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  1. 1.   Synthesis and biological evaluation of structurally diverse alpha-conformationally restricted chalcones and related analogues
  2. Maguire, Casey J.; Carlson, Graham J.; Ford, Jacob W.; Strecker, Tracy E.; Hamel,Ernest; Trawick, Mary Lynn; Pinney, Kevin G.
  3. MedChemComm. 2019, Aug 1; 10(8): 1445-1456.
  1. 2.   Structure Guided Design, Synthesis, and Biological Evaluation of Novel Benzosuberene Analogues as Inhibitors of Tubulin Polymerization
  2. Niu, Haichan; Strecker, Tracy E.; Gerberich, Jeni L.; Campbell, James W.; Saha, Debabrata; Mondal, Deboprosad; Hamel,Ernest; Chaplin, David J.; Mason, Ralph P.; Trawick, Mary Lynn; Pinney, Kevin G.
  3. JOURNAL OF MEDICINAL CHEMISTRY. 2019, JUN 13; 62(11): 5594-5615.
  1. 3.   A Pharmacologic Inhibitor of the Protease Taspase1 Effectively Inhibits Breast and Brain Tumor Growth
  2. Chen, D. Y.; Lee, Y.; Van Tine, B. A.; Searleman, A. C.; Westergard, T. D.; Liu, H.; Tu, H. C.; Takeda, S.; Dong, Y. Y.; Piwnica-Worms, D. R.; Oh, K. J.; Korsmeyer, S. J.; Hermone, A.; Gussio, R.; Shoemaker, R. H.; Cheng, E. H. Y.; Hsieh, J. J. D.
  3. Cancer Research. 2012, Feb; 72(3): 736-746.
  1. 4.   Regioselective Synthesis of Water-Soluble Monophosphate Derivatives of Combretastatin A-1
  2. Tanpure, R. P.; Nguyen, B. L.; Strecker, T. E.; Aguirre, S.; Sharma, S.; Chaplin, D. J.; Siim, B. G.; Hamel, E.; Lippert, J. W.; Pettit, G. R.; Trawick, M. L.; Pinney, K. G.
  3. Journal of Natural Products. 2011, Jul; 74(7): 1568-1574.
  1. 5.   Directed Discovery of Agents Targeting the Met Tyrosine Kinase Domain by Virtual Screening
  2. Peach, M. L.; Tan, N.; Choyke, S. J.; Giubellino, A.; Athauda, G.; Burke, T. R.; Nicklaus, M. C.; Bottaro, D. P.
  3. Journal of Medicinal Chemistry. 2009 52(4): 943-951.
  1. 6.   Antineoplastic Agents. 565. Synthesis of Combretastatin D-2 Phosphate and Dihydro-combretastatin D-2
  2. Pettit, G. R.; Quistorf, P. D.; Fry, J. A.; Herald, D. L.; Hamel, E.; Chapuis, J. C.
  3. Journal of Natural Products. 2009 72(5): 876-883.
  1. 7.   Activation of signal transducer and activator of transcription 3 through a phosphomimetic serine 727 promotes prostate tumorigenesis independent of tyrosine 705 phosphorylation
  2. Qin, H. R.; Kim, H. J.; Kim, J. Y.; Hurt, E. M.; Klarmann, G. J.; Kawasaki, B. T.; Serrat, M.; Farrar, W. L.
  3. Cancer Research. 2008 68(19): 7736-7741.
  1. 8.   Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling
  2. Baba, M.; Hong, S. B.; Sharma, N.; Warren, M. B.; Nickerson, M. L.; Iwamatsu, A.; Esposito, D.; Gillette, W. K.; Hopkins, R. F.; Hartley, J. L.; Furihata, M.; Oishi, S.; Zhen, W.; Burke, T. R.; Linehan, W. M.; Schmidt, L. S.; Zbar, B.
  3. Proceedings of the National Academy of Sciences of the United States of America. 2006, Oct; 103(42): 15552-15557.
  1. 9.   PM-20, a novel inhibitor of Cdc25A, induces extracellular signal-regulated kinase 1/2 phosphorylation and inhibits hepatocellular carcinoma growth in vitro and in vivo
  2. Kar, S.; Wang, M. F.; Yao, W.; Michejda, C. J.; Carr, B. I.
  3. Molecular Cancer Therapeutics. 2006, Jun; 5(6): 1511-1519.
  1. 10.   Inhibition of transcription factor NF-kappa B signaling proteins IKK beta and p65 through specific cysteine residues by epoxyquinone A monomer: Correlation with its anti-cancer cell growth activity
  2. Liang, M. C.; Bardhan, S.; Pace, E. A.; Rosman, D.; Beutler, J. A.; Porco, J. A.; Gilmore, T. D.
  3. Biochemical Pharmacology. 2006, FEB 28; 71(5): 634-645.
  1. 11.   New arylthioindoles: Potent inhibitors of tubulin polymerization. 2. Structure-activity relationships and molecular modeling studies
  2. De Martino, G.; Edler, M. C.; La Regina, G.; Coluccia, A.; Barbera, M. C.; Barrow, D.; Nicholson, R. I.; Chiosis, G.; Brancale, A.; Hamel, E.; Artico, M.; Silvestri, R.
  3. Journal of Medicinal Chemistry. 2006, FEB 9; 49(3): 947-954.
  1. 12.   Nitric oxide regulates prolidase activity by serine/threonine phosphorylation
  2. Surazynski, A.; Liu, Y. M.; Miltyk, W.; Phang, J. M.
  3. Journal of Cellular Biochemistry. 2005, DEC 1; 96(5): 1086-1094.
  1. 13.   A novel RING-type ubiquitin ligase breast cancer-associated gene 2 correlates with outcome in invasive breast cancer
  2. Burger, A. M.; Gao, Y. G.; Amemiya, Y.; Kahn, H. J.; Kitching, R.; Yang, Y. L.; Sun, P.; Narod, S. A.; Hanna, W. M.; Seth, A. K.
  3. Cancer Research. 2005, NOV 15; 65(22): 10401-10412.
  1. 14.   Friend spleen focus-forming virus transforms rodent fibroblasts in cooperation with a short form of the receptor tyrosine kinase Stk
  2. Nishigaki, K.; Hanson, C.; Jelacic, T.; Thompson, D.; Ruscetti, S.
  3. Proceedings of the National Academy of Sciences of the United States of America. 2005, OCT 25; 102(43): 15488-15493.
  1. 15.   Effect of EBV LMP1 targeted DNAzymes on cell proliferation and apoptosis
  2. Lu, Z. X.; Ye, M.; Yan, G. R.; Li, Q.; Tang, M.; Lee, L. M.; Sun, L. Q.; Cao, Y.
  3. Cancer Gene Therapy. 2005, JUL; 12(7): 647-654.
  1. 16.   Cancer biology and hormesis: Comments on Calabrese (2005)
  2. Anderson, L. M.
  3. Critical Reviews in Toxicology. 2005, JUL; 35(6): 583-586.
  1. 17.   Antineoplastic agents. 445. Synthesis and evaluation of structural modifications of (Z)- and (E)-combretastatin A-4
  2. Pettit, G. R.; Rhodes, M. R.; Herald, D. L.; Hamel, E.; Schmidt, J. M.; Pettitt, R. K.
  3. Journal of Medicinal Chemistry. 2005, JUN 16; 48(12): 4087-4099.
  1. 18.   Inhibition of prolidase activity by nickel causes decreased growth of proline auxotrophic CHO cells
  2. Miltylk, W.; Surazynski, A.; Kasprzak, K. S.; Fivash, M. J.; Buzard, G. S.; Phang, J. M.
  3. Journal of Cellular Biochemistry. 2005, APR 15; 94(6): 1210-1217.
  1. 19.   Role of glutathione and nucleotide excision repair in modulation of cisplatin activity with O-6-benzylguanine
  2. Fishel, M. L.; Ganicsik, M. P.; Delaney, S. M.; Zuhowski, E. G.; Maher, V. M.; Karrison, T.; Moschel, R. C.; Egorin, M. J.; Dolan, M. E.
  3. Cancer Chemotherapy and Pharmacology. 2005, APR; 55(4): 333-342.
  1. 20.   DLC-1, a Rho GTPase-activating protein with tumor suppressor function, is essential for embryonic development
  2. Durkin, M. E.; Avner, M. R.; Huh, C. G.; Yuan, B. Z.; Thorgeirsson, S. S.; Popescu, N. C.
  3. Febs Letters. 2005, FEB 14; 579(5): 1191-1196.
  1. 21.   The antitumor drug candidate 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole induces NF-kappa B activity in drug-sensitive MCF-7 cells
  2. Brantley, E.; Patel, V.; Stinson, S. F.; Trapani, V.; Hose, C. D.; Ciolino, H. P.; Yeh, G. C.; Gutkind, J. S.; Sausville, E. A.; Loaiza-Perez, A. I.
  3. Anti-Cancer Drugs. 2005, FEB; 16(2): 137-143.
  1. 22.   Nuclear receptors as negative modulators of STAT3 in multiple myeloma
  2. Wang, L. H.; Yang, X. Y.; Zhang, X. H.; Farrar, W. L.
  3. Cell Cycle. 2005, FEB; 4(2): 242-245.
  1. 23.   Secondary metabolites of Phlomis viscosa and their biological activities
  2. Calis, I.; Kirmizibekmez, H.; Beutler, J. A.; Donmez, A. A.; Yalcin, F. N.; Kilic, E.; Ozalp, M.; Ruedi, P.; Tasdemir, D.
  3. Turkish Journal of Chemistry. 2005 29(1): 71-81.
  1. 24.   Anticancer metal compounds in NCI's tumor-screening database: putative mode of action
  2. Huang, R. L.; Wallqvist, A.; Covell, D. G.
  3. Biochemical Pharmacology. 2005 69(7): 1009-1039.
  1. 25.   Assay for ubiquitin ligase activity: High-throughput screen for inhibitors of HDM2
  2. Davydov, I. V.; Woods, D.; Safiran, Y. J.; Oberoi, P.; Fearnhead, H. O.; Fang, S.; Jensen, J. P.; Weissman, A. M.; Kenten, J. H.; Vousden, K. H.
  3. Journal of Biomolecular Screening. 2004, DEC; 9(8): 695-703.
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