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  1. 1.   Hypoxia, stem cells and bone tumor
  2. Zeng, W.; Wan, R.; Zheng, Y. H.; Singh, S. R.; Wei, Y. Y.
  3. Cancer Letters. 2011, Dec; 313(2): 129-136.
  1. 2.   Multihistology, Target-Driven Pilot Trial of Oral Topotecan as an Inhibitor of Hypoxia-Inducible Factor-1 alpha in Advanced Solid Tumors
  2. Kummar, S.; Raffeld, M.; Juwara, L.; Horneffer, Y.; Strassberger, A.; Allen, D.; Steinberg, S. M.; Rapisarda, A.; Spencer, S. D.; Figg, W. D.; Chen, X. H.; Turkbey, I. B.; Choyke, P.; Murgo, A. J.; Doroshow, J. H.; Melillo, G.
  3. Clinical Cancer Research. 2011, Aug; 17(15): 5123-5131.
  1. 3.   Aminoflavone, a Ligand of the Aryl Hydrocarbon Receptor, Inhibits HIF-1 alpha Expression in an AhR-Independent Fashion
  2. Terzuoli, E.; Puppo, M.; Rapisarda, A.; Uranchimeg, B.; Cao, L. A.; Burger, A. M.; Ziche, M.; Melillo, G.
  3. Cancer Research. 2010, Sep 1; 70(17): 6837-6848.
  1. 4.   Antiangiogenic agents and HIF-1 inhibitors meet at the crossroads
  2. Rapisarda, A.; Shoemaker, R. H.; Melillo, G.
  3. Cell Cycle. 2009, Dec; 8(24): 4040-4043.
  1. 5.   Increased antitumor activity of bevacizumab in combination with hypoxia inducible factor-1 inhibition
  2. Rapisarda, A.; Hollingshead, M.; Uranchimeg, B.; Bonomi, C. A.; Borgel, S. D.; Carter, J. P.; Gehrs, B.; Raffeld, M.; Kinders, R. J.; Parchment, R.; Anver, M. R.; Shoemaker, R. H.; Melillo, G.
  3. Molecular Cancer Therapeutics. 2009 8(7): 1867-1877.
  1. 6.   Endothelial monocyte activating polypeptide-II modulates endothelial cell responses by degrading hypoxia-inducible factor-1alpha through interaction with PSMA7, a component of the proteasome
  2. Tandle, A. T.; Calvani, M.; Uranchimeg, B.; Zahavi, D.; Melillo, G.; Libutti, S. K.
  3. Experimental Cell Research. 2009 315(11): 1850-1859.
  1. 7.   Targeting hypoxia cell signaling for cancer therapy
  2. Melillo, G.
  3. Cancer and Metastasis Reviews. 2007, Jun; 26(2): 341-352.
  1. 8.   Inhibiting hypoxia-inducible factor 1 for cancer therapy
  2. Melillo, G.
  3. Molecular Cancer Research. 2006, Sep; 4(9): 601-605.
  1. 9.   Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity
  2. Kong, D. H.; Park, E. J.; Stephen, A. G.; Calvani, M.; Cardellina, J. H.; Monks, A.; Fisher, R. J.; Shoemaker, R. H.; Melillo, G.
  3. Cancer Research. 2005, OCT 1; 65(19): 9047-9055.
  1. 10.   Schedule-dependent inhibition of hypoxia-inducible factor-1 alpha protein accumulation, angiogenesis, and tumor growth by topotecan in U251-HRE glioblastoma xenografts
  2. Rapisarda, A.; Zalek, J.; Hollingshead, M.; Braunschweig, T.; Uranchimeg, B.; Bonomi, C. A.; Borgel, S. D.; Carter, J. P.; Hewitt, S. M.; Shoemaker, R. H.; Melillo, G.
  3. Cancer Research. 2004, OCT 1; 64(19): 6845-6848.
  1. 11.   Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: Mechanism and therapeutic implications
  2. Rapisarda, A.; Uranchimeg, B.; Sordet, O.; Pommier, Y.; Shoemaker, R. H.; Melillo, G.
  3. Cancer Research. 2004 64(4): 1475-1482.
  1. 12.   The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1 alpha and vascular endothelial growth factor formation
  2. Welsh, S. J.; Williams, R. R.; Birmingham, A.; Newman, D. J.; Kirkpatrick, D. L.; Powis, G.
  3. Molecular Cancer Therapeutics. 2003 2(3): 235-243.
  1. 13.   Identification of small molecule inhibitors of hypoxia- inducible factor 1 transcriptional activation pathway
  2. Rapisarda, A.; Uranchimeg, B.; Scudiero, D. A.; Selby, M.; Sausville, E. A.; Shoemaker, R. H.; Melillo, G.
  3. Cancer Research. 2002 62(15): 4316-4324.
  1. 14.   Inhibition of HIF-1-and wild-type p53-stimulated transcription by codon Arg175 p53 mutants with selective loss of functions
  2. Blagosklonny, M. V.; Giannakakou, P.; Romanova, L. Y.; Ryan, K. M.; Vousden, K. H.; Fojo, T.
  3. Carcinogenesis. 2001 22(6): 861-867.
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