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  1. 1.   Structural and mechanistic bases for resistance of the M66I capsid variant to lenacapavir
  2. Briganti, Lorenzo; Annamalai, Arun S; Bester, Stephanie M; Wei, Guochao; Andino-Moncada, Jonathan R; Singh, Satya P; Kleinpeter,Alexander; Tripathi, Meghna; Nguyen, Binh; Radhakrishnan, Rajalingam; Singh, Parmit K; Greenwood, Juliet; Schope, Lauren I; Haney, Reed; Huang, Szu-Wei; Freed, Eric O; Engelman, Alan N; Francis, Ashwanth C; Kvaratskhelia, Mamuka
  3. mBio. 2025, Apr 15; e0361324.
  1. 2.   Antiretroviral Therapy within Two Years of HIV Acquisition is Associated with Fewer Viral Blips: A Retrospective Analysis of Over 20 Years of Data from the U.S. Military HIV Natural History Study
  2. Crowell, Trevor A; Hsieh, Hsing-Chuan; Wang, Xun; Chu, Xiuping; Gayle, Britt; Berjohn, Catherine M; Blaylock, Jason M; Yabes, Joseph M; Larson, Derek T; Powers,John; O'Connell, Robert J; Ganesan, Anuradha; Agan, Brian K
  3. Clinical Infectious Diseases : an official publication of the Infectious Diseases Society of America. 2025, Mar 10;
  1. 3.   Drug-Linker Constructs Bearing Unique Dual-Mechanism Tubulin Binding Payloads Tethered through Cleavable and Non-Cleavable Linkers
  2. Ford, Jacob W; VanNatta, Jennifer M; Mondal, Deboprosad; Lin, Chen-Ming; Deng, Yuling; Bai, Ruoli; Hamel,Ernest; Trawick, Mary Lynn; Pinney, Kevin G
  3. Tetrahedron. 2025, Feb 01; 171
  1. 4.   Design, Synthesis and Biological Evaluation of 2-Phenyl Indole Analogues of OXi8006 as Colchicine Site Inhibitors of Tubulin Polymerization and Vascular Disrupting Agents
  2. Vairin, Rebecca; Tamminga, Caleb; Shi, Zhe; Borchardt, Christian; Jambulapati, Jayaram; Bai, Ruoli; Wanniarachchi, Hashini; Bueno, Lorena; Hamel,Ernest; Mason, Ralph P; Trawick, Mary Lynn; Pinney, Kevin G
  3. Bioorganic & Medicinal Chemistry. 2024, Nov 07; 118: 117981.
  1. 5.   Synthesis and Biological Evaluation of Novel 2-Aroyl Benzofuran-Based Hydroxamic Acids as Antimicrotubule Agents
  2. Mariotto, Elena; Canton, Martina; Marchioro, Chiara; Brancale, Andrea; Hamel,Ernest; Varani, Katia; Vincenzi, Fabrizio; De Ventura, Tiziano; Padroni, Chiara; Viola, Giampietro; Romagnoli, Romeo
  3. International Journal of Molecular Sciences. 2024, Jul 09; 25(14):
  1. 6.   Synthesis and biological evaluation of structurally diverse 6-aryl-3-aroyl-indole analogues as inhibitors of tubulin polymerization
  2. Ren, Wen; Deng, Yuling; Ward, Jacob D; Vairin, Rebecca; Bai,Ruoli; Wanniarachchi, Hashini I; Hamal, Khagendra B; Tankoano, Pouguiniseli E; Tamminga, Caleb S; Bueno, Lorena M A; Hamel,Ernest; Mason, Ralph P; Trawick, Mary Lynn; Pinney, Kevin G
  3. European Journal of Medicinal Chemistry. 2023, Sep 06; 263: 115794.
  1. 7.   Doubly Strapped Zwitterionic NIR-I and NIR-II Heptamethine Cyanine Dyes for Bioconjugation and Fluorescence Imaging
  2. Li,Donghao; Gamage, Rananjaya S; Oliver, Allen G; Patel,Nimit; Usama, Syed Muhammad; Kalen,Joseph; Schnermann,Martin; Smith, Bradley D
  3. Angewandte Chemie (International ed. in English). 2023, May 10; e202305062.
  1. 8.   Identification of pyrrolo[3',4':3,4]cyclohepta[1,2-d][1,2]oxazoles as promising new candidates for the treatment of lymphomas
  2. Barreca, Marilia; Spanò, Virginia; Rocca, Roberta; Bivacqua, Roberta; Gualtieri, Gianmarco; Raimondi, Maria Valeria; Gaudio, Eugenio; Bortolozzi, Roberta; Manfreda, Lorenzo; Bai,Ruoli; Montalbano, Alessandra; Alcaro, Stefano; Hamel,Ernest; Bertoni, Francesco; Viola, Giampietro; Barraja, Paola
  3. European Journal of Medicinal Chemistry. 2023, Apr 12; 254: 115372.
  1. 9.   Simple monocyclic pyrimidine analogs as microtubule targeting agents binding to the colchicine site
  2. Choudhary, Shruti; Kaku, Krishna; Robles, Andrew J; Hamel,Ernest; Mooberry, Susan L; Gangjee, Aleem
  3. Bioorganic & Medicinal Chemistry. 2023, Feb 24; 82: 117217.
  1. 10.   Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: Further chemical modifications and potential therapeutic effects against lymphomas
  2. Barreca, Marilia; Spanò, Virginia; Rocca, Roberta; Bivacqua, Roberta; Abel, Anne-Catherine; Maruca, Annalisa; Montalbano, Alessandra; Raimondi, Maria Valeria; Tarantelli, Chiara; Gaudio, Eugenio; Cascione, Luciano; Rinaldi, Andrea; Bai,Ruoli; Steinmetz, Michel O; Prota, Andrea E; Alcaro, Stefano; Hamel, Ernest; Bertoni, Francesco; Barraja, Paola
  3. European Journal of Medicinal Chemistry. 2022, Sep 08; 243: 114744.
  1. 11.   Design, Synthesis and Biological Investigation of 2-Anilino Triazolopyrimidines as Tubulin Polymerization Inhibitors with Anticancer Activities
  2. Romagnoli, Romeo; Oliva, Paola; Prencipe, Filippo; Manfredini, Stefano; Budassi, Federica; Brancale, Andrea; Ferla, Salvatore; Hamel,Ernest; Corallo, Diana; Aveic, Sanja; Manfreda, Lorenzo; Mariotto, Elena; Bortolozzi, Roberta; Viola, Giampietro
  3. Pharmaceuticals (Basel, Switzerland). 2022, Aug 21; 15(8):
  1. 12.   Cefiderocol and the Need for Higher-Quality Evidence: Methods Matter for Patients
  2. Epling, Brian P; Powers,John
  3. Antimicrobial Agents and Chemotherapy. 2022, Jul 18; e0076622.
  1. 13.   Synthesis and Biological Evaluation of Highly Active 7-Anilino Triazolopyrimidines as Potent Antimicrotubule Agents
  2. Oliva, Paola; Romagnoli, Romeo; Cacciari, Barbara; Manfredini, Stefano; Padroni, Chiara; Brancale, Andrea; Ferla, Salvatore; Hamel,Ernest; Corallo, Diana; Aveic, Sanja; Milan, Noemi; Mariotto, Elena; Viola, Giampietro; Bortolozzi, Roberta
  3. Pharmaceutics. 2022, Jun 02; 14(6):
  1. 14.   Design, Synthesis, and Biological Evaluation of 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidines as Microtubule Targeting Agents
  2. Islam, Farhana; Doshi, Arpit; Robles, Andrew J; Quadery, Tasdique M; Zhang, Xin; Zhou, Xilin; Hamel, Ernest; Mooberry, Susan L; Gangjee, Aleem
  3. Molecules . 2022, Jan 05; 27(1):
  1. 15.   Recent advances in nanoparticles mediated photothermal therapy induced tumor regression
  2. Kumar, Achalla Vaishnav Pavan; Dubey, Sunil K.; Tiwari, Sanjay; Puri,Anu; Hejmady, Siddhanth; Gorain, Bapi; Kesharwani, Prashant
  3. International Journal of Pharmaceutics. 2021, Sep 5; 606
  1. 16.   Novel pyrazolo[4,3-d]pyrimidine microtubule targeting agents (MTAs): Synthesis, structure-activity relationship, in vitro and in vivo evaluation as antitumor agents
  2. Islam, Farhana; Quadery, Tasdique M.; Bai,Ruoli; Luckett-Chastain, Lerin R.; Hamel,Ernest; Ihnat, Michael A.; Gangjee, Aleem
  3. Bioorganic & Medicinal Chemistry Letters. 2021, Jun 1; 41
  1. 17.   Potential of substituted quinazolines to interact with multiple targets in the treatment of cancer
  2. Choudhary, Shruti; Doshi, Arpit; Luckett-Chastain, Lerin; Ihnat, Michael; Hamel,Ernest; Mooberry, Susan L.; Gangjee, Aleem
  3. Bioogranic & Medicinal Chemistry. 2021, Apr 1; 35
  1. 18.   A facile synthesis of diaryl pyrroles led to the discovery of potent colchicine site antimitotic agents
  2. Romagnoli, Romeo; Oliva, Paola; Salvador, Maria Kimatrai; Manfredini, Stefano; Padroni, Chiara; Brancale, Andrea; Ferla, Salvatore; Hamel,Ernest; Ronca, Roberto; Maccarinelli, Federica; Rruga, Fatlum; Mariotto, Elena; Viola, Giampietro; Bortolozzi, Roberta
  3. European Journal of Medicinal Chemistry. 2021, Mar 15; 214
  1. 19.   The 3-D conformational shape of N-naphthyl-cyclopenta[d]pyrimidines affects their potency as microtubule targeting agents and their antitumor activity
  2. Xiang, Weiguo; Quadery, Tasdique M; Hamel,Ernest; Luckett-Chastain, Lerin R; Ihnat, Michael A; Mooberry, Susan L; Gangjee, Aleem
  3. Bioorganic & medicinal chemistry. 2021, Jan 1; 29: 115887.
  1. 20.   Unifying Mechanism for Thiol-Induced Photoswitching and Photostability of Cyanine Dyes
  2. Gidi, Yasser; Payne, Liam; Glembockyte, Viktorija; Michie, Megan S.; Schnermann,Martin; Cosa, Gonzalo
  3. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2020, JUL 22; 142(29): 12681-12689.
  1. 21.   Chemically Programmable and Switchable CAR-T Therapy
  2. Qi, Junpeng; Tsuji, Kohei; Hymel, David; Burke,Terrence; Hudecek, Michael; Rader, Christoph; Peng, Haiyong
  3. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2020, MAY 18;
  1. 22.   Bioreductively Activatable Prodrug Conjugates of Combretastatin A-1 and Combretastatin A-4 as Anticancer Agents Targeted toward Tumor-Associated Hypoxia
  2. Winn, Blake A; Devkota, Laxman; Kuch, Bunnarack; MacDonough, Matthew T; Strecker, Tracy E; Wang, Yifan; Shi, Zhe; Gerberich, Jeni L; Mondal, Deboprosad; Ramirez, Alejandro J; Hamel,Ernest; Chaplin, David J; Davis, Peter; Mason, Ralph P; Trawick, Mary Lynn; Pinney, Kevin G
  3. Journal of natural products. 2020, APR 24; 83(4): 937-954.
  1. 23.   Intravenous 5-fluoro-2'-deoxycytidine administered with tetrahydrouridine increases the proportion of p16-expressing circulating tumor cells in patients with advanced solid tumors
  2. Coyne, Geraldine O 'Sullivan; Wang,Lihua; Zlott, Jennifer; Juwara,Lamin; Covey, Joseph M; Beumer, Jan H; Cristea, Mihaela C; Newman, Edward M; Koehler, Stephen; Nieva, Jorge J; Garcia, Agustin A; Gandara, David R; Miller,Brandon; Khin,Sonny; Miller, Sarah B; Steinberg, Seth M; Rubinstein, Larry; Parchment,Ralph; Kinders,Robert; Piekarz, Richard L; Kummar, Shivaani; Chen, Alice P; Doroshow, James H
  3. Cancer chemotherapy and pharmacology. 2020, Apr 20;
  1. 24.   Interaction of diazonamide a with tubulin
  2. Bai,Ruoli; Cruz-Monserrate, Zobeida; Fenical, William; Pettit, George R; Hamel,Ernest
  3. Archives of biochemistry and biophysics. 2020, FEB 15; 680: 108217.
  1. 25.   Arf1-mediated lipid metabolism sustains cancer cells and its ablation induces anti-tumor immune responses in mice
  2. Wang,Guohao; Xu, Junji; Zhao, Jiangsha; Yin, Weiqin; Liu, Dayong; Chen, WanJun; Hou, Steven X
  3. Nature communications. 2020, Jan 10; 11(1): 220.
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