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  1. 1.   Interleukin-27 Regulates the Function of the Gastrointestinal Epithelial Barrier in a Human Tissue-Derived Organoid Model
  2. Brice, Daniel P; Murray, Graeme I; Wilson, Heather M; Porter, Ross J; Berry, Susan; Durum,Scott; McLean, Mairi H
  3. Biology. 2022, Mar 11; 11(3):
  1. 2.   The Timing and Abundance of IL-2R beta (CD122) Expression Control Thymic iNKT Cell Generation and NKT1 Subset Differentiation
  2. Won, Hee Yeun; Kim, Hye Kyung; Crossman, Assiatu; Awasthi,Roackie; Gress, Ronald E.; Park, Jung-Hyun
  3. Frontiers in immunology. 2021, May 14; 12
  1. 3.   Characterization of Recombinant Human IL-15 Deamidation and Its Practical Elimination through Substitution of Asparagine 77
  2. Nellis, D. F.; Michiel, D. F.; Jiang, M. S.; Esposito, D.; Davis, R.; Jiang, H. G.; Korrell, A.; Knapp, G. C.; Lucernoni, L. E.; Nelson, R. E.; Pritt, E. M.; Procter, L. V.; Rogers, M.; Sumpter, T. L.; Vyas, V. V.; Waybright, T. J.; Yang, X. Y.; Zheng, A. M.; Yovandich, J. L.; Gilly, J. A.; Mitra, G.; Zhu, J. W.
  3. Pharmaceutical Research. 2012, Mar; 29(3): 722-738.
  1. 4.   Comparison of GD2 binding capture ELISA assays for anti-GD2-antibodies using GD2-coated plates and a GD2-expressing cell-based ELISA
  2. Soman, G.; Yang, X. Y.; Jiang, H. G.; Giardina, S.; Mitra, G.
  3. Journal of Immunological Methods. 2011, Oct; 373(1-2): 181-191.
  1. 5.   Antitumor Activity of Hu14.18-IL2 in Patients With Relapsed/Refractory Neuroblastoma: A Children's Oncology Group (COG) Phase II Study
  2. Shusterman, S.; London, W. B.; Gillies, S. D.; Hank, J. A.; Voss, S. D.; Seeger, R. C.; Reynolds, C. P.; Kimball, J.; Albertini, M. R.; Wagner, B.; Gan, J.; Eickhoff, J.; DeSantes, K. B.; Cohn, S. L.; Hecht, T.; Gadbaw, B.; Reisfeld, R. A.; Maris, J. M.; Sondel, P. M.
  3. Journal of Clinical Oncology. 2010, Nov; 28(33): 4969-4975.
  1. 6.   Smallpox vaccine with integrated IL-15 demonstrates enhanced in vivo viral clearance in immunodeficient mice and confers long term protection against a lethal monkeypox challenge in cynomolgus monkeys
  2. Zielinski, R. J.; Smedley, J. V.; Perera, P. Y.; Silvera, P. M.; Waldmann, T. A.; Capala, J.; Perera, L. P.
  3. Vaccine. 2010, Oct; 28(43): 7081-7091.
  1. 7.   Implications for Gene Therapy-Limiting Expression of IL-2R gamma(c) Delineate Differences in Signaling Thresholds Required for Lymphocyte Development and Maintenance
  2. Orr, S. J.; Roessler, S.; Quigley, L.; Chan, T.; Ford, J. W.; O'Connor, G. M.; McVicar, D. W.
  3. Journal of Immunology. 2010, Aug; 185(3): 1393-1403.
  1. 8.   Increased CD4(+) T Cell Levels during IL-7 Administration of Antiretroviral Therapy-Treated Simian Immunodeficiency Virus-Positive Macaques Are Not Dependent on Strong Proliferative Responses
  2. Leone, A.; Rohankhedkar, M.; Okoye, A.; Legasse, A.; Axthelm, M. K.; Villinger, F.; Piatak, M.; Lifson, J. D.; Assouline, B.; Morre, M.; Picker, L. J.; Sodora, D. L.
  3. Journal of Immunology. 2010, Aug; 185(3): 1650-1659.
  1. 9.   TNF-alpha: an activator of CD4+FoxP3+TNFR2+ regulatory T cells
  2. Chen, X.; Oppenheim, J. J.
  3. Current directions in autoimmunity. 2010 11: 119-34.
  1. 10.   Immunologic and Therapeutic Synergy of IL-27 and IL-2: Enhancement of T Cell Sensitization, Tumor-Specific CTL Reactivity and Complete Regression of Disseminated Neuroblastoma Metastases in the Liver and Bone Marrow
  2. Salcedo, R.; Hixon, J. A.; Stauffer, J. K.; Jalah, R.; Brooks, A. D.; Khan, T.; Dai, R. M.; Scheetz, L.; Lincoln, E.; Back, T. C.; Powell, D.; Hurwitz, A. A.; Sayers, T. J.; Kastelein, R.; Pavlakis, G. N.; Felber, B. K.; Trinchieri, G.; Wigginton, J.
  3. Journal of Immunology. 2009 182(7): 4328-4338.
  1. 11.   Preclinical Evaluation of an Anti-CD25 Monoclonal Antibody, 7G7/B6, Armed with the beta-Emitter, Yttrium-90, as a Radioimmunotherapeutic Agent for Treating Lymphoma
  2. Zhang, M. L.; Yao, Z. S.; Garmestani, K.; Yu, S.; Goldman, C. K.; Paik, C. H.; Brechbiel, M. W.; Carrasquillo, J. A.; Waldmann, T. A.
  3. Cancer Biotherapy and Radiopharmaceuticals. 2009 24(3): 303-309.
  1. 12.   A systematic approach to biomarker discovery, Preamble to "the iSBTc-FDA taskforce on immunotherapy biomarkers"
  2. Butterfield, L. H.; Disis, M. L.; Fox, B. A.; Lee, P. P.; Khleif, S. N.; Thurin, M.; Trinchieri, G.; Wang, E.; Wigginton, J.; Chaussabel, D.; Coukos, G.; Dhodapkar, M.; Hakansson, L.; Janetzki, S.; Kleen, T. O.; Kirkwood, J. M.; Maccalli, C.
  3. Journal of Translational Medicine. 2008 6 AR 81
  1. 13.   The effect of continuous versus pericycle antiretroviral therapy on IL-2 responsiveness
  2. Healey, L. M.; Hahn, B. K.; Rehm, C. A.; Adelsberger, J.; Qin, J.; Follmann, D. A.; Tavel, J.; Kovacs, J. A.; Sereti, I.; Davey, R. T.
  3. Journal of Interferon and Cytokine Research. 2008 28(7): 455-461.
  1. 14.   CD4 T cell survival after intermittent interleukin-2 therapy is predictive of an increase in the CD4 T cell count of HIV-infected patients
  2. Read, S. W.; Lempicki, R. A.; Di Mascio, M.; Srinivasula, S.; Burke, R.; Sachau, W.; Bosche, M.; Adelsberger, J. W.; Sereti, I.; Davey, R. T.; Tavel, J. A.; Huang, C. Y.; Issaq, H. J.; Fox, S. D.; Lane, H. C.; Kovacs, J. A.
  3. Journal of Infectious Diseases. 2008 198(6): 843-850.
  1. 15.   IL-2: More than a T cell growth factor (Reprinted)
  2. Oppenheim, J. J.
  3. Journal of Immunology. 2007, Aug; 179(3): 1413-1414.
  1. 16.   Decreased CD127 expression on T cells in HIV-1-infected adults receiving antiretroviral therapy with or without intermittent IL-2 therapy
  2. Read, S. W.; Higgins, J.; Metcalf, J. A.; Stevens, R. A.; Rupert, A.; Nason, M. C.; Lane, H. C.; Sereti, I.
  3. Jaids-Journal of Acquired Immune Deficiency Syndromes. 2006, Aug; 42(5): 537-544.
  1. 17.   Glucocorticoid amplifies IL-2-dependent expansion of functional FoxP3(+)CD4(+)CD25(+) T regulatory cells in vivo and enhances their capacity to suppress EAE
  2. Chen, X.; Oppenheim, J. J.; Winkler-Pickett, R. T.; Ortaldo, J. R.; Howard, O. M. Z.
  3. European Journal of Immunology. 2006, Aug; 36(8): 2139-2149.
  1. 18.   Development of a quantitative cell-based ELISA, for a humanized anti-IL-2/IL-15 receptor beta antibody (HuMik beta(1)), and correlation with functional activity using an antigen-transfected murine cell line
  2. Yang, X. Y.; Chen, E.; Jiang, H. G.; Hartmann, W. K.; Mitra, G.; Hecht, T.; Soman, G.
  3. Journal of Immunological Methods. 2006, APR 20; 311(1-2): 71-80.
  1. 19.   Naive T-cell dynamics in human immunodeficiency virus type 1 infection: Effects of highly active antiretroviral therapy provide insights into the mechanisms of naive T-cell depletion
  2. Di Mascio, M.; Sereti, I.; Matthews, L. T.; Natarajan, V.; Adelsberger, J.; Lempicki, R.; Yoder, C.; Jones, E.; Chow, C.; Metcalf, J. A.; Sidorov, I. A.; Dimitrov, D. S.; Polis, M. A.; Kovacs, J. A.
  3. Journal of Virology. 2006, Mar; 80(6): 2665-2674.
  1. 20.   Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody
  2. Fuss, I. J.; Becker, C.; Yang, Z. Q.; Groden, C.; Hornung, R. L.; Heller, F.; Neurath, M. F.; Strober, W.; Mannon, P. J.
  3. Inflammatory Bowel Diseases. 2006, JAN; 12(1): 9-15.
  1. 21.   Limiting dilution analysis of interleukin-2 producing helper T-cell frequencies as a tool in allogeneic hematopoietic cell transplantation
  2. Petersen, S. L.; Sidorov, I. A.; Russell, C. A.; Dickmeiss, E.; Vindelov, L. L.
  3. Transplantation. 2005, SEP 15; 80(5): 573-581.
  1. 22.   In vivo hydrodynamic delivery of cDNA encoding IL-2: Rapid, sustained redistribution, activation of mouse NK cells, and therapeutic potential in the absence of NKT cells
  2. Ortaldo, J. R.; Winkler-Pickett, R. T.; Bere, E. W.; Watanabe, M.; Murphy, W. J.; Wiltrout, R. H.
  3. Journal of Immunology. 2005, JUL 15; 175(2): 693-699.
  1. 23.   CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2
  2. Tai, X. G.; Cowan, M.; Feigenbaum, L.; Singer, A.
  3. Nature Immunology. 2005, FEB; 6(2): 152-162.
  1. 24.   IL-27 mediates complete regression of orthotopic primary and metastatic murine neuroblastoma tumors: Role for CD8(+) T cells
  2. Salcedo, R.; Stauffer, J. K.; Lincoln, E.; Back, T. C.; Hixon, J. A.; Hahn, C.; Shafer-Weaver, K.; Malyguine, A.; Kastelein, R.; Wigginton, J. M.
  3. Journal of Immunology. 2004, DEC 15; 173(12): 7170-7182.
  1. 25.   Enhancer role of STAT5 in CD2 activation of IFN-gamma gene expression
  2. Gonsky, R.; Deem, R. L.; Bream, J.; Young, H. A.; Targan, S. R.
  3. Journal of Immunology. 2004, NOV 15; 173(10): 6241-6247.
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