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  1. 1.   Natural products as drug leads: An old process or the new hope for drug discovery?
  2. Kingston, D. G. I.; Newman, D. J.
  3. Idrugs. 2005, DEC; 8(12): 990-992.
  1. 2.   Crystal structures for HIV-1 reverse transcriptase in complexes with three pyridinone derivatives: A new class of non-nucleoside inhibitors effective against a broad range of drug-resistant strains
  2. Himmel, D. M.; Das, K.; Clark, A. D.; Hughes, S. H.; Benjahad, A.; Oumouch, S.; Guillemont, J.; Coupa, S.; Poncelet, A.; Csoka, I.; Meyer, C.; Andries, K.; Nguyen, C. H.; Grierson, D. S.; Arnold, E.
  3. Journal of Medicinal Chemistry. 2005, DEC 1; 48(24): 7582-7591.
  1. 3.   An estrogen receptor chimera senses ligands by nuclear translocation
  2. Martinez, E. D.; Rayasam, G. V.; Dull, A. B.; Walker, D. A.; Hager, G. L.
  3. Journal of Steroid Biochemistry and Molecular Biology. 2005, DEC; 97(4): 307-321.
  1. 4.   Antitumor activity and distribution of pyrroloiminoquinones in the sponge genus Zyzzya
  2. Dijoux, M. G.; Schnabel, P. C.; Hallock, Y. F.; Boswell, J. L.; Johnson, T. R.; Wilson, J. A.; Irel, C. M.; van Soest, R.; Boyd, M. R.; Barrows, L. R.; Cardellina, J. H.
  3. Bioorganic & Medicinal Chemistry. 2005, NOV 1; 13(21): 6035-6044.
  1. 5.   International collaboration in drug discovery and development from natural sources
  2. Cragg, G. M.; Newman, D. J.
  3. Pure and Applied Chemistry. 2005, NOV; 77(11): 1923-1942.
  1. 6.   Anthrax biosensor, protective antigen ion channel asymmetric blockade
  2. Halverson, K. M.; Panchal, R. G.; Nguyen, T. L.; Gussio, R.; Little, S. F.; Misakian, M.; Bavari, S.; Kasianowicz, J. J.
  3. Journal of Biological Chemistry. 2005, OCT 7; 280(40): 34056-34062.
  1. 7.   Drugs aimed at targeting characteristic karyotypic phenotypes of cancer cells
  2. Wallqvist, A.; Huang, R.; Covell, D. G.; Roschke, A. V.; Gelhaus, K. S.; Kirsch, I. R.
  3. Molecular Cancer Therapeutics. 2005, OCT; 4(10): 1559-1568.
  1. 8.   A common pharmacophore for a diverse set of colchicine site inhibitors using a structure-based approach
  2. Nguyen, T. L.; McGrath, C.; Hermone, A. R.; Burnett, J. C.; Zaharevitz, D. W.; Day, B. W.; Wipf, P.; Hamel, E.; Gussio, R.
  3. Journal of Medicinal Chemistry. 2005, SEP 22; 48(19): 6107-6116.
  1. 9.   Analysis of Ebola virus and VLP release using an immunocapture assay
  2. Kallstrom, G.; Warfield, K. L.; Swenson, D. L.; Mort, S.; Panchal, R. G.; Ruthel, G.; Bavari, S.; Aman, M. J.
  3. Journal of Virological Methods. 2005, JUL; 127(1): 1-9.
  1. 10.   Identification of a major restriction in HIV-1 intersubtype recombination
  2. Chin, M. P. S.; Rhodes, T. D.; Chen, J. B.; Fu, W.; Hu, W. S.
  3. Proceedings of the National Academy of Sciences of the United States of America. 2005, JUN 21; 102(25): 9002-9007.
  1. 11.   Binding affinity difference induced by the stereochemistry of the sulfoxide bridge of the cyclic peptide inhibitors of Grb2-SH2 domain: NMR studies for the structural origin
  2. Shi, Y. H.; Song, Y. L.; Lin, D. H.; Tan, J. Z.; Roller, P. P.; Li, Q.; Long, Y. Q.; Song, G. Q.
  3. Biochemical and Biophysical Research Communications. 2005, MAY 20; 330(4): 1254-1261.
  1. 12.   Homology model of the CDK1/cyclin B complex
  2. McGrath, C. F.; Pattabiraman, N.; Kellogg, G. E.; Lemcke, T.; Kunick, C.; Sausville, E. A.; Zaharevitz, D. W.; Gussio, R.
  3. Journal of Biomolecular Structure & Dynamics. 2005, APR; 22(5): 493-502.
  1. 13.   In search of a novel anti-HIV drug: Multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6dimethylphenyl] amino]-2-pyrimidinyl]amino]-benzonitrile (R278474, rilpivirine)
  2. Janssen, P. A. J.; Lewi, P. J.; Arnold, E.; Daeyaert, F.; de Jonge, M.; Heeres, J.; Koymans, L.; Vinkers, M.; Guillemont, J.; Pasquier, E.; Kukla, M.; Ludovici, D.; Andries, K.; de Bethune, M. P.; Pauwels, R.; Das, K.; Clark, A. D.; Frenkel, Y. V.; Hughes, S. H.; Medaer, B.; De Knaep, F.; Bohets, H.; De Clerck, F.; Lampo, A.; Williams, P.; Stoffels, P.
  3. Journal of Medicinal Chemistry. 2005, MAR 24; 48(6): 1901-1909.
  1. 14.   Purified Bacillus anthracis lethal toxin complex formed in Vitro and during infection exhibits functional and biological activity
  2. Panchal, R. G.; Halverson, K. M.; Ribot, W.; Lane, D.; Kenny, T.; Abshire, T. G.; Ezzell, J. W.; Hoover, T. A.; Powell, B.; Little, S.; Kasianowicz, J. J.; Bavari, S.
  3. Journal of Biological Chemistry. 2005, MAR 18; 280(11): 10834-10839.
  1. 15.   Biodiversity: A continuing source of novel drug leads
  2. Cragg, G. M.; Newman, D. J.
  3. Pure and Applied Chemistry. 2005, JAN; 77(1): 7-24.
  1. 16.   Engineering DNA topology with locked nucleosides: A structural study
  2. Maderia, M.; Wu, J.; Bax, A.; Shenoy, S.; O'Keefe, B.; Marquez, V. E.; Barchi, J. J.
  3. Nucleosides Nucleotides & Nucleic Acids. 2005 24(5-7, Sp. Iss.): 687-690.
  1. 17.   High-throughput molecular and histopathologic profiling of the tumor microenvironment in a novel transplantable model of murine neuroblastoma: New tools for pediatric drug discovery
  2. Stauffer, J. K.; Greer, B.; Lincoln, E.; Back, T. C.; Hixon, J. A.; Whiteford, C.; Eisenhofer, G.; Tsokos, M.; Weiss, W.; Khan, J.; Wigginton, J. M.
  3. Journal of Immunotherapy. 2005, NOV-DEC; 28(6): 638-639.
  1. 18.   The evolving field of biodefence: Therapeutic developments and diagnostics
  2. Burnett, J. C.; Henchal, E. A.; Schmaljohn, A. L.; Bavari, S.
  3. Nature Reviews Drug Discovery. 2005 4(4): 281-297.
  1. 19.   Molecular dynamics simulation of E-coli dihydrofolate reductase and its circular permuted variants: Relative stabilities in experiment and simulations
  2. Hu, Z. J.; Ma, B. Y.; Nussinov, R.; Southerl, W. M.
  3. Abstracts of Papers of the American Chemical Society. 2004, AUG 22; 228(Part 1): 123-COMP, Abstract U519-123-COMP, Abstract U519.
  1. 20.   Karyotypic complexity of the NCI-60 drug-screening panel
  2. Roschke, A. V.; Tonon, G.; Gehlhaus, K. S.; McTyre, N.; Bussey, K. J.; Lababidi, S.; Scudiero, D. A.; Weinstein, J. N.; Kirsch, I. R.
  3. Cancer Research. 2003 63(24): 8634-8647.
  1. 21.   Phosphoryltyrosyl mimetics in the design of peptide-based signal transduction inhibitors
  2. Burke, T. R.; Yao, Z. J.; Liu, D. G.; Voigt, J.; Gao, Y.
  3. Biopolymers. 2001 60(1): 32-44.
  1. 22.   Indanocine, a microtubule-binding indanone and a selective inducer of apoptosis in multidrug-resistant cancer cells
  2. Leoni, L. M.; Hamel, E.; Genini, D.; Shih, H. C.; Carrera, C. J.; Cottam, H. B.; Carson, D. A.
  3. Journal of the National Cancer Institute. 2000 92(3): 217-224.
  1. 23.   Interactions of the sponge-derived antimitotic tripeptide hemiasterlin with tubulin: Comparison with dolastatin 10 and cryptophycin 1
  2. Bai, R. L.; Durso, N. A.; Sackett, D. L.; Hamel, E.
  3. Biochemistry. 1999 38(43): 14302-14310.
  1. 24.   Direct photoaffinity labeling of cysteine 211 or a nearby amino acid residue of beta-tubulin by guanosine 5 '-diphosphate bound in the exchangeable site
  2. Bai, R. L.; Ewell, J. B.; Nguyen, N. Y.; Hamel, E.
  3. Journal of Biological Chemistry. 1999 274(18): 12710-12714.
  1. 25.   Discovery and development of antineoplastic agents from natural sources
  2. Cragg, G. M.; Newman, D. J.
  3. Cancer Investigation. 1999 17(2): 153-163.
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