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  1. 1.   Bioreductively Activatable Prodrug Conjugates of Combretastatin A-1 and Combretastatin A-4 as Anticancer Agents Targeted toward Tumor-Associated Hypoxia
  2. Winn, Blake A; Devkota, Laxman; Kuch, Bunnarack; MacDonough, Matthew T; Strecker, Tracy E; Wang, Yifan; Shi, Zhe; Gerberich, Jeni L; Mondal, Deboprosad; Ramirez, Alejandro J; Hamel,Ernest; Chaplin, David J; Davis, Peter; Mason, Ralph P; Trawick, Mary Lynn; Pinney, Kevin G
  3. Journal of natural products. 2020, APR 24; 83(4): 937-954.
  1. 2.   Interaction of diazonamide a with tubulin
  2. Bai,Ruoli; Cruz-Monserrate, Zobeida; Fenical, William; Pettit, George R; Hamel,Ernest
  3. Archives of biochemistry and biophysics. 2020, FEB 15; 680: 108217.
  1. 3.   Synthesis and biological evaluation of structurally diverse alpha-conformationally restricted chalcones and related analogues
  2. Maguire, Casey J.; Carlson, Graham J.; Ford, Jacob W.; Strecker, Tracy E.; Hamel,Ernest; Trawick, Mary Lynn; Pinney, Kevin G.
  3. MedChemComm. 2019, Aug 1; 10(8): 1445-1456.
  1. 4.   Structure Guided Design, Synthesis, and Biological Evaluation of Novel Benzosuberene Analogues as Inhibitors of Tubulin Polymerization
  2. Niu, Haichan; Strecker, Tracy E.; Gerberich, Jeni L.; Campbell, James W.; Saha, Debabrata; Mondal, Deboprosad; Hamel,Ernest; Chaplin, David J.; Mason, Ralph P.; Trawick, Mary Lynn; Pinney, Kevin G.
  3. JOURNAL OF MEDICINAL CHEMISTRY. 2019, JUN 13; 62(11): 5594-5615.
  1. 5.   Plumbagin, a naphthaquinone derivative induces apoptosis in BRCA 1/2 defective castrate resistant prostate cancer cells as well as prostate cancer stem-like cells
  2. Reshma, R. S.; Sreelatha, K. H.; Somasundaram, V.; Satheesh Kumar, S.; Nadhan, R.; Nair, R. S.; Srinivas, P.
  3. Pharmacological Research. 2016, Mar; 105: 134-45.
  1. 6.   Design, synthesis, and biological evaluation of water-soluble amino acid prodrug conjugates derived from combretastatin, dihydronaphthalene, and benzosuberene-based parent vascular disrupting agents
  2. Devkota, L.; Lin, C. M.; Strecker, T. E.; Wang, Y.; Tidmore, J. K.; Chen, Z.; Guddneppanavar, R.; Jelinek, C. J.; Lopez, R.; Liu, L.; Hamel, E.; Mason, R. P.; Chaplin, D. J.; Trawick, M. L.; Pinney, K. G.
  3. Bioorganic & Medicinal Chemistry. 2016, 1-Mar; 24(5): 938-56.
  1. 7.   Cancer stem cells: a systems biology view of their role in prognosis and therapy
  2. Mertins, S. D.
  3. Anti-Cancer Drugs. 2014, Apr; 25(4): 353-67.
  1. 8.   Synthesis and Antitumor Molecular Mechanism of Agents Based on Amino 2-(3 ',4 ',5 '-Trimethoxybenzoyl)benzo[b]furan: Inhibition of Tubulin and Induction of Apoptosis
  2. Romagnoli, R.; Baraldi, P. G.; Lopez-Cara, C.; Cruz-Lopez, O.; Carrion, M. D.; Salvador, M. K.; Bermejo, J.; Estevez, S.; Estevez, F.; Balzarini, J.; Brancale, A.; Ricci, A.; Chen, L. C.; Kim, J. G.; Hamel, E.
  3. Chemmedchem. 2011, Oct; 6(10): 1841-1853.
  1. 9.   Regioselective Synthesis of Water-Soluble Monophosphate Derivatives of Combretastatin A-1
  2. Tanpure, R. P.; Nguyen, B. L.; Strecker, T. E.; Aguirre, S.; Sharma, S.; Chaplin, D. J.; Siim, B. G.; Hamel, E.; Lippert, J. W.; Pettit, G. R.; Trawick, M. L.; Pinney, K. G.
  3. Journal of Natural Products. 2011, Jul; 74(7): 1568-1574.
  1. 10.   Synthesis of novel antimitotic agents based on 2-amino-3-aroyl-5-(hetero)arylethynyl thiophene derivatives
  2. Romagnoli, R.; Baraldi, P. G.; Cruz-Lopez, O.; Tolomeo, M.; Di Cristina, A.; Pipitone, R. M.; Grimaudo, S.; Balzarini, J.; Brancale, A.; Hamel, E.
  3. Bioorganic & Medicinal Chemistry Letters. 2011, May; 21(9): 2746-2751.
  1. 11.   Synthesis and Cellular Pharmacology Studies of a Series of 2-amino-3-aroyl-4-substituted Thiophene Derivatives
  2. Romagnoli, R.; Baraldi, P. G.; Pavani, M. G.; Cruz-Lopez, O.; Hamel, E.; Balzarini, J.; Brognara, E.; Zuccato, C.; Gambari, R.
  3. Medicinal Chemistry. 2010, Nov; 6(6): 329-343.
  1. 12.   Plant Natural Products in Anticancer Drug Discovery
  2. Grothaus, P. G.; Cragg, G. M.; Newman, D. J.
  3. Current Organic Chemistry. 2010, Oct; 14(16): 1781-1791.
  1. 13.   Targeting prostate cancer stem cells
  2. Crea, F.; Mathews, L. A.; Farrar, W. L.; Hurt, E. M.
  3. Anti-cancer agents in medicinal chemistry. 2009, Dec; 9(10): 1105-13.
  1. 14.   Microbial antitumor drugs: natural products of microbial origin as anticancer agents
  2. Newman, D. J.; Cragg, G. M.
  3. Current Opinion in Investigational Drugs. 2009, Dec; 10(12): 1280-96.
  1. 15.   Development of HIF-1 inhibitors for cancer therapy
  2. Onnis, B.; Rapisarda, A.; Melillo, G.
  3. Journal of Cellular and Molecular Medicine. 2009, Sep; 13(9A): 2780-6.
  1. 16.   Cytotoxic and HIF-1alpha inhibitory compounds from Crossosoma bigelovii
  2. Klausmeyer, P.; Zhou, Q.; Scudiero, D. A.; Uranchimeg, B.; Melillo, G.; Cardellina, J. H.; Shoemaker, R. H.; Chang, C. J.; McCloud, T. G.
  3. Journal of Natural Products. 2009, May 22; 72(5): 805-12.
  1. 17.   Inhibitors of the NF-kappaB activation pathway from Cryptocarya rugulosa
  2. Meragelman, T. L.; Scudiero, D. A.; Davis, R. E.; Staudt, L. M.; McCloud, T. G.; Cardellina, J. H. 2nd.; Shoemaker, R. H.
  3. Journal of Natural Products. 2009, Mar 27; 72(3): 336-9.
  1. 18.   Short and sweet: evolution of a small glycopeptide from a bladder disorder to an anticancer lead
  2. Barchi, J. J., Jr.; Kaczmarek, P.
  3. Molecular Interventions. 2009, Feb; 9(1): 14-7.
  1. 19.   Influence of the dual ABCB1 and ABCG2 inhibitor tariquidar on the disposition of oral imatinib in mice
  2. Gardner, E. R.; Smith, N. F.; Figg, W. D.; Sparreboom, A.
  3. Journal of experimental & clinical cancer research : CR. 2009 28: 99.
  1. 20.   Intracellular Activation and Deactivation of Tasidotin, an Analog of Dolastatin 15: Correlation with Cytotoxicity
  2. Bai, R.; Edler, M. C.; Bonate, P. L.; Copeland, T. D.; Pettit, G. R.; Luduena, R. F.; Hamel, E.
  3. Molecular Pharmacology. 2009 75(1): 218-226.
  1. 21.   A diaryl sulfide, sulfoxide, and sulfone bearing structural similarities to combretastatin A-4
  2. Barbosa, E. G.; Bega, L.; Beatriz, A.; Sarkar, T.; Hamel, E.; do Amaral, M. S.; de Lima, D. P.
  3. European Journal of Medicinal Chemistry. 2009 44(6): 2685-2688.
  1. 22.   Development of a cell-based assay to quantify the inflammatory potential of test substances and screen compound libraries for anti-cancer drug candidates in a high-throughput format
  2. Kozlov, S. V.
  3. Methods in molecular biology (Clifton, N.J.). 2009 512: 159-167.
  1. 23.   E-Combretastatin and E-resveratrol structural modifications: Antimicrobial and cancer cell growth inhibitory beta-E-nitrostyrenes
  2. Pettit, R. K.; Pettit, G. R.; Hamel, E.; Hogan, F.; Moser, B. R.; Wolf, S.; Pon, S.; Chapuis, J. C.; Schmidt, J. M.
  3. Bioorganic & Medicinal Chemistry. 2009 17(18): 6606-6612.
  1. 24.   Design, synthesis and structure-activity relationship of 2-(3 ',4 ',5 '-trimethoxybenzoyl)-benzo[b]furan derivatives as a novel class of inhibitors of tubulin polymerization
  2. Romagnoli, R.; Baraldi, P. G.; Carrion, M. D.; Cara, C. L.; Cruz-Lopez, O.; Tolomeo, M.; Grimaudo, S.; Di Cristina, A.; Pipitone, M. R.; Balzarini, J.; Zonta, N.; Brancale, A.; Hamel, E.
  3. Bioorganic & Medicinal Chemistry. 2009 17(19): 6862-6871.
  1. 25.   2-Arylamino-4-Amino-5-Aroylthiazoles. "One-Pot" Synthesis and Biological Evaluation of a New Class of Inhibitors of Tubulin Polymerization
  2. Romagnoli, R.; Baraldi, P. G.; Carrion, M. D.; Cruz-Lopez, O.; Cara, C. L.; Basso, G.; Viola, G.; Khedr, M.; Balzarini, J.; Mahboobi, S.; Sellmer, A.; Brancale, A.; Hamel, E.
  3. Journal of Medicinal Chemistry. 2009 52(17): 5551-5555.
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