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  1. 1.   Synthesis and Biological Evaluation of Highly Active 7-Anilino Triazolopyrimidines as Potent Antimicrotubule Agents
  2. Oliva, Paola; Romagnoli, Romeo; Cacciari, Barbara; Manfredini, Stefano; Padroni, Chiara; Brancale, Andrea; Ferla, Salvatore; Hamel,Ernest; Corallo, Diana; Aveic, Sanja; Milan, Noemi; Mariotto, Elena; Viola, Giampietro; Bortolozzi, Roberta
  3. Pharmaceutics. 2022, Jun 02; 14(6):
  1. 2.   A facile synthesis of diaryl pyrroles led to the discovery of potent colchicine site antimitotic agents
  2. Romagnoli, Romeo; Oliva, Paola; Salvador, Maria Kimatrai; Manfredini, Stefano; Padroni, Chiara; Brancale, Andrea; Ferla, Salvatore; Hamel,Ernest; Ronca, Roberto; Maccarinelli, Federica; Rruga, Fatlum; Mariotto, Elena; Viola, Giampietro; Bortolozzi, Roberta
  3. European Journal of Medicinal Chemistry. 2021, Mar 15; 214
  1. 3.   Interaction of diazonamide a with tubulin
  2. Bai,Ruoli; Cruz-Monserrate, Zobeida; Fenical, William; Pettit, George R; Hamel,Ernest
  3. Archives of biochemistry and biophysics. 2020, FEB 15; 680: 108217.
  1. 4.   Synthesis and biological evaluation of structurally diverse alpha-conformationally restricted chalcones and related analogues
  2. Maguire, Casey J.; Carlson, Graham J.; Ford, Jacob W.; Strecker, Tracy E.; Hamel,Ernest; Trawick, Mary Lynn; Pinney, Kevin G.
  3. MedChemComm. 2019, Aug 1; 10(8): 1445-1456.
  1. 5.   Synthesis and Evaluation of 1,5-Disubstituted Tetrazoles as Rigid Analogues of Combretastatin A-4 with Potent Antiproliferative and Antitumor Activity
  2. Romagnoli, R.; Baraldi, P. G.; Salvador, M. K.; Preti, D.; Tabrizi, M. A.; Brancale, A.; Fu, X. H.; Li, J.; Zhang, S. Z.; Hamel, E.; Bortolozzi, R.; Basso, G.; Viola, G.
  3. Journal of Medicinal Chemistry. 2012, Jan; 55(1): 475-488.
  1. 6.   Synthesis and Antitumor Molecular Mechanism of Agents Based on Amino 2-(3 ',4 ',5 '-Trimethoxybenzoyl)benzo[b]furan: Inhibition of Tubulin and Induction of Apoptosis
  2. Romagnoli, R.; Baraldi, P. G.; Lopez-Cara, C.; Cruz-Lopez, O.; Carrion, M. D.; Salvador, M. K.; Bermejo, J.; Estevez, S.; Estevez, F.; Balzarini, J.; Brancale, A.; Ricci, A.; Chen, L. C.; Kim, J. G.; Hamel, E.
  3. Chemmedchem. 2011, Oct; 6(10): 1841-1853.
  1. 7.   Synthesis, antiproliferative activity, and mechanism of action of a series of 2-{[(2E)-3-phenylprop-2-enoyl]amino}benzamides
  2. Raffa, D.; Maggio, B.; Plescia, F.; Cascioferro, S.; Plescia, S.; Raimondi, M. V.; Daidone, G.; Tolomeo, M.; Grimaudo, S.; Di Cristina, A.; Pipitone, R. M.; Bai, R.; Hamel, E.
  3. European Journal of Medicinal Chemistry. 2011, Jul; 46(7): 2786-2796.
  1. 8.   Antitumor Agents. 284. New Desmosdumotin B Analogues with Bicyclic B-Ring as Cytotoxic and Antitubulin Agents
  2. Nakagawa-Goto, K.; Wu, P. C.; Lai, C. Y.; Hamel, E.; Zhu, H.; Zhang, L. Y.; Kozaka, T.; Ohkoshi, E.; Goto, M.; Bastow, K. F.; Lee, K. H.
  3. Journal of Medicinal Chemistry. 2011, Mar; 54(5): 1244-1255.
  1. 9.   Synthesis and Discovery of Water-Soluble Microtubule Targeting Agents that Bind to the Colchicine Site on Tubulin and Circumvent Pgp Mediated Resistance
  2. Gangjee, A.; Zhao, Y.; Lin, L.; Raghavan, S.; Roberts, E. G.; Risinger, A. L.; Hamel, E.; Mooberry, S. L.
  3. Journal of Medicinal Chemistry. 2010, Nov; 53(22): 8116-8128.
  1. 10.   Synthesis and Cellular Pharmacology Studies of a Series of 2-amino-3-aroyl-4-substituted Thiophene Derivatives
  2. Romagnoli, R.; Baraldi, P. G.; Pavani, M. G.; Cruz-Lopez, O.; Hamel, E.; Balzarini, J.; Brognara, E.; Zuccato, C.; Gambari, R.
  3. Medicinal Chemistry. 2010, Nov; 6(6): 329-343.
  1. 11.   Synthesis and Evaluation of Haloacetyl, alpha-Bromoacryloyl and Nitrooxyacetyl Benzo[b]furan and Benzo[b]thiophene Derivatives as Potent Antiproliferative Agents Against Leukemia L1210 and K562 Cells
  2. Romagnoli, R.; Baraldi, P. G.; Carrion, M. D.; Cara, C. L.; Casolari, A.; Hamel, E.; Fabbri, E.; Gambari, R.
  3. Letters in Drug Design & Discovery. 2010, Aug; 7(7): 476-486.
  1. 12.   Substituted 2-(3 ',4 ',5 '-trimethoxybenzoyl)-benzo[b]thiophene derivatives as potent tubulin polymerization inhibitors
  2. Romagnoli, R.; Baraldi, P. G.; Carrion, M. D.; Cruz-Lopez, O.; Tolomeo, M.; Grimaudo, S.; Di Cristina, A.; Pipitone, M. R.; Balzarini, J.; Brancale, A.; Hamel, E.
  3. Bioorganic & Medicinal Chemistry. 2010, Jul; 18(14): 5114-5122.
  1. 13.   A boronic acid chalcone analog of combretastatin A-4 as a potent anti-proliferation agent
  2. Kong, Y. L.; Wang, K.; Edler, M. C.; Hamel, E.; Mooberry, S. L.; Paige, M. A.; Brown, M. L.
  3. Bioorganic & Medicinal Chemistry. 2010, Jan; 18(2): 971-977.
  1. 14.   Intracellular Activation and Deactivation of Tasidotin, an Analog of Dolastatin 15: Correlation with Cytotoxicity
  2. Bai, R.; Edler, M. C.; Bonate, P. L.; Copeland, T. D.; Pettit, G. R.; Luduena, R. F.; Hamel, E.
  3. Molecular Pharmacology. 2009 75(1): 218-226.
  1. 15.   A diaryl sulfide, sulfoxide, and sulfone bearing structural similarities to combretastatin A-4
  2. Barbosa, E. G.; Bega, L.; Beatriz, A.; Sarkar, T.; Hamel, E.; do Amaral, M. S.; de Lima, D. P.
  3. European Journal of Medicinal Chemistry. 2009 44(6): 2685-2688.
  1. 16.   Design and Synthesis of 2-(3-Benzo[b]thienyl)-6,7-methylenedioxyquinolin-4-one Analogues as Potent Antitumor Agents that Inhibit Tubulin Assembly
  2. Chang, Y. H.; Hsu, M. H.; Wang, S. H.; Huang, L. J.; Qian, K.; Morris-Natschke, S. L.; Hamel, E.; Kuo, S. C.; Lee, K. H.
  3. Journal of Medicinal Chemistry. 2009 52(15): 4883-4891.
  1. 17.   Enantioselective Synthesis of (+)-Chamaecypanone C: A Novel Microtubule Inhibitor
  2. Dong, S. W.; Hamel, E.; Bai, R. L.; Covell, D. G.; Beutler, J. A.; Porco, J. A.
  3. Angewandte Chemie-International Edition. 2009 48(8): 1494-1497.
  1. 18.   Design, synthesis and structure-activity relationship of 2-(3 ',4 ',5 '-trimethoxybenzoyl)-benzo[b]furan derivatives as a novel class of inhibitors of tubulin polymerization
  2. Romagnoli, R.; Baraldi, P. G.; Carrion, M. D.; Cara, C. L.; Cruz-Lopez, O.; Tolomeo, M.; Grimaudo, S.; Di Cristina, A.; Pipitone, M. R.; Balzarini, J.; Zonta, N.; Brancale, A.; Hamel, E.
  3. Bioorganic & Medicinal Chemistry. 2009 17(19): 6862-6871.
  1. 19.   Hybrid alpha-bromoacryloylamido chalcones. Design, synthesis and biological evaluation
  2. Romagnoli, R.; Baraldi, P. G.; Carrion, M. D.; Cruz-Lopez, O.; Cara, C. L.; Balzarini, J.; Hamel, E.; Canella, A.; Fabbri, E.; Gambari, R.; Basso, G.; Viola, G.
  3. Bioorganic & Medicinal Chemistry Letters. 2009 19(7): 2022-2028.
  1. 20.   Evolution of the total syntheses of ustiloxin natural products and their analogues
  2. Li, P. X.; Evans, C. D.; Wu, Y. Z.; Cao, B.; Hamel, E.; Joullie, M. M.
  3. Journal of the American Chemical Society. 2008 130(7): 2351-2364.
  1. 21.   Design, synthesis, and biological evaluation of thiophene analogues of chalcones
  2. Romagnoli, R.; Baraldi, P. G.; Carrion, M. D.; Cara, C. L.; Cruz-Lopez, O.; Preti, D.; Tolomeo, M.; Grimaudo, S.; Di Cristina, A.; Zonta, N.; Balzarini, J.; Brancale, A.; Sarkar, T.; Hamel, E.
  3. Bioorganic & Medicinal Chemistry. 2008 16(10): 5367-5376.
  1. 22.   Synthesis and Biological Evaluation of 2-aroyl-4-phenyl-5-hydroxybenzofurans as a New Class of Antitubulin Agents
  2. Romagnoli, R.; Baraldi, P. G.; Sarkar, T.; Cara, C. L.; Lopez, O. C.; Carrion, M. D.; Preti, D.; Tolomeo, M.; Balzarini, J.; Hamel, E.
  3. Medicinal Chemistry. 2008 4(6): 558-564.
  1. 23.   Arylthioindole inhibitors of tubulin polymerization. 3. Biological evaluation, structure-activity relationships and molecular modeling studies
  2. La Regina, G.; Edler, M. C.; Brancale, A.; Kandil, S.; Coluccia, A.; Piscitelli, F.; Hamel, E.; De Martino, G.; Matesanz, R.; Diaz, J. F.; Scovassi, A. I.; Prosperi, E.; Lavecchia, A.; Novellino, E.; Artico, M.; Silvestri, R.
  3. Journal of Medicinal Chemistry. 2007, Jun; 50(12): 2865-2874.
  1. 24.   The concise synthesis of chalcone, indanone and indenone analogues of combretastatin A4
  2. Kerr, D. J.; Hamel, E.; Jung, M. K.; Flynn, B. L.
  3. Bioorganic & Medicinal Chemistry. 2007, May; 15(9): 3290-3298.
  1. 25.   Development of two novel benzoylphenylurea sulfur analogues and evidence that the microtubule-associated protein tau is predictive of their activity in pancreatic cancer
  2. Jimeno, A.; Hallur, G.; Chan, A.; Zhang, X. F.; Cusatis, G.; Chan, F.; Shah, P.; Chen, R. B.; Hamel, E.; Garrett-Mayer, E.; Khan, S.; Hidalgo, M.
  3. Molecular Cancer Therapeutics. 2007, May; 6(5): 1509-1516.
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