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  1. 1.   Mutations in the U5 region adjacent to the primer binding site affect tRNA cleavage by human immunodeficiency virus type 1 reverse transcriptase in vivo
  2. Oh, J.; McWilliams, M. J.; Julias, J. G.; Hughes, S. H.
  3. Journal of Virology. 2008 82(2): 719-727.
  1. 2.   Crystal structures for HIV-1 reverse transcriptase in complexes with three pyridinone derivatives: A new class of non-nucleoside inhibitors effective against a broad range of drug-resistant strains
  2. Himmel, D. M.; Das, K.; Clark, A. D.; Hughes, S. H.; Benjahad, A.; Oumouch, S.; Guillemont, J.; Coupa, S.; Poncelet, A.; Csoka, I.; Meyer, C.; Andries, K.; Nguyen, C. H.; Grierson, D. S.; Arnold, E.
  3. Journal of Medicinal Chemistry. 2005, DEC 1; 48(24): 7582-7591.
  1. 3.   Crystallography and the design of anti-AIDS drugs: Conformational flexibility and positional adaptability are important in the design of non-nucleoside HIV-1 reverse transcriptase inhibitors
  2. Das, K.; Lewi, P. J.; Hughes, S. H.; Arnold, E.
  3. Progress in Biophysics and Molecular Biology. 2005, JUN; 88(2): 209-231.
  1. 4.   Fixed conformation nucleoside analogs effectively inhibit excision-proficient HIV-1 reverse transcriptases
  2. Boyer, P. L.; Julias, J. G.; Marquez, V. E.; Hughes, S. H.
  3. Journal of Molecular Biology. 2005, JAN 21; 345(3): 441-450.
  1. 5.   Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones
  2. Budihas, S. R.; Gorshkova, I.; Gaidamakov, S.; Wamiru, A.; Bona, M. K.; Parniak, M. A.; Crouch, R. J.; McMahon, J. B.; Beutler, J. A.; Le Grice, S. F. J.
  3. Nucleic Acids Research. 2005 33(4): 1249-1256.
  1. 6.   A sensitive phenotypical assay uncovers low frequency NNRTI-resistant HIV-1 RT variants in subtypes A, B, C and D from clinical samples
  2. Nissley, D. V.; Julias, J.; Flys, T.; Hughes, S.; Mellors, J.; Jackson, J. B.; Strathern, J.; Eshleman, S. H.
  3. Antiviral Therapy. 2005 10(4): S149-S149.
  1. 7.   In vitro characterization of a simian immunodeficiency virus-human immunodeficiency virus (HIV) chimera expressing HIV type 1 reverse transcriptase to study antiviral resistance in pigtail macaques
  2. Ambrose, Z.; Boltz, V.; Palmer, S.; Coffin, J. M.; Hughes, S. H.; KewalRamani, V. N.
  3. Journal of Virology. 2004, DEC; 78(24): 13553-13561.
  1. 8.   Site- and subunit-specific incorporation of unnatural amino acids into HIV-1 reverse transcriptase
  2. Klarmann, G. J.; Eisenhauer, B. M.; Yi, Z.; Sitaraman, K.; Chatterjee, D. K.; Hecht, S. M.; Le Grice, S. F. J.
  3. Protein Expression and Purification. 2004, NOV; 38(1): 37-44.
  1. 9.   Effects of the Delta 67 complex of mutations in human immunodeficiency virus type 1 reverse transcriptase on nucleoside analog excision
  2. Boyer, P. L.; Imamichi, T.; Sarafianos, S. G.; Arnold, E.; Hughes, S. H.
  3. Journal of Virology. 2004, SEP; 78(18): 9987-9997.
  1. 10.   Fixed conformation nucleoside analogs are effective against excision-proficient HIV-1 RTs
  2. Boyer, P. L.; Marquez, V. E.; Julias, J. G.; Hughes, S. H.
  3. Abstracts of Papers of the American Chemical Society. 2004, AUG 22; 228(Part 1): 167-MEDI, Abstract U937-167-MEDI, Abstract U937.
  1. 11.   Detection and characterization of rare drug resistant HIV-1 RT variants using a sensitive phenotypic assay
  2. Nissley, D. V.; Julias, J.; Mellors, J.; Hughes, S.; Strathern, J.
  3. Antiviral Therapy. 2004, AUG; 9(4): U98-U99.
  1. 12.   Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related non-nucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug-resistant HIV-1 variants
  2. Das, K.; Clark, A. D.; Lewi, P. J.; Heeres, J.; de Jonge, M. R.; Koymans, L. M. H.; Vinkers, H. M.; Daeyaert, F.; Ludovici, D. W.; Kukla, M. J.; De Corte, B.; Kavash, R. W.; Ho, C. Y.; Ye, H.; Lichtenstein, M. A.; Andries, K.; Pauwels, R.; de Bethune, M. P.; Boyer, P. L.; Clark, P.; Hughes, S. H.; Janssen, P. A. J.; Arnold, E.
  3. Journal of Medicinal Chemistry. 2004 47(10): 2550-2560.
  1. 13.   Using pyrrolo-deoxycytosine to probe RNA/DNA hybrids containing the human immunodeficiency virus type-1 3 ' polypurine tract
  2. Dash, C.; Rausch, J. W.; Le Grice, S. F. J.
  3. Nucleic Acids Research. 2004 32(4): 1539-1547.
  1. 14.   Nonnucleoside inhibitor binding affects the interactions of the fingers subdomain of human immunodeficiency virus type 1 reverse transcriptase with DNA
  2. Peletskaya, E. N.; Kogon, A. A.; Tuske, S.; Arnold, E.; Hughes, S. H.
  3. Journal of Virology. 2004 78(7): 3387-3397.
  1. 15.   Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir
  2. Tuske, S.; Sarafianos, S. G.; Clark, A. D.; Ding, J. P.; Naeger, L. K.; White, K. L.; Miller, M. D.; Gibbs, C. S.; Boyer, P. L.; Clark, P.; Wang, G.; Gaffney, B. L.; Jones, R. A.; Jerina, D. M.; Hughes, S. H.; Arnold, E.
  3. Nature Structural & Molecular Biology. 2004 11(5): 469-474.
  1. 16.   Cross-linking of the fingers subdomain of human immunodeficiency virus type 1 reverse transcriptase to template-primer
  2. Peletskaya, E. N.; Boyer, P. L.; Kogon, A. A.; Clark, P.; Kroth, H.; Sayer, J. M.; Jerina, D. M.; Hughes, S. H.
  3. Journal of Virology. 2001 75(19): 9435-9445.
  1. 17.   Similarities and differences in the RNase H activities of human immunodeficiency virus type 1 reverse transcriptase and moloney murine leukemia virus reverse transcriptase
  2. Gao, H. Q.; Sarafianos, S. G.; Arnold, E.; Hughes, S. H.
  3. Journal of Molecular Biology. 1999 294(5): 1097-1113.
  1. 18.   Effects of Mutations in the Polymerase Domain On the Polymerase, Rnase H and Strand Transfer Activities of Human Immunodeficiency Virus Type 1 Reverse Transcriptase
  2. Gao, H. Q.; Boyer, P. L.; Arnold, E.; Hughes, S. H.
  3. Journal of Molecular Biology. 1998 277(3): 559-572.
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