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  1. 1.   The effects of RNase H inhibitors and nevirapine on the susceptibility of HIV-1 to AZT and 3TC
  2. Davis, C. A.; Parniak, M. A.; Hughes, S. H.
  3. Virology. 2011, Oct; 419(2): 64-71.
  1. 2.   Phenotypic characterization of drug resistance-associated mutations in HIV-1 RT connection and RNase H domains and their correlation with thymidine analogue mutations
  2. Lengruber, R. B.; Delviks-Frankenberry, K. A.; Nikolenko, G. N.; Baumann, J.; Santos, A. F.; Pathak, V. K.; Soares, M. A.
  3. Journal of Antimicrobial Chemotherapy. 2011, Apr; 66(4): 702-708.
  1. 3.   Structural basis of HIV-1 resistance to AZT by excision
  2. Tu, X. Y.; Das, K.; Han, Q. W.; Bauman, J. D.; Clark, A. D.; Hou, X. R.; Frenkel, Y. V.; Gaffney, B. L.; Jones, R. A.; Boyer, P. L.; Hughes, S. H.; Sarafianos, S. G.; Arnold, E.
  3. Nature Structural & Molecular Biology. 2010, Oct; 17(10): 1202-+.
  1. 4.   Structural Basis for the Role of the K65R Mutation in HIV-1 Reverse Transcriptase Polymerization, Excision Antagonism, and Tenofovir Resistance
  2. Das, K.; Bandwar, R. P.; White, K. L.; Feng, J. Y.; Sarafianos, S. G.; Tuske, S.; Tu, X. Y.; Clark, A. D.; Boyer, P. L.; Hou, X. R.; Gaffney, B. L.; Jones, R. A.; Miller, M. D.; Hughes, S. H.; Arnold, E.
  3. Journal of Biological Chemistry. 2009 284(50): 35092-35100.
  1. 5.   Selection of mutations in the connection and RNase H domains of human immunodeficiency virus type 1 reverse transcriptase that increase resistance to 3 '-azido-3 '-dideoxythymidine
  2. Brehm, J. H.; Koontz, D.; Meteer, J. D.; Pathak, V.; Sluis-Cremer, N.; Mellors, J. W.
  3. Journal of Virology. 2007, Aug; 81(15): 7852-7859.
  1. 6.   The nucleoside analogs 4 ' C-Methyl thymidine and 4 ' C-Ethyl thymidine block DNA synthesis by wild-type HIV-1 RT and excision proficient NRTI resistant RT variants
  2. Boyer, P. L.; Julias, J. G.; Ambrose, Z.; Siddiqui, M. A.; MarqueZ, V. E.; Hughes, S. H.
  3. Journal of Molecular Biology. 2007, Aug; 371(4): 873-882.
  1. 7.   Transplacentally exposed human and monkey newborn infants show similar evidence of nucleoside reverse transcriptase inhibitor-induced mitochondrial toxicity
  2. Divi, R. L.; Leonard, S. L.; Kuo, M. M.; Nagashima, K.; Thamire, C.; St Claire, M. C.; Wade, N. A.; Walker, V. E.; Poirier, M. C.
  3. Environmental and Molecular Mutagenesis. 2007, Apr-May; 48(3-4): 201-209.
  1. 8.   Nucleotide excision repair and template-independent addition by HIV-1 reverse transcriptase in the presence of nucleocapsid protein
  2. Bampi, C.; Bibillo, A.; Wendeler, M.; Divita, G.; Gorelick, R. J.; Le Grice, S. F. J.; Darlix, J. L.
  3. Journal of Biological Chemistry. 2006, Apr; 281(17): 11736-11743.
  1. 9.   The level of reverse transcriptase (RT) in human immunodeficiency virus type 1 particles affects susceptibility to nonnucleoside RT inhibitors but not to lamivudine
  2. Ambrose, Z.; Julias, J. G.; Boyer, P. L.; KewalRamani, V. N.; Hughes, S. H.
  3. Journal of Virology. 2006, Mar; 80(5): 2578-2581.
  1. 10.   Azidothymidine inhibits NF-kappa B and induces Epstein-Barr virus gene expression in Burkitt lymphoma
  2. Kurokawa, M.; Ghosh, S. K.; Ramos, J. C.; Mian, A. M.; Toomey, N. L.; Cabral, L.; Whitby, D.; Barber, G. N.; Dittmer, D. P.; Harrington, W. J.
  3. Blood. 2005, JUL 1; 106(1): 235-240.
  1. 11.   Mechanism for nucleoside analog-mediated abrogation of HIV-1 replication: Balance between RNase H activity and nucleotide excision
  2. Nikolenko, G. N.; Palmer, S.; Maldarelli, F.; Mellors, J. W.; Coffin, J. M.; Pathak, V. K.
  3. Proceedings of the National Academy of Sciences of the United States of America. 2005, FEB 8; 102(6): 2093-2098.
  1. 12.   Fixed conformation nucleoside analogs effectively inhibit excision-proficient HIV-1 reverse transcriptases
  2. Boyer, P. L.; Julias, J. G.; Marquez, V. E.; Hughes, S. H.
  3. Journal of Molecular Biology. 2005, JAN 21; 345(3): 441-450.
  1. 13.   AZT resistance: why do HIV-1 and HIV-2 choose different pathways?
  2. Boyer, P. L.; Sarafianos, S. G.; Arnold, E.; Hughes, S. H.
  3. Antiviral Therapy. 2005 10(4): S92-S92.
  1. 14.   RNase H domains obtained from treatment-experienced patients increase resistance to AZT
  2. Nikolenko, G. N.; Frankenberry, K. A.; Palmer, S.; Maldarelli, F.; Mellors, J. W.; Coffin, J. M.; Pathak, V. K.
  3. Antiviral Therapy. 2005 10(4): S89-S89.
  1. 15.   Effects of the Delta 67 complex of mutations in human immunodeficiency virus type 1 reverse transcriptase on nucleoside analog excision
  2. Boyer, P. L.; Imamichi, T.; Sarafianos, S. G.; Arnold, E.; Hughes, S. H.
  3. Journal of Virology. 2004, SEP; 78(18): 9987-9997.
  1. 16.   Mitochondrial toxicity in fetal Erythrocebus patas monkeys exposed transplacentally to zidovudine plus lamivudine
  2. Gerschenson, M.; Nguyen, V.; Ewings, E. L.; Ceresa, A.; Shaw, J. A.; St Claire, M. C.; Nagashima, K.; Harbaugh, S. W.; Harbaugh, J. W.; Olivero, O. A.; Divi, R. L.; Albert, P. S.; Poirier, M. C.
  3. Aids Research and Human Retroviruses. 2004 20(1): 91-100.
  1. 17.   Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir
  2. Tuske, S.; Sarafianos, S. G.; Clark, A. D.; Ding, J. P.; Naeger, L. K.; White, K. L.; Miller, M. D.; Gibbs, C. S.; Boyer, P. L.; Clark, P.; Wang, G.; Gaffney, B. L.; Jones, R. A.; Jerina, D. M.; Hughes, S. H.; Arnold, E.
  3. Nature Structural & Molecular Biology. 2004 11(5): 469-474.
  1. 18.   Nucleoside analog resistance caused by insertions in the fingers of human immunodeficiency virus type 1 reverse transcriptase involves ATP-mediated excision
  2. Boyer, P. L.; Sarafianos, S. G.; Arnold, E.; Hughes, S. H.
  3. Journal of Virology. 2002 76(18): 9143-9151.
  1. 19.   Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptase
  2. Boyer, P. L.; Sarafianos, S. G.; Arnold, E.; Hughes, S. H.
  3. Journal of Virology. 2001 75(10): 4832-4842.
  1. 20.   Absence of structural or functional alterations in male and female reproductive organs of F1 and F2 generations derived from female mice exposed to 3 '-azido-3 '-deoxythymidine during pregnancy
  2. Diwan, B. A.; Olivero, O. A.; Poirier, M. C.
  3. Toxicology Letters. 2000 115(1): 9-15.
  1. 21.   Fetal mitochondrial heart and skeletal muscle damage in Erythrocebus patas monkeys exposed in utero to 3 '-azido-3 '-deoxythymidine
  2. Gerschenson, M.; Erhart, S. W.; Paik, C. Y.; Claire, M. C. S.; Nagashima, K.; Skopets, B.; Harbaugh, S. W.; Harbaugh, J. W.; Quan, W.; Poirier, M. C.
  3. Aids Research and Human Retroviruses. 2000 16(7): 635-644.
  1. 22.   Inhibition of the initiation of HIV-1 reverse transcription by 3 '-azido-3 '-deoxythymidine - Comparison with elongation
  2. Rigourd, M.; Lanchy, J. M.; Le Grice, S. F. J.; Ehresmann, B.; Ehresmann, C.; Marquet, R.
  3. Journal of Biological Chemistry. 2000 275(35): 26944-26951.
  1. 23.   High-level resistance to 3 '-azido-3 '-deoxythimidine due to a deletion in the reverse transcriptase gene of human immunodeficiency virus type 1
  2. Imamichi, T.; Sinha, T.; Imamichi, H.; Zhang, Y. M.; Metcalf, J. A.; Falloon, J.; Lane, H. C.
  3. Journal of Virology. 2000 74(2): 1023-1028.
  1. 24.   Multiorgan transplacental and neonatal carcinogenicity of 3 '-azido-3 '-deoxythymidine in mice
  2. Diwan, B. A.; Riggs, C. W.; Logsdon, D.; Haines, D. C.; Olivero, O. A.; Rice, J. M.; Yuspa, S. H.; Poirier, M. C.; Anderson, L. M.
  3. Toxicology and Applied Pharmacology. 1999 161(1): 82-99.
  1. 25.   Antiviral oligo- and polyribonucleotides containing selected triazolo
  2. Tutonda, M. G.; Buckheit, R. W.; Agrawal, V. K.; Broom, A. D.
  3. Journal of Medicinal Chemistry. 1998 41(25): 4958-4964.
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