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  1. 1.   Pyrrolo[2 ',3 ':3,4]cyclohepta[1,2-d][1,2]oxazoles, a New Class of Antimitotic Agents Active against Multiple Malignant Cell Types
  2. Spano, Virginia; Rocca, Roberta; Barreca, Marilia; Giallombardo, Daniele; Montalbano, Alessandra; Carbone, Anna; Raimondi, Maria Valeria; Gaudio, Eugenio; Bortolozzi, Roberta; Bai,Ruoli; Tassone, Pierfrancesco; Alcaro, Stefano; Hamel,Ernest; Viola, Giampietro; Bertoni, Francesco; Barraja, Paola
  3. JOURNAL OF MEDICINAL CHEMISTRY. 2020, OCT 22; 63(20): 12023-12042.
  1. 2.   Diaryl disulfides and thiosulfonates as combretastatin A-4 analogues: Synthesis, cytotoxicity and antitubulin activity
  2. Khodyuk, Rejane Gonçalves Diniz; Bai,Ruoli; Hamel,Ernest; Lourenço, Estela Mariana Guimarães; Barbosa, Euzébio Guimarães; Beatriz, Adilson; Dos Santos, Edson Dos Anjos; de Lima, Dênis Pires
  3. Bioorganic chemistry. 2020, AUG; 101: 104017.
  1. 3.   Synthesis and biological evaluation of structurally diverse alpha-conformationally restricted chalcones and related analogues
  2. Maguire, Casey J.; Carlson, Graham J.; Ford, Jacob W.; Strecker, Tracy E.; Hamel,Ernest; Trawick, Mary Lynn; Pinney, Kevin G.
  3. MedChemComm. 2019, Aug 1; 10(8): 1445-1456.
  1. 4.   Discovery of 7-Hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a Tubulin Polymerization Inhibitor with Potent Antiproliferative and Tumor Vascular Disrupting Properties
  2. Flynn, B. L.; Gill, G. S.; Grobelny, D. W.; Chaplin, J. H.; Paul, D.; Leske, A. F.; Lavranos, T. C.; Chalmers, D. K.; Charman, S. A.; Kostewicz, E.; Shackleford, D. M.; Morizzi, J.; Hamel, E.; Jung, M. K.; Kremmidiotis, G.
  3. Journal of Medicinal Chemistry. 2011, Sep; 54(17): 6014-6027.
  1. 5.   Convergent Synthesis and Biological Evaluation of 2-Amino-4-(3 ',4 ',5 '-trimethoxyphenyl)-5-aryl Thiazoles as Microtubule Targeting Agents
  2. Romagnoli, R.; Baraldi, P. G.; Brancale, A.; Ricci, A.; Hamel, E.; Bortolozzi, R.; Basso, G.; Viola, G.
  3. Journal of Medicinal Chemistry. 2011, Jul; 54(14): 5144-5153.
  1. 6.   A boronic acid chalcone analog of combretastatin A-4 as a potent anti-proliferation agent
  2. Kong, Y. L.; Wang, K.; Edler, M. C.; Hamel, E.; Mooberry, S. L.; Paige, M. A.; Brown, M. L.
  3. Bioorganic & Medicinal Chemistry. 2010, Jan; 18(2): 971-977.
  1. 7.   A diaryl sulfide, sulfoxide, and sulfone bearing structural similarities to combretastatin A-4
  2. Barbosa, E. G.; Bega, L.; Beatriz, A.; Sarkar, T.; Hamel, E.; do Amaral, M. S.; de Lima, D. P.
  3. European Journal of Medicinal Chemistry. 2009 44(6): 2685-2688.
  1. 8.   Synthesis and biological evaluation of 2-amino-3-(3 ',4 ',5 '-trimethoxyphenyisulfonyl)-5-aryl thiophenes as a new class of antitubulin agents
  2. Romagnoli, R.; Baraldi, P. G.; Remusat, V.; Carrion, M. D.; Cara, C. L.; Cruz-Lopez, O.; Preti, D.; Fruttarolo, F.; Tabrizi, M. A.; Balzarini, J.; Hamel, E.
  3. Medicinal Chemistry. 2007, Nov; 3(6): 507-512.
  1. 9.   4,5-Diaryl-1H-pyrrole-2-carboxylates as combretastatin A-4/lamellarin T hybrids: Synthesis and evaluation as anti-mitotic and cytotoxic agents
  2. Banwell, M. G.; Hamel, E.; Hockless, D. C. R.; Verdier-Pinard, P.; Willis, A. C.; Wong, D. J.
  3. Bioorganic & Medicinal Chemistry. 2006, Jul; 14(13): 4627-4638.
  1. 10.   New arylthioindoles: Potent inhibitors of tubulin polymerization. 2. Structure-activity relationships and molecular modeling studies
  2. De Martino, G.; Edler, M. C.; La Regina, G.; Coluccia, A.; Barbera, M. C.; Barrow, D.; Nicholson, R. I.; Chiosis, G.; Brancale, A.; Hamel, E.; Artico, M.; Silvestri, R.
  3. Journal of Medicinal Chemistry. 2006, FEB 9; 49(3): 947-954.
  1. 11.   Structure-based discovery of a boronic acid bioisostere of combretastatin A-4
  2. Kong, Y.; Grembecka, J.; Edler, M. C.; Hamel, E.; Mooberry, S. L.; Sabat, M.; Rieger, J.; Brown, M. L.
  3. Chemistry & Biology. 2005, SEP; 12(9): 1007-1014.
  1. 12.   Antineoplastic agents. 445. Synthesis and evaluation of structural modifications of (Z)- and (E)-combretastatin A-4
  2. Pettit, G. R.; Rhodes, M. R.; Herald, D. L.; Hamel, E.; Schmidt, J. M.; Pettitt, R. K.
  3. Journal of Medicinal Chemistry. 2005, JUN 16; 48(12): 4087-4099.
  1. 13.   Arylthioindoles, potent inhibitors of tubulin polymerization
  2. De Martino, G.; La Regina, G.; Coluccia, A.; Edler, M. C.; Barbera, M. C.; Brancale, A.; Wilcox, E.; Hamel, E.; Artico, M.; Silvestri, R.
  3. Journal of Medicinal Chemistry. 2004, DEC 2; 47(25): 6120-6123.
  1. 14.   A quantitative evaluation of the effects of inhibitors of tubulin assembly on polymerization induced by discodermolide, epothilone B, and paclitaxel
  2. Dabydeen, D. A.; Florence, G. J.; Paterson, I.; Hamel, E.
  3. Cancer Chemotherapy and Pharmacology. 2004 53(5): 397-403.
  1. 15.   Evaluation of antimitotic agents by quantitative comparisons of their effects on the polymerization of purified tubulin
  2. Hamel, E.
  3. Cell Biochemistry and Biophysics. 2003 38(1): 1-21.
  1. 16.   Antineoplastic agents. 487. Synthesis and biological evaluation of the antineoplastic agent 3,4-methylenedioxy-5,4 '-dimethoxy- 3 '-amino-Z-stilbene and derived amino acid amides
  2. Pettit, G. R.; Anderson, C. R.; Herald, D. L.; Jung, M. K.; Lee, D. J.; Hamel, E.; Pettit, R. K.
  3. Journal of Medicinal Chemistry. 2003 46(4): 525-531.
  1. 17.   Antineoplastic agents 442. Synthesis and biological activities of dioxostatin
  2. Pettit, G. R.; Lippert, J. W.; Boyd, M. R.; Verdier-Pinard, P.; Hamel, E.
  3. Anti-Cancer Drug Design. 2000 15(5): 361-371.
  1. 18.   Antineoplastic agents. 443. Synthesis of the cancer cell growth inhibitor hydroxyphenstatin and its sodium diphosphate prodrug
  2. Pettit, G. R.; Grealish, M. P.; Herald, D. L.; Boyd, M. R.; Hamel, E.; Pettit, R. K.
  3. Journal of Medicinal Chemistry. 2000 43(14): 2731-2737.
  1. 19.   Preparation of new anti-tubulin ligands through a dual-mode, addition-elimination reaction to a bromo-substituted alpha,beta-unsaturated sulfoxide
  2. Chen, Z.; Mocharla, V. P.; Farmer, J. M.; Pettit, G. R.; Hamel, E.; Pinney, K. G.
  3. Journal of Organic Chemistry. 2000 65(25): 8811-8815.
  1. 20.   Antineoplastic agents 393. Synthesis of the trans-isomer of combretastatin A-4 prodrug
  2. Pettit, G. R.; Rhodes, M. R.; Herald, D. L.; Chaplin, D. J.; Stratford, M. R. L.; Hamel, E.; Pettit, R. K.; Chapuis, J. C.; Oliva, D.
  3. Anti-Cancer Drug Design. 1998 13(8): 981-993.
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