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  1. 1.   Tumor-targeting Salmonella typhimurium A1-R is a highly effective general therapeutic for undifferentiated soft tissue sarcoma patient-derived orthotopic xenograft nude-mouse models
  2. Igarashi, Kentaro; Kawaguchi, Kei; Kiyuna, Tasuku; Miyake, Kentaro; Miyake, Masuyo; Singh, Arun S; Eckardt, Mark A; Nelson, Scott D; Russell, Tara A; Dry, Sarah M; Li, Yunfeng; Yamamoto, Norio; Hayashi, Katsuhiro; Kimura, Hiroaki; Miwa, Shinji; Tsuchiya, Hiroyuki; Singh, Shree Ram; Eilber, Fritz C; Hoffman, Robert M
  3. Biochemical and Biophysical Research Communications. 2018, Mar 18; 497(4): 1055-1061.
  1. 2.   Inhibition of multi-drug resistant HIV-1 reverse transcriptase by nucleoside beta-triphosphates
  2. Dash, C.; Ahmadibeni, Y.; Hanley, M. J.; Pandhare, J.; Gotte, M.; Le Grice, S. F. J.; Parang, K.
  3. Bioorganic & Medicinal Chemistry Letters. 2011, Jun; 21(12): 3519-3522.
  1. 3.   Antibody-based inhibitors of HIV infection
  2. Choudhry, V.; Zhang, M. Y.; Dimitrova, D.; Prabakaran, P.; Dimitrov, A. S.; Fouts, T. R.; Dimitrov, D. S.
  3. Expert Opinion on Biological Therapy. 2006, MAY; 6(5): 523-531.
  1. 4.   Crystal structures for HIV-1 reverse transcriptase in complexes with three pyridinone derivatives: A new class of non-nucleoside inhibitors effective against a broad range of drug-resistant strains
  2. Himmel, D. M.; Das, K.; Clark, A. D.; Hughes, S. H.; Benjahad, A.; Oumouch, S.; Guillemont, J.; Coupa, S.; Poncelet, A.; Csoka, I.; Meyer, C.; Andries, K.; Nguyen, C. H.; Grierson, D. S.; Arnold, E.
  3. Journal of Medicinal Chemistry. 2005, DEC 1; 48(24): 7582-7591.
  1. 5.   Sensitive phenotypic detection of minor drug-resistant human immunodeficiency virus type 1 reverse transcriptase variants
  2. Nissley, D. V.; Halvas, E. K.; Hoppman, N. L.; Garfinkel, D. J.; Mellors, J. W.; Strathern, J. N.
  3. Journal of Clinical Microbiology. 2005, NOV; 43(11): 5696-5704.
  1. 6.   Crystallography and the design of anti-AIDS drugs: Conformational flexibility and positional adaptability are important in the design of non-nucleoside HIV-1 reverse transcriptase inhibitors
  2. Das, K.; Lewi, P. J.; Hughes, S. H.; Arnold, E.
  3. Progress in Biophysics and Molecular Biology. 2005, JUN; 88(2): 209-231.
  1. 7.   Evolution of human immunodeficiency virus under selection and weak recombination
  2. Rouzine, I. M.; Coffin, J. M.
  3. Genetics. 2005, MAY; 170(1): 7-18.
  1. 8.   Panel of prototypical infectious molecular HIV-1 clones containing multiple nucleoside reverse transcriptase inhibitor resistance mutations
  2. Johnston, E.; Dupnik, K. M.; Gonzales, M. J.; Winters, M. A.; Rhee, S. Y.; Imamichi, T.; Shafer, R. W.
  3. Aids. 2005, APR 29; 19(7): 731-733.
  1. 9.   Fixed conformation nucleoside analogs effectively inhibit excision-proficient HIV-1 reverse transcriptases
  2. Boyer, P. L.; Julias, J. G.; Marquez, V. E.; Hughes, S. H.
  3. Journal of Molecular Biology. 2005, JAN 21; 345(3): 441-450.
  1. 10.   Taking aim at a moving target: designing drugs to inhibit drug-resistant HIV-1 reverse transcriptases
  2. Sarafianos, S. G.; Das, K.; Hughes, S. H.; Arnold, E.
  3. Current Opinion in Structural Biology. 2004, DEC; 14(6): 716-730.
  1. 11.   A novel antimicrobial indolizinium alkaloid from Aniba panurensis
  2. Klausmeyer, P.; Chmurny, G. N.; McCloud, T. G.; Tucker, K. D.; Shoemaker, R. H.
  3. Journal of Natural Products. 2004, OCT; 67(10): 1732-1735.
  1. 12.   Caffeoyl-based affinity acetylators of HIV-1 integrase as novel pharmacological
  2. Patil, S. S.; Shkriabai, N.; Zhang, X. C.; Pais, G. C. G.; Svarovskaia, E. S.; Merch, C.; Pathak, V. K.; Pommier, Y.; Le Grice, S.; Kvaratskhelia, M.; Burke, T. R.
  3. Abstracts of Papers of the American Chemical Society. 2004, AUG 22; 228(Part 1): 329-MEDI, Abstract U967-329-MEDI, Abstract U967.
  1. 13.   HIV-1 populations are large, highly diverse, and characterized by frequent recombination in drug-naive and drug-resistant individuals
  2. Maldarelli, F.; Kearney, M.; Palmer, S.; Polis, M.; Mican, J.; Stephens, R.; Rock, D.; Mellors, J.; Coffin, J.
  3. Antiviral Therapy. 2004, AUG; 9(4): U51-U51.
  1. 14.   Detection and characterization of rare drug resistant HIV-1 RT variants using a sensitive phenotypic assay
  2. Nissley, D. V.; Julias, J.; Mellors, J.; Hughes, S.; Strathern, J.
  3. Antiviral Therapy. 2004, AUG; 9(4): U98-U99.
  1. 15.   Action of Anti-HIV drugs and resistance: Reverse transcriptase inhibitors and protease inhibitors
  2. Imamichi, T.
  3. Current Pharmaceutical Design. 2004 10(32): 4039-4053.
  1. 17.   Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related non-nucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug-resistant HIV-1 variants
  2. Das, K.; Clark, A. D.; Lewi, P. J.; Heeres, J.; de Jonge, M. R.; Koymans, L. M. H.; Vinkers, H. M.; Daeyaert, F.; Ludovici, D. W.; Kukla, M. J.; De Corte, B.; Kavash, R. W.; Ho, C. Y.; Ye, H.; Lichtenstein, M. A.; Andries, K.; Pauwels, R.; de Bethune, M. P.; Boyer, P. L.; Clark, P.; Hughes, S. H.; Janssen, P. A. J.; Arnold, E.
  3. Journal of Medicinal Chemistry. 2004 47(10): 2550-2560.
  1. 18.   A potent anti-HIV immunotoxin blocks spreading infection by primary HIV type 1 isolates in multiple cell types
  2. Lueders, K. K.; De Rosa, S. C.; Valentin, A.; Pavlakis, G. N.; Roederer, M.; Hamer, D. H.
  3. Aids Research and Human Retroviruses. 2004 20(2): 145-150.
  1. 19.   Updated, blinded, multicentre comparison of the sensitivity of different technologies to detect and quantify a minor drug-resistant HIV-1 variant
  2. Halvas, E.; Aldrovandi, G.; Balfe, J. P.; Beck, I.; Boltz, V.; Frenkel, L.; Hazelwood, J.; Johnson, V.; Kearney, M.; Kovacs, A.; Kuritzkes, D.; Metzner, K.; Nissley, D.; Nowicki, M.; Ziermann, R.; Zhao, Y.; Jennings, C.; Bremer, J.; Brambilla, D.; Mellors, J.
  3. Antiviral Therapy. 2003, JUN; 8(3): U91, Abstract 92-U92, Abstract 92.
  1. 20.   Detection of rare drug-resistant HIV-1 reverse transcriptase variants using a sensitive phenotypic assay
  2. Nissley, D. V.; Halvas, E.; Garfinkel, D.; Mellors, J.; Strathern, J.
  3. Antiviral Therapy. 2003, JUN; 8(3): U92, Abstract 93-U93, Abstract 93.
  1. 21.   Analogues of caffeic acid phenylethyl ester (CAPE) as affinity covalent modifiers of HIV-1 integrase
  2. Patil, S. S.; Zhang, X. C.; Pais, G. C. G.; Kvaratskhelia, M.; Svarovskaia, E. S.; Merch, C.; Pathak, V. K.; Pommier, Y.; Le Grice, S.; Burke, T. R.
  3. Abstracts of Papers of the American Chemical Society. 2003 226(Part 2): U22-U22.
  1. 22.   Drug resistance mutations can affect dimer stability of HIV-1 protease at neutral pH
  2. Xie, D.; Gulnik, S.; Gustchina, E.; Yu, B.; Shao, W.; Qoronfleh, W.; Nathan, A.; Erickson, J. W.
  3. Protein Science. 1999 8(8): 1702-1707.
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