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  1. 1.   Pyrrolo[2 ',3 ':3,4]cyclohepta[1,2-d][1,2]oxazoles, a New Class of Antimitotic Agents Active against Multiple Malignant Cell Types
  2. Spano, Virginia; Rocca, Roberta; Barreca, Marilia; Giallombardo, Daniele; Montalbano, Alessandra; Carbone, Anna; Raimondi, Maria Valeria; Gaudio, Eugenio; Bortolozzi, Roberta; Bai,Ruoli; Tassone, Pierfrancesco; Alcaro, Stefano; Hamel,Ernest; Viola, Giampietro; Bertoni, Francesco; Barraja, Paola
  3. JOURNAL OF MEDICINAL CHEMISTRY. 2020, OCT 22; 63(20): 12023-12042.
  1. 2.   Diaryl disulfides and thiosulfonates as combretastatin A-4 analogues: Synthesis, cytotoxicity and antitubulin activity
  2. Khodyuk, Rejane Gonçalves Diniz; Bai,Ruoli; Hamel,Ernest; Lourenço, Estela Mariana Guimarães; Barbosa, Euzébio Guimarães; Beatriz, Adilson; Dos Santos, Edson Dos Anjos; de Lima, Dênis Pires
  3. Bioorganic chemistry. 2020, AUG; 101: 104017.
  1. 3.   Synthesis and biological evaluation of structurally diverse alpha-conformationally restricted chalcones and related analogues
  2. Maguire, Casey J.; Carlson, Graham J.; Ford, Jacob W.; Strecker, Tracy E.; Hamel,Ernest; Trawick, Mary Lynn; Pinney, Kevin G.
  3. MedChemComm. 2019, Aug 1; 10(8): 1445-1456.
  1. 4.   Structure Guided Design, Synthesis, and Biological Evaluation of Novel Benzosuberene Analogues as Inhibitors of Tubulin Polymerization
  2. Niu, Haichan; Strecker, Tracy E.; Gerberich, Jeni L.; Campbell, James W.; Saha, Debabrata; Mondal, Deboprosad; Hamel,Ernest; Chaplin, David J.; Mason, Ralph P.; Trawick, Mary Lynn; Pinney, Kevin G.
  3. JOURNAL OF MEDICINAL CHEMISTRY. 2019, JUN 13; 62(11): 5594-5615.
  1. 5.   Design, synthesis, and biological evaluation of water-soluble amino acid prodrug conjugates derived from combretastatin, dihydronaphthalene, and benzosuberene-based parent vascular disrupting agents
  2. Devkota, L.; Lin, C. M.; Strecker, T. E.; Wang, Y.; Tidmore, J. K.; Chen, Z.; Guddneppanavar, R.; Jelinek, C. J.; Lopez, R.; Liu, L.; Hamel, E.; Mason, R. P.; Chaplin, D. J.; Trawick, M. L.; Pinney, K. G.
  3. Bioorganic & Medicinal Chemistry. 2016, 1-Mar; 24(5): 938-56.
  1. 6.   Antineoplastic Agents. 548. Synthesis of lodo- and Diiodocombstatin Phosphate Prodrugs
  2. Pettit, G. R.; Rosenberg, H. J.; Dixon, R.; Knight, J. C.; Hamel, E.; Chapuis, J. C.; Pettit, R. K.; Hogan, F.; Sumner, B.; Ain, K. B.; Trickey-Platt, B.
  3. Journal of Natural Products. 2012, Mar; 75(3): 385-393.
  1. 7.   One-pot synthesis and biological evaluation of 2-pyrrolidinyl-4-amino-5-(3 ',4 ',5 '-trimethoxybenzoyl)thiazole: A unique, highly active antimicrotubule agent
  2. Romagnoli, R.; Baraldi, P. G.; Cara, C. L.; Salvador, M. K.; Bortolozzi, R.; Basso, G.; Viola, G.; Balzarini, J.; Brancale, A.; Fu, X. H.; Li, J.; Zhang, S. Z.; Hamel, E.
  3. European Journal of Medicinal Chemistry. 2011, Dec; 46(12): 6015-6024.
  1. 8.   Synthesis and Antitumor Molecular Mechanism of Agents Based on Amino 2-(3 ',4 ',5 '-Trimethoxybenzoyl)benzo[b]furan: Inhibition of Tubulin and Induction of Apoptosis
  2. Romagnoli, R.; Baraldi, P. G.; Lopez-Cara, C.; Cruz-Lopez, O.; Carrion, M. D.; Salvador, M. K.; Bermejo, J.; Estevez, S.; Estevez, F.; Balzarini, J.; Brancale, A.; Ricci, A.; Chen, L. C.; Kim, J. G.; Hamel, E.
  3. Chemmedchem. 2011, Oct; 6(10): 1841-1853.
  1. 9.   Discovery of 7-Hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a Tubulin Polymerization Inhibitor with Potent Antiproliferative and Tumor Vascular Disrupting Properties
  2. Flynn, B. L.; Gill, G. S.; Grobelny, D. W.; Chaplin, J. H.; Paul, D.; Leske, A. F.; Lavranos, T. C.; Chalmers, D. K.; Charman, S. A.; Kostewicz, E.; Shackleford, D. M.; Morizzi, J.; Hamel, E.; Jung, M. K.; Kremmidiotis, G.
  3. Journal of Medicinal Chemistry. 2011, Sep; 54(17): 6014-6027.
  1. 10.   Convergent Synthesis and Biological Evaluation of 2-Amino-4-(3 ',4 ',5 '-trimethoxyphenyl)-5-aryl Thiazoles as Microtubule Targeting Agents
  2. Romagnoli, R.; Baraldi, P. G.; Brancale, A.; Ricci, A.; Hamel, E.; Bortolozzi, R.; Basso, G.; Viola, G.
  3. Journal of Medicinal Chemistry. 2011, Jul; 54(14): 5144-5153.
  1. 11.   Synthesis of novel antimitotic agents based on 2-amino-3-aroyl-5-(hetero)arylethynyl thiophene derivatives
  2. Romagnoli, R.; Baraldi, P. G.; Cruz-Lopez, O.; Tolomeo, M.; Di Cristina, A.; Pipitone, R. M.; Grimaudo, S.; Balzarini, J.; Brancale, A.; Hamel, E.
  3. Bioorganic & Medicinal Chemistry Letters. 2011, May; 21(9): 2746-2751.
  1. 12.   Antitumor Agents. 284. New Desmosdumotin B Analogues with Bicyclic B-Ring as Cytotoxic and Antitubulin Agents
  2. Nakagawa-Goto, K.; Wu, P. C.; Lai, C. Y.; Hamel, E.; Zhu, H.; Zhang, L. Y.; Kozaka, T.; Ohkoshi, E.; Goto, M.; Bastow, K. F.; Lee, K. H.
  3. Journal of Medicinal Chemistry. 2011, Mar; 54(5): 1244-1255.
  1. 13.   Synthesis and Cellular Pharmacology Studies of a Series of 2-amino-3-aroyl-4-substituted Thiophene Derivatives
  2. Romagnoli, R.; Baraldi, P. G.; Pavani, M. G.; Cruz-Lopez, O.; Hamel, E.; Balzarini, J.; Brognara, E.; Zuccato, C.; Gambari, R.
  3. Medicinal Chemistry. 2010, Nov; 6(6): 329-343.
  1. 14.   Substituted 2-(3 ',4 ',5 '-trimethoxybenzoyl)-benzo[b]thiophene derivatives as potent tubulin polymerization inhibitors
  2. Romagnoli, R.; Baraldi, P. G.; Carrion, M. D.; Cruz-Lopez, O.; Tolomeo, M.; Grimaudo, S.; Di Cristina, A.; Pipitone, M. R.; Balzarini, J.; Brancale, A.; Hamel, E.
  3. Bioorganic & Medicinal Chemistry. 2010, Jul; 18(14): 5114-5122.
  1. 15.   A boronic acid chalcone analog of combretastatin A-4 as a potent anti-proliferation agent
  2. Kong, Y. L.; Wang, K.; Edler, M. C.; Hamel, E.; Mooberry, S. L.; Paige, M. A.; Brown, M. L.
  3. Bioorganic & Medicinal Chemistry. 2010, Jan; 18(2): 971-977.
  1. 16.   A diaryl sulfide, sulfoxide, and sulfone bearing structural similarities to combretastatin A-4
  2. Barbosa, E. G.; Bega, L.; Beatriz, A.; Sarkar, T.; Hamel, E.; do Amaral, M. S.; de Lima, D. P.
  3. European Journal of Medicinal Chemistry. 2009 44(6): 2685-2688.
  1. 17.   Antineoplastic Agents. 565. Synthesis of Combretastatin D-2 Phosphate and Dihydro-combretastatin D-2
  2. Pettit, G. R.; Quistorf, P. D.; Fry, J. A.; Herald, D. L.; Hamel, E.; Chapuis, J. C.
  3. Journal of Natural Products. 2009 72(5): 876-883.
  1. 18.   E-Combretastatin and E-resveratrol structural modifications: Antimicrobial and cancer cell growth inhibitory beta-E-nitrostyrenes
  2. Pettit, R. K.; Pettit, G. R.; Hamel, E.; Hogan, F.; Moser, B. R.; Wolf, S.; Pon, S.; Chapuis, J. C.; Schmidt, J. M.
  3. Bioorganic & Medicinal Chemistry. 2009 17(18): 6606-6612.
  1. 19.   Design, synthesis and structure-activity relationship of 2-(3 ',4 ',5 '-trimethoxybenzoyl)-benzo[b]furan derivatives as a novel class of inhibitors of tubulin polymerization
  2. Romagnoli, R.; Baraldi, P. G.; Carrion, M. D.; Cara, C. L.; Cruz-Lopez, O.; Tolomeo, M.; Grimaudo, S.; Di Cristina, A.; Pipitone, M. R.; Balzarini, J.; Zonta, N.; Brancale, A.; Hamel, E.
  3. Bioorganic & Medicinal Chemistry. 2009 17(19): 6862-6871.
  1. 20.   2-Arylamino-4-Amino-5-Aroylthiazoles. "One-Pot" Synthesis and Biological Evaluation of a New Class of Inhibitors of Tubulin Polymerization
  2. Romagnoli, R.; Baraldi, P. G.; Carrion, M. D.; Cruz-Lopez, O.; Cara, C. L.; Basso, G.; Viola, G.; Khedr, M.; Balzarini, J.; Mahboobi, S.; Sellmer, A.; Brancale, A.; Hamel, E.
  3. Journal of Medicinal Chemistry. 2009 52(17): 5551-5555.
  1. 21.   Synthesis and biological evaluation of 2-amino-3-(3 ',4 ',5 '-trimethoxybenzoyl)-6-substituted-4,5,6,7-tetrahydrothieno[2,3-c]pyridi ne derivatives as antimitotic agents and inhibitors of tubulin polymerization
  2. Romagnoli, R.; Baraldi, P. G.; Carrion, M. D.; Cruz-Lopez, O.; Cara, C. L.; Tolomeo, M.; Grimaudo, S.; Di Cristina, A.; Pipitone, M. R.; Balzarini, J.; Kandil, S.; Brancale, A.; Sarkar, T.; Hamel, E.
  3. Bioorganic & Medicinal Chemistry Letters. 2008 18(18): 5041-5045.
  1. 22.   Synthesis and biological evaluation of 1-methyl-2-(3 ',4 ',5 '-trimethoxybenzoyl)-3-aminoindoles as a new class of antimitotic agents and tubulin inhibitors
  2. Romagnoli, R.; Baraldi, P. G.; Sarkar, T.; Carrion, M. D.; Cara, C. L.; Cruz-Lopez, O.; Preti, D.; Tabrizi, M. A.; Tolomeo, M.; Grimaudo, S.; Di Cristina, A.; Zonta, N.; Balzarini, J.; Brancale, A.; Hsieh, H. P.; Hamel, E.
  3. Journal of Medicinal Chemistry. 2008 51(5): 1464-1468.
  1. 23.   Synthesis and biological evaluation of 2-amino-3-(3 ',4 ',5 '-trimethoxyphenyisulfonyl)-5-aryl thiophenes as a new class of antitubulin agents
  2. Romagnoli, R.; Baraldi, P. G.; Remusat, V.; Carrion, M. D.; Cara, C. L.; Cruz-Lopez, O.; Preti, D.; Fruttarolo, F.; Tabrizi, M. A.; Balzarini, J.; Hamel, E.
  3. Medicinal Chemistry. 2007, Nov; 3(6): 507-512.
  1. 24.   Synthesis and biological evaluation of 2-and 3-aminobenzo b thiophene derivatives as antimitotic agents and inhibitors of tubulin polymerization
  2. Romagnoli, R.; Baraldi, P. G.; Carrion, M. D.; Cara, C. L.; Preti, D.; Fruttarolo, F.; Pavani, M. G.; Tabrizi, M. A.; Tolomeo, M.; Grimaudo, S.; Di Cristina, A.; Balzarini, J.; Hadfield, J. A.; Brancale, A.; Hamel, E.
  3. Journal of Medicinal Chemistry. 2007, May; 50(9): 2273-2277.
  1. 25.   Synthesis and biological evaluation of 2-(3 ',4 ',5 '-trimethoxybenzoyl)-3-amino 5-aryl thiophenes as a new class of tubulin inhibitors
  2. Romagnoli, R.; Baraldi, P. G.; Remusat, V.; Carrion, M. D.; Cara, C. L.; Preti, D.; Fruttarolo, F.; Pavani, M. G.; Tabrizi, M. A.; Tolomeo, M.; Grimaudo, S.; Balzarini, J.; Jordan, M. A.; Hamel, E.
  3. Journal of Medicinal Chemistry. 2006, Oct; 49(21): 6425-6428.
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