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  1. 1.   The small molecule inhibitor NAV-2729 has a complex target profile including multiple ADP-ribosylation factor regulatory proteins
  2. Rosenberg, Eric M; Jian, Xiaoying; Soubias,Olivier; Yoon, Hye-Young; Yadav, Mukesh P; Hammoudeh, Sarah; Pallikkuth, Sandeep; Akpan, Itoro; Chen, Pei-Wen; Maity, Tapan K; Jenkins, Lisa M; Yohe,Marielle; Byrd,Robert; Randazzo, Paul A
  3. The Journal of Biological Chemistry. 2023, Feb 07; 299(3): 102992.
  1. 2.   Mechanistic Differences of Activation of Rac1(P29S) and Rac1(A159V)
  2. Senyuz, Simge; Jang,Hyunbum; Nussinov,Ruth; Keskin, Ozlem; Gursoy, Attila
  3. Journal of Physical Chemistry B. 2021, Apr 22; 125(15): 3790-3802.
  1. 3.   Sensitivity of mesothelioma cells to PARP inhibitors is not dependent on BAP1 but is enhanced by temozolomide in cells with high-Schlafen 11and low-MGMT expression
  2. Rathkey, Daniel; Khanal, Manakamana; Murai, Junko; Zhang, Jingli; Sengupta, Manjistha; Jiang, Qun; Morrow, Betsy; Evans,Christine; Chari,Raj; Fetsch, Patricia; Chung, Hye-Jung; Xi, Liqiang; Roth, Mark; Filie, Armando; Raffeld, Mark; Thomas, Anish; Pommier, Yves; Hassan, Raffit
  3. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2020, Jan 28; pii: S1556-0864(20)30035-6.
  1. 4.   Structural Basis for the Failure of the C1 Domain of Ras Guanine Nucleotide Releasing Protein 2 (RasGRP2) to Bind Phorbol Ester with High Affinity.
  2. Czikora, Agnes; Lundberg, Daniel J; Abramovitz, Adelle; Lewin, Nancy E; Kedei, Noemi; Peach, Megan L; Zhou, Xiaoling; Merritt, Raymond C; Craft, Elizabeth A; Braun, Derek C; Blumberg, Peter M
  3. The Journal of biological chemistry. 2016, May 20; 291(21): 11133-47.
  1. 5.   Plasma and CNS pharmacokinetics of O(4)-benzylfolic acid (O(4)BF) and metabolite in a non-human primate model
  2. Chuk, M. K.; Cole, D. E.; McCully, C.; Loktionova, N. A.; Pegg, A. E.; Parker, R. J.; Pauly, G.; Widemann, B. C.; Balis, F. M.; Fox, E.
  3. Cancer Chemotherapy and Pharmacology. 2011, Jun; 67(6): 1291-1297.
  1. 6.   In vitro comparison of O4-benzylfolate modulated, BCNU-induced toxicity in human bone marrow using CFU-GM and tumor cell lines
  2. Behrsing, H. P.; Furniss, M. J.; Robillard, K. A.; Tomaszewski, J. E.; Parchment, R. E.
  3. Cancer Chemotherapy and Pharmacology. 2010, May; 65(6): 1083-1091.
  1. 7.   Substitution of Aminomethyl at the Meta-Position Enhances the Inactivation of O-6-Alkylguanine-DNA Alkyltransferase by O-6-Benzylguanine
  2. Pauly, G. T.; Loktionova, N. A.; Fang, Q. M.; Vankayala, S. L.; Guida, W. C.; Pegg, A. E.
  3. Journal of Medicinal Chemistry. 2008 51(22): 7144-7153.
  1. 8.   Degradation of BRCA2 in Alkyltransferase-Mediated DNA Repair and Its Clinical Implications
  2. Philip, S.; Swaminathan, S.; Kuznetsov, S. G.; Kanugula, S.; Biswas, K.; Chang, S.; Loktionova, N. A.; Haines, D. C.; Kaldis, P.; Pegg, A. E.; Sharant, S. K.
  3. Cancer Research. 2008 68(23): 9973-9981.
  1. 9.   Inactivation of O-6-Alkylguanine-DNA alkyltransferase by folate esters of O-6-Benzyl-2'-deoxyguanosine and of O-6- 4-(Hydroxymethyl)benzyl guanine
  2. Javanmard, S.; Loktionova, N. A.; Fang, Q.; Pauly, G. T.; Pegg, A. E.; Moschel, R. C.
  3. Journal of Medicinal Chemistry. 2007, Oct; 50(21): 5193-5201.
  1. 10.   Polymorphisms in DNA repair genes and risk of non-Hodgkin's lymphoma in New South Wales, Australia
  2. Shen, M.; Purdue, M. R.; Kricker, A.; Lan, Q.; Grulich, A. E.; Vajdic, C. M.; Turner, J.; Whitby, D.; Chanock, S.; Rothman, N.; Armstrong, B. K.
  3. Haematologica-the Hematology Journal. 2007, Sep; 92(9): 1180-1185.
  1. 11.   Role of GADD34 in modulation of cisplatin cytotoxicity
  2. Fishel, M. L.; Rabik, C. A.; Bleibel, W. K.; Li, X. M.; Moschel, R. C.; Dolan, M. E.
  3. Biochemical Pharmacology. 2006, JAN 12; 71(3): 239-247.
  1. 12.   Antitumor activity and distribution of pyrroloiminoquinones in the sponge genus Zyzzya
  2. Dijoux, M. G.; Schnabel, P. C.; Hallock, Y. F.; Boswell, J. L.; Johnson, T. R.; Wilson, J. A.; Irel, C. M.; van Soest, R.; Boyd, M. R.; Barrows, L. R.; Cardellina, J. H.
  3. Bioorganic & Medicinal Chemistry. 2005, NOV 1; 13(21): 6035-6044.
  1. 13.   Phase I trial of temozolomide plus O-6-benzylguanine for patients with recurrent or progressive malignant glioma
  2. Quinn, J. A.; Desjardins, A.; Weingart, J.; Brem, H.; Dolan, M. E.; Delaney, S. M.; Vredenburgh, J.; Rich, J.; Friedman, A. H.; Reardon, D. A.; Sampson, J. H.; Pegg, A. E.; Moschel, R. C.; Birch, R.; McLendon, R. E.; Provenzale, J. M.; Gururangan, S.; Dancey, J. E.; Maxwell, J.; Tourt-Uhlig, S.; Herndon, J. E.; Bigner, D. D.; Friedman, H. S.
  3. Journal of Clinical Oncology. 2005, OCT 1; 23(28): 7178-7187.
  1. 14.   Dynamics of the antiviral activity of N-methanocarbathymidine against herpes simplex virus type 1 in cell culture
  2. Huleihel, M.; Talishanisky, M.; Ford, H.; Marquez, V. E.; Kelley, J. A.; Johns, D. G.; Agbaria, R.
  3. International Journal of Antimicrobial Agents. 2005, MAY; 25(5): 427-432.
  1. 15.   Role of glutathione and nucleotide excision repair in modulation of cisplatin activity with O-6-benzylguanine
  2. Fishel, M. L.; Ganicsik, M. P.; Delaney, S. M.; Zuhowski, E. G.; Maher, V. M.; Karrison, T.; Moschel, R. C.; Egorin, M. J.; Dolan, M. E.
  3. Cancer Chemotherapy and Pharmacology. 2005, APR; 55(4): 333-342.
  1. 16.   A bifunctional DNA repair protein from Ferroplasma acidarmanus exhibits O-6-alkylguanine-DNA alkyltransferase and endonuclease V activities
  2. Kanugula, S.; Pauly, G. T.; Moschel, R. C.; Pegg, A. E.
  3. Proceedings of the National Academy of Sciences of the United States of America. 2005, MAR 8; 102(10): 3617-3622.
  1. 17.   Determination of the stability constants and oxidation susceptibility of nickel(II) complexes with 2 '-de oxyguano sine 5 '-triphosphate and L-histidine
  2. Kaczmarek, P.; Jezowska-Bojczuk, M.; Bal, W.; Kasprzak, K. S.
  3. Journal of Inorganic Biochemistry. 2005, MAR; 99(3): 737-746.
  1. 18.   Effect of cell cycle inhibition on cisplatin-induced cytotoxicity
  2. Fishel, M. L.; Newell, D. R.; Griffin, R. J.; Davison, R.; Wang, L. Z.; Curtin, N. J.; Zuhowski, E. G.; Kasza, K.; Egorin, M. J.; Moschel, R. C.; Dolan, M. E.
  3. Journal of Pharmacology and Experimental Therapeutics. 2005, JAN; 312(1): 206-213.
  1. 19.   PROSIT, an online service to calculate pseudorotational parameters of nucleosides and nucleotides
  2. Sun, G. Y.; Voigt, J. H.; Marquez, V. E.; Nicklaus, M. C.
  3. Nucleosides Nucleotides & Nucleic Acids. 2005 24(5-7, Sp. Iss.): 1029-1032.
  1. 20.   Intra- and intercellular variations in the repair efficiency of O-6-methylguanine, and their contribution to kinetic complexity
  2. Souliotis, V. L.; Sfikakis, P. P.; Anderson, L. M.; Kyrtopoulos, S. A.
  3. Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis. 2004, DEC 21; 568(2): 155-170.
  1. 21.   Effects of mutations in the G tract of the human immunodeficiency virus type 1 polypurine tract on virus replication and RNase H cleavage
  2. Julias, J. G.; McWilliams, M. J.; Sarafianos, S. G.; Alvord, W. G.; Arnold, E.; Hughes, S. H.
  3. Journal of Virology. 2004, DEC; 78(23): 13315-13324.
  1. 22.   SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity. Part 2: Efficacy evaluations
  2. Alley, M. C.; Hollingshead, M. G.; Pacula-Cox, C. M.; W, W. R.; Hartley, J. A.; Howard, P. W.; Gregson, S. J.; Thurston, D. E.; Sausville, E. A.
  3. Cancer Research. 2004, SEP 15; 64(18): 6700-6706.
  1. 23.   Brain tumor cell lines resistant to O-6-benzylguanine/1,3-bis(2-chloroethyl)-1-nitrosourea chemotherapy have O-6 -alkylguanine-DNA alkyltransferase mutations
  2. Bacolod, M. D.; Johnson, S. P.; Pegg, A. E.; Dolan, M. E.; Moschel, R. C.; Bullock, N. S.; Fang, Q. M.; Colvin, O. M.; Modrich, P.; Bigner, D. D.; Friedman, H. S.
  3. Molecular Cancer Therapeutics. 2004, SEP; 3(9): 1127-1135.
  1. 24.   2-amino-O-4-benzylpteridines and O-4-benzylfolic acid: Potent inactivators of O-6-alkylguanine-DNA alkyltransferase and potential chemotherapy adjuvants
  2. Nelson, M. E.; Loktionova, N.; Pegg, A. E.; Moschel, R. C.
  3. Abstracts of Papers of the American Chemical Society. 2004, AUG 22; 228(Part 1): 110-MEDI, Abstract U927-110-MEDI, Abstract U927.
  1. 25.   Profiling the activity of G proteins in patient-derived tissues by rapid affinity-capture of signal transduction proteins (GRASP)
  2. Berman, D. M.; Shih, L. M.; Burke, L. A.; Veenstra, T. D.; Zhao, Y. M.; Conrads, T. P.; Kwon, S. W.; Hoang, V.; Yu, L. R.; Zhou, M.; Kurman, R. J.; Petricoin, E. F.; Liotta, L. A.
  3. Proteomics. 2004 4(3): 812-818.
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