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  1. 1.   Distinct allosteric networks in CDK4 and CDK6 in the cell cycle and in drug resistance
  2. Zhang,Wengang; Bradburn, Devin; Heidebrink, Gretchen; Liu, Yonglan; Jang,Hyunbum; Nussinov,Ruth; Kõivomägi, Mardo
  3. Journal of Molecular Biology. 2025, Mar 31; 169121.
  1. 2.   Slower CDK4 and faster CDK2 activation in the cell cycle
  2. Zhang,Wengang; Liu,Yonglan; Jang,Hyunbum; Nussinov,Ruth
  3. Structure (London, England : 1993). 2024, Apr 23;
  1. 3.   Cancer and Autism: How PTEN Mutations Degrade Function at the Membrane and Isoform Expression in the Human Brain
  2. Jang,Hyunbum; Chen, Jiaye; Iakoucheva, Lilia M; Nussinov,Ruth
  3. Journal of Molecular Biology. 2023, Dec 15; 435(24): 168354.
  1. 4.   SHP2 clinical phenotype, cancer, or RASopathies, can be predicted by mutant conformational propensities
  2. Liu,Yonglan; Zhang,Wengang; Jang,Hyunbum; Nussinov,Ruth
  3. Cellular and Molecular Life Sciences : CMLS. 2023, Dec 12; 81(1): 5.
  1. 5.   Dihydroxyphenyl- and Heteroaromatic-Based Thienopyrimidinones to Tackle HIV-1 LEDGF/p75-Dependent IN Activity
  2. Tocco, Graziella; Canton, Serena; Laus, Antonio; Caboni, Pierluigi; Le Grice, Stuart F J; Tramontano, Enzo; Esposito, Francesca
  3. Molecules (Basel, Switzerland). 2023, Sep 19; 28(18):
  1. 6.   Specific inhibition of an anticancer target, polo-like kinase 1, by allosterically dismantling its mechanism of substrate recognition
  2. Park, Jung-Eun; Kirsch, Klara; Lee, Hobin; Oliva, Paola; Ahn, Jong Il; Ravishankar, Harsha; Zeng, Yan; Fox,Stephen; Kirby, Samuel A; Badhwar, Pooja; Andresson,Thorkell; Jacobson, Kenneth A; Lee, Kyung S
  3. Proceedings of the National Academy of Sciences of the United States of America. 2023, Aug 29; 120(35): e2305037120.
  1. 7.   Allosteric regulation of autoinhibition and activation of c-Abl
  2. Liu,Yonglan; Zhang,Mingzhen; Tsai,Chung-Jung; Jang,Hyunbum; Nussinov,Ruth
  3. Computational and Structural Biotechnology Journal. 2022 20: 4257-4270.
  1. 8.   The mechanism of Raf activation through dimerization
  2. Zhang,Mingzhen; Maloney,Ryan; Jang,Hyunbum; Nussinov,Ruth
  3. Chemical Science. 2021, Dec 08; 12(47): 15609-15619.
  1. 9.   Scaffold hopping and optimisation of 3',4'-dihydroxyphenyl- containing thienopyrimidinones: synthesis of quinazolinone derivatives as novel allosteric inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H
  2. Tocco, Graziella; Esposito, Francesca; Caboni, Pierluigi; Laus, Antonio; Beutler,John; Wilson,Jennifer; Corona, Angela; Le Grice,Stuart; Tramontano, Enzo
  3. Journal of enzyme inhibition and medicinal chemistry. 2020, Dec; 35(1): 1953-1963.
  1. 10.   Autoinhibition can identify rare driver mutations and advise pharmacology
  2. Nussinov,Ruth; Tsai,Chung-Jung; Jang,Hyunbum
  3. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2020, Jan; 34(1): 16-29.
  1. 11.   Does Ras Activate Raf and PI3K Allosterically?
  2. Nussinov,Ruth; Tsai,Chung-Jung; Jang,Hyunbum
  3. Frontiers in oncology. 2019, Nov 15; 9
  1. 12.   Interaction of the N terminus of ADP-ribosylation factor with the PH domain of the GTPase-activating protein ASAP1 requires phosphatidylinositol 4,5-bisphosphate
  2. Roy, Neeladri Sekhar; Jian, Xiaoying; Soubias,Olivier; Zhai, Peng; Hall, Jessica R.; Dagher, Jessica N.; Coussens, Nathan P.; Jenkins, Lisa M.; Luo, Ruibai; Akpan, Itoro O.; Hall, Matthew D.; Byrd,Robert; Yohe, Marielle E.; Randazzo, Paul A.
  3. JOURNAL OF BIOLOGICAL CHEMISTRY. 2019, NOV 15; 294(46): 17354-17370.
  1. 13.   Structure of the primed state of the ATPase domain of chromatin remodeling factor ISWI bound to the nucleosome
  2. Chittori, Sagar; Hong, Jingjun; Bai, Yawen; Subramaniam,Sriram
  3. Nucleic acids research. 2019, SEP 26; 47(17): 9400-9409.
  1. 14.   Two PKA RIa holoenzyme states define ATP as an isoform-specific orthosteric inhibitor that competes with the allosteric activator, cAMP
  2. Lu, Tsan-Wen; Wu, Jian; Aoto, Phillip C; Weng, Jui-Hung; Ahuja, Lalima G; Sun, Nicholas; Cheng, Cecilia Y; Zhang,Ping; Taylor, Susan S
  3. Proceedings of the National Academy of Sciences of the United States of America. 2019, Aug 13; 116(33): 16347-16356.
  1. 15.   Antigen binding allosterically promotes Fc receptor recognition
  2. Zhao, Jun; Nussinov, Ruth; Ma, Buyong
  3. mAbs. 2019, Jan; 11(1): 58-74.
  1. 16.   Peptide-MHC (pMHC) binding to a human antiviral T cell receptor induces long-range allosteric communication between pMHC- and CD3-binding sites
  2. Rangarajan, Sneha; He, Yanan; Chen, Yihong; Kerzic, Melissa C.; Ma,Buyong; Gowthaman, Ragul; Pierce, Brian G.; Nussinov,Ruth; Mariuzza, Roy A.; Orban, John
  3. JOURNAL OF BIOLOGICAL CHEMISTRY. 2018, Oct 12; 293(41): 15991-16005.
  1. 17.   In Silico Methods in Antibody Design
  2. Zhao, Jun; Nussinov, Ruth; Wu, Wen-Jin; Ma, Buyong
  3. ANTIBODIES. 2018, Sep; 7(3):
  1. 18.   Local and global anatomy of antibody-protein antigen recognition
  2. Wang, Meryl; Zhu, David; Zhu, Jianwei; Nussinov, Ruth; Ma, Buyong
  3. Journal of Molecular Recognition: JMR. 2018, May; 31(5): e2693.
  1. 19.   Unraveling the molecular mechanism of interactions of the Rho GTPases Cdc42 and Rac1 with the scaffolding protein IQGAP2
  2. Ozdemir, E Sila; Jang, Hyunbum; Gursoy, Attila; Keskin, Ozlem; Li, Zhigang; Sacks, David B; Nussinov, Ruth
  3. The Journal of Biological Chemistry. 2018, Mar 9; 293(10): 3685-3699.
  1. 20.   Computational Tools for Allosteric Drug Discovery: Site Identification and Focus Library Design.
  2. Huang, Wenkang; Nussinov, Ruth; Zhang, Jian
  3. Methods in molecular biology (Clifton, N.J.). 2017 1529: 439-446.
  1. 21.   Multiple conformational selection and induced fit events take place in allosteric propagation
  2. Nussinov, R.; Ma, B.; Tsai, C. J.
  3. Biophysical Chemistry. 2014, Feb; 186: 22-30.
  1. 22.   Allosteric modulators can restore function in an amino acid neurotransmitter receptor by slightly altering intra-molecular communication pathways
  2. Nussinov, R.
  3. British Journal of Pharmacology. 2012, Apr; 165(7): 2110-2112.
  1. 23.   Disordered Proteins and Network Disorder in Network Descriptions of Protein Structure, Dynamics and Function: Hypotheses and a Comprehensive Review
  2. Csermely, P.; Sandhu, K. S.; Hazai, E.; Hoksza, Z.; Kiss, H. J. M.; Miozzo, F.; Veres, D. V.; Piazza, F.; Nussinov, R.
  3. Current Protein & Peptide Science. 2012, Feb; 13(1): 19-33.
  1. 24.   Gene-specific transcription activation via long-range allosteric shape-shifting
  2. Tsai, C. J.; Nussinov, R.
  3. Biochemical Journal. 2011, Oct; 439: 15-25.
  1. 25.   Interaction of RNA Polymerase II Fork Loop 2 with Downstream Non-template DNA Regulates Transcription Elongation
  2. Kireeva, M. L.; Domecq, C.; Coulombe, B.; Burton, Z. F.; Kashlev, M.
  3. Journal of Biological Chemistry. 2011, Sep; 286(35): 30898-30910.
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