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  1. 1.   Combination screen in multi-cell type tumor spheroids reveals interaction between aryl hydrocarbon receptor antagonists and E1 ubiquitin-activating enzyme inhibitor: Aryl-hydrocarbon receptor antagonist drug combinations
  2. Dexheimer,Tom; Coussens,Nathan; Silvers,Thomas; Jones,Eric; Chen,Lily; Fang, Jianwen; Morris, Joel; Moscow, Jeffrey A; Doroshow, James H; Teicher, Beverly A
  3. SLAS Discovery : advancing life sciences R & D. 2024, Oct 01; 29(7): 100186.
  1. 2.   Aminoflavone upregulates putative tumor suppressor miR-125b-2-3p to inhibit luminal A breast cancer stem cell-like properties
  2. Mavingire, Nicole; Campbell,Petreena; Liu, Tiantian; Wooten, Jonathan; Khan, Salma; Chen, Xin; Matthews, Jason; Wang, Charles; Brantley, Eileen
  3. Precision Clinical Medicine. 2022, Jun; 5(2): pbac008.
  1. 3.   A UVB-responsive common variant at chromosome band 7p21.1 confers tanning response and melanoma risk via regulation of the aryl hydrocarbon receptor, AHR
  2. Xu, Mai; Mehl, Lindsey; Zhang, Tongwu; Thakur, Rohit; Sowards, Hayley; Myers, Timothy; Jessop, Lea; Chesi, Alessandra; Johnson, Matthew E; Wells, Andrew D; Michael, Helen T; Bunda, Patricia; Jones, Kristine; Higson, Herbert; Hennessey, Rebecca C; Jermusyk, Ashley; Kovacs, Michael A; Landi, Maria Teresa; Iles, Mark M; Goldstein, Alisa M; Choi, Jiyeon; Chanock, Stephen J; Grant, Struan F A; Chari,Raj; Merlino, Glenn; Law, Matthew H; Brown, Kevin M
  3. American journal of human genetics. 2021, Sep 2; 108(9): 1611-1630.
  1. 4.   Diaryl disulfides and thiosulfonates as combretastatin A-4 analogues: Synthesis, cytotoxicity and antitubulin activity
  2. Khodyuk, Rejane Gonçalves Diniz; Bai,Ruoli; Hamel,Ernest; Lourenço, Estela Mariana Guimarães; Barbosa, Euzébio Guimarães; Beatriz, Adilson; Dos Santos, Edson Dos Anjos; de Lima, Dênis Pires
  3. Bioorganic chemistry. 2020, AUG; 101: 104017.
  1. 5.   Kynurenine 3-Monooxygenase Inhibition during Acute Simian Immunodeficiency Virus Infection Lowers PD-1 Expression and Improves Post-Combination Antiretroviral Therapy CD4+ T Cell Counts and Body Weight
  2. Swainson, Louise A; Ahn, Haelee; Pajanirassa, Priya; Khetarpal, Vinod; Deleage,Claire; Estes,Jake; Hunt, Peter W; Munoz-Sanjuan, Ignacio; McCune, Joseph M
  3. Journal of immunology (Baltimore, Md. : 1950). 2019, AUG 15; 203(4): 899-910.
  1. 6.   3-Aroyl-1,4-diarylpyrroles Inhibit Chronic Myeloid Leukemia Cell Growth through an Interaction with Tubulin
  2. La Regina, Giuseppe; Bai, Ruoli; Coluccia, Antonio; Famiglini, Valeria; Passacantilli, Sara; Naccarato, Valentina; Ortar, Giorgio; Mazzoccoli, Carmela; Ruggieri, Vitalba; Agriesti, Francesca; Piccoli, Claudia; Tataranni, Tiziana; Nalli, Marianna; Brancale, Andrea; Vultaggio, Stefania; Mercurio, Ciro; Varasi, Mario; Saponaro, Concetta; Sergio, Sara; Maffia, Michele; Coluccia, Addolorata Maria Luce; Hamel, Ernest; Silvestri, Romano
  3. ACS Medicinal Chemistry Letters. 2017, Apr 26; 8(5): 521-526.
  1. 7.   Plant Natural Products in Anticancer Drug Discovery
  2. Grothaus, P. G.; Cragg, G. M.; Newman, D. J.
  3. Current Organic Chemistry. 2010, Oct; 14(16): 1781-1791.
  1. 8.   The arylstibonic acid compound NSC13746 disrupts B-ZIP binding to DNA in living cells
  2. Heyerdahl, S. L.; Rozenberg, J.; Jamtgaard, L.; Rishi, V.; Varticovski, L.; Akah, K.; Scudiero, D.; Shoemaker, R. H.; Karpova, T. S.; Day, R. N.; McNally, J. G.; Vinson, C.
  3. European Journal of Cell Biology. 2010, Jul; 89(7): 564-573.
  1. 9.   Enantioselective biocatalytic reactions on (+/-)-aryl alkyl ketones with native and modified porcine pancreatic lipase
  2. Husain, M.; Kumar, V.; Kumar, R.; Shakil, N. A.; Sharma, S. K.; Prasad, A. K.; Olsen, C. E.; Gupta, R. K.; Malhotra, S. V.; Van Der Eycken, E.; Depass, A. L.; Levon, K.; Parmar, V. S.
  3. Biocatalysis and Biotransformation. 2010, Jun; 28(3): 172-184.
  1. 10.   12 Arylstibonic acids that inhibit the DNA binding of five B-ZIP dimers
  2. Rishi, V.; Oh, W. J.; Heyerdahl, S. L.; Zhao, J. F.; Scudiero, D.; Shoemaker, R. H.; Vinson, C.
  3. Journal of Structural Biology. 2010, May; 170(2): 216-225.
  1. 11.   Structural studies of series HIV-1 nonnucleoside reverse transcriptase inhibitors 1-(2,6-difluorobenzyl)-2-(2,6-difluorophenyl)-benzimidazoles with different 4-substituents
  2. Ziolkowska, N. E.; Michejda, C. J.; Bujacz, G. D.
  3. Journal of Molecular Structure. 2010, Mar; 966(1-3): 53-58.
  1. 12.   Natural product scaffolds as leads-to drugs
  2. Newman, D. J.; Cragg, G. M.
  3. Future Medicinal Chemistry. 2009, Nov; 1(8): 1415-1427.
  1. 13.   A diaryl sulfide, sulfoxide, and sulfone bearing structural similarities to combretastatin A-4
  2. Barbosa, E. G.; Bega, L.; Beatriz, A.; Sarkar, T.; Hamel, E.; do Amaral, M. S.; de Lima, D. P.
  3. European Journal of Medicinal Chemistry. 2009 44(6): 2685-2688.
  1. 14.   Novel Dithiolethione-Modified Nonsteroidal Anti-Inflammatory Drugs in Human Hepatoma HepG2 and Colon LS180 Cells
  2. Bass, S. E.; Sienkiewicz, P.; MacDonald, C. J.; Cheng, R.; Sparatore, A.; Del Soldato, P.; Roberts, D. D.; Moody, T. W.; Wink, D. A.; Yeh, G. C.
  3. Clinical Cancer Research. 2009 15(6): 1964-1972.
  1. 15.   Modulation of Carcinogen Metabolism by Nitric Oxide-Aspirin 2 Is Associated with Suppression of DNA Damage and DNA Adduct Formation
  2. MacDonald, C. J.; Cheng, R.; Roberts, D. D.; Wink, D. A.; Yeh, G. C.
  3. Journal of Biological Chemistry. 2009 284(33): 22099-22107.
  1. 16.   Novel Broad-Spectrum Bis-(Imidazolinylindole) Derivatives with Potent Antibacterial Activities against Antibiotic-Resistant Strains
  2. Panchal, R. G.; Ulrich, R. L.; Lane, D.; Butler, M. M.; Houseweart, C.; Opperman, T.; Williams, J. D.; Peet, N. P.; Moir, D. T.; Nguyen, T.; Gussio, R.; Bowlin, T.; Bavari, S.
  3. Antimicrobial Agents and Chemotherapy. 2009 53(10): 4283-4291.
  1. 17.   SYNTHESIS AND BIOLOGICAL EVALUATION OF INHIBITORS OF BOTULINUM NEUROTOXIN METALLOPROTEASE
  2. Wang, C. B.; Widom, J.; Petronijevic, F.; Burnett, J. C.; Nuss, J. E.; Bavari, S.; Gussio, R.; Wipf, P.
  3. Heterocycles. 2009 79: 487-520.
  1. 18.   Diketoacid-genre HIV-1 integrase inhibitors containing enantiomeric arylamide functionality
  2. Zhao, X. Z.; Maddali, K.; March, C.; Pommier, Y.; Burke, T. R.
  3. Bioorganic & Medicinal Chemistry. 2009 17(14): 5318-5324.
  1. 19.   Arylstibonic acids: Novel inhibitors and activators of human topoisomerase IB
  2. Kim, H.; Cardellina, J. H.; Akee, R.; Champoux, J. J.; Stivers, J. T.
  3. Bioorganic Chemistry. 2008 36(4-6): 190-197.
  1. 20.   Evolution of the total syntheses of ustiloxin natural products and their analogues
  2. Li, P. X.; Evans, C. D.; Wu, Y. Z.; Cao, B.; Hamel, E.; Joullie, M. M.
  3. Journal of the American Chemical Society. 2008 130(7): 2351-2364.
  1. 21.   The chemical defensome: Environmental sensing and response genes in the Strongylocentrotus purpuratus genome
  2. Goldstone, J. V.; Hamdoun, A.; Cole, B. J.; Howard-Ashby, M.; Nebert, D. W.; Scally, M.; Dean, M.; Epel, D.; Hahn, M. E.; Stegeman, J. J.
  3. Developmental Biology. 2006, Dec; 300(1): 366-384.
  1. 22.   The genome of the sea urchin Strongylocentrotus purpuratus
  2. Sodergren, E.; Weinstock, G. M.; Davidson, E. H.; Cameron, R. A.; Gibbs, R. A.; Weinstock, G. M.; Angerer, R. C.; Angerer, L. M.; Arnone, M. I.; Burgess, D. R.; Burke, R. D.; Cameron, R. A.; Coffman, J. A.; Davidson, E. H.; Dean, M.; Elphick, M. R.; Ettensohn, C. A.; Foltz, K. R.; Hamdoun, A.; Hynes, R. O.; Klein, W. H.; Marzluff, W.; McClay, D. R.; Morris, R. L.; Mushegian, A.; Rast, J. P.; Sodergren, E.; Smith, L. C.; Thorndyke, M. C.; Vacquier, V. D.; Weinstock, G. M.; Wessel, G. M.; Wray, G.; Zhang, L.; Sodergren, E.; Weinstock, G. M.; Angerer, R. C.; Angerer, L. M.; Cameron, R. A.; Davidson, E. H.; Elsik, C. G.; Ermolaeva, O.; Hlavina, W.; Hofmann, G.; Kitts, P.; Landrum, M. J.; Mackey, A. J.; Maglott, D.; Panopoulou, G.; Poustka, A. J.; Pruitt, K.; Sapojnikov, V.; Song, X. Z.; Souvorov, A.; Solovyev, V.; Wei, Z.; Whittaker, C. A.; Worley, K.; Zhang, L.; Sodergren, E.; Weinstock, G. M.; Durbin, K. J.; Gibbs, R. A.; Shen, Y. F.; Song, X. Z.; Worley, K.; Zhang, L.; Wray, G.; Fedrigo, O.; Garfield, D.; Haygood, R.; Primus, A.; Satija, R.; Severson, T.; Zhang, L.; Sodergren, E.; Weinstock, G. M.; Gonzalez-Garay, M. L.; Jackson, A. R.; Milosavljevic, A.; Song, X. Z.; Tong, M.; Worley, K.; Ettensohn, C. A.; Cameron, R. A.; Killian, C. E.; Landrum, M. J.; Livingston, B. T.; Wilt, F. H.; Coffman, J. A.; Marzluff, W.; Mushegian, A.; Adams, N.; Belle, R.; Carbonneau, S.; Cheung, R.; Cormier, P.; Cosson, B.; Croce, J.; Fernandez-Guerra, A.; Geneviere, A. M.; Goel, M.; Kelkar, H.; Morales, J.; Mulner-Lorillon, O.; Robertson, A. J.; Hamdoun, A.; Goldstone, J. V.; Adams, N.; Cole, B.; Dean, M.; Epel, D.; Gold, B.; Hahn, M. E.; Howard-Ashby, M.; Scally, M.; Stegeman, J. J.; Morris, R. L.; Allgood, E. L.; Cool, J.; Judkins, K. M.; McCafferty, S. S.; Musante, A. M.; Obar, R. A.; Rawson, A. P.; Rossetti, B. J.; Burgess, D. R.; Allgood, E. L.; Cool, J.; Gibbons, I. R.; Hoffman, M. P.; Judkins, K. M.; Leone, A.; McCafferty, S. S.; Morris, R. L.; Musante, A. M.; Obar, R. A.; Rawson, A. P.; Rossetti, B. J.; Wessel, G. M.; Davidson, E. H.; Cameron, R. A.; Istrail, S.; Materna, S. C.; Samanta, M. P.; Stolc, V.; Tongprasit, W.; Tu, Q.; Angerer, R. C.; Angerer, L. M.; Wei, Z.; Hynes, R. O.; Bergeron, K. F.; Brandhorst, B. P.; Burke, R. D.; Whittaker, C. A.; Whittle, J.; Cameron, R. A.; Berney, K.; Bottjer, D. J.; Calestani, C.; Davidson, E. H.; Peterson, K.; Chow, E.; Yuan, Q. A.; Elhaik, E.; Elsik, C. G.; Graur, D.; Reese, J. T.; Bosdet, I.; Heesun, S.; Marra, M. A.; Schein, J.; Dean, M.; Hamdoun, A.; Rast, J. P.; Smith, L. C.; Anderson, M. K.; Berney, K.; Brockton, V.; Buckley, K. M.; Cameron, R. A.; Cohen, A. H.; Fugmann, S. D.; Hibino, T.; Loza-Coll, M.; Majeske, A. J.; Messier, C.; Nair, S. V.; Pancer, Z.; Terwilliger, D. P.; Burke, R. D.; Elphick, M. R.; Klein, W. H.; Thorndyke, M. C.; Agca, C.; Angerer, L. M.; Arboleda, E.; Arnone, M. I.; Brandhorst, B. P.; Chen, N. S.; Churcher, A. M.; Hallbook, F.; Humphrey, G. W.; Hynes, R. O.; Idris, M. M.; Kiyama, T.; Liang, S. G.; Mellott, D.; Mu, X. Q.; Murray, G.; Olinski, R. P.; Raible, F.; Rowe, M.; Taylor, J. S.; Tessmar-Raible, K.; Wang, D.; Wilson, K. H.; Yaguchi, S.; Foltz, K. R.; Vacquier, V. D.; Wessel, G. M.; Gaasterland, T.; Galindo, B. E.; Gunaratne, H. J.; Howard-Ashby, M.; Humphrey, G. W.; Juliano, C.; Kinukawa, M.; Moy, G. W.; Neill, A. T.; Nomura, M.; Raisch, M.; Reade, A.; Roux, M. M.; Song, J. L.; Su, Y. H.; Townley, I. K.; Voronina, E.; Wong, J. L.; Arnone, M. I.; Thorndyke, M. C.; Amore, G.; Angerer, L. M.; Arboleda, E.; Branno, M.; Brown, E. R.; Cavalieri, V.; Duboc, V.; Duloquin, L.; Elphick, M. R.; Flytzanis, C.; Gache, C.; Geneviere, A. M.; Idris, M. M.; Lapraz, F.; Lepage, T.; Locascio, A.; Martinez, P.; Matassi, G.; Matranga, V.; McClay, D. R.; Morales, J.; Poustka, A. J.; Raible, F.; Range, R.; Rizzo, F.; Rottinger, E.; Rowe, M.; Tessmar-Raible, K.; Sodergren, E.; Weinstock, G. M.; Wilson, K.; McClay, D. R.; Angerer, L. M.; Arnone, M. I.; Beane, W.; Bradham, C.; Byrum, C.; Croce, J.; Duboc, V.; Duloquin, L.; Gache, C.; Geneviere, A. M.; Glenn, T.; Hibino, T.; Hussain, S.; Lapraz, F.; Lepage, T.; Livingston, B. T.; Loza, M.; Manning, G.; Miranda, E.; Miranda, E.; Range, R.; Rizzo, F.; Rottinger, E.; Thomason, R.; Walton, K.; Wei, Z.; Wessel, G. M.; Wikramanayke, A.; Wilson, K. H.; Whittaker, C.; Wu, S. Y.; Xu, R. H.; Davidson, E. H.; Arnone, M. I.; Branno, M.; Brown, C. T.; Cameron, R. A.; Chen, L. L.; Gray, R. F.; Howard-Ashby, M.; Istrail, S.; Lee, P. Y.; Locascio, A.; Martinez, P.; Materna, S. C.; Nam, J.; Oliveri, P.; Rizzo, F.; Smith, J.; Muzny, D.; Sodergren, E.; Gibbs, R. A.; Weinstock, G. M.; Bell, S.; Chacko, J.; Cree, A.; Curry, S.; Davis, C.; Dinh, H.; Dugan-Rocha, S.; Fowler, J.; Gill, R.; Hamilton, C.; Hernandez, J.; Hines, S.; Hume, J.; Jackson, L.; Jolivet, A.; Kovar, C.; Lee, S.; Lewis, L.; Miner, G.; Morgan, M.; Nazareth, L. V.; Okwuonu, G.; Parker, D.; Pu, L. L.; Shen, Y. F.; Shen, Y. F.; Wright, R.; Sea Urchin Genome Sequencing Consortium
  3. Science. 2006, Nov; 314(5801): 941-952.
  1. 23.   Crinamine from Crinum asiaticum var.japonicum inhibits hypoxia inducible factor-1 activity but not activity of hypoxia inducible factor-2
  2. Kim, Y. H.; Park, E. J.; Park, M. H.; Badarch, U.; Woldemichael, G. M.; Beutler, J. A.
  3. Biological & Pharmaceutical Bulletin. 2006, Oct; 29(10): 2140-2142.
  1. 24.   4,5-Diaryl-1H-pyrrole-2-carboxylates as combretastatin A-4/lamellarin T hybrids: Synthesis and evaluation as anti-mitotic and cytotoxic agents
  2. Banwell, M. G.; Hamel, E.; Hockless, D. C. R.; Verdier-Pinard, P.; Willis, A. C.; Wong, D. J.
  3. Bioorganic & Medicinal Chemistry. 2006, Jul; 14(13): 4627-4638.
  1. 25.   Natural products from marine invertebrates and microbes as modulators of antitumor targets
  2. Newman, D. J.; Cragg, G. M.
  3. Current Drug Targets. 2006, MAR; 7(3): 279-304.
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