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  1. 1.   Plasma and CNS pharmacokinetics of O(4)-benzylfolic acid (O(4)BF) and metabolite in a non-human primate model
  2. Chuk, M. K.; Cole, D. E.; McCully, C.; Loktionova, N. A.; Pegg, A. E.; Parker, R. J.; Pauly, G.; Widemann, B. C.; Balis, F. M.; Fox, E.
  3. Cancer Chemotherapy and Pharmacology. 2011, Jun; 67(6): 1291-1297.
  1. 2.   In vitro comparison of O4-benzylfolate modulated, BCNU-induced toxicity in human bone marrow using CFU-GM and tumor cell lines
  2. Behrsing, H. P.; Furniss, M. J.; Robillard, K. A.; Tomaszewski, J. E.; Parchment, R. E.
  3. Cancer Chemotherapy and Pharmacology. 2010, May; 65(6): 1083-1091.
  1. 3.   Inactivation of O-6-Alkylguanine-DNA alkyltransferase by folate esters of O-6-Benzyl-2'-deoxyguanosine and of O-6- 4-(Hydroxymethyl)benzyl guanine
  2. Javanmard, S.; Loktionova, N. A.; Fang, Q.; Pauly, G. T.; Pegg, A. E.; Moschel, R. C.
  3. Journal of Medicinal Chemistry. 2007, Oct; 50(21): 5193-5201.
  1. 4.   Role of GADD34 in modulation of cisplatin cytotoxicity
  2. Fishel, M. L.; Rabik, C. A.; Bleibel, W. K.; Li, X. M.; Moschel, R. C.; Dolan, M. E.
  3. Biochemical Pharmacology. 2006, JAN 12; 71(3): 239-247.
  1. 5.   Phase I trial of temozolomide plus O-6-benzylguanine for patients with recurrent or progressive malignant glioma
  2. Quinn, J. A.; Desjardins, A.; Weingart, J.; Brem, H.; Dolan, M. E.; Delaney, S. M.; Vredenburgh, J.; Rich, J.; Friedman, A. H.; Reardon, D. A.; Sampson, J. H.; Pegg, A. E.; Moschel, R. C.; Birch, R.; McLendon, R. E.; Provenzale, J. M.; Gururangan, S.; Dancey, J. E.; Maxwell, J.; Tourt-Uhlig, S.; Herndon, J. E.; Bigner, D. D.; Friedman, H. S.
  3. Journal of Clinical Oncology. 2005, OCT 1; 23(28): 7178-7187.
  1. 6.   Role of glutathione and nucleotide excision repair in modulation of cisplatin activity with O-6-benzylguanine
  2. Fishel, M. L.; Ganicsik, M. P.; Delaney, S. M.; Zuhowski, E. G.; Maher, V. M.; Karrison, T.; Moschel, R. C.; Egorin, M. J.; Dolan, M. E.
  3. Cancer Chemotherapy and Pharmacology. 2005, APR; 55(4): 333-342.
  1. 7.   Effect of cell cycle inhibition on cisplatin-induced cytotoxicity
  2. Fishel, M. L.; Newell, D. R.; Griffin, R. J.; Davison, R.; Wang, L. Z.; Curtin, N. J.; Zuhowski, E. G.; Kasza, K.; Egorin, M. J.; Moschel, R. C.; Dolan, M. E.
  3. Journal of Pharmacology and Experimental Therapeutics. 2005, JAN; 312(1): 206-213.
  1. 8.   Brain tumor cell lines resistant to O-6-benzylguanine/1,3-bis(2-chloroethyl)-1-nitrosourea chemotherapy have O-6 -alkylguanine-DNA alkyltransferase mutations
  2. Bacolod, M. D.; Johnson, S. P.; Pegg, A. E.; Dolan, M. E.; Moschel, R. C.; Bullock, N. S.; Fang, Q. M.; Colvin, O. M.; Modrich, P.; Bigner, D. D.; Friedman, H. S.
  3. Molecular Cancer Therapeutics. 2004, SEP; 3(9): 1127-1135.
  1. 9.   The repair of the tobacco specific nitrosamine derived adduct O-6-[4-oxo-4-(3-pyridyl)butyl]guanine by O-6-alkylguanine-DNA alkyltransferase variants
  2. Mijal, R. S.; Thomson, N. M.; Fleischer, N. L.; Pauly, G. T.; Moschel, R. C.; Kanugula, S.; Fang, Q. M.; Pegg, A. E.; Peterson, L. A.
  3. Chemical Research in Toxicology. 2004 17(3): 424-434.
  1. 10.   Repair of oligodeoxyribonucleotides by O-6-alkylguanine-DNA alkyltransferase
  2. Luu, K. X.; Kanugula, S.; Pegg, A. E.; Pauly, G. T.; Moschel, R. C.
  3. Biochemistry. 2002 41(27): 8689-8697.
  1. 11.   Debenzylation of O-6-benzyl-8-oxoguanine in human liver: implications for O-6-benzylguanine metabolism
  2. Long, L.; Moschel, R. C.; Dolan, M. E.
  3. Biochemical Pharmacology. 2001 61(6): 721-726.
  1. 12.   Inactivation of O-6-alkylguanine-DNA alkyltransferase by 8- substituted O-6-benzylguanine analogs in mice
  2. Ewesuedo, R. B.; Wilson, L. R.; Friedman, H. S.; Moschel, R. C.; Dolan, M. E.
  3. Cancer Chemotherapy and Pharmacology. 2001 47(1): 63-69.
  1. 13.   Thresholds of O-6-alkylguanine-DNA alkyltransferase which confer significant resistance of human glial tumor xenografts to treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea or temozolomide
  2. Kokkinakis, D. M.; Bocangel, D. B.; Schold, S. C.; Moschel, R. C.; Pegg, A. E.
  3. Clinical Cancer Research. 2001 7(2): 421-428.
  1. 14.   Inactivation of human O-6-alkylguanine-DNA alkyltransferase by modified oligodeoxyribonucleotides containing O-6-benzylguanine
  2. Pegg, A. E.; Goodtzova, K.; Loktionova, N. A.; Kanugula, S.; Pauly, G. T.; Moschel, R. C.
  3. Journal of Pharmacology and Experimental Therapeutics. 2001 296(3): 958-965.
  1. 15.   Reaction of O-6-Benzylguanine-Resistant Mutants of Human O-6-Alkylguanine-Dna Alkyltransferase With O-6-Benzylguanine in Oligodeoxyribonucleotides
  2. Pegg, A. E.; Kanugula, S.; Edara, S.; Pauly, G. T.; Moschel, R. C.; Goodtzova, K.
  3. Journal of Biological Chemistry. 1998 273(18): 10863-10867.
  1. 16.   O-6-Alkylguanine-Dna Alkyltransferase Inactivation By Ester Prodrugs of O-6-Benzylguanine Derivatives and Their Rate of Hydrolysis By Cellular Esterases
  2. Dolan, M. E.; Roy, S. K.; Garbiras, B. J.; Helft, P.; Paras, P.; Chae, M. Y.; Moschel, R. C.; Pegg, A. E.
  3. Biochemical Pharmacology. 1998 55(10): 1701-1709.
  1. 17.   Intraarterial O-6-Benzylguanine Enables the Specific Therapy of Nitrosourea-Resistant Intracranial Human Glioma Xenografts in Athymic Rats With 1,3-Bis(2-Chloroethyl)-1-Nitrosourea
  2. Kurpad, S. N.; Dolan, M. E.; McLendon, R. E.; Archer, G. E.; Moschel, R. C.; Pegg, A. E.; Bigner, D. D.; Friedman, H. S.
  3. Cancer Chemotherapy and Pharmacology. 1997 39(4): 307-316.
  1. 18.   Effect of Dna On the Inactivation of O-6-Alkylguanine-Dna Alkyltransferase By 9-Substituted O-6-Benzylguanine Derivatives
  2. Pegg, A. E.; Chung, L.; Moschel, R. C.
  3. Biochemical Pharmacology. 1997 53(10): 1559-1564.
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