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  1. 1.   Characterization of novel non-nucleoside reverse transcriptase (RT) inhibitor resistance mutations at residues 132 and 135 in the 51 kDa subunit of HIV-1 RT
  2. Nissley, D. V.; Radzio, J.; Ambrose, Z.; Sheen, C. W.; Hamamouch, N.; Moore, K. L.; Tachedjian, G.; Sluis-Cremer, N.
  3. Biochemical Journal. 2007, May; 404: 151-157.
  1. 2.   Combining mutations in HIV-1 reverse transcriptase with mutations in the HIV-1 polypurine tract affects RNase H cleavages involved in PPT utilization
  2. McWilliams, M. J.; Julias, J. G.; Sarafianos, S. G.; Alvord, W. G.; Arnold, E.; Hughes, S. H.
  3. Virology. 2006, May; 348(2): 378-388.
  1. 3.   Crystal structures for HIV-1 reverse transcriptase in complexes with three pyridinone derivatives: A new class of non-nucleoside inhibitors effective against a broad range of drug-resistant strains
  2. Himmel, D. M.; Das, K.; Clark, A. D.; Hughes, S. H.; Benjahad, A.; Oumouch, S.; Guillemont, J.; Coupa, S.; Poncelet, A.; Csoka, I.; Meyer, C.; Andries, K.; Nguyen, C. H.; Grierson, D. S.; Arnold, E.
  3. Journal of Medicinal Chemistry. 2005, DEC 1; 48(24): 7582-7591.
  1. 4.   Crystallography and the design of anti-AIDS drugs: Conformational flexibility and positional adaptability are important in the design of non-nucleoside HIV-1 reverse transcriptase inhibitors
  2. Das, K.; Lewi, P. J.; Hughes, S. H.; Arnold, E.
  3. Progress in Biophysics and Molecular Biology. 2005, JUN; 88(2): 209-231.
  1. 5.   Structural determinants of HIV-1 nucleocapsid protein for cTAR DNA binding and destabilization, and correlation with inhibition of self-primed DNA synthesis
  2. Beltz, H.; Clauss, C.; Piemont, E.; Ficheux, D.; Gorelick, R. J.; Roques, B.; Gabus, C.; Darlix, J. L.; de Rocquigny, H.; Mely, Y.
  3. Journal of Molecular Biology. 2005, MAY 20; 348(5): 1113-1126.
  1. 6.   Investigating HIV-1 polypurine tract geometry via targeted insertion of abasic lesions in the (-)-DNA template and (+)-RNA primer
  2. Yi-Brunozzi, H. Y.; Le Grice, S. F. J.
  3. Journal of Biological Chemistry. 2005, MAY 20; 280(20): 20154-20162.
  1. 7.   Attenuation of DNA replication by HIV-1 reverse transcriptase near the central termination sequence
  2. Ignatov, M. E.; Berdis, A. J.; Le Grice, S. F. J.; Barkley, M. D.
  3. Biochemistry. 2005, APR 12; 44(14): 5346-5356.
  1. 8.   Fixed conformation nucleoside analogs effectively inhibit excision-proficient HIV-1 reverse transcriptases
  2. Boyer, P. L.; Julias, J. G.; Marquez, V. E.; Hughes, S. H.
  3. Journal of Molecular Biology. 2005, JAN 21; 345(3): 441-450.
  1. 9.   Role of the beta 7-beta 8-loop in the 51kDa subunit of HIV-1 reverse transcriptase in protein stability and drug resistance
  2. Sluis-Cremer, N.; Radzio, J.; Camarasa, M. J.; Tachedjian, G.; Nissley, D.
  3. Antiviral Therapy. 2005 10(4): S99-S99.
  1. 10.   Taking aim at a moving target: designing drugs to inhibit drug-resistant HIV-1 reverse transcriptases
  2. Sarafianos, S. G.; Das, K.; Hughes, S. H.; Arnold, E.
  3. Current Opinion in Structural Biology. 2004, DEC; 14(6): 716-730.
  1. 11.   In vitro characterization of a simian immunodeficiency virus-human immunodeficiency virus (HIV) chimera expressing HIV type 1 reverse transcriptase to study antiviral resistance in pigtail macaques
  2. Ambrose, Z.; Boltz, V.; Palmer, S.; Coffin, J. M.; Hughes, S. H.; KewalRamani, V. N.
  3. Journal of Virology. 2004, DEC; 78(24): 13553-13561.
  1. 12.   Site- and subunit-specific incorporation of unnatural amino acids into HIV-1 reverse transcriptase
  2. Klarmann, G. J.; Eisenhauer, B. M.; Yi, Z.; Sitaraman, K.; Chatterjee, D. K.; Hecht, S. M.; Le Grice, S. F. J.
  3. Protein Expression and Purification. 2004, NOV; 38(1): 37-44.
  1. 13.   Effects of the Delta 67 complex of mutations in human immunodeficiency virus type 1 reverse transcriptase on nucleoside analog excision
  2. Boyer, P. L.; Imamichi, T.; Sarafianos, S. G.; Arnold, E.; Hughes, S. H.
  3. Journal of Virology. 2004, SEP; 78(18): 9987-9997.
  1. 14.   Action of Anti-HIV drugs and resistance: Reverse transcriptase inhibitors and protease inhibitors
  2. Imamichi, T.
  3. Current Pharmaceutical Design. 2004 10(32): 4039-4053.
  1. 15.   Mechanistic insights into the kinetics of HIV-1 nucleocapsid protein-facilitated tRNA annealing to the primer binding site
  2. Hargittai, M. R. S.; Gorelick, R. J.; Rouzina, L.; Musier-Forsyth, K.
  3. Journal of Molecular Biology. 2004 337(4): 951-968.
  1. 16.   Frequent dual initiation in human immunodeficiency virus-based vectors containing two primer-binding sites: a quantitative in vivo assay for function of initiation complexes
  2. Voronin, Y. A.; Pathak, V. K.
  3. Journal of Virology. 2004 78(10): 5402-5413.
  1. 17.   The Delta 67 complex of mutations enhances the ability of HIV-1 reverse transcriptase to excise zidovudine, stavudine and PMPA from blocked primers
  2. Boyer, P. L.; Imamichi, T.; Sarafianos, S. G.; Arnold, E.; Hughes, S. H.
  3. Antiviral Therapy. 2003, JUN; 8(3): U42, Abstract 30-U42, Abstract 30.
  1. 18.   Detection of rare drug-resistant HIV-1 reverse transcriptase variants using a sensitive phenotypic assay
  2. Nissley, D. V.; Halvas, E.; Garfinkel, D.; Mellors, J.; Strathern, J.
  3. Antiviral Therapy. 2003, JUN; 8(3): U92, Abstract 93-U93, Abstract 93.
  1. 19.   The Lys103Asn mutation of HIV-1 RT: A novel mechanism of drug resistance
  2. Hsiou, Y.; Ding, J. P.; Das, K.; Clark, A. D.; Boyer, P. L.; Lewi, P.; Janssen, P. A. J.; Kleim, J. P.; Rosner, M.; Hughes, S. H.; Arnold, E.
  3. Journal of Molecular Biology. 2001 309(2): 437-445.
  1. 20.   Human immunodeficiency virus type 1 nucleocapsid protein can prevent self-priming of minus-strand strong stop DNA by promoting the annealing of short oligonucleotides to hairpin sequences
  2. Driscoll, M. D.; Hughes, S. H.
  3. Journal of Virology. 2000 74(19): 8785-92.
  1. 21.   Structural and biochemical mechanisms of HIV-1 RT drug resistance
  2. Boyer, P. L.; Gao, H. Q.; Serafianos, S.; Ding, J.; Clark, P.; Clark, A.; Arnold, E.; Hughes, S. H.
  3. Conference on Retroviruses and Opportunistic Infections. 1999, 218 (abstract no. S33).
  1. 22.   A cooperative folding unit in HIV-1 protease. Implications for protein stability and occurrence of drug-induced mutations
  2. Wallqvist, A.; Smythers, G. W.; Covell, D. G.
  3. Protein Engineering. 1998 11(11): 999-1005.
  1. 23.   Structure and Mechanism of Action of Nonnucleoside Inhibitors of Hiv-1 Reverse Transcriptase - Strategies to Combat Drug Resistance
  2. Smith, R. H.; Michejda, C. J.; Hughes, S. H.; Arnold, E.; Janssen, P. A. J.; Smith, M. B. K.
  3. Theochem-Journal of Molecular Structure. 1998 423(1-2): 67-77.
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