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  1. 1.   Novel primary amine diazeniumdiolates-Chemical and biological characterization
  2. Puglisi, Melany P; Bradaric, Michael J; Pontikis, John; Cabai, Jonathan; Weyna, Theodore; Tednes, Patrick; Schretzman, Robert; Rickert, Karl; Cao, Zhao; Andrei, Daniela
  3. Drug development research. 2018, May 02;
  1. 2.   Diazeniumdiolated carbamates: A novel class of nitric oxide donors
  2. Nandurdikar, R. S.; Maciag, A. E.; Cao, Z.; Keefer, L. K.; Saavedra, J. E.
  3. Bioorganic & Medicinal Chemistry. 2012, Mar; 20(6): 2025-2029.
  1. 3.   Arylation of Sensitive 1-(Pyrrolidin-1-yl)-diazen-1-ium-diolate in Ionic Liquids
  2. Velazquez, C. A.; Lynn, G. M.; Kumar, V.; Keefer, L. K.; Malhotra, S. V.
  3. Synthetic Communications. 2010, Apr 7; 40(9): 1322-1332.
  1. 4.   Glycosylated PROLI/NO Derivatives as Nitric Oxide Prodrugs
  2. Nandurdikar, R. S.; Maciag, A. E.; Hong, S. Y.; Chakrapani, H.; Citro, M. L.; Keefer, L. K.; Saavedra, J. E.
  3. Organic Letters. 2010, Jan; 12(1): 56-59.
  1. 5.   Primary amine diazeniumdiolate ions of structure {RNN(O)NOR '}(-) as ambident nucleophiles
  2. Bohle, D. S.; Keefer, L. K.; Saavedra, J. E.
  3. Tetrahedron Letters. 2009 50(43): 5917-5919.
  1. 6.   Synthesis and evaluation of piperazine and homopiperazine analogues of JS-K, an anti-cancer lead compound
  2. Nandurdikar, R. S.; Maciag, A. E.; Citro, M. L.; Shami, P. J.; Keefer, L. K.; Saavedra, J. E.; Chakrapani, H.
  3. Bioorganic & Medicinal Chemistry Letters. 2009 19(10): 2760-2762.
  1. 7.   Synthesis, mechanistic studies, and anti-proliferative activity of glutathione/glutathione S-transferase-activated nitric oxide prodrugs
  2. Chakrapani, H.; Kalathur, R. C.; Maciag, A. E.; Citro, M. L.; Ji, X. H.; Keefer, L. K.; Saavedra, J. E.
  3. Bioorganic & Medicinal Chemistry. 2008 16(22): 9764-9771.
  1. 8.   Second-generation aspirin and indomethacin prodrugs possessing an O-2-(Acetoxymethyl)-1-(2-carboxypyrrolidin-1-yl)diazenium-1,2-diolate nitric oxide donor moiety: Design, synthesis, biological evaluation, and nitric oxide release studies
  2. Velazquez, C. A.; Chen, Q. H.; Citro, M. L.; Keefer, L. K.; Knaus, E. E.
  3. Journal of Medicinal Chemistry. 2008 51(6): 1954-1961.
  1. 9.   O-2-Acetoxymethyl-protected diazeniumdiolate-based NSAIDs (NONO-NSAIDs): Synthesis, nitric oxide release, and biological evaluation studies
  2. Velazquez, C. A.; Rao, P. N. P.; Citro, M. L.; Keefer, L. K.; Knaus, E. E.
  3. Bioorganic & Medicinal Chemistry. 2007, Jul; 15(14): 4767-4774.
  1. 10.   Metabolism of a liver-selective nitric oxide-releasing agent, V-PYRRO/NO, by human microsomal cytochromes P450
  2. Inami, K.; Nims, R. W.; Srinivasan, A.; Citro, M. L.; Saavedra, J. E.; Cederbaum, A. I.; Keefer, L. K.
  3. Nitric Oxide-Biology and Chemistry. 2006, Jun; 14(4): 309-315.
  1. 11.   PABA/NO as an anticancer lead: Analogue synthesis, structure revision, solution chemistry, reactivity toward glutathione, and in vitro activity
  2. Saavedra, J. E.; Srinivasan, A.; Buzard, G. S.; Davies, K. M.; Waterhouse, D. J.; Inami, K.; Wilde, T. C.; Citro, M. L.; Cuellar, M.; Deschamps, J. R.; Parrish, D.; Shami, P. J.; Findlay, V. J.; Townsend, D. M.; Tew, K. D.; Singh, S.; Jia, L.; Ji, X. H.; Keefer, L. K.
  3. Journal of Medicinal Chemistry. 2006, FEB 9; 49(3): 1157-1164.
  1. 12.   Comparison of the NO and HNO donating properties of diazeniumdiolates: Primary amine adducts release HNO in vivo
  2. Miranda, K. M.; Katori, T.; de Holding, C. L. T.; Thomas, L.; Ridnour, L. A.; MeLendon, W. J.; Cologna, S. M.; Dutton, A. S.; Champion, H. C.; Mancardi, D.; Tocchetti, C. G.; Saavedra, J. E.; Keefer, L. K.; Houk, K. N.; Fukuto, J. M.; Kass, D. A.; Paolocci, N.; Wink, D. A.
  3. Journal of Medicinal Chemistry. 2005, DEC 29; 48(26): 8220-8228.
  1. 13.   E/Z conformation and the vibrational spectroscopy of Me2NN(O)=NOMe
  2. Bohle, D. S.; Ivanic, J.; Saavedra, J. E.; Smith, K. N.; Wang, Y. N.
  3. Journal of Physical Chemistry A. 2005, DEC 15; 109(49): 11317-11321.
  1. 14.   Effect of hydrophobic structure on the catalysis of nitric oxide release from zwitterionic diazeniumdiolates in surfactant and liposome media
  2. Dinh, B.; Dove, K.; Jappar, D.; Hrabie, J. A.; Davies, K. M.
  3. Nitric Oxide-Biology and Chemistry. 2005, NOV; 13(3): 204-209.
  1. 15.   Diazeniumdiolate ions as leaving groups in anomeric displacement reactions: A protection-deprotection strategy for ionic diazeniumdiolates
  2. Showalter, B. M.; Reynolds, M. M.; Valdez, C. A.; Saavedra, J. E.; Davies, K. M.; Klose, J. R.; Chmurny, G. N.; Citro, M. L.; Barchi, J. J.; Merz, S. I.; Meyerhoff, M. E.; Keefer, L. K.
  3. Journal of the American Chemical Society. 2005, OCT 19; 127(41): 14188-14189.
  1. 16.   Chemistry of the diazeniumdiolates: Z reversible arrow E isomerism
  2. Wang, Y. N.; Bohle, D. S.; Bonifant, C. L.; Chmurny, G. N.; Collins, J. R.; Davies, K. M.; Deschamps, J.; Flippen-Anderson, J. L.; Keefer, L. K.; Klose, J. R.; Saavedra, J. E.; Waterhouse, D. J.; Ivanic, J.
  3. Journal of the American Chemical Society. 2005, APR 20; 127(15): 5388-5395.
  1. 17.   Chemistry of the diazeniumdiolates. O- versus N-alkylation of the RNH[N(O)NO](-) ion
  2. Saavedra, J. E.; Bohle, D. S.; Smith, K. N.; George, C.; Deschamps, J. R.; Parrish, D.; Ivanic, J.; Wang, Y. N.; Citro, M. L.; Keefer, L. K.
  3. Journal of the American Chemical Society. 2004, OCT 13; 126(40): 12880-12887.
  1. 18.   Analytical challenges faced in designing potential anticancer agents from nitric oxide (NO)-releasing diazeniumdiolate prodrugs
  2. Waterhouse, D. J.; Saavedra, J. E.; Citro, M. L.; Buzard, G. S.; Ji, X. H.; Xu, X.; Fox, S. D.; Veenstra, T. D.; Keefer, L. K.
  3. Abstracts of Papers of the American Chemical Society. 2004, MAR 28; 227(081-ANYL, Part 1): U91-U91.
  1. 19.   Chemistry of the diazeniumdiolates. RHN[N(O)NO](-) ions as progenitors of both nitroxyl and nitric oxide
  2. Srinivasan, A.; Citro, M. L.; Davies, K. M.; Espey, M. G.; Keefer, L. K.; Miranda, K. M.; Ridnour, L. A.; Saavedra, J. E.; Thomas, L.; Thomas, D. D.; Waterhouse, D. J.; Wink, D. A.
  3. Chemical Research in Toxicology. 2004 17(12, Abstract 54): 1769-1769.
  1. 20.   Nitric oxide prodrugs and metallochemotherapeutics: JS-K and CB-3-100 enhance arsenic and cisplatin cytolethality by increasing cellular accumulation
  2. Liu, J.; Li, C. X.; Qu, W.; Leslie, E.; Bonifant, C. L.; Buzard, G. S.; Saavedra, J. E.; Keefer, L. K.; Waalkes, M. P.
  3. Molecular Cancer Therapeutics. 2004 3(6): 709-714.
  1. 21.   Synthesis and chemistry of diazeniumdiolate anions from hindered amines
  2. Showalter, B. M.; Saavedra, J. E.; Citro, M. L.; Keefer, L. K.
  3. Abstracts of Papers of the American Chemical Society. 2003 225(Part 2): U224-U224.
  1. 22.   JS-K, a glutathione/glutathione S-transferase-activated nitric oxide (NO) donor of the diazeniumdiolate class with potent antineoplastic activity
  2. Waterhouse, D. J.; Saavedra, J. E.; Wang, L. Y.; Buzard, G. S.; Diwan, B. A.; Singh, S. V.; Davies, K. M.; Citro, M. L.; Ji, X. H.; Shami, P. J.; Keefer, L. K.
  3. Abstracts of Papers of the American Chemical Society. 2003 225(Part 2): U194-U194.
  1. 23.   Mechanistic insight into exclusive nitric oxide recovery from a carbon-bound diazeniumdiolate
  2. Arnold, E. V.; Citro, M. L.; Saavedra, E. A.; Davies, K. M.; Keefer, L. K.; Hrabie, J. A.
  3. Nitric Oxide-Biology and Chemistry. 2002 7(2): 103-108.
  1. 24.   Qualitative thin-layer and high-performance liquid chromatographic analysis of 1-substituted diazen-1-ium-1,2- diolates on aminopropyl-bonded silica gel
  2. Fitzhugh, A. L.; Anadu, N. O.; Waterhouse, D. J.; Hrabie, J. A.; Saavedra, J. E.; Keefer, L. K.
  3. Analytical Biochemistry. 2002 301(1): 97-102.
  1. 25.   Comparison of responses to novel nitric oxide donors in the feline pulmonary vascular bed
  2. De Witt, B. J.; Marrone, J. R.; Kaye, A. D.; Keefer, L. K.; Kadowitz, P. J.
  3. European Journal of Pharmacology. 2001 430(2-3): 311-315.
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