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  1. 1.   JS-K, a nitric oxide prodrug, induces DNA damage and apoptosis in HBV-positive hepatocellular carcinoma HepG2.2.15 cell
  2. Liu, Zhengyun; Li, Guangmin; Gou, Ying; Xiao, Dongyan; Luo, Guo; Saavedra, Joseph; Liu, Jie; Wang, Huan
  3. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017, Aug; 92: 989-997.
  1. 2.   The nitric oxide donor JS-K sensitizes U87 glioma cells to repetitive irradiation
  2. Heckler, Max; Osterberg, Nadja; Guenzle, Jessica; Thiede-Stan, Nina Kristin; Reichardt, Wilfried; Weidensteiner, Claudia; Saavedra, Joseph; Weyerbrock, Astrid
  3. Tumour Biology. 2017, Jun 27; 39(6): 1-11.
  1. 3.   Effects of JS-K, a novel anti-cancer nitric oxide prodrug, on gene expression in human hepatoma Hep3B cells
  2. Dong, Ray; Wang, Xueqian; Wang, Huan; Liu, Zhengyun; Liu, Jie; Saavedra, Joseph
  3. BIOMEDICINE & PHARMACOTHERAPY. 2017, Apr; 88: 367-373.
  1. 4.   Growth-inhibitory and chemosensitizing effects of the glutathione-S-transferase-p-activated nitric oxide donor PABA/NO in malignant gliomas
  2. Kogias, E.; Osterberg, N.; Baumer, B.; Psarras, N.; Koentges, C.; Papazoglou, A.; Saavedra, J. E.; Keefer, L. K.; Weyerbrock, A.
  3. International Journal of Cancer. 2012, Mar; 130(5): 1184-1194.
  1. 5.   JS-K, a Glutathione S-Transferase-Activated Nitric Oxide Donor With Antineoplastic Activity in Malignant Gliomas
  2. Weyerbrock, A.; Osterberg, N.; Psarras, N.; Baumer, B.; Kogias, E.; Werres, A.; Bette, S.; Saavedra, J. E.; Keefer, L. K.; Papazoglou, A.
  3. Neurosurgery. 2012, Feb; 70(2): 497-510.
  1. 6.   Activation of the c-Jun N-terminal Kinase/Activating Transcription Factor 3 (ATF3) Pathway Characterizes Effective Arylated Diazeniumdiolate-Based Nitric Oxide-Releasing Anticancer Prodrugs
  2. Maciag, A. E.; Nandurdikar, R. S.; Hong, S. Y.; Chakrapan, H.; Diwan, B.; Morris, N. L.; Shami, P. J.; Shiao, Y. H.; Anderson, L. M.; Keefer, L. K.; Saavedra, J. E.
  3. Journal of Medicinal Chemistry. 2011, Nov; 54(22): 7751-7758.
  1. 7.   Fifty Years of Diazeniumdiolate Research. From Laboratory Curiosity to Broad-Spectrum Biomedical Advances
  2. Keefer, L. K.
  3. Acs Chemical Biology. 2011, Nov; 6(11): 1147-1155.
  1. 8.   JS-K, a nitric oxide-releasing prodrug, induces breast cancer cell death while sparing normal mammary epithelial cells
  2. McMurtry, V.; Saavedra, J. E.; Nieves-Alicea, R.; Simeone, A. M.; Keefer, L. K.; Tari, A. M.
  3. International Journal of Oncology. 2011, Apr; 38(4): 963-971.
  1. 9.   JS-K; a nitric oxide-releasing prodrug, modulates beta-catenin/TCF signaling in leukemic Jurkat cells: Evidence of an S-nitrosylated mechanism
  2. Nath, N.; Chattopadhyay, M.; Pospishi, L.; Cieciura, L. Z.; Goswami, S.; Kodela, R.; Saavedra, J. E.; Keefer, L. K.; Kashfi, K.
  3. Biochemical Pharmacology. 2010, Dec; 80(11): 1641-1649.
  1. 10.   Macrophage-dependent nitric oxide expression regulates tumor cell detachment and metastasis after IL-2/anti-CD40 immunotherapy
  2. Weiss, J. M.; Ridnour, L. A.; Back, T.; Hussain, S. P.; He, P. J.; Maciag, A. E.; Keefer, L. K.; Murphy, W. J.; Harris, C. C.; Wink, D. A.; Wiltrout, R. H.
  3. Journal of Experimental Medicine. 2010, Oct 25; 207(11): 2455-2467.
  1. 11.   Nitrogen-bound diazeniumdiolated amidines
  2. Biswas, D.; Deschamps, J. R.; Keefer, L. K.; Hrabie, J. A.
  3. Chemical Communications. 2010, Aug 21; 46(31): 5799-5801.
  1. 12.   Arylation of Sensitive 1-(Pyrrolidin-1-yl)-diazen-1-ium-diolate in Ionic Liquids
  2. Velazquez, C. A.; Lynn, G. M.; Kumar, V.; Keefer, L. K.; Malhotra, S. V.
  3. Synthetic Communications. 2010, Apr 7; 40(9): 1322-1332.
  1. 13.   JS-K has potent anti-angiogenic activity in vitro and inhibits tumour angiogenesis in a multiple myeloma model in vivo
  2. Kiziltepe, T.; Anderson, K. C.; Kutok, J. L.; Jia, L.; Boucher, K. M.; Saavedra, J. E.; Keefer, L. K.; Shami, P. J.
  3. Journal of Pharmacy and Pharmacology. 2010, Jan; 62(1): 145-151.
  1. 14.   Nitric oxide prodrug JS-K inhibits ubiquitin E1 and kills tumor cells retaining wild-type p53
  2. Kitagaki, J.; Yang, Y.; Saavedra, J. E.; Colburn, N. H.; Keefer, L. K.; Perantoni, A. O.
  3. Oncogene. 2009 28(4): 619-624.
  1. 15.   Gene expression profiling for nitric oxide prodrug JS-K to kill HL-60 myeloid leukemia cells
  2. Liu, J.; Malavya, S.; Wang, X. Q.; Saavedra, J. E.; Keefer, L. K.; Tokar, E.; Qu, W.; Waalkes, M. P.; Shami, P. J.
  3. Genomics. 2009 94(1): 32-38.
  1. 16.   Synthesis and evaluation of piperazine and homopiperazine analogues of JS-K, an anti-cancer lead compound
  2. Nandurdikar, R. S.; Maciag, A. E.; Citro, M. L.; Shami, P. J.; Keefer, L. K.; Saavedra, J. E.; Chakrapani, H.
  3. Bioorganic & Medicinal Chemistry Letters. 2009 19(10): 2760-2762.
  1. 17.   JS-K, an arylating nitric oxide (NO) donor, has synergistic anti-leukemic activity with cytarabine (ARA-C)
  2. Shami, P. J.; Maciag, A. E.; Eddington, J. K.; Udupi, V.; Kosak, K. M.; Saavedra, J. E.; Keefer, L. K.
  3. Leukemia Research. 2009 33(11): 1525-1529.
  1. 18.   Aryl Bis(diazeniumdiolates): Potent Inducers of S-Glutathionylation of Cellular Proteins and Their in Vitro Antiproliferative Activities
  2. Andrei, D.; Maciag, A. E.; Chakrapani, H.; Citro, M. L.; Keefer, L. K.; Saavedra, J. E.
  3. Journal of Medicinal Chemistry. 2008 51(24): 7944-7952.
  1. 19.   Synthesis, mechanistic studies, and anti-proliferative activity of glutathione/glutathione S-transferase-activated nitric oxide prodrugs
  2. Chakrapani, H.; Kalathur, R. C.; Maciag, A. E.; Citro, M. L.; Ji, X. H.; Keefer, L. K.; Saavedra, J. E.
  3. Bioorganic & Medicinal Chemistry. 2008 16(22): 9764-9771.
  1. 20.   Cell-Permeable Esters of Diazeniumdiolate-Based Nitric Oxide Prodrugs
  2. Chakrapani, H.; Maciag, A. E.; Citro, M. L.; Keefer, L. K.; Saavedra, J. E.
  3. Organic Letters. 2008 10(22): 5155-5158.
  1. 21.   JS-K, a nitric oxide prodrug, induces cytochrome c release and caspase activation in HL-60 myeloid leukemia cells
  2. Udupi, V.; Yu, M.; Malaviya, S.; Saavedra, J. E.; Shami, P. J.
  3. Leukemia Research. 2006, Oct; 30(10): 1279-1283.
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