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  1. 1.   Quantitation of Active Pharmaceutical Ingredients in Polymeric Drug Products Using Elemental Analysis
  2. Xu,Jie; Hu, Yingwen; Clogston,Jeffrey
  3. Methods in Molecular Biology (Clifton, N.J.). 2024 2789: 35-43.
  1. 2.   Plasma Stability and Plasma Metabolite Concentration-Time Profiles of Oligo(Lactic Acid)8-Paclitaxel Prodrug Loaded Polymeric Micelles
  2. Repp, Lauren; Skoczen,Sarah; Rasoulianboroujeni, Morteza; Stern,Steve; Kwon, Glen S
  3. The AAPS Journal. 2023, Apr 11; 25(3): 39.
  1. 3.   Application of a Scavenger Receptor A1-Targeted Polymeric Prodrug Platform for Lymphatic Drug Delivery in HIV
  2. Stevens,David; Adiseshaiah, Pavan; Dasa,Siva Sai Krishna; Potter,Tim; Skoczen,Sarah; Snapp,Kelsie; Cedrone,Edward; Patel,Nimit; Busman-Sahay, Kathleen; Rosen, Elias P.; Sykes, Craig; Cottrell, Mackenzie; Dobrovolskaia,Marina; Estes, Jacob D.; Kashuba, Angela D. M.; Stern,Steve
  3. MOLECULAR PHARMACEUTICS. 2020, OCT 5; 17(10): 3794-3812.
  1. 4.   Total drug quantification in prodrugs using an automated elemental analyzer
  2. Hu,Yingwen; Stevens,David; Man, Sonny; Crist,Rachael; Clogston,Jeffrey
  3. Drug delivery and translational research. 2019, Dec; 9(6): 1057-1066.
  1. 5.   Bioreductively activatable prodrug conjugates of phenstatin designed to target tumor hypoxia
  2. Winn, Blake A; Shi, Zhe; Carlson, Graham J; Wang, Yifan; Nguyen, Benson L; Kelly, Evan M; Ross, R David; Hamel, Ernest; Chaplin, David J; Trawick, Mary L; Pinney, Kevin G
  3. Bioorganic & medicinal chemistry letters. 2017, Feb 01; 27(3): 636-641.
  1. 6.   Design, synthesis, and biological evaluation of water-soluble amino acid prodrug conjugates derived from combretastatin, dihydronaphthalene, and benzosuberene-based parent vascular disrupting agents
  2. Devkota, L.; Lin, C. M.; Strecker, T. E.; Wang, Y.; Tidmore, J. K.; Chen, Z.; Guddneppanavar, R.; Jelinek, C. J.; Lopez, R.; Liu, L.; Hamel, E.; Mason, R. P.; Chaplin, D. J.; Trawick, M. L.; Pinney, K. G.
  3. Bioorganic & Medicinal Chemistry. 2016, 1-Mar; 24(5): 938-56.
  1. 7.   Growth-inhibitory and chemosensitizing effects of the glutathione-S-transferase-p-activated nitric oxide donor PABA/NO in malignant gliomas
  2. Kogias, E.; Osterberg, N.; Baumer, B.; Psarras, N.; Koentges, C.; Papazoglou, A.; Saavedra, J. E.; Keefer, L. K.; Weyerbrock, A.
  3. International Journal of Cancer. 2012, Mar; 130(5): 1184-1194.
  1. 8.   Diazeniumdiolated carbamates: A novel class of nitric oxide donors
  2. Nandurdikar, R. S.; Maciag, A. E.; Cao, Z.; Keefer, L. K.; Saavedra, J. E.
  3. Bioorganic & Medicinal Chemistry. 2012, Mar; 20(6): 2025-2029.
  1. 9.   Antineoplastic Agents. 548. Synthesis of lodo- and Diiodocombstatin Phosphate Prodrugs
  2. Pettit, G. R.; Rosenberg, H. J.; Dixon, R.; Knight, J. C.; Hamel, E.; Chapuis, J. C.; Pettit, R. K.; Hogan, F.; Sumner, B.; Ain, K. B.; Trickey-Platt, B.
  3. Journal of Natural Products. 2012, Mar; 75(3): 385-393.
  1. 10.   Nitric oxide donor, V-PROLI/NO, provides protection against arsenical induced toxicity in rat liver cells: Requirement for Cyp1a1
  2. Qu, W.; Cheng, L. D.; Dill, A. L.; Saavedra, J. E.; Hong, S. Y.; Keefer, L. K.; Waalkes, M. P.
  3. Chemico-Biological Interactions. 2011, Aug; 193(1): 88-96.
  1. 11.   Regioselective Synthesis of Water-Soluble Monophosphate Derivatives of Combretastatin A-1
  2. Tanpure, R. P.; Nguyen, B. L.; Strecker, T. E.; Aguirre, S.; Sharma, S.; Chaplin, D. J.; Siim, B. G.; Hamel, E.; Lippert, J. W.; Pettit, G. R.; Trawick, M. L.; Pinney, K. G.
  3. Journal of Natural Products. 2011, Jul; 74(7): 1568-1574.
  1. 12.   Novel protection-deprotection strategies in diazeniumdiolate chemistry: synthesis of V-IPA/NO
  2. Nandurdikar, R. S.; Keefer, L. K.; Saavedra, J. E.
  3. Chemical Communications. 2011, Jun 21; 47(23): 6710-6712.
  1. 13.   The Nitric Oxide Prodrug V-PROLI/NO Inhibits Cellular Uptake of Proline
  2. Hong, S. Y.; Borchert, G. L.; Maciag, A. E.; Nandurdikar, R. S.; Saavedra, J. E.; Keefer, L. K.; Phang, J. M.; Chakrapani, H.
  3. Acs Medicinal Chemistry Letters. 2010, Nov; 1(8): 386-389.
  1. 14.   Click Reaction in Conjunction with Diazeniumdiolate Chemistry: Developing High-Load Nitric Oxide Donors
  2. Oladeinde, O. A.; Hong, S. Y.; Holland, R. J.; Maciag, A. E.; Keefer, L. K.; Saavedra, J. E.; N, urdikar
  3. Organic Letters. 2010, Oct; 12(19): 4256-4259.
  1. 15.   Nitrogen-bound diazeniumdiolated amidines
  2. Biswas, D.; Deschamps, J. R.; Keefer, L. K.; Hrabie, J. A.
  3. Chemical Communications. 2010, Aug 21; 46(31): 5799-5801.
  1. 16.   Soft alkyl ether prodrugs of a model phenolic drug: the effect of incorporation of ethyleneoxy groups on transdermal delivery
  2. Thomas, J. D.; Majumdar, S.; Sloan, K. B.
  3. Molecules (Basel, Switzerland). 2009 14(10): 4231-45.
  1. 17.   An improved synthesis of V-PROLI/NO, a cytochrome P450-activated nitric oxide prodrug
  2. Hong, S. Y.; Nandurdikar, R. S.; Keefer, L. K.; Saavedra, J. E.; Chakrapani, H.
  3. Tetrahedron Letters. 2009 50(31): 4545-4548.
  1. 18.   Synthesis and evaluation of piperazine and homopiperazine analogues of JS-K, an anti-cancer lead compound
  2. Nandurdikar, R. S.; Maciag, A. E.; Citro, M. L.; Shami, P. J.; Keefer, L. K.; Saavedra, J. E.; Chakrapani, H.
  3. Bioorganic & Medicinal Chemistry Letters. 2009 19(10): 2760-2762.
  1. 19.   E-Combretastatin and E-resveratrol structural modifications: Antimicrobial and cancer cell growth inhibitory beta-E-nitrostyrenes
  2. Pettit, R. K.; Pettit, G. R.; Hamel, E.; Hogan, F.; Moser, B. R.; Wolf, S.; Pon, S.; Chapuis, J. C.; Schmidt, J. M.
  3. Bioorganic & Medicinal Chemistry. 2009 17(18): 6606-6612.
  1. 20.   Aryl Bis(diazeniumdiolates): Potent Inducers of S-Glutathionylation of Cellular Proteins and Their in Vitro Antiproliferative Activities
  2. Andrei, D.; Maciag, A. E.; Chakrapani, H.; Citro, M. L.; Keefer, L. K.; Saavedra, J. E.
  3. Journal of Medicinal Chemistry. 2008 51(24): 7944-7952.
  1. 21.   Synthesis, mechanistic studies, and anti-proliferative activity of glutathione/glutathione S-transferase-activated nitric oxide prodrugs
  2. Chakrapani, H.; Kalathur, R. C.; Maciag, A. E.; Citro, M. L.; Ji, X. H.; Keefer, L. K.; Saavedra, J. E.
  3. Bioorganic & Medicinal Chemistry. 2008 16(22): 9764-9771.
  1. 22.   Cell-Permeable Esters of Diazeniumdiolate-Based Nitric Oxide Prodrugs
  2. Chakrapani, H.; Maciag, A. E.; Citro, M. L.; Keefer, L. K.; Saavedra, J. E.
  3. Organic Letters. 2008 10(22): 5155-5158.
  1. 23.   Griffithsin, a potent HIV entry inhibitor, is an excellent candidate for anti-HIV microbicide
  2. Emau, P.; Tian, B.; O'Keefa, B. R.; Mori, T.; McMahon, J. B.; Palmer, K. E.; Jiang, Y.; Bekele, G.; Tsai, C. C.
  3. Journal of Medical Primatology. 2007, Aug; 36(4-5): 244-253.
  1. 24.   Metabolism of a liver-selective nitric oxide-releasing agent, V-PYRRO/NO, by human microsomal cytochromes P450
  2. Inami, K.; Nims, R. W.; Srinivasan, A.; Citro, M. L.; Saavedra, J. E.; Cederbaum, A. I.; Keefer, L. K.
  3. Nitric Oxide-Biology and Chemistry. 2006, Jun; 14(4): 309-315.
  1. 25.   Benzoylphenylurea sulfur analogues with potent antitumor activity
  2. Hallur, G.; Jimeno, A.; Dalrymple, S.; Zhu, T.; Jung, M. K.; Hidaleo, M.; Isaacs, J. T.; Sukumar, S.; Hamel, E.; Khan, S. R.
  3. Journal of Medicinal Chemistry. 2006, Apr; 49(7): 2357-2360.
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