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  1. 1.   Phosphonic acid-containing inhibitors of tyrosyl-DNA phosphodiesterase 1
  2. Zhao,Xue Zhi; Wang, Wenjie; Lountos,George; Tropea, Joseph E; Needle,Danielle; Pommier, Yves; Burke,Terrence
  3. Frontiers in Chemistry. 2022, Aug 16; 10: 910953.
  1. 2.   The indenoisoquinoline LMP517: a novel antitumor agent targeting both TOP1 and TOP2
  2. Marzi, Laetitia; Sun, Yilun; Huang, Shar-Yin N; James,Amy; Difilippantonio,Simone; Pommier, Yves
  3. Molecular cancer therapeutics. 2020, AUG; 19(8): 1589-1597.
  1. 3.   A Phase I, Randomized, Controlled Clinical Study of CC-11050 in People Living With HIV With Suppressed Plasma Viremia on Antiretroviral Therapy (APHRODITE)
  2. Boulougoura, Afroditi; Gabriel, Erin; Laidlaw, Elizabeth; Khetani, Vikram; Arakawa, Ken; Higgins, Jeanette; Rupert, Adam; Gorelick, Robert J; Lumbard,Keith; Pau, Alice; Poole, April; Kibiy, Angela; Kumar, Princy; Sereti, Irini
  3. Open forum infectious diseases. 2019, Jun; 6(6): ofz246.
  1. 4.   Synthesis, anti-cancer screening and tyrosyl-DNA phosphodiesterase 1 (Tdp1) inhibition activity of novel piperidinyl sulfamides
  2. Jun, Jung Ho; Kumar, Vineet; Dexheimer, Thomas S; Wedlich, Iwona; Nicklaus, Marc; Pommier, Yves; Malhotra, Sanjay V
  3. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2018, Jan 01; 111: 337-348.
  1. 5.   Identification of Natural Products That Inhibit the Catalytic Function of Human Tyrosyl-DNA Phosphodiesterase (TDP1)
  2. Bermingham, Alun; Price, Edmund; Marchand, Christophe; Chergui, Adel; Naumova, Alena; Whitson, Emily L; Haugh Krumpe, Lauren; Goncharova, Katya; Evans, Jason; McKee, Tawnya; Henrich, Curtis; Pommier, Yves; O'Keefe, Barry
  3. SLAS discovery. 2017, Oct; 22(9): 1093-1105.
  1. 6.   The Proteasome Ubiquitin Receptor hRpn13 and Its Interacting Deubiquitinating Enzyme Uch37 Are Required for Proper Cell Cycle Progression
  2. Randles, L.; Anchoori, R. K.; Roden, R. B.; Walters, K. J.
  3. The Journal of biological chemistry. 2016, 15-Apr; 291(16): 8773-83.
  1. 7.   Inhibitors of human tyrosyl-DNA phospodiesterase (hTdp1) developed by virtual screening using ligand-based pharmacophores
  2. Weidlich, I. E.; Dexheimer, T.; March, C.; Antony, S.; Pommier, Y.; Nicklaus, M. C.
  3. Bioorganic & Medicinal Chemistry. 2010, Jan; 18(1): 182-189.
  1. 8.   Identification of PDE4D as a Proliferation Promoting Factor in Prostate Cancer Using a Sleeping Beauty Transposon-Based Somatic Mutagenesis Screen
  2. Rahrmann, E. P.; Collier, L. S.; Knutson, T. P.; Doyal, M. E.; Kuslak, S. L.; Green, L. E.; Malinowski, R. L.; Roethe, L.; Akagi, K.; Waknitz, M.; Huang, W.; Largaespada, D. A.; Marker, P. C.
  3. Cancer Research. 2009 69(10): 4388-4397.
  1. 9.   2 '-deoxy-N4-[2-(4-nitrophenyl)ethoxycarbonyl]-5-azacytidine: A novel inhibitor of DNA methyltransferase that requires activation by human carboxylesterase
  2. Byun, H. M.; Choi, S. H.; Laird, P. W.; Trinh, B.; Siddiqui, M. A.; Marquez, V. E.; Yang, A. S.
  3. Cancer Letters. 2008 266(2): 238-248.
  1. 10.   The regulation of acetylcholinesterase by cis-elements within intron I in cultured contracting myotubes
  2. Cohen, T. V.; R, all
  3. Journal of Neurochemistry. 2006, Aug; 98(3): 723-734.
  1. 11.   Brain-specific deletion of neuropathy target esterase/swisscheese results in neurodegeneration
  2. Akassoglou, K.; Malester, B.; Xu, J. X.; Tessarollo, L.; Rosenbluth, J.; Chao, M. V.
  3. Proceedings of the National Academy of Sciences of the United States of America. 2004 101(14): 5075-5080.
  1. 12.   Discordant regulation of granzyme H and granzyme B expression in human lymphocytes
  2. Sedelies, K. A.; Sayers, T. J.; Edwards, K. M.; Chen, W. S.; Pellicci, D. G.; Godfrey, D. I.; Trapani, J. A.
  3. Journal of Biological Chemistry. 2004 279(25): 26581-26587.
  1. 13.   Inositol 1,4,5-trisphosphate receptor ubiquitination is mediated by mammalian Ubc7, a component of the endoplasmic reticulum-associated degradation pathway, and is inhibited by chelation of intracellular Zn2+
  2. Webster, J. M.; Tiwari, S.; Weissman, A. M.; Wojcikiewicz, R. J. H.
  3. Journal of Biological Chemistry. 2003 278(40): 38238-38246.
  1. 14.   SNT1/FRS2 mediates germinal vesicle breakdown induced by an activated FGF receptor1 in Xenopus oocytes
  2. Mood, K.; Friesel, R.; Daar, I. O.
  3. Journal of Biological Chemistry. 2002 277(36): 33196-33204.
  1. 15.   Biophysical characterization of cyclic nucleotide phosphodiesterases
  2. Hofmann, A.; Tarasov, S.; Grella, M.; Ruvinov, S.; Nasr, F.; Filipowicz, W.; Wlodawer, A.
  3. Biochemical and Biophysical Research Communications. 2002 291(4): 875-883.
  1. 16.   Intracellular localization of 7-benzylamino-6-chloro-2- piperazino-4-pyrrolidino-pteridine in membrane structures impeding the inhibition of cytosolic cyclic AMP-specific phosphodiesterase
  2. Marko, D.; Merz, K. H.; Kunz, C.; Muller, A.; Tarasova, N.; Eisenbr, G.
  3. Biochemical Pharmacology. 2002 63(4): 669-676.
  1. 17.   Use of COMPARE analysis to discover functional analogues of bleomycin
  2. Deng, J. Z.; Newman, D. J.; Hecht, S. M.
  3. Journal of Natural Products. 2000 63(9): 1269-1272.
  1. 18.   Sequence context effects on mutational properties of cis-opened benzo
  2. Ponten, I.; Sayer, J. M.; Pilcher, A. S.; Yagi, H.; Kumar, S.; Jerina, D. M.; Dipple, A.
  3. Biochemistry. 1999 38(3): 1144-1152.
  1. 19.   Molecular Mechanisms of Immune-Mediated Lysis of Murine Renal Cancer - Differential Contributions of Perforin-Dependent Versus Fas-Mediated Pathways in Lysis By Nk and T Cells
  2. Sayers, T. J.; Brooks, A. D.; Lee, J. K.; Fenton, R. G.; Komschlies, K. L.; Wigginton, J. M.; Winklerpickett, R.; Wiltrout, R. H.
  3. Journal of Immunology. 1998 161(8): 3957-3965.
  1. 20.   Assignment of the Mouse Pde7a Gene to the Proximal Region of Chromosome 3 and of the Human Pde7a Gene to Chromosome 8q13
  2. Han, P.; Fletcher, C. F.; Copeland, N. G.; Jenkins, N. A.; Yaremko, L. M.; Michaeli, T.
  3. Genomics. 1998 48(2): 275-276.
  1. 21.   O-6-Alkylguanine-Dna Alkyltransferase Inactivation By Ester Prodrugs of O-6-Benzylguanine Derivatives and Their Rate of Hydrolysis By Cellular Esterases
  2. Dolan, M. E.; Roy, S. K.; Garbiras, B. J.; Helft, P.; Paras, P.; Chae, M. Y.; Moschel, R. C.; Pegg, A. E.
  3. Biochemical Pharmacology. 1998 55(10): 1701-1709.
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