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  1. 1.   Systematic characterization of multi-omics landscape between gut microbial metabolites and GPCRome in Alzheimer's disease
  2. Qiu, Yunguang; Hou, Yuan; Gohel, Dhruv; Zhou, Yadi; Xu, Jielin; Bykova, Marina; Yang, Yuxin; Leverenz, James B; Pieper, Andrew A; Nussinov,Ruth; Caldwell, Jessica Z K; Brown, J Mark; Cheng, Feixiong
  3. Cell Reports. 2024, Apr 21; 43(5): 114128.
  1. 2.   The fidelity of transcription in human cells
  2. Chung, Claire; Verheijen, Bert M; Zhang, Xinmin; Huang, Biao; Coakley, Aeowynn; McGann, Eric; Wade, Emily; Dinep-Schneider, Olivia; LaGosh, Jessica; Anagnostou, Maria-Eleni; Simpson, Stephen; Thomas, Kelly; Ernst, Mimi; Rattray, Allison; Lynch, Michael; Kashlev,Mikhail; Benayoun, Berenice A; Li, Zhongwei; Strathern,Jeffrey; Gout, Jean-Francois; Vermulst, Marc
  3. Proceedings of the National Academy of Sciences of the United States of America. 2023, Jan 31; 120(5): e2210038120.
  1. 3.   Graph embedding and Gaussian mixture variational autoencoder network for end-to-end analysis of single-cell RNA sequencing data
  2. Xu, Junlin; Xu, Jielin; Meng, Yajie; Lu, Changcheng; Cai, Lijun; Zeng, Xiangxiang; Nussinov,Ruth; Cheng, Feixiong
  3. Cell Reports Methods. 2023, Jan 23; 3(1): 100382.
  1. 4.   Harnessing endophenotypes and network medicine for Alzheimer's drug repurposing
  2. Fang, Jiansong; Pieper, Andrew A.; Nussinov,Ruth; Lee, Garam; Bekris, Lynn; Leverenz, James B.; Cummings, Jeffrey; Cheng, Feixiong
  3. Medicinal research reviews. 2020, NOV; 40(6): 2386-2426.
  1. 5.   HSF1 physically neutralizes amyloid oligomers to empower overgrowth and bestow neuroprotection
  2. Tang,Zijian; Su,Kuo-Hui; Xu, Meng; Dai,Chengkai
  3. Science advances. 2020, Nov; 6(46): pii: eabc6871.
  1. 6.   Computational Investigation of Gantenerumab and Crenezumab Recognition of A beta Fibrils in Alzheimer's Disease Brain Tissue
  2. Chen, Yujie; Wei, Guanghong; Zhao, Jun; Nussinov,Ruth; Ma, Buyong
  3. ACS CHEMICAL NEUROSCIENCE. 2020, OCT 21; 11(20): 3233-3244.
  1. 7.   Medin Oligomer Membrane Pore Formation: A Potential Mechanism of Vascular Dysfunction
  2. Younger, Scott; Jang,Hyunbum; Davies, Hannah A; Niemiec, Martin J; Garcia, Joe G N; Nussinov,Ruth; Migrino, Raymond Q; Madine, Jillian; Arce, Fernando T
  3. Biophysical journal. 2020, JUN 2; 118(11): 2769-2782.
  1. 8.   Recent strategies and advances in the fabrication of nano lipid carriers and their application towards brain targeting
  2. Agrawal, Mukta; Saraf, Swarnlata; Saraf, Shailendra; Dubey, Sunil Kumar; Puri,Anu; Patel, Ravish J.; Ravichandiran, V.; Murty, Upadhyayula Suryanarayana; Alexander, Amit
  3. Journal of controlled release : official journal of the Controlled Release Society. 2020, May 10; 321: 372-415.
  1. 9.   Concordance of Clinical Alzheimer Diagnosis and Neuropathological Features at Autopsy
  2. Gauthreaux, Kathryn; Bonnett,Tyler; Besser, Lilah M; Brenowitz, Willa D; Teylan, Merilee; Mock, Charles; Chen, Yen-Chi; Chan, Kwun C G; Keene, C Dirk; Zhou, Xiao-Hua; Kukull, Walter A
  3. Journal of neuropathology and experimental neurology. 2020, MAY; 79(5): 465-473.
  1. 10.   Estimating associations between antidepressant use and incident mild cognitive impairment in older adults with depression
  2. Han, Fang; Bonnett,Tyler; Brenowitz, Willa D; Teylan, Merilee A; Besser, Lilah M; Chen, Yen-Chi; Chan, Gary; Cao, Ke-Gang; Gao, Ying; Zhou, Xiao-Hua
  3. PloS one. 2020, JAN 17; 15(1): e0227924.
  1. 11.   deepDR: A network-based deep learning approach to in silico drug repositioning
  2. Zeng, Xiangxiang; Zhu, Siyi; Liu, Xiangrong; Zhou, Yadi; Nussinov,Ruth; Cheng, Feixiong
  3. Bioinformatics (Oxford, England). 2019, DEC 15; 35(24): 5191-5198.
  1. 12.   Structural disorder in four-repeat Tau fibrils reveals a new mechanism for barriers to cross-seeding of Tau isoforms
  2. Weismiller, Hilary A.; Murphy, Rachel; Wei, Guanghong; Ma,Buyong; Nussinov,Ruth; Margittai, Martin
  3. JOURNAL OF BIOLOGICAL CHEMISTRY. 2018, NOV 9; 293(45): 17336-17348.
  1. 13.   Molecular Recognition between A-Specific Single-Domain Antibody and A Misfolded Aggregates
  2. Zhang, Mingzhen; Zheng, Jie; Nussinov, Ruth; Ma, Buyong
  3. ANTIBODIES. 2018, Sep; 7(3):
  1. 14.   Protein kinase Ca gain-of-function variant in Alzheimer's disease displays enhanced catalysis by a mechanism that evades down-regulation
  2. Callender, Julia A; Yang, Yimin; Lordén, Gema; Stephenson, Natalie L; Jones, Alexander C; Brognard, John; Newton, Alexandra C
  3. Proceedings of the National Academy of Sciences of the United States of America. 2018, Jun 12; 115(24): E5497-E5505.
  1. 15.   Mechanisms of recognition of amyloid-beta (A beta) monomer, oligomer, and fibril by homologous antibodies
  2. Zhao, Jun; Nussinov, Ruth; Ma, Buyong
  3. Journal of Biological Chemistry. 2017, Nov 3; 292(44): 18325-18343.
  1. 16.   Androgen alleviates neurotoxicity of ß-amyloid peptide (Aß) by promoting microglial clearance of Aß and inhibiting microglial inflammatory response to Aß
  2. Yao, Peng-Le; Zhuo, Shu; Mei, Hong; Chen, Xiao-Fang; Li, Na; Zhu, Teng-Fei; Chen, Shi-Ting; Wang, Jiming; Hou, Rui-Xing; Le, Ying-Ying
  3. CNS Neuroscience & Therapeutics. 2017, NOV; 23(11): 855-865.
  1. 17.   Amyloid beta Ion Channels in a Membrane Comprising Brain Total Lipid Extracts
  2. Lee, Joon; Kim, Young Hun; Arce, Fernando T.; Gillman, Alan L.; Jang, Hyunbum; Kagan, Bruce L.; Nussinov, Ruth; Yang, Jerry; Lal, Ratnesh
  3. ACS CHEMICAL NEUROSCIENCE. 2017, Jun 21; 8(6): 1348-1357.
  1. 18.   Amylin-Abeta oligomers at atomic resolution using molecular dynamics simulations: a link between Type 2 diabetes and Alzheimer's disease
  2. Baram, M.; Atsmon-Raz, Y.; Ma, B.; Nussinov, R.; Miller, Y.
  3. Physical chemistry chemical physics : PCCP. 2016, 28-Jan; 18(4): 2330-8.
  1. 19.   Antimicrobial Properties of Amyloid Peptides
  2. Kagan, B. L.; Jang, H.; Capone, R.; Arce, F. T.; Ramachandran, S.; Lal, R.; Nussinov, R.
  3. Molecular Pharmaceutics. 2012, Apr; 9(4): 708-717.
  1. 20.   All-D-Enantiomer of beta-Amyloid Peptide Forms Ion Channels in Lipid Bilayers
  2. Capone, R.; Jang, H.; Kotler, S. A.; Connelly, L.; Arce, F. T.; Ramachandran, S.; Kagan, B. L.; Nussinov, R.; Lal, R.
  3. Journal of Chemical Theory and Computation. 2012, Mar; 8(3): 1143-1152.
  1. 21.   CCAAT/enhancer binding protein delta (CEBPD) elevating PTX3 expression inhibits macrophage-mediated phagocytosis of dying neuron cells
  2. Ko, C. Y.; Chang, L. H.; Lee, Y. C.; Sterneck, E.; Cheng, C. P.; Chen, S. H.; Huang, A. M.; Tseng, J. T.; Wang, J. M.
  3. Neurobiology of Aging. 2012, Feb; 33(2):
  1. 22.   DNA immunization with HBsAg-based particles expressing a B cell epitope of amyloid beta-peptide attenuates disease progression and prolongs survival in a mouse model of Alzheimer's disease
  2. Olkhanud, P. B.; Mughal, M.; Ayukawa, K.; Malchinkhuu, E.; Bodogai, M.; Feldman, N.; Rothman, S.; Lee, J. H.; Chigurupati, S.; Okun, E.; Nagashima, K.; Mattson, M. P.; Biragyn, A.
  3. Vaccine. 2012, Feb; 30(9): 1650-1658.
  1. 23.   Polymorphism of amyloid beta peptide in different environments: implications for membrane insertion and pore formation
  2. Arce, F. T.; Jang, H. B.; Ramachandran, S.; Landon, P. B.; Nussinov, R.; Lal, R.
  3. Soft Matter. 2011, Jun 7; 7(11): 5267-5273.
  1. 25.   Variations in Apolipoprotein E Frequency With Age in a Pooled Analysis of a Large Group of Older People
  2. McKay, G. J.; Silvestri, G.; Chakravarthy, U.; Dasari, S.; Fritsche, L. G.; Weber, B. H.; Keilhauer, C. N.; Klein, M. L.; Francis, P. J.; Klaver, C. C.; Vingerling, J. R.; Ho, L.; De Jong, P.; Dean, M.; Sawitzke, J.; Baird, P. N.; Guymer, R. H.; Stambolian, D.; Orlin, A.; Seddon, J. M.; Peter, I.; Wright, A. F.; Hayward, C.; Lotery, A. J.; Ennis, S.; Gorin, M. B.; Weeks, D. E.; Kuo, C. L.; Hingorani, A. D.; Sofat, R.; Cipriani, V.; Swaroop, A.; Othman, M.; Kanda, A.; Chen, W.; Abecasis, G. R.; Yates, J. R.; Webster, A. R.; Moore, A. T.; Seland, J. H.; Rahu, M.; Soubrane, G.; Tomazzoli, L.; Topouzis, F.; Vioque, J.; Young, I. S.; Fletcher, A. E.; Patterson, C. C.
  3. American Journal of Epidemiology. 2011, Jun; 173(12): 1357-1364.
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