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  1. 1.   A Novel Biological Activity of the STAT3 Inhibitor Stattic in Inhibiting Glutathione Reductase and Suppressing the Tumorigenicity of Human Cervical Cancer Cells via a ROS-Dependent Pathway
  2. Xia, Yuchen; Wang, Guihua; Jiang, Manli; Liu, Xueting; Zhao, Yan; Song, Yinghui; Jiang, Binyuan; Zhu, Demao; Hu, Ling; Zhang, Zhao; Cao, Ting; Wang,Jiming; Hu, Jinyue
  3. OncoTargets and therapy. 2021, Jul 5; 14: 4047-4060.
  1. 2.   Biochemical and biological studies of mouse APOBEC3
  2. Nair, S.; Sanchez-Martinez, S.; Ji, X.; Rein, A.
  3. Journal of Virology. 2014, Apr; 88(7): 3850-60.
  1. 3.   Modulation of Liver L-gamma-Glutamyl-L-cysteinylglycine Homeostasis By N-Acetyl-Glucosamine-thiazolidine-4(R)-carboxylic Acid in Mice
  2. Liu, J.; Cai, W. D.; Liu, W. S.; Han, B. Q.; Chang, J.; Yang, Y.
  3. American Journal of the Medical Sciences. 2012, Apr; 343(4): 310-315.
  1. 4.   Growth-inhibitory and chemosensitizing effects of the glutathione-S-transferase-p-activated nitric oxide donor PABA/NO in malignant gliomas
  2. Kogias, E.; Osterberg, N.; Baumer, B.; Psarras, N.; Koentges, C.; Papazoglou, A.; Saavedra, J. E.; Keefer, L. K.; Weyerbrock, A.
  3. International Journal of Cancer. 2012, Mar; 130(5): 1184-1194.
  1. 5.   Application of a water-soluble pyridyl disulfide amine linker for use in Cu-free click bioconjugation
  2. Thomas, J. D.; Burke, T. R.
  3. Tetrahedron Letters. 2011, Aug; 52(33): 4316-4319.
  1. 6.   Arsenic-Specific Stem Cell Selection During Malignant Transformation
  2. Tokar, E. J.; Qu, W.; Liu, J.; Liu, W.; Webber, M. M.; Phang, J. M.; Waalkes, M. P.
  3. Journal of the National Cancer Institute. 2010, May; 102(9): 638-649.
  1. 7.   Stabilization of the Nitric Oxide (NO) Prodrugs and Anticancer Leads, PABA/NO and Double JS-K, through Incorporation into PEG-Protected Nanoparticles
  2. Kumar, V.; Hong, S. Y.; Maciag, A. E.; Saavedra, J. E.; Adamson, D. H.; Prud'homme, R. K.; Keefer, L. K.; Chakrapani, H.
  3. Molecular Pharmaceutics. 2010, Jan-Feb; 7(1): 291-298.
  1. 8.   Nitric oxide prodrug JS-K inhibits ubiquitin E1 and kills tumor cells retaining wild-type p53
  2. Kitagaki, J.; Yang, Y.; Saavedra, J. E.; Colburn, N. H.; Keefer, L. K.; Perantoni, A. O.
  3. Oncogene. 2009 28(4): 619-624.
  1. 9.   Gene expression profiling for nitric oxide prodrug JS-K to kill HL-60 myeloid leukemia cells
  2. Liu, J.; Malavya, S.; Wang, X. Q.; Saavedra, J. E.; Keefer, L. K.; Tokar, E.; Qu, W.; Waalkes, M. P.; Shami, P. J.
  3. Genomics. 2009 94(1): 32-38.
  1. 10.   Modulation of Carcinogen Metabolism by Nitric Oxide-Aspirin 2 Is Associated with Suppression of DNA Damage and DNA Adduct Formation
  2. MacDonald, C. J.; Cheng, R.; Roberts, D. D.; Wink, D. A.; Yeh, G. C.
  3. Journal of Biological Chemistry. 2009 284(33): 22099-22107.
  1. 11.   The Nitric Oxide Prodrug JS-K and Its Structural Analogues as Cancer Therapeutic Agents
  2. Maciag, A. E.; Saavedra, J. E.; Chakrapani, H.
  3. Anti-cancer agents in medicinal chemistry. 2009 9(7): 798-803.
  1. 12.   Synthesis and evaluation of piperazine and homopiperazine analogues of JS-K, an anti-cancer lead compound
  2. Nandurdikar, R. S.; Maciag, A. E.; Citro, M. L.; Shami, P. J.; Keefer, L. K.; Saavedra, J. E.; Chakrapani, H.
  3. Bioorganic & Medicinal Chemistry Letters. 2009 19(10): 2760-2762.
  1. 13.   Structure Mechanism Insights and the Role of Nitric Oxide Donation Guide the Development of Oxadiazole-2-Oxides as Therapeutic Agents against Schistosomiasis
  2. Rai, G.; Sayed, A. A.; Lea, W. A.; Luecke, H. F.; Chakrapani, H.; Prast-Nielsen, S.; Jadhav, A.; Leister, W.; Shen, M.; Inglese, J.; Austin, C. P.; Keefer, L.; Arner, E.; Simeonov, A.; Maloney, D. J.; Williams, D. L.; Thomas, C. J.
  3. Journal of Medicinal Chemistry. 2009 52(20): 6474-6483.
  1. 14.   Synthesis, mechanistic studies, and anti-proliferative activity of glutathione/glutathione S-transferase-activated nitric oxide prodrugs
  2. Chakrapani, H.; Kalathur, R. C.; Maciag, A. E.; Citro, M. L.; Ji, X. H.; Keefer, L. K.; Saavedra, J. E.
  3. Bioorganic & Medicinal Chemistry. 2008 16(22): 9764-9771.
  1. 15.   GSTM1 and GSTT1 gene deletions and the risk for nasopharyngeal carcinoma in Han Chinese
  2. Guo, X. C.; O'Brien, S. J.; Zeng, Y.; Nelson, G. W.; Winkler, C. A.
  3. Cancer Epidemiology Biomarkers & Prevention. 2008 17(7): 1760-1763.
  1. 16.   Selective restoration of the selenoprotein population in a mouse hepatocyte selenoproteinless background with different mutant selenocysteine tRNAs lacking Um34
  2. Carlson, B. A.; Moustafa, M. E.; Sengupta, A.; Schweizer, U.; Shrimali, R.; Rao, M.; Zhong, N.; Wang, S.; Feigenbaum, L.; Lee, B. J.; Gladyshev, V. N.; Hatfield, D. L.
  3. Journal of Biological Chemistry. 2007, Nov; 282(45): 32591-32602.
  1. 17.   Nitric oxide prodrugs: Diazeniumdiolate anions of hindered secondary Amines
  2. Chakrapani, H.; Showalter, B. M.; Citro, M. L.; Keefer, L. K.; Saavedra, J. E.
  3. Organic Letters. 2007, Oct; 9(22): 4551-4554.
  1. 18.   Decreased selenoprotein expression alters the immune response during influenza virus infection in mice
  2. Sheridan, P. A.; Zhong, N. X.; Carlson, B. A.; Perella, C. M.; Hatfield, D. L.; Beck, M. A.
  3. Journal of Nutrition. 2007, Jun; 137(6): 1466-1471.
  1. 19.   Identification of a unique epigenetic sub-microenvironment in prostate cancer
  2. Rodriguez-Canales, J.; Hanson, J. C.; Tangrea, M. A.; Erickson, H. S.; Albert, P. S.; Wallis, B. S.; Richardson, A. M.; Pinto, P. A.; Linehan, W. M.; Gillespie, J. W.; Merin, M. J.; Libutti, S. K.; Woodson, K. G.; Emmert-Buck, M. R.; Chuaqui, R. F.
  3. Journal of Pathology. 2007, Mar; 211(4): 410-419.
  1. 20.   Effects of selenium supplementation on expression of glutathione peroxidase isoforms in cultured human lung adenocarcinoma cell lines
  2. Romanowska, M.; Kikawa, K. D.; Fields, J. R.; Maciag, A.; North, S. L.; Shiao, Y. H.; Kasprzak, K. S.; Anderson, L. M.
  3. Lung Cancer. 2007, Jan; 55(1): 35-42.
  1. 21.   Environmental genotoxicants/carcinogens and childhood cancer: Bridgeable gaps in scientific knowledge
  2. Anderson, L. M.
  3. Mutation Research-Genetic Toxicology and Environmental Mutagenesis. 2006, Sep; 608(2): 136-156.
  1. 22.   Antitumor activity of JS-K O-2-(2,4-dinitrophenyl) 1- (4-ethoxycarbonyl)piperazin-1-yl diazen-1-ium-1,2-diolate and related O-2-Aryl diazeniumdiolates in vitro and in vivo
  2. Shami, P. J.; Saavedra, J. E.; Bonifant, C. L.; Chu, J. X.; Udupi, V.; Malaviya, S.; Carr, B. I.; Kar, S.; Wang, M. F.; Jia, L.; Ji, X. H.; Keefer, L. K.
  3. Journal of Medicinal Chemistry. 2006, Jul; 49(14): 4356-4366.
  1. 23.   Variation in genes relevant to aromatic hydrocarbon metabolism and the risk of adult brain tumors
  2. De Roos, A. J.; Rothman, N.; Brown, M.; Bell, D. A.; Pittman, G. S.; Shapiro, W. R.; Selker, R. G.; Fine, H. A.; Black, P. M.; Inskip, P. D.
  3. Neuro-Oncology. 2006, Apr; 8(2): 145-155.
  1. 24.   Transcriptomic analysis of an in vitro murine model of ovarian carcinoma: Functional similarity to the human disease and identification of prospective tumoral markers and targets
  2. Urzua, U.; Roby, K. F.; Gangi, L. M.; Cherry, J. M.; Powell, J. I.; Munroe, D. J.
  3. Journal of Cellular Physiology. 2006, MAR; 206(3): 594-602.
  1. 25.   PABA/NO as an anticancer lead: Analogue synthesis, structure revision, solution chemistry, reactivity toward glutathione, and in vitro activity
  2. Saavedra, J. E.; Srinivasan, A.; Buzard, G. S.; Davies, K. M.; Waterhouse, D. J.; Inami, K.; Wilde, T. C.; Citro, M. L.; Cuellar, M.; Deschamps, J. R.; Parrish, D.; Shami, P. J.; Findlay, V. J.; Townsend, D. M.; Tew, K. D.; Singh, S.; Jia, L.; Ji, X. H.; Keefer, L. K.
  3. Journal of Medicinal Chemistry. 2006, FEB 9; 49(3): 1157-1164.
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