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Biological evaluation of imidazolium- and ammonium-based salts as HIV-1 integrase inhibitors

  1. Author:
    Maddali, K.
    Kumar, V.
    March, C.
    Pommier, Y.
    Malhotra, S. V.

  2. Author Address

    [Maddali, Kasthuraiah; Marchand, Christophe; Pommier, Yves] NCI, Mol Pharmacol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA. [Kumar, Vineet; Malhotra, Sanjay V.] NCI, Lab Synthet Chem, SAIC Frederick Inc, Frederick, MD 21702 USA.;Pommier, Y, NCI, Mol Pharmacol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.;pommier@nih.gov malhotrasa@mail.nih.gov
    1. Year: 2011
    2. Date: Feb
  2. Journal: Medchemcomm
    1. 2
    2. 2
    3. Pages: 143-150
  4. Type of Article: Article
  5. ISSN: 2040-2503
  1. Abstract:

    Ammonium- and imidazolium-based ionic salts were studied for their application as inhibitors of HIV-1 integrase (IN). These compounds were active in the inhibition of both the 3'-processing (3'-P) and strand transfer (ST) steps of the integration reaction. A correlation of activity with chain length of the alkyl substituent in both classes of ionic salts was observed.

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External Sources

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  2. DOI: 10.1039/c0md00201a
  3. View record in Web of Science®
  4. WOS: 000288297100008

Library Notes

  1. Fiscal Year: FY2010-2011
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