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  1. 1.   Inhibition of Ribosome Biogenesis in vivo Causes p53-Dependent Death and p53-Independent Dysfunction
  2. Cho, Charles J; Nguyen, Thanh; Rougeau, Amala K; Huang, Yang-Zhe; To, Sarah; Lin, Xiaobo; Thalalla Gamage,Supuni; Meier,Jordan; Mills, Jason C
  3. Cellular and Molecular Gastroenterology and Hepatology. 2025, Mar 11; 101496.
  1. 2.   Olaparib in treatment-refractory isocitrate dehydrogenase 1 (IDH1)- and IDH2-mutant cholangiocarcinoma: Safety and antitumor activity from the phase 2 National Cancer Institute 10129 trial
  2. Cecchini, Michael; Pilat, Mary Jo; Uboha, Nataliya; Azad, Nilofer S; Cho, May; Davis, Elizabeth J; Ahnert, Jordi Rodon; Tinoco, Gabriel; Shapiro, Geoffrey I; Khagi, Simon; Powers, Benjamin; Spencer, Kristen; Groisberg, Roman; Drappatz, Jan; Chen, Li; Das,Bishu; Bao, Xun; Li, Jing; Narayan, Azeet; Vu, Dennis; Patel, Abhijit; Niger, Monica; Doroshow, Deborah; Durecki, Diane; Boerner, Scott A; Bindra, Ranjit; Ivy, Percy; Shyr, Derek; Shyr, Yu; LoRusso, Patricia M
  3. Cancer. 2025, Feb 15; 131(4): e35755.
  1. 3.   Modulation of the Substrate Preference of a MYST Acetyltransferase by a Scaffold Protein
  2. Sengupta, Raghuvir N; Brodsky, Oleg; Bingham, Patrick; Diehl, Wade C; Ferre, RoseAnn; Greasley, Samantha E; Johnson, Eric; Kraus, Michelle; Lieberman, Whitney; Meier,Jordan; Paul, Thomas A; Maegley, Karen A
  3. The Journal of Biological Chemistry. 2025, Feb 03; 108262.
  1. 4.   Allosteric modulation of NF1 GAP: Differential distributions of catalytically competent populations in loss-of-function and gain-of-function mutants
  2. Xu,Liang; Jang,Hyunbum; Nussinov,Ruth
  3. Protein Science : a publication of the Protein Society. 2025, Feb; 34(2): e70042.
  1. 5.   Comparative Analyses of Antiviral Potencies of Second-Generation Integrase Strand Transfer Inhibitors (INSTIs) and the Developmental Compound 4d Against a Panel of Integrase Quadruple Mutants
  2. Smith,Steven; Zhao,Xuezhi; Hughes,Stephen; Burke,Terrence
  3. Viruses. 2025, Jan 16; 17(1):
  1. 6.   The differential interactomes of the KRAS splice variants identify BIRC6 as a ubiquitin ligase for KRAS4A
  2. Kochen Rossi, Juan; Nuevo-Tapioles, Cristina; O'Keefe, Rachel A; Hunkeler, Moritz; Schmoker, Anna M; Fissore-O'Leary, Mercedes; Su, Wenjuan; Ahearn, Ian M; Branco, Cristina; Cheong, Hakyung; Esposito,Dom; Clotea, Ioana; Ueberheide, Beatrix; Fischer, Eric S; Philips, Mark R
  3. Cell Reports. 2024, Dec 19; 44(1): 115087.
  1. 7.   Two hearts beat as one: the debate over RAS dimers continues
  2. Stephen,Andy
  3. Trends in Biochemical Sciences. 2024, Nov; 49(11): 933-935.
  1. 8.   Producing recombinant proteins in Vibrio natriegens
  2. Smith,Matthew; Hernández, José Sánchez; Messing,Simon; Ramakrishnan,Nitya; Higgins,Brianna; Mehalko,Jennifer; Perkins,Shelley; Wall,Vanessa; Grose,Carissa; Frank,Peter; Cregger, Julia; Le,Vi; Johnson,Adam; Sherekar, Mukul; Pagonis,Morgan; Drew,Matt; Hong,Min; Widmeyer, Stephanie R T; Denson,John-Paul; Snead,Kelly; Poon,Ivy; Waybright,Tim; Champagne, Allison; Esposito,Dom; Jones,Jane; Taylor,Troy; Gillette,Bill
  3. Microbial Cell Factories. 2024, Jul 24; 23(1): 208.
  1. 9.   Enhancing precision in colorectal cancer surgery: development of an LGR5-targeting RSPO1 peptide mimetic as a contrast agent for intraoperative fluorescence molecular imaging
  2. Parasido, Erika; Ribeiro, Patricia; Chingle,Ramesh; Rohwetter, Thomas; Gupta, Nikita; Avetian, George; Bladelli, Elisa; Pierobon, Mariaelena; Chen, Yu; Tang, Qinggong; Schnermann,Martin; Rodriguez, Olga; Burke,Terrence; Burke, Terrence R; Albanese, Chris; Ihemelandu, Chukwuemeka
  3. Cell Cycle (Georgetown, Tex.). 2024, Jul 10; 1-12.
  1. 10.   Regulation of RAF family kinases: new insights from recent structural and biochemical studies
  2. Spencer-Smith, Russell; Morrison,Deborah
  3. Biochemical Society Transactions. 2024, June 26; 52(3): 1061-1069.
  1. 11.   Preclinical Therapeutic Efficacy of RAF/MEK/ERK and IGF1R/AKT/mTOR Inhibition in Neuroblastoma
  2. Stauffer,Stacey; Roth, Jacob S; Hernandez, Edjay R; Kowalczyk, Joshua T; Sealover, Nancy E; Hebron,Katie; James,Amy; Isanogle,Kristine; Riffle, Lisa A; Ileva,Lilia; Luo, Xiaoling; Chen, Jin-Qiu; Kedei, Noemi; Kortum, Robert L; Lei, Haiyan; Shern, Jack F; Kalen,Joseph; Edmondson, Elijah F; Hall, Matthew D; Difilippantonio,Simone; Thiele, Carol J; Yohe,Marielle
  3. Cancers. 2024, Jun 25; 16(13):
  1. 12.   K128 ubiquitination constrains RAS activity by expanding its binding interface with GAP proteins
  2. Magits, Wout; Steklov, Mikhail; Jang,Hyunbum; Sewduth, Raj N; Florentin, Amir; Lechat, Benoit; Sheryazdanova, Aidana; Zhang, Mingzhen; Simicek, Michal; Prag, Gali; Nussinov,Ruth; Sablina, Anna
  3. The EMBO Journal. 2024, Jun 10;
  1. 13.   RAS and SHOC2 Roles in RAF Activation and Therapeutic Considerations
  2. Bonsor,Daniel; Simanshu,Dhirendra
  3. Annual Review of Cancer Biology. 2024, Jun; 8: 97-113.
  1. 14.   A dual-luciferase bioluminescence system for the assessment of cellular therapies
  2. Torres Chavez, Alejandro G; McKenna, Mary K; Balasubramanian, Kishore; Riffle,Lisa; Patel,Nimit; Kalen,Joseph; St Croix,Brad; Leen, Ann M; Bajgain,Pradip
  3. Molecular Therapy. Oncology. 2024, Mar 21; 32(1): 200763.
  1. 15.   Adapting recombinant bacterial alkaline phosphatase for nucleotide exchange of small GTPases
  2. Frank,Peter; Hong, Min; Higgins, Brianna; Perkins, Shelley; Taylor, Troy; Wall,Vanessa; Drew,Matt; Waybright, Timothy; Gillette,Bill; Esposito,Dom; Messing, Simon
  3. Protein Expression and Purification. 2024, Feb 21; 106446.
  1. 16.   Distinct uptake and elimination profiles for trastuzumab, human IgG and biocytin-TMR in experimental HER2+ brain metastases of breast cancer
  2. Silvestri, Vanesa L; Tran, Andy D; Chung, Monika; Chung, Natalie; Gril, Brunilde; Robinson,Christina; Difilippantonio,Simone; Wei, Debbie; Kruhlak, Michael J; Peer, Cody J; Figg, W Douglas; Khan, Imran; Steeg, Patricia S
  3. Neuro-Oncology. 2024, Feb 13;
  1. 17.   Inhibition of Plasmodium falciparum plasmepsins by drugs targeting HIV-1 protease: A way forward for antimalarial drug discovery
  2. Mishra, Vandana; Deshmukh, Anuradha; Rathore, Ishan; Chakraborty, Satadru; Patankar, Swati; Gustchina,Alla; Wlodawer,Alexander; Yada, Rickey Y; Bhaumik, Prasenjit
  3. Current Research in Structural Biology. 2024, Jan 17; 7: 100128.
  1. 18.   Revealing the mechanism of action of a first-in-class covalent inhibitor of KRASG12C (ON) and other functional properties of oncogenic KRAS by 31P NMR
  2. Sharma,Alok; Pei, Jun; Yang, Yue; Dyba,Marcin; Smith,Brian; Rabara,Dana; Larsen,Erik; Lightstone, Felice C; Esposito,Dom; Stephen,Andy; Wang, Bin; Beltran, Pedro J; Wallace, Eli; Nissley,Dwight; McCormick, Frank; Maciag,Anna
  3. The Journal of Biological Chemistry. 2024, Jan 16; 300(2): 105650.
  1. 19.   Purification of Circular RNAs Using Poly(A) Tailing Followed by RNase R Digestion
  2. Xiao, Mei-Sheng; Wilusz, Jeremy E
  3. Methods in Molecular Biology (Clifton, N.J.). 2024 2765: 3-19.
  1. 20.   SHP2 clinical phenotype, cancer, or RASopathies, can be predicted by mutant conformational propensities
  2. Liu,Yonglan; Zhang,Wengang; Jang,Hyunbum; Nussinov,Ruth
  3. Cellular and Molecular Life Sciences : CMLS. 2023, Dec 12; 81(1): 5.
  1. 21.   Revealing KRas4b topology on the membrane surface
  2. Shree, Shweta; McLean, Mark A; Stephen,Andy; Sligar, Stephen G
  3. Biochemical and Biophysical Research Communications. 2023, Oct 20; 678: 122-127.
  1. 22.   Dihydroxyphenyl- and Heteroaromatic-Based Thienopyrimidinones to Tackle HIV-1 LEDGF/p75-Dependent IN Activity
  2. Tocco, Graziella; Canton, Serena; Laus, Antonio; Caboni, Pierluigi; Le Grice, Stuart F J; Tramontano, Enzo; Esposito, Francesca
  3. Molecules (Basel, Switzerland). 2023, Sep 19; 28(18):
  1. 23.   Investigating the NRAS 5' UTR as a target for small molecules
  2. Balaratnam,Sumirtha; Torrey, Zachary R; Calabrese,Dave; Banco, Michael T; Yazdani, Kamyar; Liang, Xiao; Fullenkamp,Chris; Seshadri,Sri; Holewinski,Ronald; Andresson,Thorkell; Ferré-D'Amaré, Adrian R; Incarnato, Danny; Schneekloth,Jay
  3. Cell Chemical Biology. 2023, Jun 15; 30(6): 643-657.e8.
  1. 24.   Robust regulation of transcription pausing in Escherichia coli by the ubiquitous elongation factor NusG
  2. Yakhnin,Alex; Bubunenko,Mikhail; Mandell, Zachary F; Lubkowska,Lucyna; Husher, Sara; Babitzke, Paul; Kashlev,Mikhail
  3. Proceedings of the National Academy of Sciences of the United States of America. 2023, Jun 13; 120(24): e2221114120.
  1. 25.   The Ribosomal S6 Kinase 2 (RSK2)-SPRED2 complex regulates phosphorylation of RSK substrates and MAPK signaling
  2. Lopez, Jocelyne; Bonsor,Daniel; Sale, Matthew J; Urisman, Anatoly; Mehalko,Jennifer; Cabanski-Dunning, Miranda; Castel, Pau; Simanshu,Dhirendra; McCormick, Frank
  3. The Journal of Biological Chemistry. 2023, May 04; 104789.
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