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  1. 1.   Chronic Low-Level IFN-gamma Expression Disrupts Mitochondrial Complex I Activity in Renal Macrophages: An Early Mechanistic Driver of Lupus Nephritis Pathogenesis
  2. Bae, Heekyong R; Shin, Su-Kyung; Lee, Ji-Yoon; Ko, Yeo Jin; Kim, Suntae; Young,Howard; Kwon, Eun-Young
  3. International Journal of Molecular Sciences. 2024, Dec 25; 26(1):
  1. 2.   Interleukin-2-mediated NF-kB-dependent mRNA splicing modulates interferon gamma protein production
  2. Van Gelder, Rachel D; Gokhale, Nandan S; Genoyer, Emmanuelle; Omelia, Dylan S; Anderson,Steve; Young,Howard; Savan, Ram
  3. EMBO Reports. 2024, Nov 22;
  1. 3.   Severe Clinical Phenotypes of Heterozygous Females With X-Linked Chronic Granulomatous Disease
  2. Patel, Niraj C; Younger, M Elizabeth M; Williams, Kelli; Matias Lopes, Joao Pedro; Kuhns,Doug; Patel, Meera N; Miranda, Mary Ann; Marciano, Beatriz E; Deal, Christin Lawler; Leiding, Jennifer W
  3. The journal of Allergy and Clinical Immunology. In Practice. 2024, Sep 25;
  1. 4.   Aberrant CD8+T cells drive reproductive dysfunction in female mice with elevated IFN-gamma levels
  2. Bafor, Enitome E; Erwin-Cohen, Rebecca A; Martin, Toni; Baker, Clayton; Kimmel, Adrienne E; Duverger, Olivier; Fenimore, John M; Ramba, Meredith; Spindel, Thea; Hess, Megan M; Sanford, Michael; Lazarevic, Vanja; Benayoun, Bérénice A; Young, Howard A; Valencia, Julio C
  3. Frontiers in Immunology. 2024, Apr 18; 15: 1368572.
  1. 5.   Multifaceted roles for STAT3 in gammaherpesvirus latency revealed through in vivo B cell knockout models
  2. Hogan, Chad H; Owens, Shana M; Reynoso, Glennys V; Liao, Yifei; Meyer,Thomas; Zelazowska, Monika A; Liu, Bin; Li, Xiaofan; Grosskopf, Anna K; Khairallah, Camille; Kirillov, Varvara; Reich, Nancy C; Sheridan, Brian S; McBride, Kevin M; Gewurz, Benjamin E; Hickman, Heather D; Forrest, J Craig; Krug, Laurie T
  3. mBio. 2024, Jan 03; e0299823.
  1. 6.   Reduced Antibodies and Innate Cytokine Changes in SARS-CoV-2 BNT162b2 mRNA Vaccinated Transplant Patients With Hematological Malignancies
  2. Bergamaschi, Cristina; Pagoni, Maria; Rosati,Margherita; Angel, Matthew; Tzannou, Ifigeneia; Vlachou, Margarita; Darmani, Ismini; Ullah,Amirah; Bear,Jenifer; Devasundaram,Santhi; Burns,Robert; Baltadakis, Ioannis; Gigantes, Stavros; Dimopoulos, Meletios-Athanasios; Pavlakis,George; Terpos, Evangelos; Felber,Barbara
  3. Frontiers in Immunology. 2022 13: 899972.
  1. 7.   Distinct Biomarker Profiles and TCR Sequence Diversity Characterize the Response to PD-L1 Blockade in a Mouse Melanoma Model
  2. El Meskini,Rajaa; Atkinson,Devon; Kulaga, Alan; Abdelmaksoud,Abdalla; Gumprecht, Michelle; Pate, Nathan; Hayes, Susana; Oberst, Michael; Kaplan, Ian M.; Raber, Patrick; Van Dyke, Terry; Sharan,Shyam; Hollingsworth, Robert; Day, Chi-Ping; Merlino, Glenn; Ohler,Zoe
  3. Molecular cancer research : MCR. 2021, Aug 1; 19(8): 1422-1436.
  1. 8.   IFN gamma Is a Key Link between Obesity and Th1-Mediated AutoImmune Diseases
  2. Bae,Heekyong; Choi, Myung-Sook; Kim, Suntae; Young,Howard; Gershwin, M. Eric; Jeon, Seon-Min; Kwon, Eun-Young
  3. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021, Jan; 22(1):
  1. 9.   Ischemia reperfusion-induced metastasis is resistant to PPAR? agonist pioglitazone in a murine model of colon cancer
  2. Tashiro, Yoshihiko; Nishino, Hiroto; Higuchi, Takashi; Sugisawa, Norihiko; Fukuda, Yasunari; Yamamoto, Jun; Inubushi, Sachiko; Aoki, Takeshi; Murakami, Masahiko; Singh,Shree Ram; Bouvet, Michael; Hoffman, Robert M
  3. Scientific reports. 2020, Oct 29; 10(1): 18565.
  1. 10.   The Cytokine Receptor IL-7Ra Impairs IL-2 Receptor Signaling and Constrains the In Vitro Differentiation of Foxp3+ Treg Cells
  2. Waickman, Adam T; Keller, Hilary R; Kim, Tae-Hyoun; Luckey, Megan A; Tai, Xuguang; Hong, Changwan; Molina-París, Carmen; Walsh,Scott; Park, Jung-Hyun
  3. iScience. 2020, AUG 21; 23(8): 101421.
  1. 11.   Combination of PARP Inhibitor Olaparib, and PD-L1 Inhibitor Durvalumab, in Recurrent Ovarian Cancer: a Proof-of-Concept Phase II Study
  2. Lampert, Erika J.; Zimmer, Alexandra; Padget, Michelle; Cimino-Mathews, Ashley; Nair, Jayakumar R.; Liu, Yingmiao; Swisher, Elizabeth M.; Hodge, James W.; Nixon, Andrew B.; Villanueva,Erin; Bagheri, Mohammad H.; Levy, Elliott; Radke, Marc R.; Lipkowitz, Stanley; Annunziata, Christina M.; Taube, Janis M.; Steinberg, Seth M.; Lee, Jung-Min
  3. CLINICAL CANCER RESEARCH. 2020, AUG 15; 26(16): 4268-4279.
  1. 12.   Target identification among known drugs by deep learning from heterogeneous networks
  2. Zeng, Xiangxiang; Zhu, Siyi; Lu, Weiqiang; Liu, Zehui; Huang, Jin; Zhou, Yadi; Fang, Jiansong; Huang, Yin; Guo, Huimin; Li, Lang; Trapp, Bruce D.; Nussinov,Ruth; Eng, Charis; Loscalzo, Joseph; Cheng, Feixiong
  3. CHEMICAL SCIENCE. 2020, Feb 21; 11(7): 1775-1797.
  1. 13.   Pioglitazone, an agonist of PPAR?, reverses doxorubicin-resistance in an osteosarcoma patient-derived orthotopic xenograft model by downregulating P-glycoprotein expression
  2. Higuchi, Takashi; Sugisawa, Norihiko; Miyake, Kentaro; Oshiro, Hiromichi; Yamamoto, Norio; Hayashi, Katsuhiro; Kimura, Hiroaki; Miwa, Shinji; Igarashi, Kentaro; Kline,Zoey; Bouvet, Michael; Singh,Shree Ram; Tsuchiya, Hiroyuki; Hoffman, Robert M
  3. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019, Oct; 118: 109356.
  1. 14.   Differential Activation of the Transcription Factor IRF1 Underlies the Distinct Immune Responses Elicited by Type I and Type III Interferons
  2. Forero, Adriana; Ozarkar, Snehal; Li,Hongchuan; Lee, Chia Heng; Hemann, Emily A; Nadjsombati, Marija S; Hendricks, Matthew R; So, Lomon; Green, Richard; Roy, Chandra N; Sarkar, Saumendra N; von Moltke, Jakob; Anderson,Steve; Gale, Michael; Savan, Ram
  3. Immunity. 2019, SEP 17; 51(3): 451-+.
  1. 15.   IFN-gamma: A cytokine at the right time, is in the right place
  2. Burke,Daniel; Young,Howard
  3. Seminars in immunology. 2019, JUN; 43(Special Issue: SI):
  1. 16.   Evaluation of Pharmacodynamic Responses to Cancer Therapeutic Agents Using DNA Damage Markers
  2. Wilsker,Deborah; Barrett, Allison M.; Dull,Angie; Lawrence,Scott; Hollingshead,Melinda; Chen, Alice; Kummar, Shivaani; Parchment,Ralph; Doroshow, James H.; Kinders,Robert
  3. Clinical cancer research : an official journal of the American Association for Cancer Research. 2019, MAY 15; 25(10): 3084-3095.
  1. 17.   Inherited p40(phox) deficiency differs from classic chronic granulomatous disease
  2. van de Geer, Annemarie; Nieto-Patlan, Alejandro; Kuhns, Doug; Tool, Anton T. J.; Arias, Andres A.; Bouaziz, Matthieu; de Boer, Martin; Luis Franco, Jose; Gazendam, Roel P.; van Hamme, John L.; van Houdt, Michel; van Leeuwen, Karin; Verkuijlen, Paul J. H.; van den Berg, Timo K.; Alzate, Juan F.; Arango-Franco, Carlos A.; Batura, Vritika; Bernasconi, Andrea R.; Boardman, Barbara; Booth, Claire; Burns, Siobhan O.; Cabarcas, Felipe; Bensussan, Nadine Cerf; Charbit-Henrion, Fabienne; Corveleyn, Anniek; Deswarte, Caroline; Esnaola Azcoiti, Maria; Foell, Dirk; Gallin, John I.; Garces, Carlos; Guedes, Margarida; Hinze, Claas H.; Holland, Steven M.; Hughes, Stephen M.; Ibanez, Patricio; Malech, Harry L.; Meyts, Isabelle; Moncada-Velez, Marcela; Moriya, Kunihiko; Neves, Esmeralda; Oleastro, Matias; Perez, Laura; Rattina, Vimel; Oleaga-Quintas, Carmen; Warner, Neil; Muise, Aleixo M.; Serafin Lopez, Jeanet; Trindade, Eunice; Vasconcelos, Julia; Vermeire, Severine; Wittkowski, Helmut; Worth, Austen; Abel, Laurent; Dinauer, Mary C.; Arkwright, Peter D.; Roos, Dirk; Casanova, Jean-Laurent; Kuijpers, Taco W.; Bustamante, Jacinta
  3. Journal of Clinical Investigation. 2018, Aug 31; 128(9): 3957-3975.
  1. 18.   Effect of Calcium Carbonate Encapsulation on the Activity of Orally Administered CpG Oligonucleotides
  2. Kayraklioglu, Neslihan; Scheiermann, Julia; Alvord, W. Gregory; Klinman, Dennis
  3. MOLECULAR THERAPY-NUCLEIC ACIDS. 2017, Sep 15; 8: 243-249.
  1. 19.   Centriole triplet microtubules are required for stable centriole formation and inheritance in human cell
  2. Wang, Jennifer T.; Kong, Dong; Hoerner, Christian R.; Loncarek, Jadranka; Stearns, Tim
  3. ELIFE. 2017, SEP 14; 6
  1. 20.   A new hope for obesity management: Boron inhibits adipogenesis in progenitor cells through the Wnt/beta-catenin pathway
  2. Dogan, Aysegul; Demirci, Selarni; Apdik, Huseyin; Bayrak, Omer Faruk; Gulluoglu, Sukru; Tuysuz, Emre Can; Gusev, Oleg; Rizvanov, Albert A.; Nikerel, Emrah; Sahin, Fikrettin
  3. METABOLISM-CLINICAL AND EXPERIMENTAL. 2017, Apr; 69: 130-142.
  1. 21.   Phosphorylated fraction of H2AX as a measurement for DNA damage in cancer cells and potential applications of a novel assay
  2. Ji, Jay; Zhang, Yiping; Redon, Christophe E.; Reinhold, William C.; Chen, Alice P.; Fogli, Laura K.; Holbeck, Susan L.; Parchment, Ralph; Hollingshead, Melinda; Tomaszewski, Joseph E.; Dudon, Quentin; Pommier, Yves; Doroshow, James H.; Bonner, William M.
  3. PLOS ONE. 2017, Feb 3; 12(2): e0171582.
  1. 22.   Regulation of IFN-gamma Expression
  2. Fenimore, John; Young, Howard
  3. Advances in Experimental Medicine and Biology. 2016 941: 1-19.
  1. 23.   Delineation of antigen-specific and antigen-nonspecific CD8(+) memory T-cell responses after cytokine-based cancer immunotherapy
  2. Tietze, J. K.; Wilkins, D. E. C.; Sckisel, G. D.; Bouchlaka, M. N.; Alderson, K. L.; Weiss, J. M.; Ames, E.; Bruhn, K. W.; Craft, N.; Wiltrout, R. H.; Longo, D. L.; Lanier, L. L.; Blazar, B. R.; Redelman, D.; Murphy, W. J.
  3. Blood. 2012, Mar; 119(13): 3073-3083.
  1. 24.   A Phase I Study of Veliparib in Combination with Metronomic Cyclophosphamide in Adults with Refractory Solid Tumors and Lymphomas
  2. Kummar, S.; Ji, J. P.; Morgan, R.; Lenz, H. J.; Puhalla, S. L.; Belani, C. P.; Gandara, D. R.; Allen, D.; Kiesel, B.; Beumer, J. H.; Newman, E. M.; Rubinstein, L.; Chen, A.; Zhang, Y. P.; Wang, L. H.; Kinders, R. J.; Parchment, R. E.; Tomaszewski, J. E.; Doroshow, J. H.
  3. Clinical Cancer Research. 2012, Mar; 18(6): 1726-1734.
  1. 25.   Analytical characterization of ch14.18 A mouse-human chimeric disialoganglioside-specific therapeutic antibody
  2. Soman, G.; Kallarakal, A. T.; Michiel, D.; Yang, X. Y.; Saptharishi, N.; Jiang, H. G.; Giardina, S.; Gilly, J.; Mitra, G.
  3. Mabs. 2012, Jan-Feb; 4(1): 84-100.
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