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  1. 1.   Olaparib in treatment-refractory isocitrate dehydrogenase 1 (IDH1)- and IDH2-mutant cholangiocarcinoma: Safety and antitumor activity from the phase 2 National Cancer Institute 10129 trial
  2. Cecchini, Michael; Pilat, Mary Jo; Uboha, Nataliya; Azad, Nilofer S; Cho, May; Davis, Elizabeth J; Ahnert, Jordi Rodon; Tinoco, Gabriel; Shapiro, Geoffrey I; Khagi, Simon; Powers, Benjamin; Spencer, Kristen; Groisberg, Roman; Drappatz, Jan; Chen, Li; Das,Bishu; Bao, Xun; Li, Jing; Narayan, Azeet; Vu, Dennis; Patel, Abhijit; Niger, Monica; Doroshow, Deborah; Durecki, Diane; Boerner, Scott A; Bindra, Ranjit; Ivy, Percy; Shyr, Derek; Shyr, Yu; LoRusso, Patricia M
  3. Cancer. 2025, Feb 15; 131(4): e35755.
  1. 2.   Mismatch repair protein MLH1 suppresses replicative stress in BRCA2 deficient breast tumors
  2. Sengodan,Satheesh; Hu, Xiaoju; Peddibhotla, Vaishnavi; Balamurugan, Kuppusamy; Mitrophanov,Alex; McKennett,Lois; Kharat, Suhas S; Sanawar, Rahul; Singh, Vinod Kumar; Albaugh,Mary; Burkett,Sandra; Zhao,Yongmei; Tran,Bao; Malys,Tyler; Sterneck,Esta; De, Subhajyoti; Sharan,Shyam
  3. The Journal of Clinical Investigation. 2024, Jan 25; 134(7):
  1. 3.   Sequencing-based functional assays for classification of BRCA2 variants in mouse ESCs
  2. Biswas,Kajal; Mitrophanov,Alex; Sahu,Sounak; Sullivan,Teresa; Southon,Eileen; Nousome,Darryl; Reid, Susan; Narula, Sakshi; Smolen, Julia; Sengupta, Trisha; Riedel-Topper, Maximilian; Kapoor, Medha; Babbar, Anav; Stauffer,Stacey; Cleveland, Linda; Tandon, Mayank; Malys,Tyler; Sharan,Shyam
  3. Cell Reports Methods. 2023, Nov 20; 3(11): 100628.
  1. 4.   1H, 15N, 13C resonance assignments for proteasome shuttle factor hHR23a
  2. Chen,Xiang; Walters,Kylie
  3. Biomolecular NMR Assignments. 2023, Oct 09;
  1. 5.   Partial deletions of the autoregulatory C-terminal domain of Artemis and their effect on its nuclease activity
  2. Anne-Esguerra, Z; Wu, Mousheng; Watanabe, Go; Flint,Andrew; Lieber, Michael R
  3. DNA Repair. 2022, Oct 28; 120: 103422.
  1. 6.   Molecular Features of Cancers Exhibiting Exceptional Responses to Treatment
  2. Wheeler, David A; Takebe, Naoko; Hinoue, Toshinori; Hoadley, Katherine A; Cardenas, Maria F; Hamilton, Alina M; Laird, Peter W; Wang, Linghua; Johnson, Adrienne; Dewal, Ninad; Miller, Vincent; Piñeyro, David; Castro de Moura, Manuel; Esteller, Manel; Shen, Hui; Zenklusen, Jean Claude; Tarnuzzer, Roy; McShane, Lisa M; Tricoli, James V; Williams, Paul M; Lubensky, Irina; O'Sullivan-Coyne, Geraldine; Kohn, Elise C; Little, Richard F; White, Jeffrey; Malik, Shakun; Harris, Lyndsay; Weil, Carol; Chen, Alice P; Karlovich,Chris; Rodgers, Brian; Shankar, Lalitha; Jacobs, Paula; Nolan, Tracy; Hu, Jianhong; Muzny, Donna M; Doddapaneni, Harshavardhan; Korchina, Viktoriya; Gastier-Foster, Julie; Bowen, Jay; Leraas, Kristen; Edmondson,Elijah; Doroshow, James H; Conley, Barbara A; Ivy, S Percy; Staudt, Louis M
  3. Cancer Cell. 2021, Jan 11; 39(1): 38-53.e7.
  1. 7.   Phosphorylation of SMURF2 by ATM exerts a negative feedback control of DNA damage response
  2. Tang, Liu-Ya; Thomas, Adam; Zhou, Ming; Zhang, Ying E
  3. The Journal of biological chemistry. 2020, Dec 25; 295(52): 18485-18493.
  1. 8.   SL-BioDP: Multi-Cancer Interactive Tool for Prediction of Synthetic Lethality and Response to Cancer Treatment
  2. Deng,Xiang; Das, Shaoli; Valdez,Kristin; Camphausen, Kevin; Shankavaram, Uma
  3. Cancers. 2019, Nov; 11(11): pii: E1682.
  1. 9.   Durvalumab in Combination with Olaparib in Patients with Relapsed Small Cell Lung Cancer: Results from a Phase II Study
  2. Thomas, Anish; Vilimas, Rasa; Trindade, Christopher; Erwin-Cohen,Rebecca; Roper, Nitin; Xi, Liqiang; Krishnasamy, Venkatesh; Levy, Elliot; Mammen, Andy; Nichols, Samantha; Chen, Yuanbin; Velcheti, Vamsidhar; Yin, Faye; Szabo, Eva; Pommier, Yves; Steinberg, Seth M; Trepel, Jane B; Raffeld, Mark; Young,Howard; Khan, Javed; Hewitt, Stephen; Lee, Jung-Min
  3. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2019, AUG; 14(8): 1447-1457.
  1. 10.   Replication Stress Shapes a Protective Chromatin Environment across Fragile Genomic Regions
  2. Kim, Jeongkyu; Sturgill, David; Sebastian, Robin; Khurana, Simran; Tran, Andy D; Edwards, Garrett B; Kruswick, Alex; Burkett, Sandra; Hosogane, Eri K; Hannon, William W; Weyemi, Urbain; Bonner, William M; Luger, Karolin; Oberdoerffer, Philipp
  3. Molecular Cell. 2018, Jan 4; 69(1): 36-47.
  1. 11.   Advances in using PARP inhibitors to treat cancer
  2. Kummar, S.; Chen, A.; Parchment, R. E.; Kinders, R. J.; Ji, J.; Tomaszewski, J. E.; Doroshow, J. H.
  3. Bmc Medicine. 2012, Mar; 10
  1. 12.   Genetic Variation in Base Excision Repair Pathway Genes, Pesticide Exposure, and Prostate Cancer Risk
  2. Barry, K. H.; Koutros, S.; Bemdt, S. I.; Andreotti, G.; Hoppin, J. A.; Sandler, D. P.; Burdette, L. A.; Yeager, M.; Freeman, L. E. B.; Lubin, J. H.; Ma, X. M.; Zheng, T. Z.; Alavanja, M. C. R.
  3. Environmental Health Perspectives. 2011, Dec; 119(12): 1726-1732.
  1. 13.   Increased Expression of DNA Repair Genes in Invasive Human Pancreatic Cancer Cells
  2. Mathews, L. A.; Cabarcas, S. M.; Hurt, E. M.; Zhang, X. H.; Jaffee, E. M.; Farrar, W. L.
  3. Pancreas. 2011, Jul; 40(5): 730-739.
  1. 14.   DNA repair: the culprit for tumor-initiating cell survival?
  2. Mathews, L. A.; Cabarcas, S. M.; Farrar, W. L.
  3. Cancer and Metastasis Reviews. 2011, Jun; 30(2): 185-197.
  1. 15.   The RAG1 V(D)J recombinase/ubiquitin ligase promotes ubiquitylation of acetylated, phosphorylated histone 3.3
  2. Jones, J. M.; Bhattacharyya, A.; Simkus, C.; Vallieres, B.; Veenstra, T. D.; Zhou, M.
  3. Immunology Letters. 2011, May; 136(2): 156-162.
  1. 16.   CCAAT/enhancer binding protein delta (C/EBP delta, CEBPD)-mediated nuclear import of FANCD2 by IPO4 augments cellular response to DNA damage
  2. Wang, J.; Sarkar, T. R.; Zhou, M.; Sharan, S.; Ritt, D. A.; Veenstra, T. D.; Morrison, D. K.; Huang, A. M.; Sterneck, E.
  3. Proceedings of the National Academy of Sciences of the United States of America. 2010, Sep; 107(37): 16131-16136.
  1. 17.   DNA repair gene polymorphisms and risk of adult meningioma, glioma, and acoustic neuroma
  2. Rajaraman, P.; Hutchinson, A.; Wichner, S.; Black, P. M.; Fine, H. A.; Loeffler, J. S.; Selker, R. G.; Shapiro, W. R.; Rothman, N.; Linet, M. S.; Inskip, P. D.
  3. Neuro-Oncology. 2010, Jan; 12(1): 37-48.
  1. 18.   Expression of human BRCA1 variants in mouse ES cells allows functional analysis of BRCA1 mutations
  2. Chang, S.; Biswas, K.; Martin, B. K.; Stauffer, S.; Sharan, S. K.
  3. Journal of Clinical Investigation. 2009, Oct; 119(10): 3160-71.
  1. 19.   Environmental genotoxicants/carcinogens and childhood cancer: Bridgeable gaps in scientific knowledge
  2. Anderson, L. M.
  3. Mutation Research-Genetic Toxicology and Environmental Mutagenesis. 2006, Sep; 608(2): 136-156.
  1. 20.   Enhancement of in vitro and in vivo tumor cell radiosensitivity by the DNA methylation inhibitor zebularine
  2. Dote, H.; Cerna, D.; Burgan, W. E.; Carter, D. J.; Cerra, M. A.; Hollingshead, M. G.; Camphausen, K.; Tofilon, P. J.
  3. Clinical Cancer Research. 2005, JUN 15; 11(12): 4571-4579.
  1. 21.   A bifunctional DNA repair protein from Ferroplasma acidarmanus exhibits O-6-alkylguanine-DNA alkyltransferase and endonuclease V activities
  2. Kanugula, S.; Pauly, G. T.; Moschel, R. C.; Pegg, A. E.
  3. Proceedings of the National Academy of Sciences of the United States of America. 2005, MAR 8; 102(10): 3617-3622.
  1. 22.   Epigenetic silencing of the human nucleotide excision repair gene, hHR23B, in interleukin-6-responsive multiple myeloma KAS-6/1 cells
  2. Pengt, B.; Hodge, D. R.; Thomas, S. B.; Cherry, J. M.; Munroe, D. J.; Pompeia, C.; Xiao, W. H.; Farrar, W. L.
  3. Journal of Biological Chemistry. 2005, FEB 11; 280(6): 4182-4187.
  1. 23.   Cellular 8-oxo-7,8-dihydro-2 '-deoxyguanosine 5 '-triphosphate pyrophosphohydrolase activity of human and mouse MTH1 proteins does not depend on the proliferation rate
  2. Bialkowski, K.; Kasprzak, K. S.
  3. Free Radical Biology and Medicine. 2004, NOV 15; 37(10): 1534-1541.
  1. 24.   Two essential splice lariat branchpoint sequences in one intron in a xeroderma pigmentosum DNA repair gene: mutations result in reduced XPC mRNA levels that correlate with cancer risk
  2. Khan, S. G.; Metin, A.; Gozukara, E.; Inui, H.; Shahlavi, T.; Muniz-Medina, V.; Baker, C. C.; Ueda, T.; Aiken, J. R.; Schneider, T. D.; Kraemer, K. H.
  3. Human Molecular Genetics. 2004 13(3): 343-352.
  1. 25.   BRCA2 deficiency in mice leads to meiotic impairment and infertility
  2. Sharan, S. K.; Pyle, A.; Coppola, V.; Babus, J.; Swaminathan, S.; Benedict, J.; Swing, D.; Martin, B. K.; Tessarollo, L.; Evans, J. P.; Flaws, J. A.; H, el
  3. Development. 2004 131(1): 131-142.
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