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  1. 1.   Selenium Ameliorates Acetaminophen-Induced Oxidative Stress via MAPK and Nrf2 Pathways in Mice
  2. Indumathi, Mylanayakanahosahalli Chandrashekar; Swetha, Kamatam; Kandahalli Venkataranga Nayaka,Abhilasha; Siddappa, Shiva; Kumar, Shivamadhaiah Manjula; Prasad, Govinda Keerthi; Chen, Chu-Huang; Marathe, Gopal Kedihithlu
  3. Biological Trace Element Research. 2023, Sep 13;
  1. 2.   Novel protection-deprotection strategies in diazeniumdiolate chemistry: synthesis of V-IPA/NO
  2. Nandurdikar, R. S.; Keefer, L. K.; Saavedra, J. E.
  3. Chemical Communications. 2011, Jun 21; 47(23): 6710-6712.
  1. 3.   The Nitric Oxide Prodrug V-PROLI/NO Inhibits Cellular Uptake of Proline
  2. Hong, S. Y.; Borchert, G. L.; Maciag, A. E.; Nandurdikar, R. S.; Saavedra, J. E.; Keefer, L. K.; Phang, J. M.; Chakrapani, H.
  3. Acs Medicinal Chemistry Letters. 2010, Nov; 1(8): 386-389.
  1. 4.   An improved synthesis of V-PROLI/NO, a cytochrome P450-activated nitric oxide prodrug
  2. Hong, S. Y.; Nandurdikar, R. S.; Keefer, L. K.; Saavedra, J. E.; Chakrapani, H.
  3. Tetrahedron Letters. 2009 50(31): 4545-4548.
  1. 5.   Improved synthesis of V-PYRRO/NO, a liver-selective nitric oxide prodrug, and analogues
  2. Hong, S. Y.; Saavedra, J. E.; Keefer, L. K.; Chakrapani, H.
  3. Tetrahedron Letters. 2009 50(18): 2069-2071.
  1. 6.   V-PROLI/NO, a nitric oxide donor prodrug, protects liver cells from arsenic-induced toxicity
  2. Qu, W.; Liu, J.; Dill, A. L.; Saavedra, J. E.; Keefer, L. K.; Waalkes, M. P.
  3. Cancer Science. 2009 100(3): 382-388.
  1. 7.   The nitric oxide prodrug, V-PYRRO/NO, mitigates arsenic-induced liver cell toxicity and apoptosis
  2. Qu, W.; Liu, J.; Fuquay, R.; Saavedra, J. E.; Keefer, L. K.; Waalkes, M. P.
  3. Cancer Letters. 2007, Oct; 256(2): 238-245.
  1. 8.   Inactivation of oxidized and S-nitrosylated mitochondrial proteins in alcoholic fatty liver of rats
  2. Moon, K. H.; Hood, B. L.; Kim, B. J.; Hardwick, J. P.; Conrads, T. P.; Veenstra, T. D.; Song, B. Y. J.
  3. Hepatology. 2006, Nov; 44(5): 1218-1230.
  1. 9.   Metabolism of a liver-selective nitric oxide-releasing agent, V-PYRRO/NO, by human microsomal cytochromes P450
  2. Inami, K.; Nims, R. W.; Srinivasan, A.; Citro, M. L.; Saavedra, J. E.; Cederbaum, A. I.; Keefer, L. K.
  3. Nitric Oxide-Biology and Chemistry. 2006, Jun; 14(4): 309-315.
  1. 10.   Limited protective role of V-PYRRO/NO against cholestasis produced by alpha-naphthylisothiocyanate in mice
  2. Liu, J.; He, Y. Y.; Chignell, C. F.; Clark, J.; Myers, P.; Saavedra, J. E.; Waalkes, M. P.
  3. Biochemical Pharmacology. 2005, JUL 1; 70(1): 144-151.
  1. 11.   The CYP2E1-humanized transgenic mouse: Role of CYP2E1 in acetaminophen hepatotoxicity
  2. Cheung, C.; Yu, A. M.; Ward, J. M.; Krausz, K. W.; Akiyama, T. E.; Feigenbaum, L.; Gonzalez, F. J.
  3. Drug Metabolism and Disposition. 2005, MAR; 33(3): 449-457.
  1. 12.   The nitric oxide prodrug, V-PYRRO/NO, protects against cadmium toxicity and apoptosis at the cellular level
  2. Qu, W.; Liu, J.; Fuquay, R.; Shimoda, R.; Sakurai, T.; Saavedra, J. E.; Keefer, L. K.; Waalkes, M. P.
  3. Nitric Oxide-Biology and Chemistry. 2005, MAR; 12(2): 114-120.
  1. 13.   Enhanced acetaminophen toxicity by activation of the pregnane X receptor
  2. Guo, G. L.; Moffit, J. S.; Ward, J. M.; Aleksunes, L. A.; Slitt, A. L.; Kliewer, S. A.; Manautou, J. E.; Gonzalez, F. J.
  3. Toxicological Sciences. 2004, DEC; 82(2): 374-380.
  1. 14.   CpG oligodeoxynucleotides improve the response to hepatitis B immunization in healthy and SIV-infected rhesus macaques
  2. Verthelyi, D.; Wang, V. W.; Lifson, J. D.; Klinman, D. M.
  3. Aids. 2004 18(7): 1003-1008.
  1. 15.   The nitric oxide donor, V-PYRRONO, protects against acetaminophen-induced nephrotoxicity in mice
  2. Li, C. X.; Liu, J.; Saavedra, J. E.; Keefer, L. K.; Waalkes, M. P.
  3. Toxicology. 2003 189(3): 173-180.
  1. 16.   Protection Against Acetaminophen Toxicity in Cyp1a2 and Cyp2e1 Double-Null Mice
  2. Zaher, H.; Buters, J. T. M.; Ward, J. M.; Bruno, M. K.; Lucas, A. M.; Stern, S. T.; Cohen, S. D.; Gonzalez, F. J.
  3. Toxicology and Applied Pharmacology. 1998 152(1): 193-199.
  1. 17.   Suppression of Kupffer Cell Function Prevents Cadmium Induced Hepatocellular Necrosis in the Male Sprague-Dawley Rat
  2. Sauer, J. M.; Waalkes, M. P.; Hooser, S. B.; Kuester, R. K.; McQueen, C. A.; Sipes, I. G.
  3. Toxicology. 1997 121(2): 155-164.
  1. 18.   Testosterone Pretreatment Mitigates Cadmium Toxicity in Male C57 Mice But Not in C3h Mice
  2. Shimada, H.; Bare, R. M.; Hochadel, J. F.; Waalkes, M. P.
  3. Toxicology. 1997 116(1-3): 183-191.
  1. 19.   Progesterone Pretreatment Enhances Cellular Sensitivity to Cadmium Despite a Marked Activation of the Metallothionein Gene
  2. Shimada, H.; Hochadel, J. F.; Waalkes, M. P.
  3. Toxicology and Applied Pharmacology. 1997 142(1): 178-185.
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