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  1. 1.   4 '-C-Methyl-2 '-Deoxyadenosine and 4 '-C-Ethyl-2 '-Deoxyadenosine Inhibit HIV-1 Replication
  2. Vu, B. C.; Boyer, P. L.; Siddiqui, M. A.; Marquez, V. E.; Hughes, S. H.
  3. Antimicrobial Agents and Chemotherapy. 2011, May; 55(5): 2379-2389.
  1. 2.   Apparent defects in processive DNA synthesis, strand transfer, and primer elongation of met-184 mutants of HIV-1 reverse transcriptase derive solely from a dNTP utilization defect
  2. Gao, L.; Hanson, M. N.; Balakrishnan, M.; Boyer, P. L.; Roques, B. P.; Hughes, S. H.; Kim, B.; Bambara, R. A.
  3. Journal of Biological Chemistry. 2008 283(14): 9196-9205.
  1. 3.   The triphosphate of beta-D-4 '-C-ethynyl-2 ',3 '-dideoxycytidine is the preferred enantiomer substrate for HIV reverse transcriptase
  2. Siddiqui, M. A.; Marquez, V. E.
  3. Bioorganic & Medicinal Chemistry. 2007, Jan; 15(1): 283-287.
  1. 4.   Transplacentally exposed human and monkey newborn infants show similar evidence of nucleoside reverse transcriptase inhibitor-induced mitochondrial toxicity
  2. Divi, R. L.; Leonard, S. L.; Kuo, M. M.; Nagashima, K.; Thamire, C.; St Claire, M. C.; Wade, N. A.; Walker, V. E.; Poirier, M. C.
  3. Environmental and Molecular Mutagenesis. 2007, Apr-May; 48(3-4): 201-209.
  1. 5.   A 4 '-C-ethynyl-2 ',3 '-dideoxynucleoside analogue highlights the role of the 3 '-OH in anti-HIV active 4 '-C-ethynyl-2 '-deoxy nucleosides
  2. Siddiqui, M. A.; Hughes, S. H.; Boyer, P. L.; Mitsuya, H.; Van, Q. N.; George, C.; Sarafinanos, S. G.; Marquez, V. E.
  3. Journal of Medicinal Chemistry. 2004, OCT 7; 47(21): 5041-5048.
  1. 6.   Mutations at position 184 of human immunodeficiency virus type-1 reverse transcriptase affect virus titer and viral DNA synthesis
  2. Julias, J. G.; Boyer, P. L.; McWilliams, M. J.; Alvord, W. G.; Hughes, S. H.
  3. Virology. 2004 322(1): 13-21.
  1. 7.   Structures of HIV-1 reverse transcriptase with pre- and post- translocation AZTMP-terminated DNA
  2. Sarafianos, S. G.; Clark, A. D.; Das, K.; Tuske, S.; Birktoft, J. J.; Ilankumaran, P.; Ramesha, A. R.; Sayer, J. M.; Jerina, D. M.; Boyer, P. L.; Hughes, S. H.; Arnold, E.
  3. Embo Journal. 2002 21(23): 6614-6624.
  1. 8.   Mutation of the catalytic domain of the foamy virus reverse transcriptase leads to loss of processivity and infectivity
  2. Rinke, C. S.; Boyer, P. L.; Sullivan, M. D.; Hughes, S. H.; Linial, M. L.
  3. Journal of Virology. 2002 76(15): 7560-7570.
  1. 9.   Nucleoside analog resistance caused by insertions in the fingers of human immunodeficiency virus type 1 reverse transcriptase involves ATP-mediated excision
  2. Boyer, P. L.; Sarafianos, S. G.; Arnold, E.; Hughes, S. H.
  3. Journal of Virology. 2002 76(18): 9143-9151.
  1. 10.   Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptase
  2. Boyer, P. L.; Sarafianos, S. G.; Arnold, E.; Hughes, S. H.
  3. Journal of Virology. 2001 75(10): 4832-4842.
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