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  1. 2.   Novel Arf1 Inhibitors Drive Cancer Stem Cell Aging and Potentiate Anti-Tumor Immunity
  2. Wang, Yuetong; Li, Qiaoming; Ding, Yahui; Luo, Chenfei; Yang, Jun; Wang, Na; Jiang, Ning; Yao, Tiange; Wang, Guohao; Shi, Guoming; Hou, Steven X
  3. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). 2024, Sep 03; e2404442.
  1. 3.   K128 ubiquitination constrains RAS activity by expanding its binding interface with GAP proteins
  2. Magits, Wout; Steklov, Mikhail; Jang,Hyunbum; Sewduth, Raj N; Florentin, Amir; Lechat, Benoit; Sheryazdanova, Aidana; Zhang, Mingzhen; Simicek, Michal; Prag, Gali; Nussinov,Ruth; Sablina, Anna
  3. The EMBO Journal. 2024, Jun 10;
  1. 4.   Disruption of Ca2+/calmodulin:KSR1 interaction lowers ERK activation
  2. Thines, Louise; Jang,Hyunbum; Li, Zhigang; Sayedyahossein, Samar; Maloney, Ryan; Nussinov,Ruth; Sacks, David B
  3. Protein Science : a publication of the Protein Society. 2024, May; 33(5): e4982.
  1. 5.   SHP2 clinical phenotype, cancer, or RASopathies, can be predicted by mutant conformational propensities
  2. Liu,Yonglan; Zhang,Wengang; Jang,Hyunbum; Nussinov,Ruth
  3. Cellular and Molecular Life Sciences : CMLS. 2023, Dec 12; 81(1): 5.
  1. 6.   Revealing KRas4b topology on the membrane surface
  2. Shree, Shweta; McLean, Mark A; Stephen,Andy; Sligar, Stephen G
  3. Biochemical and Biophysical Research Communications. 2023, Oct 20; 678: 122-127.
  1. 7.   Double knockin mice show NF-?B trajectories in immune signaling and aging
  2. Rahman, Shah Md Toufiqur; Aqdas, Mohammad; Martin, Erik W; Tomassoni Ardori,Francesco; Songkiatisak, Preeyaporn; Oh, Kyu-Seon; Uderhardt, Stefan; Yun, Sangwon; Claybourne, Quia C; McDevitt, Ross A; Greco, Valentina; Germain, Ronald N; Tessarollo, Lino; Sung, Myong-Hee
  3. Cell Reports. 2022, Nov 22; 41(8): 111682.
  1. 8.   A Heterozygous Gain-of-Function Variant in IKBKB Associated with Autoimmunity and Autoinflammation
  2. Sacco, Keith; Kuehn, Hye Sun; Kawai, Tomoki; Alsaati, Nouf; Smith, Lauren; Davila, Blachy; Bundy, Vanessa; Kuhns,Doug; Dobbs, Kerry; Delmonte, Ottavia; Notarangelo, Luigi D; Rosenzweig, Sergio D; Keller, Michael D
  3. Journal of Clinical Immunology. 2022, Nov 15;
  1. 9.   ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1
  2. Su, Wenjing; Mukherjee, Radha; Yaeger, Rona; Son, Jieun; Xu, Jianing; Na, Na; Merna Timaul, Neilawattie; Hechtman, Jaclyn; Paroder, Viktoriya; Lin, Mika; Mattar, Marissa; Qiu, Juan; Chang, Qing; Zhao, Huiyong; Zhang, Jonathan; Little, Megan; Adachi, Yuta; Han, Sae-Won; Taylor, Barry S; Ebi, Hiromichi; Abdel-Wahab, Omar; de Stanchina, Elisa; Rudin, Charles M; Jänne, Pasi A; McCormick, Frank; Yao, Zhan; Rosen, Neal
  3. Molecular Cell. 2022, May 14;
  1. 10.   The seventh international RASopathies symposium: Pathways to a cure-expanding knowledge, enhancing research, and therapeutic discovery
  2. Kontaridis, Maria I; Roberts, Amy E; Schill, Lisa; Schoyer, Lisa; Stronach, Beth; Andelfinger, Gregor; Aoki, Yoko; Axelrad, Marni E; Bakker, Annette; Bennett, Anton M; Broniscer, Alberto; Castel, Pau; Chang, Caitlin A; Cyganek, Lukas; Das, Tirtha K; den Hertog, Jeroen; Galperin, Emilia; Garg, Shruti; Gelb, Bruce D; Gordon, Kristiana; Green, Tamar; Gripp, Karen W; Itkin, Maxim; Kiuru, Maija; Korf, Bruce R; Livingstone, Jeff R; López-Juárez, Alejandro; Magoulas, Pilar L; Mansour, Sahar; Milner, Theresa; Parker, Elisabeth; Pierpont, Elizabeth I; Plouffe, Kevin; Rauen, Katherine A; Shankar, Suma P; Smith, Shane B; Stevenson, David A; Tartaglia, Marco; Van, Richard; Wagner,Morgan; Ware, Stephanie M; Zenker, Martin
  3. American Journal of Medical Genetics. Part A. 2022, Mar 09;
  1. 11.   IKKa-deficient lung adenocarcinomas generate an immunosuppressive microenvironment by overproducing Treg-inducing cytokines
  2. Song, Na-Young; Li,Xin; Ma, Buyong; Willette-Brown, Jami; Zhu,Feng; Jiang, Chengfei; Su,Ling; Shetty,Jyoti; Zhao,Yongmei; Shi,Gongping; Banerjee, Sayantan; Wu,Xiaolin; Tran,Bao; Nussinov,Ruth; Karin, Michael; Hu,Yinling
  3. Proceedings of the National Academy of Sciences of the United States of America. 2022, Feb 08; 119(6): e2120956119.
  1. 12.   Zic5 stabilizes Gli3 via a non-transcriptional mechanism during retinal development
  2. Sun,Jian; Yoon,Jaeho; Lee,Moonsup; Lee,Hyun Kyung; Hwang,Rich Yooseok; Daar,Ira
  3. Cell Reports. 2022, Feb 01; 38(5):
  1. 13.   Combination of Wnt/ß-Catenin Targets S100A4 and DKK1 Improves Prognosis of Human Colorectal Cancer
  2. Dahlmann, Mathias; Monks, Anne; Harris,Erik; Kobelt, Dennis; Osterland, Marc; Khaireddine, Fadi; Herrmann, Pia; Kemmner, Wolfgang; Burock, Susen; Walther, Wolfgang; Shoemaker, Robert H; Stein, Ulrike
  3. Cancers. 2021, Dec 22; 14(1):
  1. 14.   A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor
  2. Huang, Yongjian; Ognjenovic,Jana; Karandur, Deepti; Miller, Kate; Merk,Alan; Subramaniam, Sriram; Kuriyan, John
  3. eLife. 2021, Nov 30; 10
  1. 15.   Yap-Sox9 signaling determines hepatocyte plasticity and lineage-specific hepatocarcinogenesis
  2. Liu, Yuchen; Zhuo, Shu; Zhou, Yaxing; Ma, Lichun; Sun,David; Wu,Xiaolin; Wang, Xin Wei; Gao, Bin; Yang, Yingzi
  3. Journal of hepatology. 2021, Nov 15;
  1. 16.   Drugging multiple same-allele driver mutations in cancer
  2. Nussinov,Ruth; Zhang,Mingzhen; Maloney,Ryan; Jang, Hyunbum
  3. Expert Opinion on Drug Discovery. 2021, Aug; 16(8): 823-828.
  1. 17.   The Structural Basis of Akt PH Domain Interaction with Calmodulin
  2. Weako,Jackson; Jang, Hyunbum; Keskin, Ozlem; Nussinov,Ruth; Gursoy, Attila
  3. Biophysical Journal. 2021, May 18; 120(10): 1994-2008.
  1. 18.   New Therapeutic Opportunities for the Treatment of Squamous Cell Carcinomas: A Focus on Novel Driver Kinases
  2. Bensen, Ryan; Brognard,John
  3. International Journal of Molecular Sciences. 2021, Mar; 22(6):
  1. 19.   Inhibition of Nonfunctional Ras
  2. Nussinov,Ruth; Jang, Hyunbum; Gursoy, Attila; Keskin, Ozlem; Gaponenko, Vadim
  3. Cell Chemical Biology. 2021, Feb 18; 28(2): 121-133.
  1. 20.   Rigosertib Induces Mitotic Arrest and Apoptosis in RAS-Mutated Rhabdomyosarcoma and Neuroblastoma
  2. Kowalczyk, Joshua T.; Wan, Xiaolin; Hernandez, Edjay R.; Luo, Ruibai; Lyons, Gaelyn C.; Wilson, Kelli M.; Gallardo, Devorah C.; Isanogle,Kristine; Robinson,Christina; Mendoza, Arnulfo; Heske, Christine M.; Chen, Jinqui-Qiu; Luo, Xiaoling; Kelly, Alexander E.; Difilippantonio,Simone; Robey, Robert W.; Thomas, Craig J.; Sackett, Dan L.; Morrison,Deborah; Randazzo, Paul A.; Jenkins, Lisa M. Miller; Yohe, Marielle E.
  3. MOLECULAR CANCER THERAPEUTICS. 2021, Feb 1; 20(2): 307-319.
  1. 21.   Promoterless Transposon Mutagenesis Drives Solid Cancers via Tumor Suppressor Inactivation
  2. Aiderus, Aziz; Contreras-Sandoval, Ana M; Meshey, Amanda L; Newberg, Justin Y; Ward, Jerrold M; Swing,Debbie; Copeland, Neal G; Jenkins, Nancy A; Mann, Karen M; Mann, Michael B
  3. Cancers. 2021, Jan 09; 13(2):
  1. 22.   C-CBL is required for inhibition of angiogenesis through modulating JAK2/STAT3 activity in ROP development
  2. Chen, Shimei; Sun, Qiao; Sun, Dandan; Willette Brown,Jami; Anderson,Matthew; Gu, Qing; Lewandoski,Mark; Hu, Yinling; Zhu,Feng; Wei, Fang; Zhang, Jian
  3. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020, DEC; 132: 110856.
  1. 23.   Heterogeneous adaptation of cysteine reactivity to a covalent oncometabolite
  2. Perez,Minervo; Bak, Daniel W.; Bergholtz, Sarah E.; Crooks, Daniel R.; Arimilli, Bhargav Srinivas; Yang, Youfeng; Weerapana, Eranthie; Linehan, W. Marston; Meier,Jordan
  3. JOURNAL OF BIOLOGICAL CHEMISTRY. 2020, SEP 25; 295(39): 13410-13418.
  1. 24.   An Extended Conformation for K48 Ubiquitin Chains Revealed by the hRpn2:Rpn13:K48-Diubiquitin Structure
  2. Lu,Xiuxiu; Ebelle, Danielle L; Matsuo,Hiroshi; Walters,Kylie
  3. Structure (London, England : 1993). 2020, May 5; 28(5): 495-506.e3.
  1. 25.   Biochemical and structural analyses reveal that the tumor suppressor neurofibromin (NF1) forms a high-affinity dimer
  2. Sherekar,Mukul; Han, Sae-Won; Ghirlando, Rodolfo; Messing,Simon; Drew,Matt; Rabara,Dana; Waybright,Tim; Juneja, Puneet; O'Neill, Hugh; Stanley, Christopher B; Bhowmik, Debsindhu; Ramanathan, Arvind; Subramaniam,Sriram; Nissley,Dwight; Gillette,Bill; McCormick, Frank; Esposito,Dom
  3. The Journal of biological chemistry. 2020, JAN 24; 295(4): 1105-1119.
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