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  1. 1.   Pyrrolo[2 ',3 ':3,4]cyclohepta[1,2-d][1,2]oxazoles, a New Class of Antimitotic Agents Active against Multiple Malignant Cell Types
  2. Spano, Virginia; Rocca, Roberta; Barreca, Marilia; Giallombardo, Daniele; Montalbano, Alessandra; Carbone, Anna; Raimondi, Maria Valeria; Gaudio, Eugenio; Bortolozzi, Roberta; Bai,Ruoli; Tassone, Pierfrancesco; Alcaro, Stefano; Hamel,Ernest; Viola, Giampietro; Bertoni, Francesco; Barraja, Paola
  3. JOURNAL OF MEDICINAL CHEMISTRY. 2020, OCT 22; 63(20): 12023-12042.
  1. 2.   Coibamide A Targets Sec61 to Prevent Biogenesis of Secretory and Membrane Proteins
  2. Tranter, Dale; Paatero, Anja O.; Kawaguchi, Shinsaku; Kazemi, Soheila; Serrill, Jeffrey D.; Kellosalo, Juho; Vogel, Walter K.; Richter, Uwe; Mattos, Daphne R.; Wan, Xuemei; Thornburg,Chris; Oishi, Shinya; McPhail, Kerry L.; Ishmael, Jane E.; Paavilainen, Ville O.
  3. ACS CHEMICAL BIOLOGY. 2020, AUG 21; 15(8): 2125-2136.
  1. 3.   Advances in Breast Cancer Therapy Using Nitric Oxide and Nitroxyl Donor Agents
  2. Basudhar, Debashree; Miranda, Katrina M.; Wink, David; Ridnour, Lisa
  3. REDOX-ACTIVE THERAPEUTICS. 2016; : 377-403.
  1. 4.   Antineoplastic Agents. 548. Synthesis of lodo- and Diiodocombstatin Phosphate Prodrugs
  2. Pettit, G. R.; Rosenberg, H. J.; Dixon, R.; Knight, J. C.; Hamel, E.; Chapuis, J. C.; Pettit, R. K.; Hogan, F.; Sumner, B.; Ain, K. B.; Trickey-Platt, B.
  3. Journal of Natural Products. 2012, Mar; 75(3): 385-393.
  1. 5.   Synthesis and Antitumor Molecular Mechanism of Agents Based on Amino 2-(3 ',4 ',5 '-Trimethoxybenzoyl)benzo[b]furan: Inhibition of Tubulin and Induction of Apoptosis
  2. Romagnoli, R.; Baraldi, P. G.; Lopez-Cara, C.; Cruz-Lopez, O.; Carrion, M. D.; Salvador, M. K.; Bermejo, J.; Estevez, S.; Estevez, F.; Balzarini, J.; Brancale, A.; Ricci, A.; Chen, L. C.; Kim, J. G.; Hamel, E.
  3. Chemmedchem. 2011, Oct; 6(10): 1841-1853.
  1. 6.   Discovery of 7-Hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a Tubulin Polymerization Inhibitor with Potent Antiproliferative and Tumor Vascular Disrupting Properties
  2. Flynn, B. L.; Gill, G. S.; Grobelny, D. W.; Chaplin, J. H.; Paul, D.; Leske, A. F.; Lavranos, T. C.; Chalmers, D. K.; Charman, S. A.; Kostewicz, E.; Shackleford, D. M.; Morizzi, J.; Hamel, E.; Jung, M. K.; Kremmidiotis, G.
  3. Journal of Medicinal Chemistry. 2011, Sep; 54(17): 6014-6027.
  1. 7.   Metallic radionuclides in the development of diagnostic and therapeutic radiopharmaceuticals
  2. Bhattacharyya, S.; Dixit, M.
  3. Dalton Transactions. 2011, Jun 21; 40(23): 6112-6128.
  1. 8.   Synthesis of novel antimitotic agents based on 2-amino-3-aroyl-5-(hetero)arylethynyl thiophene derivatives
  2. Romagnoli, R.; Baraldi, P. G.; Cruz-Lopez, O.; Tolomeo, M.; Di Cristina, A.; Pipitone, R. M.; Grimaudo, S.; Balzarini, J.; Brancale, A.; Hamel, E.
  3. Bioorganic & Medicinal Chemistry Letters. 2011, May; 21(9): 2746-2751.
  1. 9.   Comparison between 3-Nitrooxyphenyl acetylsalicylate (NO-ASA) and O-2-(acetylsalicyloxymethyl)-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (NONO-ASA) as Safe Anti-Inflammatory, Analgesic, Antipyretic, Antioxidant Prodrugs
  2. Chattopadhyay, M.; Velazquez, C. A.; Pruski, A.; Nia, K. V.; Abdellatif, K. R.; Keefer, L. K.; Kashfi, K.
  3. Journal of Pharmacology and Experimental Therapeutics. 2010, Nov; 335(2): 443-450.
  1. 10.   Synthesis and Discovery of Water-Soluble Microtubule Targeting Agents that Bind to the Colchicine Site on Tubulin and Circumvent Pgp Mediated Resistance
  2. Gangjee, A.; Zhao, Y.; Lin, L.; Raghavan, S.; Roberts, E. G.; Risinger, A. L.; Hamel, E.; Mooberry, S. L.
  3. Journal of Medicinal Chemistry. 2010, Nov; 53(22): 8116-8128.
  1. 11.   The Assembly-Inducing Laulimalide/Peloruside A Binding Site on Tubulin: Molecular Modeling and Biochemical Studies with [H-3]Peloruside A
  2. Nguyen, T. L.; Xu, X. M.; Gussio, R.; Ghosh, A. K.; Hamel, E.
  3. Journal of Chemical Information and Modeling. 2010, Nov; 50(11): 2019-2028.
  1. 12.   Synthesis and Evaluation of Haloacetyl, alpha-Bromoacryloyl and Nitrooxyacetyl Benzo[b]furan and Benzo[b]thiophene Derivatives as Potent Antiproliferative Agents Against Leukemia L1210 and K562 Cells
  2. Romagnoli, R.; Baraldi, P. G.; Carrion, M. D.; Cara, C. L.; Casolari, A.; Hamel, E.; Fabbri, E.; Gambari, R.
  3. Letters in Drug Design & Discovery. 2010, Aug; 7(7): 476-486.
  1. 13.   Substituted 2-(3 ',4 ',5 '-trimethoxybenzoyl)-benzo[b]thiophene derivatives as potent tubulin polymerization inhibitors
  2. Romagnoli, R.; Baraldi, P. G.; Carrion, M. D.; Cruz-Lopez, O.; Tolomeo, M.; Grimaudo, S.; Di Cristina, A.; Pipitone, M. R.; Balzarini, J.; Brancale, A.; Hamel, E.
  3. Bioorganic & Medicinal Chemistry. 2010, Jul; 18(14): 5114-5122.
  1. 14.   Structural analogues of schweinfurthin F: Probing the steric, electronic, and hydrophobic properties of the D-ring substructure
  2. Ulrich, N. C.; Kodet, J. G.; Mente, N. R.; Kuder, C. H.; Beutler, J. A.; Hohl, R. J.; Wiemer, D. F.
  3. Bioorganic & Medicinal Chemistry. 2010, Feb; 18(4): 1676-1683.
  1. 15.   Design and Synthesis of 2-(3-Benzo[b]thienyl)-6,7-methylenedioxyquinolin-4-one Analogues as Potent Antitumor Agents that Inhibit Tubulin Assembly
  2. Chang, Y. H.; Hsu, M. H.; Wang, S. H.; Huang, L. J.; Qian, K.; Morris-Natschke, S. L.; Hamel, E.; Kuo, S. C.; Lee, K. H.
  3. Journal of Medicinal Chemistry. 2009 52(15): 4883-4891.
  1. 16.   New Arylthioindoles and Related Bioisosteres at the Sulfur Bridging Group. 4. Synthesis, Tubulin Polymerization, Cell Growth Inhibition, and Molecular Modeling Studies
  2. La Regina, G.; Sarkar, T.; Bai, R. L.; Edler, M. C.; Saletti, R.; Coluccia, A.; Piscitelli, F.; Minelli, L.; Gatti, V.; Mazzoccoli, C.; Palermo, V.; Mazzoni, C.; Falcone, C.; Scovassi, A. I.; Giansanti, V.; Campiglia, P.; Porta, A.; Maresca, B.
  3. Journal of Medicinal Chemistry. 2009 52(23): 7512-7527.
  1. 17.   Antineoplastic Agents. 565. Synthesis of Combretastatin D-2 Phosphate and Dihydro-combretastatin D-2
  2. Pettit, G. R.; Quistorf, P. D.; Fry, J. A.; Herald, D. L.; Hamel, E.; Chapuis, J. C.
  3. Journal of Natural Products. 2009 72(5): 876-883.
  1. 18.   Design, synthesis and structure-activity relationship of 2-(3 ',4 ',5 '-trimethoxybenzoyl)-benzo[b]furan derivatives as a novel class of inhibitors of tubulin polymerization
  2. Romagnoli, R.; Baraldi, P. G.; Carrion, M. D.; Cara, C. L.; Cruz-Lopez, O.; Tolomeo, M.; Grimaudo, S.; Di Cristina, A.; Pipitone, M. R.; Balzarini, J.; Zonta, N.; Brancale, A.; Hamel, E.
  3. Bioorganic & Medicinal Chemistry. 2009 17(19): 6862-6871.
  1. 19.   Design and synthesis of paclitaxel conjugated with an ErbB2-Recognizing pepticle, EC-1
  2. Li, P.; Jiang, S.; Pero, S. C.; Oligino, L.; Krag, D. N.; Michejda, C. J.; Roller, P. P.
  3. Biopolymers. 2007, Nov; 87(4): 225-230.
  1. 20.   Structural insight into the pharmacophore pocket of human glutamate carboxypeptidase II
  2. Barinka, C.; Rovenska, M.; Mlcochova, P.; Hlouchova, K.; Plechanovova, A.; Majer, P.; Tsukamoto, T.; Slusher, B. S.; Konvalinka, J.; Lubkowski, J.
  3. Journal of Medicinal Chemistry. 2007, Jul; 50(14): 3267-3273.
  1. 21.   Synergistic effects of peloruside a and laulimalide with taxoid site drugs, but not with each other, on tubulin assembly
  2. Hamel, E.; Day, B. W.; Miller, J. H.; Jung, M. K.; Northcote, P. T.; Ghosh, A. K.; Curran, D. P.; Cushman, M.; Nicolaou, K. C.; Paterson, I.; Sorensen, E. J.
  3. Molecular Pharmacology. 2006, Nov; 70(5): 1555-1564.
  1. 22.   Synthesis and evaluation of indenoisoquinoline topoisomerase I inhibitors substituted with nitrogen heterocycles
  2. Nagarajan, M.; Morrell, A.; Ioanoviciu, A.; Antony, S.; Kohlhagen, G.; Agama, K.; Hollingshead, M.; Pommier, Y.; Cushman, M.
  3. Journal of Medicinal Chemistry. 2006, Oct; 49(21): 6283-6289.
  1. 23.   Evaluation of indenoisoquinoline topoisomerase I inhibitors using a hollow fiber assay
  2. Morrell, A.; Jayaraman, M.; Nagarajan, M.; Fox, B. M.; Meckley, M. R.; Ioanoviciu, A.; Pommier, Y.; Antony, S.; Hollineshead, M.; Cushman, M.
  3. Bioorganic & Medicinal Chemistry Letters. 2006, Aug; 16(16): 4395-4399.
  1. 24.   Tubulin assembly, taxoid site binding, and cellular effects of the microtubule-stabilizing agent dictyostatin
  2. Madiraju, C.; Edler, M. C.; Hamel, E.; Raccor, B. S.; Balachandran, R.; Zhu, G. Y.; Giuliano, K. A.; Vogt, A.; Shin, Y. S.; Fournier, J. H.; Fukui, Y. H.; Bruckner, A. M.; Curran, D. P.; Day, B. W.
  3. Biochemistry. 2005, NOV 15; 44(45): 15053-15063.
  1. 25.   A common pharmacophore for a diverse set of colchicine site inhibitors using a structure-based approach
  2. Nguyen, T. L.; McGrath, C.; Hermone, A. R.; Burnett, J. C.; Zaharevitz, D. W.; Day, B. W.; Wipf, P.; Hamel, E.; Gussio, R.
  3. Journal of Medicinal Chemistry. 2005, SEP 22; 48(19): 6107-6116.
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