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  1. 1.   The effects of RNase H inhibitors and nevirapine on the susceptibility of HIV-1 to AZT and 3TC
  2. Davis, C. A.; Parniak, M. A.; Hughes, S. H.
  3. Virology. 2011, Oct; 419(2): 64-71.
  1. 2.   Mechanisms of HIV-1 drug resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors
  2. Nikolenko, G. N.; Kotelkin, A. T.; Oreshkova, S. F.; Ilyichev, A. A.
  3. Molecular Biology. 2011, Feb; 45(1): 93-109.
  1. 3.   The "Connection" Between HIV Drug Resistance and RNase H
  2. Delviks-Frankenberry, K. A.; Nikolenko, G. N.; Pathak, V. K.
  3. Viruses-Basel. 2010, Jul; 2(7): 1476-1503.
  1. 4.   A Novel Molecular Mechanism of Dual Resistance to Nucleoside and Nonnucleoside Reverse Transcriptase Inhibitors
  2. Nikolenko, G. N.; Delviks-Frankenberry, K. A.; Pathak, V. K.
  3. Journal of Virology. 2010, May; 84(10): 5238-5249.
  1. 5.   The mutation T477A in HIV-1 reverse transcriptase (RT) restores normal proteolytic processing of RT in virus with Gag-Pol mutated in the p51-RNH cleavage site
  2. Abram, M. E.; Sarafianos, S. G.; Parniak, M. A.
  3. Retrovirology. 2010, Feb; 7: 9.
  1. 6.   Novel approaches to inhibiting HIV-1 replication
  2. Adamson, C. S.; Freed, E. O.
  3. Antiviral Research. 2010, Jan; 85(1): 119-141.
  1. 7.   HIV-1 Reverse Transcriptase Can Simultaneously Engage Its DNA/RNA Substrate at Both DNA Polymerase and RNase H Active Sites: Implications for RNase H Inhibition
  2. Beilhartz, G. L.; Wendeler, M.; Baichoo, N.; Rausch, J.; Le Grice, S.; Gotte, M.
  3. Journal of Molecular Biology. 2009 388(3): 462-474.
  1. 8.   Structure of HIV-1 Reverse Transcriptase with the Inhibitor beta-Thujaplicinol Bound at the RNase H Active Site
  2. Himmel, D. M.; Maegley, K. A.; Pauly, T. A.; Bauman, J. D.; Das, K.; Dharia, C.; Clark, A. D.; Ryan, K.; Hickey, M. J.; Love, R. A.; Hughes, S. H.; Bergqvist, S.; Arnold, E.
  3. Structure. 2009 17(12): 1625-1635.
  1. 9.   The effects of alternate polypurine tracts (PPTs) and mutations of sequences adjacent to the PPT on viral replication and cleavage specificity of the Rous sarcoma virus reverse transcriptase
  2. Chang, K. W.; Oh, J.; Alvord, W. G.; Hughes, S. H.
  3. Journal of Virology. 2008 82(17): 8592-8604.
  1. 10.   Madurahydroxylactone derivatives as dual inhibitors of human immunodeficiency virus type 1 integrase and RNase H
  2. March, C.; Beutler, J. A.; Wamiru, A.; Budihas, S.; Mollmann, U.; Heinisch, L.; Mellors, J. W.; Le Grice, S. F.; Pommier, Y.
  3. Antimicrobial Agents and Chemotherapy. 2008 52(1): 361-364.
  1. 11.   Mutations in the U5 region adjacent to the primer binding site affect tRNA cleavage by human immunodeficiency virus type 1 reverse transcriptase in vivo
  2. Oh, J.; McWilliams, M. J.; Julias, J. G.; Hughes, S. H.
  3. Journal of Virology. 2008 82(2): 719-727.
  1. 12.   Structural probing of the HIV-1 polypurine tract RNA : DNA hybrid using classic nucleic acid ligands
  2. Turner, K. B.; Brinson, R. G.; Yi-Brunozzi, H. Y.; Rausch, J. W.; Miller, J. T.; Le Grice, S.; Marino, J. P.; Fabris, D.
  3. Nucleic Acids Research. 2008 36(8): 2799-2810.
  1. 13.   Human immunodeficiency virus type 1 cDNAs produced in the presence of APOBEC3G exhibit defects in plus-strand DNA transfer and integration
  2. Mbisa, J. L.; Barr, R.; Thomas, J. A.; Vandegraaff, N.; Dorweiler, I. J.; Svarovskaia, E. S.; Brown, W. L.; Mansky, L. M.; Gorelick, R. J.; Harris, R. S.; Engelman, A.; Pathak, V. K.
  3. Journal of Virology. 2007, Jul; 81(13): 7099-7110.
  1. 14.   In vitro analysis of the effects of mutations in the G-tract of the human immunodeficiency virus type 1 polypurine tract on RNase H cleavage specificity
  2. Jones, F. D.; Hughes, S. H.
  3. Virology. 2007, Apr; 360(2): 341-349.
  1. 15.   Exploiting structurally diverse nucleoside analogs as probes of reverse transcription complexes
  2. Rausch, J. W.; Le Grice, S. F. J.
  3. Current HIV Research. 2007, Jan; 5(1): 11-22.
  1. 16.   Combining mutations in HIV-1 reverse transcriptase with mutations in the HIV-1 polypurine tract affects RNase H cleavages involved in PPT utilization
  2. McWilliams, M. J.; Julias, J. G.; Sarafianos, S. G.; Alvord, W. G.; Arnold, E.; Hughes, S. H.
  3. Virology. 2006, May; 348(2): 378-388.
  1. 17.   HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site
  2. Himmel, D. M.; Sarafianos, S. G.; Dharmasena, S.; Hossain, M. M.; McCoy-Simandle, K.; Ilina, T.; Clark, A. D.; Knight, J. L.; Julias, J. G.; Clark, P. K.; Krogh-Jespersen, K.; Levy, R. M.; Hughes, S. H.; Parniak, M. A.; Arnold, E.
  3. Acs Chemical Biology. 2006 1(11): 702-712.
  1. 18.   Investigating HIV-1 polypurine tract geometry via targeted insertion of abasic lesions in the (-)-DNA template and (+)-RNA primer
  2. Yi-Brunozzi, H. Y.; Le Grice, S. F. J.
  3. Journal of Biological Chemistry. 2005, MAY 20; 280(20): 20154-20162.
  1. 19.   Mechanism for nucleoside analog-mediated abrogation of HIV-1 replication: Balance between RNase H activity and nucleotide excision
  2. Nikolenko, G. N.; Palmer, S.; Maldarelli, F.; Mellors, J. W.; Coffin, J. M.; Pathak, V. K.
  3. Proceedings of the National Academy of Sciences of the United States of America. 2005, FEB 8; 102(6): 2093-2098.
  1. 20.   Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones
  2. Budihas, S. R.; Gorshkova, I.; Gaidamakov, S.; Wamiru, A.; Bona, M. K.; Parniak, M. A.; Crouch, R. J.; McMahon, J. B.; Beutler, J. A.; Le Grice, S. F. J.
  3. Nucleic Acids Research. 2005 33(4): 1249-1256.
  1. 21.   Functional roles of carboxylate residues comprising the DNA polymerase active site triad of Ty3 reverse transcriptase
  2. Bibillo, A.; Lener, D.; Klarmann, G. J.; Le Grice, S. F. J.
  3. Nucleic Acids Research. 2005 33(1): 171-181.
  1. 22.   Effects of mutations in the G tract of the human immunodeficiency virus type 1 polypurine tract on virus replication and RNase H cleavage
  2. Julias, J. G.; McWilliams, M. J.; Sarafianos, S. G.; Alvord, W. G.; Arnold, E.; Hughes, S. H.
  3. Journal of Virology. 2004, DEC; 78(23): 13315-13324.
  1. 23.   Site- and subunit-specific incorporation of unnatural amino acids into HIV-1 reverse transcriptase
  2. Klarmann, G. J.; Eisenhauer, B. M.; Yi, Z.; Sitaraman, K.; Chatterjee, D. K.; Hecht, S. M.; Le Grice, S. F. J.
  3. Protein Expression and Purification. 2004, NOV; 38(1): 37-44.
  1. 24.   Action of Anti-HIV drugs and resistance: Reverse transcriptase inhibitors and protease inhibitors
  2. Imamichi, T.
  3. Current Pharmaceutical Design. 2004 10(32): 4039-4053.
  1. 25.   Using pyrrolo-deoxycytosine to probe RNA/DNA hybrids containing the human immunodeficiency virus type-1 3 ' polypurine tract
  2. Dash, C.; Rausch, J. W.; Le Grice, S. F. J.
  3. Nucleic Acids Research. 2004 32(4): 1539-1547.
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