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  1. 1.   SHP2 clinical phenotype, cancer, or RASopathies, can be predicted by mutant conformational propensities
  2. Liu,Yonglan; Zhang,Wengang; Jang,Hyunbum; Nussinov,Ruth
  3. Cellular and Molecular Life Sciences : CMLS. 2023, Dec 12; 81(1): 5.
  1. 2.   Mapping the KRAS Proteoform Landscape in Colorectal Cancer Identifies Truncated KRAS4B that Decreases MAPK Signaling
  2. Adams, Lauren M; Dehart,Caroline; Drown, Bryon S; Anderson, Lissa C; Bocik,William; Boja, Emily S; Hiltke, Tara M; Hendrickson, Christopher L; Rodriguez, Henry; Caldwell, Michael; Vafabakhsh, Reza; Kelleher, Neil L
  3. The Journal of Biological Chemistry. 2022, Dec 02; 299(1): 102768.
  1. 3.   The mechanism of Raf activation through dimerization
  2. Zhang,Mingzhen; Maloney,Ryan; Jang,Hyunbum; Nussinov,Ruth
  3. Chemical Science. 2021, Dec 08; 12(47): 15609-15619.
  1. 4.   The quaternary assembly of KRas4B with Raf-1 at the membrane
  2. Jang,Hyunbum; Zhang,Mingzhen; Nussinov,Ruth
  3. Computational and Structural Biotechnology Journal. 2020, Mar 25; 18: 737-748.
  1. 5.   Biochemical and structural analyses reveal that the tumor suppressor neurofibromin (NF1) forms a high-affinity dimer
  2. Sherekar,Mukul; Han, Sae-Won; Ghirlando, Rodolfo; Messing,Simon; Drew,Matt; Rabara,Dana; Waybright,Tim; Juneja, Puneet; O'Neill, Hugh; Stanley, Christopher B; Bhowmik, Debsindhu; Ramanathan, Arvind; Subramaniam,Sriram; Nissley,Dwight; Gillette,Bill; McCormick, Frank; Esposito,Dom
  3. The Journal of biological chemistry. 2020, JAN 24; 295(4): 1105-1119.
  1. 6.   Quantitative biophysical analysis defines key components modulating recruitment of the GTPase KRAS to the plasma membrane
  2. Bindu, Lakshman; Messing, Simon; Schmid, Eva M.; Clogston, Jeffrey; Gillette, Bill; Esposito, Dom; Kessing, Bailey; Fletcher, Daniel A.; Nissley, Dwight; McCormick, Frank; Stephen, Andy; Jean-Francois, Frantz
  3. JOURNAL OF BIOLOGICAL CHEMISTRY. 2019, Feb 8; 294(6): 2193-2207.
  1. 7.   Raf-1 Cysteine-Rich Domain Increases the Affinity of K-Ras/Raf at the Membrane, Promoting MAPK Signaling
  2. Li, Shuai; Jang, Hyunbum; Zhang, Jian; Nussinov, Ruth
  3. Structure . 2018, Mar 6; 26(3): 513-+.
  1. 8.   RAS Proteins and Their Regulators in Human Disease
  2. Simanshu, Dhirendra; Nissley, Dwight; McCormick, Frank
  3. Cell. 2017, Jun 29; 170(1): 17-33.
  1. 9.   Genetic Inactivation of ERK1 and ERK2 in Chondrocytes Promotes Bone Growth and Enlarges the Spinal Canal
  2. Sebastian, A.; Matsushita, T.; Kawanami, A.; Mackem, S.; Landreth, G. E.; Murakami, S.
  3. Journal of Orthopaedic Research. 2011, Mar; 29(3): 375-379.
  1. 10.   A role for mixed lineage kinases in regulating transcription factor CCAAT/enhancer-binding protein-beta-dependent gene expression in response to interferon-gamma
  2. Roy, S. K.; Shuman, J. D.; Platanias, L. C.; Shapiro, P. S.; Reddy, S. P. M.; Johnson, P. F.; Kalvakolanu, D. V.
  3. Journal of Biological Chemistry. 2005, JUL 1; 280(26): 24462-24471.
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