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  1. 1.   Mutagenicity of N-ethyl-N-nitrosourea, N-methyl-N-nitrosourea, methyl methanesulfonate and ethyl methanesulfonate in the developing Syrian hamster fetus
  2. Donovan, P.; Smith, G.
  3. Mutation Research-Genetic Toxicology and Environmental Mutagenesis. 2010, Jun; 699(1-2): 55-57.
  1. 2.   In vitro comparison of O4-benzylfolate modulated, BCNU-induced toxicity in human bone marrow using CFU-GM and tumor cell lines
  2. Behrsing, H. P.; Furniss, M. J.; Robillard, K. A.; Tomaszewski, J. E.; Parchment, R. E.
  3. Cancer Chemotherapy and Pharmacology. 2010, May; 65(6): 1083-1091.
  1. 3.   Substitution of Aminomethyl at the Meta-Position Enhances the Inactivation of O-6-Alkylguanine-DNA Alkyltransferase by O-6-Benzylguanine
  2. Pauly, G. T.; Loktionova, N. A.; Fang, Q. M.; Vankayala, S. L.; Guida, W. C.; Pegg, A. E.
  3. Journal of Medicinal Chemistry. 2008 51(22): 7144-7153.
  1. 4.   Degradation of BRCA2 in Alkyltransferase-Mediated DNA Repair and Its Clinical Implications
  2. Philip, S.; Swaminathan, S.; Kuznetsov, S. G.; Kanugula, S.; Biswas, K.; Chang, S.; Loktionova, N. A.; Haines, D. C.; Kaldis, P.; Pegg, A. E.; Sharant, S. K.
  3. Cancer Research. 2008 68(23): 9973-9981.
  1. 5.   Potent inhibition of human apurinic/apyrimidinic endonuclease 1 by arylstibonic acids
  2. Seiple, L. A.; Cardellina, J. H.; Akee, R.; Stivers, J. T.
  3. Molecular Pharmacology. 2008 73(3): 669-677.
  1. 6.   Phase I trial of temozolomide plus O-6-benzylguanine for patients with recurrent or progressive malignant glioma
  2. Quinn, J. A.; Desjardins, A.; Weingart, J.; Brem, H.; Dolan, M. E.; Delaney, S. M.; Vredenburgh, J.; Rich, J.; Friedman, A. H.; Reardon, D. A.; Sampson, J. H.; Pegg, A. E.; Moschel, R. C.; Birch, R.; McLendon, R. E.; Provenzale, J. M.; Gururangan, S.; Dancey, J. E.; Maxwell, J.; Tourt-Uhlig, S.; Herndon, J. E.; Bigner, D. D.; Friedman, H. S.
  3. Journal of Clinical Oncology. 2005, OCT 1; 23(28): 7178-7187.
  1. 7.   A bifunctional DNA repair protein from Ferroplasma acidarmanus exhibits O-6-alkylguanine-DNA alkyltransferase and endonuclease V activities
  2. Kanugula, S.; Pauly, G. T.; Moschel, R. C.; Pegg, A. E.
  3. Proceedings of the National Academy of Sciences of the United States of America. 2005, MAR 8; 102(10): 3617-3622.
  1. 8.   Sensitization of pancreatic tumor xenografts to carmustine and temozolomide by inactivation of their O-6-methylguanine-DNA methyltransferase with O-6-benzylguanine or O-6-benzyl-2 '- deoxyguanosine
  2. Kokkinakis, D. M.; Ahmed, M. M.; Chendil, D.; Moschel, R. C.; Pegg, A. E.
  3. Clinical Cancer Research. 2003 9(10, Part 1): 3801-3807.
  1. 9.   O-6-benzylguanine-mediated enhancement of chemotherapy
  2. Friedman, H. S.; Keir, S.; Pegg, A. E.; Houghton, P. J.; Colvin, O. M.; Moschel, R. C.; Bigner, D. D.; Dolan, M. E.
  3. Molecular Cancer Therapeutics. 2002 1(11): 943-948.
  1. 10.   Phase II trial of carmustine plus O-6-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma
  2. Quinn, J. A.; Pluda, J.; Dolan, M. E.; Delaney, S.; Kaplan, R.; Rich, J. N.; Friedman, A. H.; Reardon, D. A.; Sampson, J. H.; Colvin, O. M.; Haglund, M. M.; Pegg, A. E.; Moschel, R. C.; McLendon, R. E.; Provenzale, J. M.; Gururangan, S.; Tourt-Uhlig, S.; Herndon, J. E.; Bigner, D. D.; Friedman, H. S.
  3. Journal of Clinical Oncology. 2002 20(9): 2277-2283.
  1. 11.   DNA adducts and liver DNA replication in rats during chronic exposure to N-nitrosodimethylamine (NDMA) and their relationships to the dose-dependence of NDMA hepatocarcinogenesis
  2. Souliotis, V. L.; Henneman, J. R.; Reed, C. D.; Chhabra, S. K.; Diwan, B. A.; Anderson, L. M.; Kyrtopoulos, S. A.
  3. Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis. 2002 500(1-2): 75-87.
  1. 12.   Debenzylation of O-6-benzyl-8-oxoguanine in human liver: implications for O-6-benzylguanine metabolism
  2. Long, L.; Moschel, R. C.; Dolan, M. E.
  3. Biochemical Pharmacology. 2001 61(6): 721-726.
  1. 13.   Thresholds of O-6-alkylguanine-DNA alkyltransferase which confer significant resistance of human glial tumor xenografts to treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea or temozolomide
  2. Kokkinakis, D. M.; Bocangel, D. B.; Schold, S. C.; Moschel, R. C.; Pegg, A. E.
  3. Clinical Cancer Research. 2001 7(2): 421-428.
  1. 14.   Inactivation of human O-6-alkylguanine-DNA alkyltransferase by modified oligodeoxyribonucleotides containing O-6-benzylguanine
  2. Pegg, A. E.; Goodtzova, K.; Loktionova, N. A.; Kanugula, S.; Pauly, G. T.; Moschel, R. C.
  3. Journal of Pharmacology and Experimental Therapeutics. 2001 296(3): 958-965.
  1. 15.   Mutagenesis by O-6-methyl-, O-6-ethyl-, and O-6-benzylguanine and O-4-methylthymine in human cells: Effects of O-6- alkylguanine-DNA alkyltransferase and mismatch repair
  2. Pauly, G. T.; Moschel, R. C.
  3. Chemical Research in Toxicology. 2001 14(7): 894-900.
  1. 16.   Phase I trial of carmustine plus O-6-benzylguanine for patients with recurrent or progressive malignant glioma
  2. Friedman, H. S.; Pluda, J.; Quinn, J. A.; Ewesuedo, R. B.; Long, L.; Friedman, A. H.; Cokgor, I.; Colvin, O. M.; Haglund, M. M.; Ashley, D. M.; Rich, J. N.; Sampson, J.; Pegg, A. E.; Moschel, R. C.; McLendon, R. E.; Provenzale, J. M.; Stewart, E. S.; Tourt-Uhlig, S.; Garcia-Turner, A. M.; Herndon, J. E.; Bigner, D. D.; Dolan, M. E.
  3. Journal of Clinical Oncology. 2000 18(20): 3522-3528.
  1. 17.   Plasma and cerebrospinal fluid pharmacokinetics of O-6- benzylguanine and analogues in nonhuman primates
  2. Long, L.; Berg, S. L.; Roy, S. K.; McCully, C. L.; Song-Yoo, H. W.; Moschel, R. C.; Balis, F. M.; Dolan, M. E.
  3. Clinical Cancer Research. 2000 6(9): 3662-3669.
  1. 18.   O-6-benzylguanine-mediated enhancement of nitrosourea activity in Mer(-) central nervous system tumor xenografts - implications for clinical trials
  2. Keir, S. T.; Dolan, M. E.; Pegg, A. E.; Lawless, A.; Moschel, R. C.; Bigner, D. D.; Friedman, H. S.
  3. Cancer Chemotherapy and Pharmacology. 2000 45(6): 437-440.
  1. 19.   Potentiation of BCNU antitumor efficacy by 9-substituted O-6-benzylguanines. Effect of metabolism
  2. Kokkinakis, D. M.; Moschel, R. C.; Pegg, A. E.; Schold, S. C.
  3. Cancer Chemotherapy and Pharmacology. 2000 45(1): 69-77.
  1. 20.   Phase I Trial of O-6-Benzylguanine For Patients Undergoing Surgery For Malignant Glioma
  2. Friedman, H. S.; Kokkinakis, D. M.; Pluda, J.; Friedman, A. H.; Cokgor, I.; Haglund, M. M.; Ashley, D. M.; Rich, J.; Dolan, M. E.; Pegg, A. E.; Moschel, R. C.; McLendon, R. E.; Kerby, T.; Herndon, J. E.; Bigner, D. D.; Schold, S. C.
  3. Journal of Clinical Oncology. 1998 16(11): 3570-3575.
  1. 21.   Reaction of O-6-Benzylguanine-Resistant Mutants of Human O-6-Alkylguanine-Dna Alkyltransferase With O-6-Benzylguanine in Oligodeoxyribonucleotides
  2. Pegg, A. E.; Kanugula, S.; Edara, S.; Pauly, G. T.; Moschel, R. C.; Goodtzova, K.
  3. Journal of Biological Chemistry. 1998 273(18): 10863-10867.
  1. 22.   O-6-Alkylguanine-Dna Alkyltransferase Inactivation By Ester Prodrugs of O-6-Benzylguanine Derivatives and Their Rate of Hydrolysis By Cellular Esterases
  2. Dolan, M. E.; Roy, S. K.; Garbiras, B. J.; Helft, P.; Paras, P.; Chae, M. Y.; Moschel, R. C.; Pegg, A. E.
  3. Biochemical Pharmacology. 1998 55(10): 1701-1709.
  1. 23.   Intraarterial O-6-Benzylguanine Enables the Specific Therapy of Nitrosourea-Resistant Intracranial Human Glioma Xenografts in Athymic Rats With 1,3-Bis(2-Chloroethyl)-1-Nitrosourea
  2. Kurpad, S. N.; Dolan, M. E.; McLendon, R. E.; Archer, G. E.; Moschel, R. C.; Pegg, A. E.; Bigner, D. D.; Friedman, H. S.
  3. Cancer Chemotherapy and Pharmacology. 1997 39(4): 307-316.
  1. 24.   Repair of O-6-Benzylguanine By the Escherichia Coli Ada and Ogt and the Human O6-Alkylguanine-Dna Alkyltransferases
  2. Goodtzova, K.; Kanugula, S.; Edara, S.; Pauly, G. T.; Moschel, R. C.; Pegg, A. E.
  3. Journal of Biological Chemistry. 1997 272(13): 8332-8339.
  1. 25.   Effect of Dna On the Inactivation of O-6-Alkylguanine-Dna Alkyltransferase By 9-Substituted O-6-Benzylguanine Derivatives
  2. Pegg, A. E.; Chung, L.; Moschel, R. C.
  3. Biochemical Pharmacology. 1997 53(10): 1559-1564.
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