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  1. 1.   Systemic inflammatory Th1 cytokines during Trypanosoma cruzi infection disrupt the typical anatomical cell distribution and phenotypic/functional characteristics of various cell subsets within the thymus
  2. Viano, Estefania; Baez, Natalia S; Savid-Frontera, Constanza; Baigorrí, Eliana; Dinatale, Brenda; Pacini, Maria Florencia; Bulfoni Balbi, Camila; Gonzalez, Florencia Belén; Fozzatti, Laura; Lidón, Nicolas L; Young,Howard; Hodge, Deborah; Cerban, Fabio; Stempin, Cinthia; Pérez, Ana Rosa; Rodriguez Galán, Maria Cecilia
  3. Microbes and Infection. 2024, Apr 12; 105337.
  1. 2.   Safety levels of systemic IL-12 induced by cDNA expression as a cancer therapeutic
  2. Savid-Frontera, Constanza; Viano, Maria E; Baez, Natalia S; Reynolds, Della; Matellon, Mariana; Young,Howard; Rodriguez-Galan, Maria C
  3. Immunotherapy. 2021, Nov 16;
  1. 3.   IFN-gamma: A cytokine at the right time, is in the right place
  2. Burke,Daniel; Young,Howard
  3. Seminars in immunology. 2019, JUN; 43(Special Issue: SI):
  1. 4.   Molecular mechanisms of heparin-induced modulation of human interleukin 12 bioactivity
  2. Nguyen, Khue G.; Gillam, Francis B.; Hopkins, Jared J.; Jayanthi, Srinivas; Gundampati, Ravi Kumar; Su, Guowei; Bear,Jenifer; Pilkington, Guy R.; Jalah, Rashmi; Felber,Barbara; Liu, Jian; Thallapuranam, Suresh Kumar; Zaharoff, David A.
  3. JOURNAL OF BIOLOGICAL CHEMISTRY. 2019, Mar 22; 294(12): 4412-4424.
  1. 5.   Th1 Differentiation Drives the Accumulation of Intravascular, Non-protective CD4 T Cells during Tuberculosis.
  2. Sallin, Michelle A; Sakai, Shunsuke; Kauffman, Keith D; Young, Howard; Zhu, Jinfang; Barber, Daniel L
  3. Cell reports. 2017, Mar 28; 18(13): 3091-3104.
  1. 6.   CD8 alpha(+) Dendritic Cells Are the Critical Source of Interleukin-12 that Controls Acute Infection by Toxoplasma gondii Tachyzoites
  2. Mashayekhi, M.; Sandau, M. M.; Dunay, I. R.; Frickel, E. M.; Khan, A.; Goldszmid, R. S.; Sher, A.; Ploegh, H. L.; Murphy, T. L.; Sibley, L. D.; Murphy, K. M.
  3. Immunity. 2011, Aug; 35(2): 249-259.
  1. 7.   Tumor-Specific CD8(+) T Cells Expressing Interleukin-12 Eradicate Established Cancers in Lymphodepleted Hosts
  2. Kerkar, S. P.; Muranski, P.; Kaiser, A.; Boni, A.; Sanchez-Perez, L.; Yu, Z. Y.; Palmer, D. C.; Reger, R. N.; Borman, Z. A.; Zhang, L.; Morgan, R. A.; Gattinoni, L.; Rosenberg, S. A.; Trinchieri, G.; Restifo, N. P.
  3. Cancer Research. 2010, Sep; 70(17): 6725-6734.
  1. 8.   Long-lasting humoral and cellular immune responses and mucosal dissemination after intramuscular DNA immunization
  2. Patel, V.; Valentin, A.; Kulkarni, V.; Rosati, M.; Bergamaschi, C.; Jalah, R.; Alicea, C.; Minang, J. T.; Trivett, M. T.; Ohlen, C.; Zhao, J.; Robert-Guroff, M.; Khan, A. S.; Draghia-Akli, R.; Felber, B. K.; Pavlakis, G. N.
  3. Vaccine. 2010, Jul; 28(30): 4827-4836.
  1. 9.   Functional plasticity of macrophages: in situ reprogramming of tumor-associated macrophages
  2. Stout, R. D.; Watkins, S. K.; Suttles, J.
  3. Journal of Leukocyte Biology. 2009 86(5): 1105-1109.
  1. 10.   Immunotherapy of cancer by IL-12-based cytokine combinations
  2. Weiss, J. M.; Subleski, J. J.; Wigginton, J. M.; Wiltrout, R. H.
  3. Expert Opinion on Biological Therapy. 2007, Nov; 7(11): 1705-1721.
  1. 11.   Macaques co-immunized with SIVgag/pol-HIVenv and IL-12 plasmid have increased cellular responses
  2. Robinson, T. M.; Sidhui, M. K.; Pavlakis, G. N.; Felber, B. K.; Silvera, P.; Lewis, M. G.; Eldridge, J.; Weiner, D. B.; Boyer, J. D.
  3. Journal of Medical Primatology. 2007, Aug; 36(4-5): 276-284.
  1. 12.   IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis
  2. Kullberg, M. C.; Jankovic, D.; Feng, C. G.; Hue, S.; Gorelick, P. L.; McKenzie, B. S.; Cua, D. J.; Powrie, F.; Cheever, A. W.; Maloy, K. J.; Sher, A.
  3. Journal of Experimental Medicine. 2006, Oct; 203(11): 2485-2494.
  1. 13.   Proteasome inhibition to maximize the apoptotic potential of cytokine therapy for murine neuroblastoma tumors
  2. Khan, T.; Stauffer, J. K.; Williams, R.; Hixon, J. A.; Salcedo, R.; Lincoln, E.; Back, T. C.; Powell, D.; Lockett, S.; Arnold, A. C.; Sayers, T. J.; Wigginton, J. M.
  3. Journal of Immunology. 2006, MAY 15; 176(10): 6302-6312.
  1. 14.   Unraveling the pros and cons of interferon-gamma gene regulation
  2. Young, H. A.
  3. Immunity. 2006, MAY; 24(5): 506-507.
  1. 15.   A dose sparing effect by plasmid encoded IL-12 adjuvant on a SlVgag-plasmid DNA vaccine in rhesus macaques
  2. Schadeck, E. B.; Sidhu, M.; Egan, M. A.; Chong, S. Y.; Piacente, P.; Masood, A.; Garcia-H, D.; Cappello, S.; Roopch, V.; Megati, S.; Quiroz, J.; Boyer, J. D.; Felber, B. K.; Pavlakis, G. N.; Weiner, D. B.; Eldridge, J. H.; Israel, Z. R.
  3. Vaccine. 2006, May; 24(21): 4677-4687.
  1. 16.   Failure of HIV-exposed CD4(+) T cells to activate dendritic cells is reversed by restoration of CD40/CD154 interactions
  2. Zhang, R.; Lifson, J. D.; Chougnet, C.
  3. Blood. 2006, Mar; 107(5): 1989-1995.
  1. 17.   Regulation of ITAM-positive receptors: role of IL-12 and IL-18
  2. Ortaldo, J. R.; Winkler-Pickett, R.; Wigginton, J.; Horner, M.; Bere, E. W.; Mason, A. T.; Bhat, N.; Cherry, J.; Sanford, M.; Hodge, D. L.; Young, H. A.
  3. Blood. 2006, FEB 15; 107(4): 1468-1475.
  1. 18.   Therapeutic modulation of Akt activity and antitumor efficacy of interleukin-12 against orthotopic murine neuroblastoma
  2. Khan, T.; Hixon, J. A.; Stauffer, J. K.; Lincoln, E.; Back, T. C.; Brenner, J.; Lockett, S.; Nagashima, K.; Powell, D.; Wigginton, J. M.
  3. Journal of the National Cancer Institute. 2006, FEB 1; 98(3): 190-202.
  1. 19.   Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody
  2. Fuss, I. J.; Becker, C.; Yang, Z. Q.; Groden, C.; Hornung, R. L.; Heller, F.; Neurath, M. F.; Strober, W.; Mannon, P. J.
  3. Inflammatory Bowel Diseases. 2006, JAN; 12(1): 9-15.
  1. 20.   Multicolor fluorescence-based approaches for imaging cytokine-induced alterations in the neovascularization, growth, metastasis, and apoptosis of murine neuroblastoma tumors
  2. Stauffer, J. K.; Khan, T.; Salcedo, R.; Hixon, J. A.; Lincoln, E.; Back, T. C.; Wigginton, J. M.
  3. Journal of Immunotherapy. 2006, MAR-APR; 29(2): 151-164.
  1. 21.   Cytokines as critical co-stimulatory molecules in modulating the immune response of natural killer cells
  2. Young, H. A.; Ortaldo, J.
  3. Cell Research. 2006, Jan; 16(1): 20-24.
  1. 22.   Human tumor antigen MUC1 is chemotactic for immature dendritic cells and elicits maturation but does not promote Th1 type immunity
  2. Carlos, C. A.; Dong, H. F.; Howard, O. M. Z.; Oppenheim, J. J.; Hanisch, F. G.; Finn, O. J.
  3. Journal of Immunology. 2005, AUG 1; 175(3): 1628-1635.
  1. 23.   Treatment of mice with IL-12 DNA constructs leads to augmented NK activity in lungs but low IFN-gamma release - Implications for Bordetella pertussis infections following aerosol challenge
  2. Carter, C. R. D.; Dagg, B. M.; Whitmore, K. M.; Keeble, J. R.; Asokanathan, C.; Rodgers, A.; Watanabe, M.; Xing, D.; Walker, K. B.
  3. Cytokine. 2005, MAY 7; 30(3): 100-108.
  1. 24.   Toxicity vs antitumor effects of hydrodynamic IL-12 (interleukin-12) and IL-18 cDNA injections
  2. Rodriguez-Galan, M. C.; Watanabe, M.; Young, H. A.
  3. Faseb Journal. 2005, MAR 7; 19(5, Part 2, Suppl. S): A1406-A1406.
  1. 25.   Synergistic effect of IL-2, IL-12, and IL-18 on thymocyte apoptosis and Th1/Th2 cytokine expression
  2. Rodriguez-Galan, M. C.; Bream, J. H.; Farr, A.; Young, H. A.
  3. Journal of Immunology. 2005, MAR 1; 174(5): 2796-2804.
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