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  1. 1.   NMR 1H, 13C, and 15N resonance assignments of the oncogenic Q61R variant of human NRAS in the active, GTP-bound conformation
  2. Sharma,Alok; Tonelli, Marco; Dyba,Marcin; Esposito,Dominic; Esposito,Dominic; Nissley,Dwight; McCormick, Frank; Maciag,Anna
  3. Biomolecular NMR Assignments. 2025, May 02;
  1. 2.   Allosteric modulation of NF1 GAP: Differential distributions of catalytically competent populations in loss-of-function and gain-of-function mutants
  2. Xu,Liang; Jang,Hyunbum; Nussinov,Ruth
  3. Protein Science : a publication of the Protein Society. 2025, Feb; 34(2): e70042.
  1. 3.   Producing recombinant proteins in Vibrio natriegens
  2. Smith,Matthew; Hernández, José Sánchez; Messing,Simon; Ramakrishnan,Nitya; Higgins,Brianna; Mehalko,Jennifer; Perkins,Shelley; Wall,Vanessa; Grose,Carissa; Frank,Peter; Cregger, Julia; Le,Vi; Johnson,Adam; Sherekar, Mukul; Pagonis,Morgan; Drew,Matt; Hong,Min; Widmeyer, Stephanie R T; Denson,John-Paul; Snead,Kelly; Poon,Ivy; Waybright,Tim; Champagne, Allison; Esposito,Dom; Jones,Jane; Taylor,Troy; Gillette,Bill
  3. Microbial Cell Factories. 2024, Jul 24; 23(1): 208.
  1. 4.   Adapting recombinant bacterial alkaline phosphatase for nucleotide exchange of small GTPases
  2. Frank,Peter; Hong, Min; Higgins, Brianna; Perkins, Shelley; Taylor, Troy; Wall,Vanessa; Drew,Matt; Waybright, Timothy; Gillette,Bill; Esposito,Dom; Messing, Simon
  3. Protein Expression and Purification. 2024, Feb 21; 106446.
  1. 5.   Revealing the mechanism of action of a first-in-class covalent inhibitor of KRASG12C (ON) and other functional properties of oncogenic KRAS by 31P NMR
  2. Sharma,Alok; Pei, Jun; Yang, Yue; Dyba,Marcin; Smith,Brian; Rabara,Dana; Larsen,Erik; Lightstone, Felice C; Esposito,Dom; Stephen,Andy; Wang, Bin; Beltran, Pedro J; Wallace, Eli; Nissley,Dwight; McCormick, Frank; Maciag,Anna
  3. The Journal of Biological Chemistry. 2024, Jan 16; 300(2): 105650.
  1. 6.   Spatial Mechano-Signaling Regulation of GTPases through Non-Degradative Ubiquitination
  2. Sewduth, Raj N; Carai, Paolo; Ivanisevic, Tonci; Zhang, Mingzhen; Jang,Hyunbum; Lechat, Benoit; Van Haver, Delphi; Impens, Francis; Nussinov,Ruth; Jones, Elizabeth; Sablina, Anna
  3. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). 2023, Nov 09; e2303367.
  1. 7.   GAP positions catalytic H-Ras residue Q61 for GTP hydrolysis in molecular dynamics simulations, complicating chemical rescue of Ras deactivation
  2. Patel, Lara A; Waybright,Tim; Stephen,Andy; Neale, Chris
  3. Computational Biology and Chemistry. 2023, Mar 01; 104: 107835.
  1. 8.   The small molecule inhibitor NAV-2729 has a complex target profile including multiple ADP-ribosylation factor regulatory proteins
  2. Rosenberg, Eric M; Jian, Xiaoying; Soubias,Olivier; Yoon, Hye-Young; Yadav, Mukesh P; Hammoudeh, Sarah; Pallikkuth, Sandeep; Akpan, Itoro; Chen, Pei-Wen; Maity, Tapan K; Jenkins, Lisa M; Yohe,Marielle; Byrd,Robert; Randazzo, Paul A
  3. The Journal of Biological Chemistry. 2023, Feb 07; 299(3): 102992.
  1. 9.   Small GTPase Ran: Depicting the nucleotide-specific conformational landscape of the functionally important C-terminus
  2. Czigleczki, Janka; de Resende Lara, Pedro Tulio; Dudas, Balint; Jang,Hyunbum; Perahia, David; Nussinov,Ruth; Balog, Erika
  3. Frontiers in Molecular Biosciences. 2023, Jan 16; 10: 1111574.
  1. 10.   Thermal Shift Assay for Small GTPase Stability Screening: Evaluation and Suitability
  2. Kopra, Kari; Valtonen, Salla; Mahran, Randa; Kapp, Jonas N; Hassan, Nazia; Gillette,Bill; Dennis, Bryce; Li, Lianbo; Westover, Kenneth D; Plückthun, Andreas; Härmä, Harri
  3. International Journal of Molecular Sciences. 2022, Jun 26; 23(13):
  1. 11.   ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1
  2. Su, Wenjing; Mukherjee, Radha; Yaeger, Rona; Son, Jieun; Xu, Jianing; Na, Na; Merna Timaul, Neilawattie; Hechtman, Jaclyn; Paroder, Viktoriya; Lin, Mika; Mattar, Marissa; Qiu, Juan; Chang, Qing; Zhao, Huiyong; Zhang, Jonathan; Little, Megan; Adachi, Yuta; Han, Sae-Won; Taylor, Barry S; Ebi, Hiromichi; Abdel-Wahab, Omar; de Stanchina, Elisa; Rudin, Charles M; Jänne, Pasi A; McCormick, Frank; Yao, Zhan; Rosen, Neal
  3. Molecular Cell. 2022, May 14;
  1. 12.   Regulation of GTPase function by autophosphorylation
  2. Johnson, Christian W; Seo, Hyuk-Soo; Terrell,Elizabeth; Yang, Moon-Hee; KleinJan, Fenneke; Gebregiworgis, Teklab; Gasmi-Seabrook, Genevieve M C; Geffken, Ezekiel A; Lakhani, Jimit; Song, Kijun; Bashyal, Puspalata; Popow, Olesja; Paulo, Joao A; Liu, Andrea; Mattos, Carla; Marshall, Christopher B; Ikura, Mitsuhiko; Morrison, Deborah K; Dhe-Paganon, Sirano; Haigis, Kevin M
  3. Molecular Cell. 2022, Feb 18; 82(5): 950-968.e14.
  1. 13.   Solution structure and dynamics of the mitochondrial-targeted GTPase-activating protein (GAP) VopE by an integrated NMR/SAXS approach
  2. Smith, Kyle P; Lee, Woonghee; Tonelli, Marco; Lee, Yeongjoon; Light, Samuel H; Cornilescu,Gabriel; Chakravarthy, Srinivas
  3. Protein Science : a Publication of the Protein Society. 2022, Feb 08; 31(5):
  1. 14.   Classical RAS proteins are not essential for paradoxical ERK activation induced by RAF inhibitors
  2. Lai, Lick Pui; Fer,Nicole; Burgan,William; Wall,Vanessa; Xu,Bingfang; Soppet,Daniel; Esposito,Dom; Nissley,Dwight; McCormick, Frank
  3. Proceedings of the National Academy of Sciences of the United States of America. 2022, Feb 01; 119(5):
  1. 15.   The dynamic nature of the K-Ras/calmodulin complex can be altered by oncogenic mutations
  2. Abdelkarim, Hazem; Leschinsky, Nicholas; Jang, Hyunbum; Banerjee, Avik; Nussinov,Ruth; Gaponenko, Vadim
  3. Current Opinion in Structural Biology. 2021, Dec; 71: 164-170.
  1. 16.   NMR H-1, C-13, N-15 backbone resonance assignments of the T35S and oncogenic T35S/Q61L mutants of human KRAS4b in the active, GppNHp-bound conformation
  2. Sharma, Alok K.; Dyba, Marcin; Tonelli, Marco; Smith, Brian; Gillette, William K.; Esposito, Dominic; Nissley, Dwight; McCormick, Frank; Maciag, Anna E.
  3. Biomolecular NMR Assignments. 2021, Oct 22;
  1. 17.   Normal Mode Analysis of KRas4B Reveals Partner Specific Dynamics
  2. Eren, Meryem; Tuncbag, Nurcan; Jang,Hyunbum; Nussinov,Ruth; Gursoy, Attila; Keskin, Ozlem
  3. The journal of physical chemistry. B. 2021, May 27; 125(20): 5210-5221.
  1. 18.   Mechanistic Differences of Activation of Rac1(P29S) and Rac1(A159V)
  2. Senyuz, Simge; Jang,Hyunbum; Nussinov,Ruth; Keskin, Ozlem; Gursoy, Attila
  3. Journal of Physical Chemistry B. 2021, Apr 22; 125(15): 3790-3802.
  1. 19.   Active and Inactive Cdc42 Differ in Their Insert Region Conformational Dynamics
  2. Haspel, Nurit; Jang,Hyunbum; Nussinov,Ruth
  3. Biophysical journal. 2021, Jan 19; 120(2): 306-318.
  1. 20.   Overproduction of a dominant mutant of the conserved Era GTPase inhibits cell division in Escherichia coli
  2. Zhou, Xiaomei; Peters, Howard K; Li,Xintian; Costantino,Nina; Kumari,Vandana; Shi,Genbin; Tu, Chao; Cameron, Todd A; Haeusser, Daniel P; Vega, Daniel E; Ji, Xinhua; Margolin, William; Court,Don
  3. Journal of bacteriology. 2020, NOV; 202(21): pii: JB.00342-20.
  1. 21.   Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR
  2. Yan,Wupeng; Markegard, Evan; Dharmaiah, Srisathiyanarayanan; Urisman, Anatoly; Drew, Matthew; Esposito,Dom; Scheffzek, Klaus; Nissley,Dwight; McCormick, Frank; Simanshu,Dhirendra
  3. Cell reports. 2020, Jul 21; 32(3): 107909.
  1. 22.   The protein kinase MAP3K19 phosphorylates MAP2Ks and thereby activates ERK and JNK kinases and increases viability of KRAS-mutant lung cancer cells
  2. Hoang, Van T.; Nyswaner,Katherine; Torres-Ayuso,Pedro; Brognard,John
  3. JOURNAL OF BIOLOGICAL CHEMISTRY. 2020, JUN 19; 295(25): 8470-8479.
  1. 23.   The Mystery of Rap1 Suppression of Oncogenic Ras
  2. Nussinov,Ruth; Jang,Hyunbum; Zhang,Mingzhen; Tsai,Chung-Jung; Sablina, Anna A.
  3. Trends in cancer. 2020, May; 6(5): 369-379.
  1. 24.   Placental defects lead to embryonic lethality in mice lacking the Formin and PCP proteins Daam1 and Daam2
  2. Nakaya, Masa-Aki; Gudmundsson,Kristbjorn; Komiya, Yuko; Keller,Jonathan; Habas, Raymond; Yamaguchi,Terry; Ajima, Rieko
  3. PloS one. 2020, APR 30; 15(4): e0232025.
  1. 25.   Optimization of sortase A ligation for flexible engineering of complex protein systems
  2. Li,Jess; Zhang,Yue; Soubias,Olivier; Khago,Domarin; Chao, Fa-an; Li, Yifei; Shaw, Katherine; Byrd,Robert
  3. JOURNAL OF BIOLOGICAL CHEMISTRY. 2020, FEB 28; 295(9): 2664-2675.
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