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  1. 1.   The outcome of TGFß antagonism in metastatic breast cancer models in vivo reflects a complex balance between tumor-suppressive and pro-progression activities of TGFß
  2. Yang, Yuan; Yang, Howard; Tang, Binwu; Wu, Alex Man Lai; Flanders, Kathleen C; Moshkovich, Nellie; Weinberg, Douglas S; Welsh, Michael A; Weng, Jia; Ochoa, Humberto J; Hu, Tiffany Y; Herrmann, Michelle A; Chen, Jinqiu; Edmondson,Elijah; Simpson, R Mark; Liu, Fang; Liu, Huaitian; Lee, Maxwell; Wakefield, Lalage M
  3. Clinical cancer research : an official journal of the American Association for Cancer Research. 2020, FEB; 26(3): 643-656.
  1. 2.   Phase I Trial of M7824 (MSB0011359C), a Bifunctional Fusion Protein Targeting PD-L1 and TGF beta, in Advanced Solid Tumors
  2. Strauss, Julius; Heery, Christopher R.; Schlom, Jeffrey; Madan, Ravi A.; Cao, Liang; Kang, Zhigang; Lamping, Elizabeth; Marte, Jennifer L.; Donahue, Renee N.; Grenga, Italia; Cordes, Lisa; Christensen, Olaf; Mahnke, Lisa; Helwig, Christoph; Gulley, James L.
  3. Clinical Cancer Research. 2018, Mar 15; 24(6): 1287-1295.
  1. 3.   ERBIN deficiency links STAT3 and TGF-beta pathway defects with atopy in humans
  2. Lyons, J. J.; Liu, Y.; Ma, C. A.; Yu, X.; O'Connell, M. P.; Lawrence, M. G.; Zhang, Y.; Karpe, K.; Zhao, M.; Siegel, A. M.; Stone, K. D.; Nelson, C.; Jones, Nina; DiMaggio, T.; Darnell, D. N.; Mendoza-Caamal, E.; Orozco, L.; Hughes, J. D.; McElwee, J.; Hohman, R. J.; Frischmeyer-Guerrerio, P. A.; Rothenberg, M. E.; Freeman, A. F.; Holland, S. M.; Milner, J. D.
  3. JOURNAL OF EXPERIMENTAL MEDICINE. 2017, 2017-03-01; 214(3): 669-680.
  1. 4.   Cumulative mechanisms of lymphoid tissue fibrosis and T cell depletion in HIV-1 and SIV infections
  2. Zeng, M.; Smith, A. J.; Wietgrefe, S. W.; Southern, P. J.; Schacker, T. W.; Reilly, C. S.; Estes, J. D.; Burton, G. F.; Silvestri, G.; Lifson, J. D.; Carlis, J. V.; Haase, A. T.
  3. Journal of Clinical Investigation. 2011, Mar; 121(3): 998-1008.
  1. 5.   Epimorphic regeneration in mice is p53-independent
  2. Arthur, L. M.; Demarest, R. M.; Clark, L.; Gourevitch, D.; Bedelbaeva, K.; Anderson, R.; Snyder, A.; Capobianco, A. J.; Lieberman, P.; Feigenbaum, L.; Heber-Katz, E.
  3. Cell Cycle. 2010, Sep; 9(18): 3667-3673.
  1. 6.   Transient Inhibition of Transforming Growth Factor-beta 1 in Human Diabetic CD34(+) Cells Enhances Vascular Reparative Functions
  2. Bhatwadekar, A. D.; Guerin, E. P.; Jarajapu, Y. P. R.; Caballero, S.; Sheridan, C.; Kent, D.; Kennedy, L.; Lansang, M. C.; Ruscetti, F. W.; Pepine, C. J.; Higgins, P. J.; Bartelmez, S. H.; Grant, M. B.
  3. Diabetes. 2010, Aug; 59(8): 2010-2019.
  1. 7.   Synergy of IL-23 and Th17 Cytokines: New Light on Inflammatory Bowel Disease
  2. Shen, W.; Durum, S. K.
  3. Neurochemical Research. 2010, Jun; 35(6): 940-946.
  1. 8.   The macrophage in HIV-1 infection: From activation to deactivation?
  2. Herbein, G.; Varin, A.
  3. Retrovirology. 2010, Apr; 7: 15.
  1. 9.   Regulatory T Cells Modulate Th17 Responses in Patients with Positive Tuberculin Skin Test Results
  2. Babu, S.; Bhat, S. Q.; Kumar, N. P.; Kumaraswami, V.; Nutman, T. B.
  3. Journal of Infectious Diseases. 2010, Jan; 201(1): 20-31.
  1. 10.   Accelerated thymic atrophy as a result of elevated homeostatic expression of the genes encoded by the TNF/lymphotoxin cytokine locus
  2. Liepinsh, D. J.; Kruglov, A. A.; Galimov, A. R.; Shakhov, A. N.; Shebzukhov, Y. V.; Kuchmiy, A. A.; Grivennikov, S. I.; Tumanov, A. V.; Drutskaya, M. S.; Feigenbaum, L.; Kuprash, D. V.; Nedospasov, S. A.
  3. European Journal of Immunology. 2009 39(10): 2906-2915.
  1. 11.   Functional plasticity of macrophages: in situ reprogramming of tumor-associated macrophages
  2. Stout, R. D.; Watkins, S. K.; Suttles, J.
  3. Journal of Leukocyte Biology. 2009 86(5): 1105-1109.
  1. 12.   Development of regulatory T cells requires IL-7R alpha stimulation by IL-7 or TSLP
  2. Mazzucchelli, R.; Hixon, J. A.; Spolski, R.; Chen, X.; Li, W. Q.; Hall, V. L.; Willette-Brown, J.; Hurwitz, A. A.; Leonard, W. J.; Durum, S. K.
  3. Blood. 2008, Oct 15; 112(8): 3283-3292.
  1. 13.   ELIspot displays a better detection over ELISA of T helper (Th) 2-type cytokine-production by ex vivo-stimulated antigen-specific T cells from human peripheral blood
  2. Minang, J. T.; Arestrom, I.; Ahlborg, N.
  3. Immunological Investigations. 2008 37(4): 279-291.
  1. 14.   Tumor-specific Th17-polarized cells eradicate large established melanoma
  2. Muranski, P.; Boni, A.; Antony, P. A.; Cassard, L.; Irvine, K. R.; Kaiser, A.; Paulos, C. M.; Palmer, D. C.; Touloukian, C. E.; Ptak, K.; Gattinoni, L.; Wrzesinski, C.; Hinrichs, C. S.; Kerstann, K. W.; Feigenbaum, L.; Chan, C. C.; Restifo, N. P.
  3. Blood. 2008 112(2): 362-373.
  1. 15.   Hydrolytic reactivity trends among potential prodrugs of the O-2-glycosylated diazeniumdiolate family. Targeting nitric oxide to macrophages for antileishmanial activity
  2. Valdez, C. A.; Saavedra, J. E.; Showalter, B. M.; Davies, K. M.; Wilde, T. C.; Citro, M. L.; Barchi, J. J.; Deschamps, J. R.; Parrish, D.; El-Gayar, S.; Schleicher, U.; Bogdan, C.; Keefer, L. K.
  3. Journal of Medicinal Chemistry. 2008 51(13): 3961-3970.
  1. 16.   Essential Role of Chromatin Remodeling Protein Bptf in Early Mouse Embryos and Embryonic Stem Cells
  2. Landry, J.; Sharov, A. A.; Piao, Y. L.; Sharova, L. V.; Xiao, H.; Southon, E.; Matta, J.; Tessarollo, L.; Zhang, Y. E.; Ko, M.; Kuehn, M. R.; Yamaguchi, T. P.; Wu, C.
  3. Plos Genetics. 2008 4(10):
  1. 17.   Transforming growth factor beta 1 (TGFB1) gene polymorphisms and risk of advanced colorectal adenoma
  2. Berndt, S. I.; Huang, W. Y.; Chatterjee, N.; Yeager, M.; Welch, R.; Chanock, S. J.; Weissfeld, J. L.; Schoen, R. E.; Hayes, R. B.
  3. Carcinogenesis. 2007, Sep; 28(9): 1965-1970.
  1. 18.   The nuclear envelope protein MAN1 regulates TGF beta signaling and vasculogenesis in the embryonic yolk sac
  2. Cohen, T. V.; Kosti, O.; Stewart, C. L.
  3. Development. 2007, Apr; 134(7): 1385-1395.
  1. 19.   Interleukin-15 but not interleukin-7 abrogates vaccine-induced decrease in virus level in simian immunodeficiency virus(mac251)-infected macaques
  2. Hryniewicz, A.; Price, D. A.; Moniuszko, M.; Boasso, A.; Edghill-Spano, Y.; West, S. M.; Venzon, D.; Vaccari, M.; Tsai, W. P.; Tryniszewska, E.; Nacsa, J.; Villinger, F.; Ansari, A. A.; Trindade, C. J.; Morre, M.; Brooks, D.; Arlen, P.; Brown, H. J.; Kitchen, C. M. R.; Zack, J. A.; Douek, D. C.; Shearer, G. M.; Lewis, M. G.; Koup, R. A.; Franchini, G.
  3. Journal of Immunology. 2007, Mar; 178(6): 3492-3504.
  1. 20.   Wilms' tumorigenesis is altered by misexpression of the transcriptional co-activator, CITED1
  2. Lovvorn, H. N.; Boyle, S.; Shi, G.; Shyr, Y.; Wills, M. L.; Perantoni, A. O.; de Caestecker, M.
  3. Journal of Pediatric Surgery. 2007, Mar; 42(3): 474-481.
  1. 21.   Simian immunodeficiency virus-induced lymphatic tissue fibrosis is mediated by transforming growth factor beta 1-positive regulatory T cells and begins in early infection
  2. Estes, J. D.; Wietgrefe, S.; Schacker, T.; Southern, P.; Beilman, G.; Reilly, C.; Milush, J. M.; Lifson, J. D.; Sodora, D. L.; Carlis, J. V.; Haase, A. T.
  3. Journal of Infectious Diseases. 2007, Feb; 195(4): 551-561.
  1. 22.   TGFBR3 loss and consequences in prostate cancer
  2. Sharifi, N.; Hurt, E. M.; Kawasaki, B. T.; Farrar, W. L.
  3. Prostate. 2007, Feb; 67(3): 301-311.
  1. 23.   T cell tolerance to tumors and cancer immunotherapy
  2. Shafer-Weaver, K.; Anderson, M.; Malyguine, A.; Hurwitz, A. A.
  3. Immune-Mediated Diseases: From Theory to Therapy. 2007; 601 : 357-368.
  1. 24.   Levels of Smad7 regulate Smad and mitogen activated kinases (MAPKs) signaling and controls erythroid and megakaryocytic differentiation of erythroleukemia cells
  2. Akel, S.; Bertolette, D.; Petrow-Sadowski, C.; Ruscetti, F. W.
  3. Platelets. 2007 18(8): 566-578.
  1. 25.   Unraveling the pros and cons of interferon-gamma gene regulation
  2. Young, H. A.
  3. Immunity. 2006, MAY; 24(5): 506-507.
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