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  1. 1.   Simple monocyclic pyrimidine analogs as microtubule targeting agents binding to the colchicine site
  2. Choudhary, Shruti; Kaku, Krishna; Robles, Andrew J; Hamel,Ernest; Mooberry, Susan L; Gangjee, Aleem
  3. Bioorganic & Medicinal Chemistry. 2023, Feb 24; 82: 117217.
  1. 2.   Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: Further chemical modifications and potential therapeutic effects against lymphomas
  2. Barreca, Marilia; Spanò, Virginia; Rocca, Roberta; Bivacqua, Roberta; Abel, Anne-Catherine; Maruca, Annalisa; Montalbano, Alessandra; Raimondi, Maria Valeria; Tarantelli, Chiara; Gaudio, Eugenio; Cascione, Luciano; Rinaldi, Andrea; Bai,Ruoli; Steinmetz, Michel O; Prota, Andrea E; Alcaro, Stefano; Hamel, Ernest; Bertoni, Francesco; Barraja, Paola
  3. European Journal of Medicinal Chemistry. 2022, Sep 08; 243: 114744.
  1. 3.   Design, Synthesis, and Biological Evaluation of 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidines as Microtubule Targeting Agents
  2. Islam, Farhana; Doshi, Arpit; Robles, Andrew J; Quadery, Tasdique M; Zhang, Xin; Zhou, Xilin; Hamel, Ernest; Mooberry, Susan L; Gangjee, Aleem
  3. Molecules . 2022, Jan 05; 27(1):
  1. 4.   Novel pyrazolo[4,3-d]pyrimidine microtubule targeting agents (MTAs): Synthesis, structure-activity relationship, in vitro and in vivo evaluation as antitumor agents
  2. Islam, Farhana; Quadery, Tasdique M.; Bai,Ruoli; Luckett-Chastain, Lerin R.; Hamel,Ernest; Ihnat, Michael A.; Gangjee, Aleem
  3. Bioorganic & Medicinal Chemistry Letters. 2021, Jun 1; 41
  1. 5.   Pyrrolo[2 ',3 ':3,4]cyclohepta[1,2-d][1,2]oxazoles, a New Class of Antimitotic Agents Active against Multiple Malignant Cell Types
  2. Spano, Virginia; Rocca, Roberta; Barreca, Marilia; Giallombardo, Daniele; Montalbano, Alessandra; Carbone, Anna; Raimondi, Maria Valeria; Gaudio, Eugenio; Bortolozzi, Roberta; Bai,Ruoli; Tassone, Pierfrancesco; Alcaro, Stefano; Hamel,Ernest; Viola, Giampietro; Bertoni, Francesco; Barraja, Paola
  3. JOURNAL OF MEDICINAL CHEMISTRY. 2020, OCT 22; 63(20): 12023-12042.
  1. 6.   Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2-d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors
  2. Romagnoli, Romeo; Prencipe, Filippo; Oliva, Paola; Baraldi, Stefania; Baraldi, Pier Giovanni; Schiaffino Ortega, Santiago; Chayah, Mariem; Kimatrai Salvador, Maria; Carlota Lopez-Cara, Luisa; Brancale, Andrea; Ferla, Salvatore; Hamel,Ernest; Ronca, Roberto; Bortolozzi, Roberta; Mariotto, Elena; Mattiuzzo, Elena; Viola, Giampietro
  3. JOURNAL OF MEDICINAL CHEMISTRY. 2019, Feb 14; 62(3): 1274-1290.
  1. 7.   Tetrahydroisoquinoline Sulfamates as Potent Microtubule Disruptors: Synthesis, Antiproliferative and Antitubulin Activity of Dichlorobenzyl-Based Derivatives, and a Tubulin Cocrystal Structure
  2. Dohle, Wolfgang; Prota, Andrea E.; Menchon, Gregory; Hamel,Ernest; Steinmetz, Michel O.; Potter, Barry V. L.
  3. ACS omega. 2019, Jan 31; 4(1): 755-764.
  1. 8.   Quinazolinone-Based Anticancer Agents: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Tubulin Co-crystal Structure
  2. Dohle, Wolfgang; Jourdan, Fabrice L.; Menchon, Gregory; Prota, Andrea E.; Foster, Paul A.; Mannion, Pascoe; Hamel, Ernest; Thomas, Mark P.; Kasprzyk, Philip G.; Ferrandis, Eric; Steinmetz, Michel O.; Leese, Mathew P.; Potter, Barry V. L.
  3. JOURNAL OF MEDICINAL CHEMISTRY. 2018, Feb 8; 61(3): 1031-1044.
  1. 9.   2-Alkoxycarbonyl-3-arylamino-5-substituted thiophenes as a novel class of antimicrotubule agents: Design, synthesis, cell growth and tubulin polymerization inhibition
  2. Romagnoli, Romeo; Kimatrai Salvador, Maria; Schiaffino Ortega, Santiago; Baraldi, Pier Giovanni; Oliva, Paola; Baraldi, Stefania; Lopez-Cara, Luisa Carlota; Brancale, Andrea; Ferla, Salvatore; Hamel, Ernest; Balzarini, Jan; Liekens, Sandra; Mattiuzzo, Elena; Basso, Giuseppe; Viola, Giampietro
  3. European Journal of Medicinal Chemistry. 2018, Jan 1; 143: 683-698.
  1. 10.   Discovery of 7-Hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a Tubulin Polymerization Inhibitor with Potent Antiproliferative and Tumor Vascular Disrupting Properties
  2. Flynn, B. L.; Gill, G. S.; Grobelny, D. W.; Chaplin, J. H.; Paul, D.; Leske, A. F.; Lavranos, T. C.; Chalmers, D. K.; Charman, S. A.; Kostewicz, E.; Shackleford, D. M.; Morizzi, J.; Hamel, E.; Jung, M. K.; Kremmidiotis, G.
  3. Journal of Medicinal Chemistry. 2011, Sep; 54(17): 6014-6027.
  1. 11.   Synthesis and Antitumor Activity of 1,5-Disubstituted 1,2,4-Triazoles as Cis-Restricted Combretastatin Analogues
  2. Romagnoli, R.; Baraldi, P. G.; Cruz-Lopez, O.; Cara, C. L.; Carrion, M. D.; Brancale, A.; Hamel, E.; Chen, L. C.; Bortolozzi, R.; Basso, G.; Viola, G.
  3. Journal of Medicinal Chemistry. 2010, May; 53(10): 4248-4258.
  1. 12.   Synthesis, Antitubulin, and Antiproliferative SAR of Analogues of 2-Methoxyestradiol-3,17-O,O-bis-sulfamate
  2. Jourdan, F.; Leese, M. P.; Dohle, W.; Hamel, E.; Ferrandis, E.; Newman, S. P.; Purohit, A.; Reed, M. J.; Potter, B. V. L.
  3. Journal of Medicinal Chemistry. 2010, Apr; 53(7): 2942-2951.
  1. 13.   CB694, a novel antimitotic with antitumor activities
  2. Weiderhold, K. N.; Randall-Hiubek, D. A.; Polin, L. A.; Hamel, E.; Mooberry, S. L
  3. International Journal of Cancer. 2006, FEB 15; 118(4): 1032-1040.
  1. 14.   A common pharmacophore for a diverse set of colchicine site inhibitors using a structure-based approach
  2. Nguyen, T. L.; McGrath, C.; Hermone, A. R.; Burnett, J. C.; Zaharevitz, D. W.; Day, B. W.; Wipf, P.; Hamel, E.; Gussio, R.
  3. Journal of Medicinal Chemistry. 2005, SEP 22; 48(19): 6107-6116.
  1. 15.   A quantitative evaluation of the effects of inhibitors of tubulin assembly on polymerization induced by discodermolide, epothilone B, and paclitaxel
  2. Dabydeen, D. A.; Florence, G. J.; Paterson, I.; Hamel, E.
  3. Cancer Chemotherapy and Pharmacology. 2004 53(5): 397-403.
  1. 16.   Synthesis and biological evaluation of a focused mixture library of analogues of the antimitotic marine natural product curacin A
  2. Wipf, P.; Reeves, J. T.; Balachandran, R.; Giuliano, K. A.; Hamel, E.; Day, B. W.
  3. Journal of the American Chemical Society. 2000 122(39): 9391-9395.
  1. 17.   Antineoplastic agents 440. Asymmetric synthesis and evaluation of the combretastatin A-1 SAR probes (1S,2S)- and (1R,2R)-1,2-dihydroxy-1-(2 ',3 '-dihydroxy-4 '-methoxyphenyl)-2-(3 '',4 '',5 ''-trimethoxyphenyl)-ethane
  2. Pettit, G. R.; Lippert, J. W.; Herald, D. L.; Hamel, E.; Pettit, R. K.
  3. Journal of Natural Products. 2000 63(7): 969-974.
  1. 18.   Preparation of new anti-tubulin ligands through a dual-mode, addition-elimination reaction to a bromo-substituted alpha,beta-unsaturated sulfoxide
  2. Chen, Z.; Mocharla, V. P.; Farmer, J. M.; Pettit, G. R.; Hamel, E.; Pinney, K. G.
  3. Journal of Organic Chemistry. 2000 65(25): 8811-8815.
  1. 19.   Biosynthesis of radiolabeled curacin A and its rapid and apparently irreversible binding to the colchicine site of tubulin
  2. Verdier-Pinard, P.; Sitachitta, N.; Rossi, J. V.; Sackett, D. L.; Gerwick, W. H.; Hamel, E.
  3. Archives of Biochemistry and Biophysics. 1999 370(1): 51-58.
  1. 20.   Purification, characterization, and drug susceptibility of tubulin from Leishmania
  2. Werbovetz, K. A.; Brendle, J. J.; Sackett, D. L.
  3. Molecular and Biochemical Parasitology. 1999 98(1): 53-65.
  1. 21.   Cellular Targets of the Anti-Breast Cancer Agent Z-1,1-Dichloro-2,3-Diphenylcyclopropane - Type Ii Estrogen Binding Sites and Tubulin
  2. Terhaar, E.; Hamel, E.; Balachandran, R.; Day, B. W.
  3. Anticancer Research. 1997 17(3C): 1861-1869.
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