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  1. 1.   JS-K, a nitric oxide prodrug, induces DNA damage and apoptosis in HBV-positive hepatocellular carcinoma HepG2.2.15 cell
  2. Liu, Zhengyun; Li, Guangmin; Gou, Ying; Xiao, Dongyan; Luo, Guo; Saavedra, Joseph; Liu, Jie; Wang, Huan
  3. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017, Aug; 92: 989-997.
  1. 2.   Effects of JS-K, a novel anti-cancer nitric oxide prodrug, on gene expression in human hepatoma Hep3B cells
  2. Dong, Ray; Wang, Xueqian; Wang, Huan; Liu, Zhengyun; Liu, Jie; Saavedra, Joseph
  3. BIOMEDICINE & PHARMACOTHERAPY. 2017, Apr; 88: 367-373.
  1. 3.   Arylation of Sensitive 1-(Pyrrolidin-1-yl)-diazen-1-ium-diolate in Ionic Liquids
  2. Velazquez, C. A.; Lynn, G. M.; Kumar, V.; Keefer, L. K.; Malhotra, S. V.
  3. Synthetic Communications. 2010, Apr 7; 40(9): 1322-1332.
  1. 4.   Gene expression profiling for nitric oxide prodrug JS-K to kill HL-60 myeloid leukemia cells
  2. Liu, J.; Malavya, S.; Wang, X. Q.; Saavedra, J. E.; Keefer, L. K.; Tokar, E.; Qu, W.; Waalkes, M. P.; Shami, P. J.
  3. Genomics. 2009 94(1): 32-38.
  1. 5.   O-2-Acetoxymethyl-protected diazeniumdiolate-based NSAIDs (NONO-NSAIDs): Synthesis, nitric oxide release, and biological evaluation studies
  2. Velazquez, C. A.; Rao, P. N. P.; Citro, M. L.; Keefer, L. K.; Knaus, E. E.
  3. Bioorganic & Medicinal Chemistry. 2007, Jul; 15(14): 4767-4774.
  1. 6.   Injectable formulation of disodium 1-[2-(carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolate (PROLI/NO), an ultrafast nitric oxide donor prodrug
  2. Waterhouse, D. J.; Saavedra, J. E.; Davies, K. M.; Citro, M. L.; Xu, X.; Powell, D. A.; Grimes, G. J.; Potti, G. K.; Keefer, L. K.
  3. Journal of Pharmaceutical Sciences. 2006, JAN; 95(1): 108-115.
  1. 7.   Limited protective role of V-PYRRO/NO against cholestasis produced by alpha-naphthylisothiocyanate in mice
  2. Liu, J.; He, Y. Y.; Chignell, C. F.; Clark, J.; Myers, P.; Saavedra, J. E.; Waalkes, M. P.
  3. Biochemical Pharmacology. 2005, JUL 1; 70(1): 144-151.
  1. 8.   Qualitative thin-layer and high-performance liquid chromatographic analysis of 1-substituted diazen-1-ium-1,2- diolates on aminopropyl-bonded silica gel
  2. Fitzhugh, A. L.; Anadu, N. O.; Waterhouse, D. J.; Hrabie, J. A.; Saavedra, J. E.; Keefer, L. K.
  3. Analytical Biochemistry. 2002 301(1): 97-102.
  1. 9.   Induction of penile erection by intracavernosal and transurethral administration of novel nitric oxide donors in the cat
  2. Champion, H. C.; Bivalacqua, T. J.; Wang, R.; Kadowitz, P. J.; Keefer, L. K.; Saavedra, J. E.; Hrabie, J. A.; Doherty, P. C.; Hellstrom, W. J. G.
  3. Journal of Urology. 1999 161(6): 2013-2019.
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