] Univ Hawaii, John A Burns Sch Med, Hawaii Ctr AIDS, Honolulu, HI 96822 USA. [Haubrich, Richard; Little, Susan J.; Richman, Douglas D.; Taplitz, Randy A.] Univ Calif San Diego, San Diego, CA 92103 USA. [Riddler, Sharon] Univ Pittsburgh, Pittsburgh, PA USA. [Daar, Eric S.; Hardy, W. David; Yang, Otto O.] Univ Calif Los Angeles, Los Angeles, CA USA. [Ribaudo, Heather J.] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA. [Agan, Brian] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Agarwal, Shanu] Summa Hlth Syst, Akron, OH USA. [Allen, Brady L.; Lee, David M.] Uptown Phys Grp, Dallas, TX USA. [Altidor, Sherly; Metroka, Craig E.] St Lukes Roosevelt Hosp, New York, NY 10025 USA. [Altschuler, Eric L.; Mohammed, Debbie Y.] Univ Med & Dent New Jersey, New Jersey Med Sch, Univ Hosp, Newark, NJ 07103 USA. [Anastos, Kathryn] Montefiore Med Ctr, Albert Einstein Coll Med, Bronx, NY 10467 USA. [Anderson, Ben] St Leonards Med Ctr, St Leonards, NSW, Australia. [Anderson, Val; Andrady, Ushan] Ysbyty Gwynedd Hosp, Bangor, Gwynedd, Wales. [Antoniskis, Diana; Man, Alan; Rumbaugh, Elease] Kaiser Permanente, Portland, OR USA. [Barbaro, Daniel; Hupert, Mark J.; Johnson, Heather] Tarrant Cty Infect Dis Associates, Ft Worth, TX USA. [Bartczak, J.] Rowan Tree Med, Wilton Manors, FL USA. [Barton, Simon] Chelsea & Westminster Hosp, St Stephens Ctr, London, England. [Bellos, Nicholaos C.] SW Infect Dis Associates, Dallas, TX USA. [Berger, Judith] St Barnabas Hosp, Bronx, NY USA. [Bernard, Nicole F.] McGill Univ, Montreal Gen Hosp, Ctr Hlth, Res Inst, Montreal, PQ H3G 1A4, Canada. [Bernard, Annette M.] Thacker Thompson & Bernard, Atlanta, GA USA. [Bodner, Stanley J.] Vanderbilt Univ, Sch ofMedicine, Hermitage, TN USA. [Bolan, Robert K.] LA Gay & Lesbian Ctr, Los Angeles, CA USA. [Boudreaux, Emilie T.] Louisiana State Univ, Hlth Sci Ctr, Univ Med Ctr E Clin, Lafayatte, LA USA. [Braun, James F.] Callen Lorde Community Hlth Ctr, Phys Res Network, New York, NY USA. [Brndjar, Jon E.] Brndjar Med Associates, Allentown, PA USA. [Brown, Stephen J.] AIDS Res Alliance, Los Angeles, CA USA. [Brown, Katherine] David Powell Community Hlth Ctr, Austin, TX USA. [Brown, Sheldon T.] James J Peters VA Med Ctr, Bronx, NY USA. [Burack, Jedidiah] Sunrise Med Grp, Brooklyn, NY USA. [Bush, Larry M.] Univ Miami, Miller Sch Med, Lake Worth, FL USA. [Cafaro, Virginia] WellSpring Med Grp, San Francisco, CA USA. [Campbell, John] Moses Cone Hlth Syst, Greensboro, NC USA. [Carlson, Robert H.] HealthPartners Infect Dis, St Paul, MN USA. [Carmichael, J. Kevin] El Rio Special Immunol Associates, Tucson, AZ USA. [Casey, Kathleen K.; McIntyre, Dawn] Jersey Shore Univ, Med Ctr, Neptune, NJ USA. [Cavacuiti, Chris; Cornelson, Brian] St Michaels Hosp, Toronto, ON M5B 1W8, Canada. [Celestin, Gregory] PATH Ctr, Brooklyn Hosp Ctr, Brooklyn, NY USA. [Chambers, Steven T.] Univ Otago, Christchurch, New Zealand. [Chez, Nancy] HELP Project Samaritan, Bronx, NY USA. [Chirch, Lisa M.; Dunham, Eleanor; Joly, Jennifer] David E Rogers Ctr HIV AIDS Care, Southampton, NY USA. [Cimoch, Paul J.; Walworth, Charles] Ctr Special Immunol, Fountain Valley, CA USA. [Cohen, Daniel; Mayer, Kenneth Hugh] Fenway Community Hlth, Boston, MA USA. [Cohn, Lillian E.] 9th St Internal Med Associates, Philadelphia, PA USA. [Conway, Brian] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada. [Cooper, David A.] Natl Ctr HIV Epidemiol & Clin Res, Sydney, NSW, Australia. [Cox, David T.] Metro Infect Dis Consultants, Indianapolis, IN USA. [Cristofano, Michael V.] John H Stroger Hosp Cook Cty, Chicago, IL USA. [Cuchural, George, Jr.] New England Qual Care Alliance, Braintree, MA USA. [Czartoski, Julie L.; Lee, Jean M. L.; McElrath, M. Juliana] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [Dahman, Joseph M.] Desert AIDS Project, Palm Springs, CA USA. [Daly, Jennifer S.] Univ Massachusetts, Mem Med Ctr, Worcester, MA 01605 USA. [Davis, Kristine] Univ Iowa Hosp & Clin, Iowa City, IA 52242 USA. [DeJesus, Edwin] Orlando Immunol Ctr, Orlando, FL USA. [Dietz, Craig A.] Kansas City Free Hlth Clin, Kansas City, MO USA. [Ellerin, Todd B.] S Shore Hosp, Weymouth, MA USA. [Eron, Joseph J.; Menezes, Prema] Univ N Carolina, Chapel Hill, NC USA. [Fangman, John J. W.] AIDS Resource Ctr Wisconsin, Milwaukee, WI USA. [Ferlazzo, Helen; Stein, Francine] Visiting Nurse Assoc Cent New Jersey, Ctr Community Hlth, Asbury Pk, NJ USA. [Fidler, Sarah; Winston, Alan] Univ London Imperial Coll Sci Technol & Med, London, England. [Fleenor-Ford, Anita] Heartland Clin, Paducah, KY USA. [Frankel, Renee] Morristown Mem Hosp, Morristown, NJ USA. [Fuchs, Jonathan D.] San Francisco Dept Publ Hlth, San Francisco, CA USA. [Fuller, Jon D.; Skolnik, Paul R.] Boston Univ, Med Ctr, Boston, MA USA. [Gaberman, Jonna] Baystate Med Ctr, Springfield, MA USA. [Gallant, Joel E.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. [Gaultier, Cyril R.] Tower Infect Dis, Los Angeles, CA USA. [Gebre, Wondwoosen] Nassau Univ Med Ctr, E Meadow, NY USA. [Gilman, Frank D.; Kurisu, Wayne] Sharp Rees Stealy Med Ctr, San Diego, CA USA. [Gilson, Ian] Med Coll Wisconsin, Milwaukee, WI 53226 USA. [Goepfert, Paul A.; Heath, Sonya] Univ Alabama, Birmingham, AL USA. [Gottlieb, Michael S.] Synergy Hematol & Oncol, Los Angeles, CA USA. [Goulston, Claudia] Univ Utah, Salt Lake City, UT USA. [Groger, Richard K.] S Dayton Acute Care Consultants, Dayton, OH USA. [Haber, Stuart; Shay, William] St Vincents Hosp, New York, NY USA. [Hardwicke, Robin] Univ Texas Hlth Sci Ctr, Houston, TX USA. [Harrigan, P. Richard] British Columbia Ctr Excellence HIV AIDS, Vancouver, BC, Canada. [Hawkins, Trevor N.; Veikley, Wenoah] SW CARE Ctr, Santa Fe, NM USA. [Henry, W. Keith] Hennepin Cty Med Ctr, Minneapolis, MN 55415 USA. [Hladek, Melissa] Catholic Univ Amer, Sch Nursing, Washington, DC 20064 USA. [Hoffman, Robert P.] St Johns Mercy Med Ctr, Springfield, MA USA. [Horton, James M.] CMC Myers Pk Med Ctr, Charlotte, NC USA. [Hsu, Ricky K.; Liguori, Michael A.] NYU, Med Ctr, New York, NY 10016 USA. [Huhn, Gregory D.] Ruth M Rothshon Care Ctr, Chicago, IL USA. [Illeman, Mark L.] Feldman Med Grp, San Francisco, CA USA. [Jaeger, Hans] HIV Res & Clin Care Ctr, Munich, Germany. [Jellinger, Robert M.] Albany Med Coll, Albany, NY 12208 USA. [John, Mina] Murdoch Univ, Murdoch, WA 6150, Australia. [Johnson, Kay] Univ Cincinnati, Cincinnati, OH USA. [Jordan, Wilbert C.] OASIS Clin, Los Angeles, CA USA. [Kauffman, Carol A.] VA Ann Arbor Healthcare Syst, Ann Arbor, MI USA. [Khanlou, Homayoon] AIDS Healthcare Fdn, Los Angeles, CA USA. [Killian, Robert K.] Capitol Hill Med, Seattle, WA USA. [Kim, David D.] Astor Med Grp, New York, NY USA. [Kinder, Clifford A.] Kinder Med Grp, Miami, FL USA. [Kirchner, Jeffrey T.] Lancaster Gen Hosp, Lancaster, PA USA. [Kogelman, Laura; McGovern, Barbara H.] Tufts Med Ctr, Boston, MA USA. [Kojic, Erna Milunka] Brown Univ, Alpert Med Sch, Providence, RI 02912 USA. [Korthuis, Todd] Oregon Hlth & Sci Univ, Portland, OR 97201 USA. [Lanzafame, Massimiliano] GB Rossi Hosp, Verona, Italy. [Lederman, Michael M.] Case Western Reserve Univ, Cleveland, OH 44106 USA. [Lee, Marah J.] LifeWay, Ft Lauderdale, FL USA. [Lee, Edward T. Y.] St Claire Med Associate, Toronto, ON, Canada. [Lemoine, Janice] Greater Lawrence Family Hlth Ctr, Lawrence, MA USA. [Llibre, Josep M.] Hosp Badalona Germans Trias & Pujol, Barcelona, Spain. [Lopez, Alvaro J.] Infect Dis Consultants, Tucker, GA USA. [Loutfy, Mono R.; Ostrowski, Mario] Univ Toronto, Toronto, ON, Canada. [Loy, Dawn; Prokesch, Richard C.; Vega, Vilma M.] Infect Dis Associates, Sarasota, FL USA. [Marconi, Vincent C.] Emory Univ, Sch Med, Atlanta, GA USA. [Markowitz, Martin] Rockefeller Univ, Aaron Diamond AIDS Res Ctr, New York, NY 10021 USA. [Martin, Harold L., Jr.] Pk Nicollet Clin, St Louis, MN USA. [McGhee, Theresa A.] Absolute Care, Atlanta, GA USA. [Mcleod, Gavin X.] Columbia Univ, Coll Phys & Surg, New York, NY USA. [Mesa, Greg] Highland Med Associates, Hendersonville, NC USA. [Meyer-Olson, Dirk] Hannover Med Sch, Abt Klin Immunol, D-30623 Hannover, Germany. [Miller, Andy O.] Hosp Special Surg, New York, NY 10021 USA. [Mounzer, Karam C.] Philadelphia FIGHT, Philadelphia, PA USA. [Nagin, Iris] Lower E Side Serv Ctr, New York, NY USA. [Nielsen, Craig] Univ Colorado, Aurora, CO USA. [Norene, David L.] Sutter Med Grp, Sacramento, CA USA. [O'Connor, David H.; Sosman, James M.] Univ Wisconsin, Madison, WI USA. [Okulicz, Jason] Brooke Army Med Ctr, San Antonio, TX USA. [Oldfield, Edward C., III] Eastern Virginia Med Sch, Norfolk, VA 23501 USA. [Olender, Susan A.] Columbia Univ, Med Ctr, New York, NY USA. [Owen, William F., Jr.] CA Pacific Med Ctr, San Francisco, CA USA. [Parsonnet, Jeffrey] Dartmouth Hitchcock Med Ctr, Lebanon, NH 03766 USA. [Pavlatos, Andrew M.] St Joseph Hosp, Chicago, IL USA. [Pincus, Jonathan M.] Codman Sq Hlth Ctr, Dorchester, MA USA. [Pisani, Leandro; Rodriguez, Milagros; Saenz, Luis; Santiago, Steven] CARE Resource, Miami, FL USA. [Price, Lawrence Jay] Castro Mission Hlth Ctr, San Francisco, CA USA. [Proia, Laurie] Rush Med Coll, Chicago, IL 60612 USA. [Pujet, Heather Calderon] Boulder Community Hosp, Boulder, CO USA. [Ramgopal, Moti] Midway Immunol & Res Ctr, Ft Pierce, FL USA. [Rausch, Michael] Aerztezentrum Nollendorfpl, Berlin, Germany. [Ravishankar, J.] Suny Downstate Med Ctr, Brooklyn, NY 11203 USA. [Rhame, Frank S.] Clin 42, Minneapolis, MN USA. [Richards, Constance Shamuyarira] King Edward Mem Hosp, Paget, Bermuda. [Rodes, Berta] Hosp Carlos III, Fdn Invest Biomed, Madrid, Spain. [Rose, Richard C., III] Summit Med Grp, Knoxville, TN USA. [Rosenthal, Daniel] Med Consultants S Florida, Coral Springs, FL USA. [Ross, Polly E.] Western N Carolina Community Hlth Serv, Asheville, NC USA. [Rubin, David S.] New York Hosp, Queens Med Ctr, Flushing, NY USA. [Salvaggio, Michelle R.] Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA. [Sanchez, William C.] Georgetown Univ, Med Ctr, Washington, DC 20007 USA. [Sanjana, Veeraf M.] Village Care Hlth Ctr, New York, NY USA. [Schuitemaker, Hanneke; van't Wout, Angelique] Univ Amsterdam, Acad Med Ctr, NL-1105 AZ Amsterdam, Netherlands. [Sestak, Philip M.] St Pauls Hosp, Vancouver, BC V6Z 1Y6, Canada. [Shalit, Peter] Swedish Med Ctr, Seattle, WA USA. [Shirvani, Vivian N.] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA. [Silebi, Vanessa I.] Mercy Hosp, Miami, FL USA. [Sizemore, James M., Jr.] Univ Tennessee, Chattanooga, TN USA. [Sokol-Anderson, Marcia] St Louis Univ, St Louis, MO 63103 USA. [Stabile, Paul] William F Ryan Community Hlth Ctr, New York, NY USA. [Stapleton, Jack T.] Univ Iowa, Iowa City, IA USA. [Starrett, Sheree] Rivington House & Village Care, New York, NY USA. [Stellbrink, Hans-Jurgen] Infekt Med Ctr Hamburg, Hamburg, Germany. [Sterman, F. Lisa] Calif Pacific Med Ctr, San Francisco, CA USA. [Stone, David R.] Lemuel Shattuck Hosp, Boston, MA USA. [Tambussi, Giuseppe] Fdn San Raffaele Del Monte Tabor, Milan, Italy. [Tedaldi, Ellen M.] Temple Univ, Sch Med, Philadelphia, PA 19122 USA. [Torres, Richard] Yale Univ, Sch Med, Bridgeport, CT USA. [Tosiello, Lorraine] Jersey City Med Ctr, Jersey City, NJ USA. [Tremblay, Cecile] Univ Montreal, Montreal, PQ, Canada. [Tribble, Marc A.] Baylor Univ, Med Ctr, Dallas, TX USA. [Trinh, Phuong D.] Montgomery Infect Dis Associates, Silver Spring, MD USA. [Vaccaro, Anthony] Northwestern Univ, Chicago, IL 60611 USA. [Valadas, Emilia] Hosp Santa Maria, Fac Med Lisboa, Lisbon, Portugal. [Vanig, Thanes J.] Spectrum Med Grp, Phoenix, AZ USA. 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    1. Year: 2010
    2. Date: Dec
  2. Journal: Science
    1. 330
    2. 6010
    3. Pages: 1551-1557
  4. Type of Article: Article
  5. ISSN: 0036-8075
  1. Abstract:

    Infectious and inflammatory diseases have repeatedly shown strong genetic associations within the major histocompatibility complex (MHC); however, the basis for these associations remains elusive. To define host genetic effects on the outcome of a chronic viral infection, we performed genome-wide association analysis in a multiethnic cohort of HIV-1 controllers and progressors, and we analyzed the effects of individual amino acids within the classical human leukocyte antigen (HLA) proteins. We identified >300 genome-wide significant single-nucleotide polymorphisms (SNPs) within the MHC and none elsewhere. Specific amino acids in the HLA-B peptide binding groove, as well as an independent HLA-C effect, explain the SNP associations and reconcile both protective and risk HLA alleles. These results implicate the nature of the HLA-viral peptide interaction as the major factor modulating durable control of HIV infection.

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External Sources

  1. View Full Text
  2. DOI: 10.1126/science.1195271
  3. View record in Web of Science®
  4. WOS: 000285153500069

Library Notes

  1. Fiscal Year: FY2010-2011
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