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  1. 1.   Modulation of Target Antigen Density Improves CAR T-cell Functionality and Persistence
  2. Ramakrishna, Sneha; Highfill, Steven L.; Walsh, Zachary; Nguyen, Sang M.; Lei, Haiyan; Shern, Jack F.; Qin, Haiying; Kraft, Ira L.; Stetler-Stevenson, Maryalice; Yuan, Constance M.; Hwang, Jennifer D.; Feng,Yang; Zhu, Zhongyu; Dimitrov, Dimiter; Shah, Nirali N.; Fry, Terry J.
  3. CLINICAL CANCER RESEARCH. 2019, Sep 1; 25(17): 5329-5341.
  1. 2.   alpha-Arylidene Diacylglycerol-Lactones (DAG-Lactones) as Selective Ras Guanine-Releasing Protein 3 (RasGRP3) Ligands
  2. Ann, Jihyae; Czikora, Agnes; Saini, Amandeep S.; Zhou, Xiaoling; Mitchell, Gary A.; Lewin, Nancy E.; Peach, Megan; Blumberg, Peter M.; Lee, Jeewoo
  3. Journal of Medicinal Chemistry. 2018, Jul 26; 61(14): 6261-6276.
  1. 3.   Crosstalk between PKC alpha and PI3K/AKT Signaling Is Tumor Suppressive in the Endometrium
  2. Hsu, Alice; Lum, Michelle A.; Shim, Kang-Sup; Frederick, Peter J.; Morrison, Carl D.; Chen, Baojiang; Lele, Subodh M.; Sheinin, Yuri M.; Daikoku, Takiko; Dey, Sudhansu K.; Leone, Gustavo; Black, Adrian R.; Black, Jennifer D.
  3. CELL REPORTS. 2018, Jul 17; 24(3): 655-669.
  1. 4.   Ceramide Transfer Protein and Cancer
  2. Scheffer, L.; Raghavendra, P. R.; Ma, J. J.; Acharya, J. K.
  3. Anti-cancer agents in medicinal chemistry. 2011, Nov; 11(9): 904-910.
  1. 5.   N-Methyl-Substituted Fluorescent DAG-Indololactone Isomers Exhibit Dramatic Differences in Membrane Interactions and Biological Activity
  2. Gal, N.; Kolusheva, S.; Kedei, N.; Telek, A.; Naeem, T. A.; Lewin, N. E.; Lim, L.; Mannan, P.; Garfield, S. H.; El Kazzouli, S.; Sigano, D. M.; Marquez, V. E.; Blumberg, P. M.; Jelinek, R.
  3. Chembiochem. 2011, Oct; 12(15): 2331-2340.
  1. 6.   Role of vascular K(ATP) channels in blood pressure variability after sinoaortic denervation in rats
  2. Yang, Z. W.; Li, D. J.; Liu, C.; Han, P.; Yang, Y. L.; Su, D. F.; Shen, F. M.
  3. Acta Pharmacologica Sinica. 2011, Feb; 32(2): 194-200.
  1. 7.   Membrane-Surface Anchoring of Charged Diacylglycerol-Lactones Correlates with Biological Activities
  2. Raifman, O.; Kolusheva, S.; El Kazzouli, S.; Sigano, D. M.; Kedei, N.; Lewin, N. E.; Lopez-Nicolas, R.; Ortiz-Espin, A.; Gomez-Fernandez, J. C.; Blumberg, P. M.; Marquez, V. E.; Corbalan-Garcia, S.; Jelinek, R.
  3. Chembiochem. 2010, Sep; 11(14): 2003-2009.
  1. 8.   Molecular Modeling, Total Synthesis, and Biological Evaluations of C9-Deoxy Bryostatin 1
  2. Keck, G. E.; Poudel, Y. B.; Rudra, A.; Stephens, J. C.; Kedei, N.; Lewin, N. E.; Peach, M. L.; Blumberg, P. M.
  3. Angewandte Chemie-International Edition. 2010, Jun 21; 49(27): 4580-4584.
  1. 9.   Membrane anchoring of diacylglycerol lactones substituted with rigid hydrophobic acyl domains correlates with biological activities
  2. Raifman, O.; Kolusheva, S.; Comin, M. J.; Kedei, N.; Lewin, N. E.; Blumberg, P. M.; Marquez, V. E.; Jelinek, R.
  3. Febs Journal. 2010, Jan; 277(1): 233-243.
  1. 10.   Development of a High-Throughput Cell-Based Reporter Assay to Identify Stabilizers of Tumor Suppressor Pdcd4
  2. Blees, J. S.; Schmid, T.; Thomas, C. L.; Baker, A. R.; Benson, L.; Evans, J. R.; Goncharova, E. I.; Colburn, N. H.; McMahon, J. B.; Henrich, C. J.
  3. Journal of Biomolecular Screening. 2010, Jan; 15(1): 21-29.
  1. 11.   Conformationally Constrained Analogues of Diacylglycerol (DAG). 31. Modulation of the Biological Properties of Diacylgycerol Lactones (DAG-lactones) Containing Rigid-Rod Acyl Groups Separated from the Core Lactone by Spacer Units of Different Lengths
  2. Comin, M. J.; Czifra, G.; Kedei, N.; Telek, A.; Lewin, N. E.; Kolusheva, S.; Velasquez, J. F.; Kobylarz, R.; Jelinek, R.; Blumberg, P. M.; Marquez, V. E.
  3. Journal of Medicinal Chemistry. 2009 52(10): 3274-3283.
  1. 12.   Ceramides: Branched alkyl chains in the sphingolipid siblings of diacylglycerol improve biological potency
  2. Kang, J. H.; Garg, H.; Sigano, D. M.; Francella, N.; Blumenthal, R.; Marquez, V. E.
  3. Bioorganic & Medicinal Chemistry. 2009 17(4): 1498-1505.
  1. 13.   Lipid-Modulated Pharmacophore Nanorods Assembled at the Air/Water Interface
  2. Philosof-Mazor, L.; Volinsky, R.; Jopp, J.; Blumberg, P.; Rapaport, H.; Marquez, V. E.; Jelinek, R.
  3. Chemphyschem. 2009 10(15): 2615-2619.
  1. 14.   ARC (NSC 188491) has identical activity to Sangivamycin (NSC 65346) including inhibition of both P-TEFb and PKC
  2. Stockwin, L. H.; Yu, S. X.; Stotler, H.; Hollingshead, M. G.; Newton, D. L.
  3. Bmc Cancer. 2009 9(63): 1-13.
  1. 15.   Conformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activities
  2. Duan, D.; Sigano, D. M.; Kelley, J. A.; Lai, C. C.; Lewin, N. E.; Kedei, N.; Peach, M. L.; Lee, J.; Abeyweera, T. P.; Rotenberg, S. A.; Kim, H.; Kim, Y. H.; El Kazzouli, S.; Chung, J. U.; Young, H. A.; Young, M. R.; Baker, A.; Colburn, N. H.
  3. Journal of Medicinal Chemistry. 2008 51(17): 5198-5220.
  1. 16.   Conformationally constrained analogues of diacylglycerol. 30. An investigation of diacylglycerol-lactones containing heteroaryl groups reveals compounds with high selectivity for Ras guanyl nucleotide-releasing proteins
  2. El Kazzouli, S.; Lewin, N. E.; Blumberg, P. M.; Marquez, V. E.
  3. Journal of Medicinal Chemistry. 2008 51(17): 5371-5386.
  1. 17.   Self-assembly and lipid interactions of diacylglycerol lactone derivatives studied at the air/water interface
  2. Philosof-Mazor, L.; Volinsky, R.; Comin, M. J.; Lewin, N. E.; Kedei, N.; Blumberg, P. M.; Marquez, V. E.; Jelinek, R.
  3. Langmuir. 2008 24(19): 11043-11052.
  1. 18.   Conformationally constrained analogues of diacylglycerol (DAG). 28. DAG-dioxolanones reveal a new additional interaction site in the C1b domain of PKC delta
  2. Choi, Y.; Pu, Y.; Peach, M. L.; Kang, J. H.; Lewin, N. E.; Sigano, D. M.; Garfield, S. H.; Blumberg, P. M.; Marquez, V. E.
  3. Journal of Medicinal Chemistry. 2007, Jul; 50(15): 3465-3481.
  1. 19.   A high-throughput cell-based assay to identify specific inhibitors of transcription factor AP-1
  2. Ruocco, K. M.; Goncharova, E. I.; Young, M. R.; Colburn, N. H.; McMahon, J. B.; Henrich, C. J.
  3. Journal of Biomolecular Screening. 2007, Feb; 12(1): 133-139.
  1. 20.   The regulation of acetylcholinesterase by cis-elements within intron I in cultured contracting myotubes
  2. Cohen, T. V.; R, all
  3. Journal of Neurochemistry. 2006, Aug; 98(3): 723-734.
  1. 21.   Actin is the primary cellular receptor of bistramide A
  2. Statsuk, A. V.; Bai, R. L.; Baryza, J. L.; Verma, V. A.; Hamel, E.; Wender, P. A.; Kozmin, S. A.
  3. Nature Chemical Biology. 2005, DEC; 1(7): 383-388.
  1. 22.   Evidence for the involvement of tyrosine kinase ZAP 70 in nuclear retinoid receptor-dependent transactivation in T lymphocytes
  2. Ishaq, M.; DeGray, G.; Natarajan, V.
  3. Journal of Biological Chemistry. 2005, OCT 7; 280(40): 34152-34158.
  1. 23.   ATP-regulated module (ARM) of the atrial natriuretic factor receptor guanylate cyclase
  2. Duda, T.; Venkataraman, V.; Ravichandran, S.; Sharma, R. K.
  3. Peptides. 2005, JUN; 26(6): 969-984.
  1. 24.   Inositol hexaphosphate (IP6) blocks proliferation of human breast cancer cells through a PKC delta-dependent increase in p27(Kip1) and decrease in retinoblastoma protein (pRb) phosphorylation
  2. Vucenik, I.; Ramakrishna, G.; Tantivejkul, K.; Anderson, L. M.; Ramljak, D.
  3. Breast Cancer Research and Treatment. 2005, MAY; 91(1): 35-45.
  1. 25.   PKC delta plays opposite roles in growth mediated by wild-type Kit and an oncogenic Kit mutant
  2. Jelacic, T.; Linnekin, D.
  3. Blood. 2005, MAR 1; 105(5): 1923-1929.
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