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Importance of macrophage inflammatory protein-la and splenic macrophages in neurodegeneration induced by PVC-211 murine leukemia virus

  1. Author:
    Li, X. J.
    Zhang, X. A.
    Cmarik, J. L.
    Ruscetti, S.

  2. Author Address

    [Li, Xiujie; Zhang, Xiang; Cmarik, Joan L.; Ruscetti, Sandra] NCI, Lab Canc Prevent, Frederick, MD 21702 USA.;Ruscetti, S, NCI, Lab Canc Prevent, Bldg 567,Room 152, Frederick, MD 21702 USA.;ruscetts@mail.nih.gov
    1. Year: 2011
    2. Date: Jan
  2. Journal: Virology
    1. 409
    2. 2
    3. Pages: 198-203
  4. Type of Article: Article
  5. ISSN: 0042-6822
  1. Abstract:

    We recently reported that infection of rats with the neurodegenerative disease-causing retrovirus PVC-211 MuLV results in elevated levels of the chemokine MIP-1 alpha followed by the accumulation of activated microglia in the brain. To investigate the importance of MIP-1 alpha in recruitment of microglia to the brain, we treated rats with MIP-1 alpha antibodies before and after PVC-211 MuLV infection. This caused a delay in the development of paralysis which was associated with a decrease in activated microglia without affecting virus expression. To determine the source of activated microglia, rats were splenectomized 4 days after virus infection. Splenectomized rats showed a delay in disease development that was associated with decreased numbers of activated microglia without affecting virus expression. Together, these results suggest that MIP-1 alpha is directly involved in the neurodegeneration induced in rats by PVC-211 MuLV by recruiting macrophages/microglia from the periphery into regions of the brain that eventually become diseased. Published by Elsevier Inc.

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External Sources

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  2. DOI: 10.1016/j.virol.2010.10.012
  3. View record in Web of Science®
  4. WOS: 000286366800007

Library Notes

  1. Fiscal Year: FY2010-2011
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