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  1. 1.   alpha-Arylidene Diacylglycerol-Lactones (DAG-Lactones) as Selective Ras Guanine-Releasing Protein 3 (RasGRP3) Ligands
  2. Ann, Jihyae; Czikora, Agnes; Saini, Amandeep S.; Zhou, Xiaoling; Mitchell, Gary A.; Lewin, Nancy E.; Peach, Megan; Blumberg, Peter M.; Lee, Jeewoo
  3. Journal of Medicinal Chemistry. 2018, Jul 26; 61(14): 6261-6276.
  1. 2.   Reversing the Paradigm: Protein Kinase C as a Tumor Suppressor
  2. Newton, Alexandra C.; Brognard, John
  3. TRENDS IN PHARMACOLOGICAL SCIENCES. 2017, May; 38(5): 438-447.
  1. 3.   Structural Basis for the Failure of the C1 Domain of Ras Guanine Nucleotide Releasing Protein 2 (RasGRP2) to Bind Phorbol Ester with High Affinity.
  2. Czikora, Agnes; Lundberg, Daniel J; Abramovitz, Adelle; Lewin, Nancy E; Kedei, Noemi; Peach, Megan L; Zhou, Xiaoling; Merritt, Raymond C; Craft, Elizabeth A; Braun, Derek C; Blumberg, Peter M
  3. The Journal of biological chemistry. 2016, May 20; 291(21): 11133-47.
  1. 4.   N-Methyl-Substituted Fluorescent DAG-Indololactone Isomers Exhibit Dramatic Differences in Membrane Interactions and Biological Activity
  2. Gal, N.; Kolusheva, S.; Kedei, N.; Telek, A.; Naeem, T. A.; Lewin, N. E.; Lim, L.; Mannan, P.; Garfield, S. H.; El Kazzouli, S.; Sigano, D. M.; Marquez, V. E.; Blumberg, P. M.; Jelinek, R.
  3. Chembiochem. 2011, Oct; 12(15): 2331-2340.
  1. 5.   High Throughput Extraction of Plant, Marine and Fungal Specimens for Preservation of Biologically Active Molecules
  2. McCloud, T. G.
  3. Molecules. 2010, Jul; 15(7): 4526-4563.
  1. 6.   Molecular Modeling, Total Synthesis, and Biological Evaluations of C9-Deoxy Bryostatin 1
  2. Keck, G. E.; Poudel, Y. B.; Rudra, A.; Stephens, J. C.; Kedei, N.; Lewin, N. E.; Peach, M. L.; Blumberg, P. M.
  3. Angewandte Chemie-International Edition. 2010, Jun 21; 49(27): 4580-4584.
  1. 7.   Conformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activities
  2. Duan, D.; Sigano, D. M.; Kelley, J. A.; Lai, C. C.; Lewin, N. E.; Kedei, N.; Peach, M. L.; Lee, J.; Abeyweera, T. P.; Rotenberg, S. A.; Kim, H.; Kim, Y. H.; El Kazzouli, S.; Chung, J. U.; Young, H. A.; Young, M. R.; Baker, A.; Colburn, N. H.
  3. Journal of Medicinal Chemistry. 2008 51(17): 5198-5220.
  1. 8.   Conformationally constrained analogues of diacylglycerol. 30. An investigation of diacylglycerol-lactones containing heteroaryl groups reveals compounds with high selectivity for Ras guanyl nucleotide-releasing proteins
  2. El Kazzouli, S.; Lewin, N. E.; Blumberg, P. M.; Marquez, V. E.
  3. Journal of Medicinal Chemistry. 2008 51(17): 5371-5386.
  1. 9.   Conformationally constrained analogues of diacylglycerol (DAG). 28. DAG-dioxolanones reveal a new additional interaction site in the C1b domain of PKC delta
  2. Choi, Y.; Pu, Y.; Peach, M. L.; Kang, J. H.; Lewin, N. E.; Sigano, D. M.; Garfield, S. H.; Blumberg, P. M.; Marquez, V. E.
  3. Journal of Medicinal Chemistry. 2007, Jul; 50(15): 3465-3481.
  1. 10.   Conformationally constrained analogues of diacylglycerol. 26. Exploring the chemical space surrounding the C1 domain of protein kinase C with DAG-lactones containing aryl groups at the sn-1 and sn-2 positions
  2. Kang, J. H.; Benzaria, S.; Sigano, D. M.; Lewin, N. E.; Pu, Y. M.; Peach, M. L.; Blumberg, P. M.; Marquez, V. E.
  3. Journal of Medicinal Chemistry. 2006, Jun; 49(11): 3185-3203.
  1. 11.   Conformationally constrained analogues of diacylglycerol (DAG). 23. Hydrophobic ligand-protein interactions versus ligand-lipid interactions of DAG-lactones with protein kinase C (PK-C)
  2. Tamamura, H.; Sigano, D. M.; Lewin, N. E.; Peach, M. L.; Nicklaus, M. C.; Blumberg, P. M.; Marquez, V. E.
  3. Journal of Medicinal Chemistry. 2004, SEP 23; 47(20): 4858-4864.
  1. 12.   Conformationally constrained diacylglycerol (DAG) analogs: 4-C-hydroxyethyl-5-O-acyl-2,3-dideoxy-D-glyceropentono-1,4-lactone analogs as protein kinase C (PKC) ligands
  2. Lee, J.; Kim, S. Y.; Kang, J. H.; Acs, G.; Acs, P.; Blumberg, P. M.; Marquez, V. E.
  3. European Journal of Medicinal Chemistry. 2004 39(1): 69-77.
  1. 13.   Induction of tumors of the liver, lung, ovary and adrenal in adult mice after brief maternal gestational exposure to inorganic arsenic: promotional effects of postnatal phorbol ester exposure on hepatic and pulmonary, but not dermal cancers
  2. Waalkes, M. P.; Ward, J. M.; Diwan, B. A.
  3. Carcinogenesis. 2004 25(1): 133-141.
  1. 14.   Conformationally constrained analogues of diacylglycerol. 20. The search for an elusive binding site on protein kinase C through relocation of the carbonyl pharmacophore along the sn-1 side chain of 1,2-diacylglycerol lactones
  2. Tamamura, H.; Sigano, D. M.; Lewin, N. E.; Blumberg, P. M.; Marquez, V. E.
  3. Journal of Medicinal Chemistry. 2004 47(3): 644-655.
  1. 15.   Mechanisms underlying arsenic carcinogenesis: hypersensitivity of mice exposed to inorganic arsenic during gestation
  2. Waalkes, M. P.; Liu, J.; Ward, J. M.; Diwan, L. A.
  3. Toxicology. 2004 198(1-3): 31-38.
  1. 16.   Conformationally constrained analogues of diacylglycerol. 21. A solid-phase method of synthesis of diacylglycerol lactones as a prelude to a combinatorial approach for the synthesis of protein kinase C isozyme-specific ligands
  2. Duan, D. H.; Lewin, N. E.; Sigano, D. M.; Blumberg, P. M.; Marquez, V. E.
  3. Journal of Medicinal Chemistry. 2004 47(12): 3248-3254.
  1. 17.   Arachidonic acid triggers an oxidative burst in leukocytes
  2. Pompeia, C.; Cury-Boaventura, M. F.; Curi, R.
  3. Brazilian Journal of Medical and Biological Research. 2003 36(11): 1549-1560.
  1. 18.   Conformationally constrained analogues of diacylglycerol (DAG). Effect on protein kinase C (PK-C) binding by the isosteric replacement of Sn-1 and Sn-2 esters in DAG-lactones
  2. Kang, J. H.; Chung, H. E.; Kim, S. Y.; Kim, Y.; Lee, J.; Lewin, N. E.; Pearce, L. V.; Blumberg, P. M.; Marquez, V. E.
  3. Bioorganic & Medicinal Chemistry. 2003 11(12): 2529-2539.
  1. 19.   Rational design of drugs that induce human immunodeficiency virus replication
  2. Hamer, D. H.; Bocklandt, S.; McHugh, L.; Chun, T. W.; Blumberg, P. M.; Sigano, D. M.; Marquez, V. E.
  3. Journal of Virology. 2003 77(19): 10227-10236.
  1. 20.   Synthetic diacylglycerols (DAG) and DAG-lactones as activators of protein kinase C (PK-C)
  2. Marquez, V. E.; Blumberg, P. M.
  3. Accounts of Chemical Research. 2003 36(6): 434-443.
  1. 21.   Isolation and structure of pedilstatin from a Republic of Maldives Pedilanthus sp
  2. Pettit, G. R.; Ducki, S.; Tan, R.; Gardella, R. S.; McMahon, J. B.; Boyd, M. R.; Blumberg, P. M.; Lewin, N. E.; Doubek, D. L.; Tackett, L. P.; Williams, M. D.
  3. Journal of Natural Products. 2002 65(9): 1262-1265.
  1. 22.   Diacylglycerol (DAG)-lactones, a new class of protein kinase C (PKC) agonists, induce apoptosis in LNCaP prostate cancer cells by selective activation of PKC alpha
  2. Garcia-Bermejo, M. L.; Leskow, F. C.; Fujii, T.; Wang, Q. M.; Blumberg, P. M.; Ohba, M.; Kuroki, T.; Han, K. C.; Lee, J.; Marquez, V. E.; Kazanietz, M. G.
  3. Journal of Biological Chemistry. 2002 277(1): 645-655.
  1. 23.   An optimized protein kinase C activating diacylglycerol combining high binding affinity (K-i) with reduced lipophilicity (log P)
  2. Nacro, K.; Sigano, D. M.; Yan, S. Q.; Nicklaus, M. C.; Pearce, L. L.; Lewin, N. E.; Garfield, S. H.; Blumberg, P. M.; Marquez, V. E.
  3. Journal of Medicinal Chemistry. 2001 44(12): 1892-1904.
  1. 24.   Conformationally constrained analogues of diacylglycerol. 18. The incorporation of a hydroxamate moiety into diacylglycerol- lactones reduces lipophilicity and helps discriminate between sn-1 and sn-2 binding modes to protein kinase c (PK-C). Implications for isozyme specificity
  2. Lee, J.; Han, K. C.; Kang, J. H.; Pearce, L. L.; Lewin, N. E.; Yan, S. Q.; Benzaria, S.; Nicklaus, M. C.; Blumberg, P. M.; Marquez, V. E.
  3. Journal of Medicinal Chemistry. 2001 44(25): 4309-4312.
  1. 25.   Tumor promoter benzoyl peroxide induces sulfhydryl oxidation in protein kinase C: Its reversibility is related to the cellular resistance to peroxide-induced cytotoxicity
  2. Gopalakrishna, R.; Gundimeda, U.; Anderson, W. B.; Colburn, N. H.; Slaga, T. J.
  3. Archives of Biochemistry and Biophysics. 1999 363(2): 246-258.
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