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  1. 1.   Drug-Linker Constructs Bearing Unique Dual-Mechanism Tubulin Binding Payloads Tethered through Cleavable and Non-Cleavable Linkers
  2. Ford, Jacob W; VanNatta, Jennifer M; Mondal, Deboprosad; Lin, Chen-Ming; Deng, Yuling; Bai, Ruoli; Hamel,Ernest; Trawick, Mary Lynn; Pinney, Kevin G
  3. Tetrahedron. 2025, Feb 01; 171
  1. 2.   Design, Synthesis and Biological Evaluation of 2-Phenyl Indole Analogues of OXi8006 as Colchicine Site Inhibitors of Tubulin Polymerization and Vascular Disrupting Agents
  2. Vairin, Rebecca; Tamminga, Caleb; Shi, Zhe; Borchardt, Christian; Jambulapati, Jayaram; Bai, Ruoli; Wanniarachchi, Hashini; Bueno, Lorena; Hamel,Ernest; Mason, Ralph P; Trawick, Mary Lynn; Pinney, Kevin G
  3. Bioorganic & Medicinal Chemistry. 2024, Nov 07; 118: 117981.
  1. 3.   Synthesis and Biological Evaluation of Novel 2-Aroyl Benzofuran-Based Hydroxamic Acids as Antimicrotubule Agents
  2. Mariotto, Elena; Canton, Martina; Marchioro, Chiara; Brancale, Andrea; Hamel,Ernest; Varani, Katia; Vincenzi, Fabrizio; De Ventura, Tiziano; Padroni, Chiara; Viola, Giampietro; Romagnoli, Romeo
  3. International Journal of Molecular Sciences. 2024, Jul 09; 25(14):
  1. 4.   Synthesis and biological evaluation of structurally diverse 6-aryl-3-aroyl-indole analogues as inhibitors of tubulin polymerization
  2. Ren, Wen; Deng, Yuling; Ward, Jacob D; Vairin, Rebecca; Bai,Ruoli; Wanniarachchi, Hashini I; Hamal, Khagendra B; Tankoano, Pouguiniseli E; Tamminga, Caleb S; Bueno, Lorena M A; Hamel,Ernest; Mason, Ralph P; Trawick, Mary Lynn; Pinney, Kevin G
  3. European Journal of Medicinal Chemistry. 2023, Sep 06; 263: 115794.
  1. 5.   Novel Indole-Pyrazole Hybrids as Potential Tubulin-Targeting Agents; Synthesis, antiproliferative evaluation, and molecular modeling studies
  2. Hawash, Mohammed; Ergun, Sezen Guntekin; Kahraman, Deniz Cansen; Olgac, Abdurrahman; Hamel,Ernest; Cetin-Atalay, Rengul; Baytas, Sultan Nacak
  3. Journal of Molecular Structure. 2023, Aug 05; 1285
  1. 6.   Structure Guided Design, Synthesis, and Biological Evaluation of Oxetane-Containing Indole Analogues
  2. Ren, Wen; Vairin, Rebecca; Ward, Jacob D; Francis, Ricardo; VanNatta, Jenny; Bai,Ruoli; Tankoano, Pouguiniseli E; Deng, Yuling; Hamel,Ernest; Trawick, Mary Lynn; Pinney, Kevin G
  3. Bioorganic & Medicinal Chemistry. 2023, Jun 29; 92: 117400.
  1. 7.   RS6077 induces mitotic arrest and selectively activates cell death in human cancer cell lines and in a lymphoma tumor in vivo
  2. Sebastiani, Jessica; Puxeddu, Michela; Nalli, Marianna; Bai,Ruoli; Altieri, Ludovica; Rovella, Paola; Gaudio, Eugenio; Trisciuoglio, Daniela; Spriano, Filippo; Lavia, Patrizia; Fionda, Cinzia; Masci, Domiziana; Urbani, Andrea; Bigogno, Chiara; Dondio, Giulio; Hamel,Ernest; Bertoni, Francesco; Silvestri, Romano; La Regina, Giuseppe
  3. European Journal of Medicinal Chemistry. 2022, Dec 05; 246: 114997.
  1. 8.   Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: Further chemical modifications and potential therapeutic effects against lymphomas
  2. Barreca, Marilia; Spanò, Virginia; Rocca, Roberta; Bivacqua, Roberta; Abel, Anne-Catherine; Maruca, Annalisa; Montalbano, Alessandra; Raimondi, Maria Valeria; Tarantelli, Chiara; Gaudio, Eugenio; Cascione, Luciano; Rinaldi, Andrea; Bai,Ruoli; Steinmetz, Michel O; Prota, Andrea E; Alcaro, Stefano; Hamel, Ernest; Bertoni, Francesco; Barraja, Paola
  3. European Journal of Medicinal Chemistry. 2022, Sep 08; 243: 114744.
  1. 9.   Synthesis and Biological Evaluation of Highly Active 7-Anilino Triazolopyrimidines as Potent Antimicrotubule Agents
  2. Oliva, Paola; Romagnoli, Romeo; Cacciari, Barbara; Manfredini, Stefano; Padroni, Chiara; Brancale, Andrea; Ferla, Salvatore; Hamel,Ernest; Corallo, Diana; Aveic, Sanja; Milan, Noemi; Mariotto, Elena; Viola, Giampietro; Bortolozzi, Roberta
  3. Pharmaceutics. 2022, Jun 02; 14(6):
  1. 10.   Effects of substituent pattern on the intracellular target of antiproliferative benzo[b]thiophenyl chromone derivatives
  2. Saito, Yohei; Taniguchi, Yukako; Hirazawa, Sachika; Miura, Yuta; Tsurimoto, Hiroyuki; Nakayoshi, Tomoki; Oda, Akifumi; Hamel,Ernest; Yamashita, Katsumi; Goto, Masuo; Nakagawa-Goto, Kyoko
  3. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2021, OCT 15; 222
  1. 11.   Discovery of pyrrole derivatives for the treatment of glioblastoma and chronic myeloid leukemia
  2. Puxeddu, Michela; Shen, Hongliang; Bai,Ruoli; Coluccia, Antonio; Bufano, Marianna; Nalli, Marianna; Sebastiani, Jessica; Brancaccio, Diego; Da Pozzo, Eleonora; Tremolanti, Chiara; Martini, Claudia; Orlando, Viviana; Biagioni, Stefano; Sinicropi, Maria Stefania; Ceramella, Jessica; Iacopetta, Domenico; Coluccia, Addolorata Maria Luce; Hamel,Ernest; Liu, Te; Silvestri, Romano; La Regina, Giuseppe
  3. European journal of medicinal chemistry. 2021, Oct 5; 221
  1. 12.   Deciphering the key heterocyclic scaffolds in targeting microtubules, kinases and carbonic anhydrases for cancer drug development
  2. Peerzada, Mudasir Nabi; Hamel,Ernest; Bai,Ruoli; Supuran, Claudiu T.; Azam, Amir
  3. Pharmacology & therapeutics. 2021, Sep; 225
  1. 13.   A facile synthesis of diaryl pyrroles led to the discovery of potent colchicine site antimitotic agents
  2. Romagnoli, Romeo; Oliva, Paola; Salvador, Maria Kimatrai; Manfredini, Stefano; Padroni, Chiara; Brancale, Andrea; Ferla, Salvatore; Hamel,Ernest; Ronca, Roberto; Maccarinelli, Federica; Rruga, Fatlum; Mariotto, Elena; Viola, Giampietro; Bortolozzi, Roberta
  3. European Journal of Medicinal Chemistry. 2021, Mar 15; 214
  1. 14.   Insight on [1,3]thiazolo[4,5-e]isoindoles as tubulin polymerization inhibitors
  2. Spano, Virginia; Barreca, Marilia; Rocca, Roberta; Bortolozzi, Roberta; Bai, Ruoli; Carbone, Anna; Raimondi, Maria Valeria; Piccionello, Antonio Palumbo; Montalbano, Alessandra; Alcaro, Stefano; Hamel, Ernest; Viola, Giampietro; Barraja, Paola
  3. European Journal of Medicinal Chemistry. 2021, Feb 15; 212
  1. 15.   Pyrrolo[2 ',3 ':3,4]cyclohepta[1,2-d][1,2]oxazoles, a New Class of Antimitotic Agents Active against Multiple Malignant Cell Types
  2. Spano, Virginia; Rocca, Roberta; Barreca, Marilia; Giallombardo, Daniele; Montalbano, Alessandra; Carbone, Anna; Raimondi, Maria Valeria; Gaudio, Eugenio; Bortolozzi, Roberta; Bai,Ruoli; Tassone, Pierfrancesco; Alcaro, Stefano; Hamel,Ernest; Viola, Giampietro; Bertoni, Francesco; Barraja, Paola
  3. JOURNAL OF MEDICINAL CHEMISTRY. 2020, OCT 22; 63(20): 12023-12042.
  1. 16.   Design, synthesis, in vitro and in vivo biological evaluation of 2-amino-3-aroylbenzo[b]furan derivatives as highly potent tubulin polymerization inhibitors
  2. Oliva, Paola; Romagnoli, Romeo; Manfredini, Stefano; Brancale, Andrea; Ferla, Salvatore; Hamel,Ernest; Ronca, Roberto; Maccarinelli, Federica; Giacomini, Arianna; Rruga, Fatlum; Mariotto, Elena; Viola, Giampietro; Bortolozzi, Roberta
  3. European journal of medicinal chemistry. 2020, AUG 15; 200: 112448.
  1. 17.   Diaryl disulfides and thiosulfonates as combretastatin A-4 analogues: Synthesis, cytotoxicity and antitubulin activity
  2. Khodyuk, Rejane Gonçalves Diniz; Bai,Ruoli; Hamel,Ernest; Lourenço, Estela Mariana Guimarães; Barbosa, Euzébio Guimarães; Beatriz, Adilson; Dos Santos, Edson Dos Anjos; de Lima, Dênis Pires
  3. Bioorganic chemistry. 2020, AUG; 101: 104017.
  1. 18.   Bioreductively Activatable Prodrug Conjugates of Combretastatin A-1 and Combretastatin A-4 as Anticancer Agents Targeted toward Tumor-Associated Hypoxia
  2. Winn, Blake A; Devkota, Laxman; Kuch, Bunnarack; MacDonough, Matthew T; Strecker, Tracy E; Wang, Yifan; Shi, Zhe; Gerberich, Jeni L; Mondal, Deboprosad; Ramirez, Alejandro J; Hamel,Ernest; Chaplin, David J; Davis, Peter; Mason, Ralph P; Trawick, Mary Lynn; Pinney, Kevin G
  3. Journal of natural products. 2020, APR 24; 83(4): 937-954.
  1. 19.   Synthesis and Biological Evaluation of New Antitubulin Agents Containing 2-(3',4',5'-trimethoxyanilino)-3,6-disubstituted-4,5,6,7-tetrahydrothieno[2,3-c]pyridine Scaffold
  2. Romagnoli, Romeo; Prencipe, Filippo; Oliva, Paola; Cacciari, Barbara; Balzarini, Jan; Liekens, Sandra; Hamel,Ernest; Brancale, Andrea; Ferla, Salvatore; Manfredini, Stefano; Zurlo, Matteo; Finotti, Alessia; Gambari, Roberto
  3. Molecules (Basel, Switzerland). 2020, Apr 07; 25(7): pii : molecules25071690.
  1. 20.   Design, synthesis and biological evaluation of 2-alkoxycarbonyl-3-anilinoindoles as a new class of potent inhibitors of tubulin polymerization
  2. Romagnoli, Romeo; Prencipe, Filippo; Oliva, Paola; Kimatrai Salvador, Maria; Brancale, Andrea; Ferla, Salvatore; Hamel,Ernest; Viola, Giampietro; Bortolozzi, Roberta; Persoons, Leentje; Balzarini, Jan; Liekens, Sandra; Schols, Dominique
  3. Bioorganic chemistry. 2020, APR; 97: 103665.
  1. 21.   S-(4-methoxyphenyl)-4-methoxybenzenesulfonothioate as a promising lead compound for the development a renal carcinoma agent
  2. Namtes, Camila I; Pereira, Ingrid D; Bai,Ruoli; Hamel,Ernest; Burnett,Jim; de Oliveira, Rodrigo J; Matos, Maria de F C; Beatriz, Adilson; Yonekawa, Murilo K A; Perdomo, Renata T; de Lima, Dênis P; Bogo, Danielle; Dos Santos, Edson Dos Anjos
  3. ChemMedChem. 2020, JAN 16;
  1. 22.   Structure-activity relationship studies and in vitro and in vivo anticancer activity of novel 3-aroyl-1,4-diarylpyrroles against solid tumors and hematological malignancies
  2. Puxeddu, Michela; Shen, Hongliang; Bai,Ruoli; Coluccia, Antonio; Nalli, Marianna; Mazzoccoli, Carmela; Da Pozzo, Eleonora; Cavallini, Chiara; Martini, Claudia; Orlando, Viviana; Biagioni, Stefano; Mazzoni, Cristina; Coluccia, Addolorata Maria Luce; Hamel,Ernest; Liu, Te; Silvestri, Romano; La Regina, Giuseppe
  3. European journal of medicinal chemistry. 2020, Jan 1; 185: 111828.
  1. 23.   Expansion microscopy for the analysis of centrioles and cilia
  2. Sahabandu, N; Kong,Dong; Magidson,Valentin; Nanjundappa, R; Sullenberger,Catherine; Mahjoub, M; Loncarek,Jadranka
  3. Journal of microscopy. 2019, Nov 19;
  1. 24.   Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors
  2. Romagnoli, Romeo; Oliva, Paola; Salvador, Maria Kimatrai; Camacho, Maria Encarnacion; Padroni, Chiara; Brancale, Andrea; Ferla, Salvatore; Hamel,Ernest; Ronca, Roberto; Grillo, Elisabetta; Bortolozzi, Roberta; Rruga, Fatlum; Mariotto, Elena; Viola, Giampietro
  3. European journal of medicinal chemistry. 2019, NOV 1; 181: 111577.
  1. 25.   Evaluating the effects of fluorine on biological properties and metabolic stability of some antitubulin 3-substituted 7-phenyl-pyrroloquinolinones
  2. Bortolozzi, Roberta; Carta, Davide; Prà, Matteo Dal; Antoniazzi, Giuseppe; Mattiuzzo, Elena; Sturlese, Mattia; Di Paolo, Veronica; Calderan, Laura; Moro, Stefano; Hamel,Ernest; Quintieri, Luigi; Ronca, Roberto; Viola, Giampietro; Ferlin, Maria Grazia
  3. European journal of medicinal chemistry. 2019, Sep 15; 178: 297-314.
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