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  1. 1.   Oral recombinant methioninase increases TRAIL receptor-2 expression to regress pancreatic cancer in combination with agonist tigatuzumab in an orthotopic mouse model
  2. Yamamoto, Jun; Miyake, Kentaro; Han, Qinghong; Tan, Yuying; Inubushi, Sachiko; Sugisawa, Norihiko; Higuchi, Takashi; Tashiro, Yoshihiko; Nishino, Hiroto; Homma, Yuki; Matsuyama, Ryusei; Chawla, Sant P; Bouvet, Michael; Singh,Shree Ram; Endo, Itaru; Hoffman, Robert M
  3. Cancer letters. 2020, NOV 1; 492: 174-184.
  1. 2.   Recombinant Methioninase Combined With Tumor-targeting Salmonella typhimurium A1-R Induced Regression in a PDOX Mouse Model of Doxorubicin-resistant Dedifferentiated Liposarcoma
  2. Igarashi, Kentaro; Kawaguchi, Kei; Zhao, Ming; Han, Qinghong; Tan, Yuying; Kiyuna, Tasuku; Miyake, Kentaro; Higuchi, Takashi; Nelson, Scott D; Dry, Sarah M; Li, Yunfeng; Yamamoto, Norio; Hayashi, Katsuhiro; Kimura, Hiroaki; Miwa, Shinji; Singh,Shree Ram; Tsuchiya, Hiroyuki; Hoffman, Robert M
  3. Anticancer research. 2020, May; 40(5): 2515-2523.
  1. 3.   Combination of oral recombinant methioninase and decitabine arrests a chemotherapy-resistant undifferentiated soft-tissue sarcoma patient-derived orthotopic xenograft mouse model
  2. Higuchi, Takashi; Han, Qinghong; Miyake, Kentaro; Oshiro, Hiromichi; Sugisawa, Norihiko; Tan, Yuying; Yamamoto, Norio; Hayashi, Katsuhiro; Kimura, Hiroaki; Miwa, Shinji; Igarashi, Kentaro; Bouvet, Michael; Singh,Shree Ram; Tsuchiya, Hiroyuki; Hoffman, Robert M
  3. Biochemical and biophysical research communications. 2020, FEB 26; 523(1): 135-139.
  1. 4.   Oral recombinant methioninase combined with oxaliplatinum and 5-fluorouracil regressed a colon cancer growing on the peritoneal surface in a patient-derived orthotopic xenograft mouse model
  2. Park, Jun Ho; Han, Qinghong; Zhao, Ming; Tan, Yuying; Higuchi, Takashi; Yoon, Sang Nam; Sugisawa, Norihiko; Yamamoto, Jun; Bouvet, Michael; Clary, Bryan; Singh,Shree Ram; Hoffman, Robert M
  3. Tissue & cell. 2019, Dec; 61: 109-114.
  1. 5.   The combination of oral-recombinant methioninase and azacitidine arrests a chemotherapy-resistant osteosarcoma patient-derived orthotopic xenograft mouse model
  2. Higuchi, Takashi; Sugisawa, Norihiko; Yamamoto, Jun; Oshiro, Hiromichi; Han, Qinghong; Yamamoto, Norio; Hayashi, Katsuhiro; Kimura, Hiroaki; Miwa, Shinji; Igarashi, Kentaro; Tan, Yuying; Kuchipudi, Shreya; Bouvet, Michael; Singh,Shree Ram; Tsuchiya, Hiroyuki; Hoffman, Robert M
  3. Cancer chemotherapy and pharmacology. 2019, Nov 08;
  1. 6.   Efficacy of oral recombinant methioninase combined with oxaliplatinum and 5-fluorouracil on primary colon cancer in a patient-derived orthotopic xenograft mouse model
  2. Park, Jun Ho; Zhao, Ming; Han, Qinghong; Sun, Yu; Higuchi, Takashi; Sugisawa, Norihiko; Yamamoto, Jun; Singh,Shree Ram; Clary, Bryan; Bouvet, Michael; Hoffman, Robert M
  3. Biochemical and biophysical research communications. 2019, Oct 15; 518(2): 306-310.
  1. 7.   Oral Recombinant Methioninase Overcomes Colorectal-cancer Liver Metastasis Resistance to the Combination of 5-Fluorouracil and Oxaliplatinum in a Patient-derived Orthotopic Xenograft Mouse Model
  2. Oshiro, Hiromichi; Tome, Yasunori; Kiyuna, Tasuku; Yoon, Sang Nam; Lwin, Thinzar M; Han, Qinghong; Tan, Yuying; Miyake, Kentaro; Higuchi, Takashi; Sugisawa, Norihiko; Katsuya, Yuki; Park, Jun Ho; Zang, Zhiying; Razmjooei, Sahar; Bouvet, Michael; Clary, Bryan; Singh,Shree Ram; Kanaya, Fuminori; Nishida, Kotaro; Hoffman, Robert M
  3. Anticancer research. 2019, Sep; 39(9): 4667-4671.
  1. 8.   Combining Tumor-Selective Bacterial Therapy with Salmonella typhimurium A1-R and Cancer Metabolism Targeting with Oral Recombinant Methioninase Regressed an Ewing's Sarcoma in a Patient-Derived Orthotopic Xenograft Model
  2. Miyake, Kentaro; Kiyuna, Tasuku; Li, Shukuan; Han, Qinghong; Tan, Yuying; Zhao, Ming; Oshiro, Hiromichi; Kawaguchi, Kei; Higuchi, Takashi; Zhang, Zhiying; Razmjooei, Sahar; Barangi, Maryam; Wangsiricharoen, Sintawat; Murakami, Takashi; Singh, Arun S.; Li, Yunfeng; Nelson, Scott D.; Eilber, Fritz C.; Bouvet, Michael; Hiroshima, Yukihiko; Chishima, Takashi; Matsuyama, Ryusei; Singh,Shree Ram; Endo, Itaru; Hoffman, Robert M.
  3. Chemotherapy. 2019, Feb; 63(5): 278-283.
  1. 9.   Metabolic targeting with recombinant methioninase combined with palbociclib regresses a doxorubicin-resistant dedifferentiated liposarcoma
  2. Igarashi, Kentaro; Kawaguchi, Kei; Kiyuna, Tasuku; Miyake, Kentaro; Miyaki, Masuyo; Yamamoto, Norio; Hayashi, Katsuhiro; Kimura, Hiroaki; Miwa, Shinji; Higuchi, Takashi; Singh, Arun S.; Chmielowski, Bartosz; Nelson, Scott D.; Russell, Tara A.; Eckardt, Mark A.; Dry, Sarah M.; Li, Yunfeng; Singh,Shree Ram; Chawla, Sant P.; Eilber, Fritz C.; Tsuchiya, Hiroyuki; Hoffman, Robert M.
  3. Biochemical and biophysical research communications. 2018, Dec 2; 506(4): 912-917.
  1. 10.   Combination therapy of tumor-targeting Salmonella typhimurium A1-R and oral recombinant methioninase regresses a BRAF-V600E-negative melanoma
  2. Kawaguchi, Kei; Higuchi, Takashi; Li, Shukuan; Han, Qinghong; Tan, Yuying; Igarashi, Kentaro; Zhao, Ming; Miyake, Kentaro; Kiyuna, Tasuku; Miyake, Masuyo; Ohshiro, Hiromichi; Sugisawa, Norihiko; Zhang, Zhiying; Razmjooei, Sahar; Wangsiricharoen, Sintawat; Chmielowski, Bartosz; Nelson, Scott D; Russell, Tara A; Dry, Sarah M; Li, Yunfeng; Eckardt, Mark A; Singh, Arun S; Singh, Shree Ram; Eilber, Fritz C; Unno, Michiaki; Hoffman, Robert M
  3. Biochemical and Biophysical Research Communications. 2018, Sep 18; 503(4): 3086-3092.
  1. 11.   Recombinant methioninase in combination with DOX overcomes first-line DOX resistance in a patient-derived orthotopic xenograft nude-mouse model of undifferentiated spindle-cell sarcoma
  2. Igarashi, Kentaro; Kawaguchi, Kei; Li, Shukuan; Han, Qinghong; Tan, Yuying; Murakami, Takashi; Kiyuna, Tasuku; Miyake, Kentaro; Miyake, Masuyo; Singh, Arun S; Eckhardt, Mark A; Nelson, Scott D; Russell, Tara A; Dry, Sarah M; Li, Yunfeng; Yamamoto, Norio; Hayashi, Katsuhiro; Kimura, Hiroaki; Miwa, Shinji; Tsuchiya, Hiroyuki; Singh, Shree Ram; Eilber, Fritz C; Hoffman, Robert M
  3. Cancer Letters. 2018, MAR 28; 417: 168-173.
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